Best Enzyme Supplements of 2025

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 16, 2025

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Enzyme supplements are becoming increasingly popular as people seek ways to support their digestive health. These supplements contain various enzymes that help break down food in the digestive system, making it easier for the body to absorb nutrients. Some of the most common enzymes found in these supplements include protease, amylase, and lipase. Protease helps break down proteins, amylase aids in the digestion of carbohydrates, and lipase helps break down fats. Enzyme supplements are available in various forms, including capsules, powders, and chewable tablets, and can be used to support overall digestive health or to address specific digestive issues.

At a Glance: Our Top Picks

NOW Supplements Super Enzymes Cover #TOP 1
NOW Supplements Super Enzymes
ftb score rating icon 9.9
Physician's CHOICE Digestive Enzymes Cover #TOP 2
Physician's CHOICE Digestive Enzymes
ftb score rating icon 9.8
Zenwise Probiotic Digestive Multi Enzymes Cover #TOP 3
Zenwise Probiotic Digestive Multi Enzymes
ftb score rating icon 9.6

Top 10 Enzyme Supplements

#TOP 1

NOW Supplements Super Enzymes

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NOW Supplements Super Enzymes Cover
NOW Foods Supplements, Super Enzymes, Formulated with Bromelain, Ox Bile, Pancreatin and Papain,180 Capsules

NOW Supplements Super Enzymes is a comprehensive blend of enzymes that supports healthy digestion. Formulated with bromelain, ox bile, pancreatin and papain, Super Enzymes helps to optimize the breakdown of fats, carbohydrates and protein. It is Soy Free, Made without Gluten, Keto Friendly and GMP Quality Assured. Customers have reported that it helps with digestive issues, bloating, slow metabolism, and acid indigestion. It is easy to swallow and comes in capsule form.

What We Like
Reduces bloating and discomfort
Improves nutrient absorption
Safe and affordable
Full-spectrum enzyme support
What We Don't Like
May cause night discomfort
Effectiveness might decrease over time
#TOP 2

Physician's CHOICE Digestive Enzymes

Physician's CHOICE Digestive Enzymes Cover
Physician's CHOICE Digestive Enzymes - Multi Enzymes, Organic Prebiotics & Probiotics for Digestive Health & Gut Health - Meal Time Discomfort Relief & Bloating - Dual Action Approach - 60 CT

Physician's CHOICE Enzymes is a powerful digestive health supplement designed to provide relief from mealtime discomfort. With 16 beneficial enzymes, it helps digest proteins, carbs, fruits, veggies, beans, dairy, and fats, making it suitable for all diets. The dual action approach combines digestive enzymes with prebiotics and probiotics to promote healthy digestion and gut function. The probiotics in this supplement are specially selected for their ability to survive the harsh gut environment, and the organic prebiotics fuel the growth of healthy bacteria in the gut. Crafted based on scientific research, Physician's CHOICE Enzymes are 3rd-party tested for purity and potency, ensuring a safety assured standard of quality. Take control of your digestive health with Physician's CHOICE Enzymes.

What We Like
Effective for digestive health
Easy to take capsules
Affordable compared to other brands
Quick relief from discomfort
Supports normal gastrointestinal function
What We Don't Like
Some may prefer other brands
Herbal taste not appealing
#TOP 3

Zenwise Probiotic Digestive Multi Enzymes

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Zenwise Probiotic Digestive Multi Enzymes Cover
Zenwise Health Digestive Enzymes for Gut Health - Probiotic Multi Enzymes with Prebiotics and Probiotics for Women and Men for Digestive Health and Bloating Relief, Daily Enzymes for Digestion -180 CT

Zenwise Health's Probiotic Digestive Multi Enzymes is a pre-meal plant-powered pill formulated to help women and men find relief from occasional bloating, gas, and discomfort. This advanced enzyme + prebiotic, probiotic non-GMO formula tackles hard-to-digest foods and is clinically proven to be reliably alive. It contains botanical bounty such as turmeric, ginger, green papaya, inulin, apple pectin, bladderwrack, fennel, and wakame to aid gut health and stomach comfort. Each bottle contains 180 capsules, and it is suggested to take one capsule before each meal.

What We Like
Improves digestion significantly
Reduces gas and bloating
Easy to swallow
Positive impact on bowel movements
Effective for travel-related digestion
What We Don't Like
Mild stomach discomfort reported
Need to take with meals
#TOP 4

Source Naturals Essential Enzymes

Source Naturals Essential Enzymes Cover
Source Naturals Essential Enzymes 500mg Bio-Aligned Multiple Supplement Herbal Defense for Digestion, Gas & Constipation Relief - Strong Immune System Support* - 120 Capsules

Source Naturals Essential Enzymes is a bio-aligned multiple supplement herbal defense for digestion, gas, and constipation relief. It helps the body breakdown proteins, fats, milk sugars, fiber and carbohydrates, and is ideal for those who are busy or eat out. Customers have reported that it helps to regulate their stomach, works great without a high price, and has helped them avoid GERD. It is a great supplement for anyone with GI issues or bodybuilders who are consuming a large amount of calories daily.

What We Like
Effective for digestion support
Helps reduce bloating
No unpleasant taste or smell
Promotes weight management
Good value for price
What We Don't Like
May cause issues for gastritis patients

Double Wood's VitaZyme Digestive Blend

Double Wood's VitaZyme Digestive Blend Cover
Digestive Enzymes - 800mg Blend of All 10 Most Essential Digestive and Pancreatic Enzymes (Amylase, Lipase, Bromelain, Lactase, Papain, Protease, Cellulase, Maltase, Invertase) by Double Wood

Double Wood's VitaZyme Digestive Blend is a powerful 800mg blend of all 10 most essential digestive and pancreatic enzymes. It contains Amylase, Lipase, Bromelain, Lactase, Papain, Protease, Cellulase, Maltase, Invertase, and Glucoamylase to break down proteins, fats, and carbohydrates. It is Non-GMO, Gluten Free, and manufactured and tested for safety in the USA. Customers have reported improved digestion, bloating relief, and better absorption of nutrition.

What We Like
Effective for digestion issues
Affordable price point
Helps with gas and bloating
Good quality enzymes
Quick delivery
What We Don't Like
Some prefer other brands
#TOP 6

NatureBell Digestive Enzymes with Probiotics

BA-NB-DE240C
NatureBell Digestive Enzymes with Probiotics Cover
NatureBell Digestive Enzymes with Probiotics and Prebiotics, 240 Veggie Capsules | Gut & Digestive Health Support – 20 Enzyme & 5 Prebiotic Pancreatic Enzyme Complex | Non-GMO, Vegan Friendly

NatureBell Digestive Enzymes offers a comprehensive blend of digestive support in a convenient veggie capsule. With 240 capsules in a bottle, you can enjoy an 8-month supply, making it easy to incorporate into your daily routine. Each serving combines 20 digestive enzymes and 5 prebiotics, promoting better digestion and nutrient absorption. This unique formulation helps to alleviate bloating and supports overall gut health. Designed for both men and women, it aims to enhance your digestive balance and keep your gut flora thriving.

What We Like
Effective digestive aid
Improves digestion noticeably
Reduces bloating and discomfort
Convenient one-capsule dosage
Good value for the price
What We Don't Like
Strong odor of veggie capsules
No noticeable improvement for some
#TOP 7

Sports Research Digestive Enzymes

Sports Research Digestive Enzymes Cover
Sports Research Digestive Enzymes with Probiotics & Ginger - Plant Based for Dairy, Protein, Sugar & Carbs - Non-GMO Verified & Vegan Friendly (90 Veggie Capsules)

Sports Research Digestive Enzymes with Probiotics and Ginger is a plant-based supplement designed to help the body properly digest proteins, fats and carbohydrates, resulting in better nutrient absorption and less digestive discomfort. It is Non-GMO Project Verified, Vegan Certified and Gluten Free. Customers have reported positive results in their digestive system since taking this supplement.

What We Like
Effective for digestive issues
High-quality ingredients
Positive customer service experience
Competitive pricing
Easy to swallow capsules
What We Don't Like
Large capsule size
May interfere with medications
#TOP 8

Carlyle Digestive Enzymes with 14 Probiotic Strains

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Carlyle Digestive Enzymes with 14 Probiotic Strains Cover
Carlyle Digestive Enzymes | with Probiotics & Prebiotics | 180 Capsules | Non-GMO and Gluten Free Supplement for Men & Women

Carlyle Digestive Enzymes with 14 Probiotic Strains is a non-GMO and gluten-free supplement that provides full-spectrum digestive support. It contains bromelain and comes in quick-release capsules that can be taken before or after meals. Customers have reported improved regularity and reduced bloating and stomach pain. Some customers have not seen the desired results.

What We Like
Gluten and dairy free
Effective for digestion
Affordable price
Large quantity per bottle
Helps with IBS symptoms
What We Don't Like
Not the highest potency
#TOP 9

Wholesome Wellness Digestive Enzymes

digestive-enzymes
Green
Wholesome Wellness Digestive Enzymes Cover
Wholesome Wellness Digestive Enzymes 1000MG Plus Prebiotics & Probiotics Supplement, 180 Capsules, Organic Plant-Based Vegan Formula for Digestion & Lactose with Amylase & Bromelain,3-6 Months Supply

Wholesome Wellness Digestive Enzymes is a plant-based, organic supplement that helps improve digestion and gut health. With a 1000 MG dose of clinical grade digestive enzymes and a 10 billion CFU 10 strain probiotic with prebiotics, this supplement provides relief from bloating, flatulence, fat, pancreatic, and bowel cleansing. The Advanced Multi Enzyme System helps digest a variety of foods, including fried, spicy, raw, processed food, dairy, protein, salts, carb / carbohydrate, vitamin and acidic diet fruits and veggies. The supplement also contains a powerful 10 billion CFU dose of 10 different probiotic strains clinically shown to enhance preventions & immune system response.

What We Like
Effective for digestion issues
Quick absorption and fast-acting
Plant-based and vegan formula
Improves energy and overall health
Easy to swallow
What We Don't Like
Some users prefer other brands
Limited information disclosure

American Health Super Papaya Plus Digestive Enzyme Chewable Tablets

American Health Super Papaya Plus Digestive Enzyme Chewable Tablets Cover
American Health Super Papaya Enzyme Plus Chewable Tablets, Natural Papaya Flavor - Promotes Digestion & Nutrient Absorption, Contains Papain & Other Enzymes - 360 Count

American Health Super Papaya Plus Digestive Enzyme Chewable Tablets are a great-tasting, vegetarian formula that helps with digestion and nutrient absorption. It contains papain and other enzymes, as well as peppermint and chlorophyll to freshen breath and reduce bad taste. Customers have found it to be helpful with inefficient digestion, nausea, upset stomach, acid reflux, and digestion. It is gluten-free, wheat-free, lactose-free, egg-free, preservative-free, yeast-free, milk-free, soy-free, grapefruit-free, sodium-free, and artificial color-free.

What We Like
Effective for digestion
Great taste
Convenient large bottle size
Fast relief from discomfort
Helps prevent GI issues
What We Don't Like
Availability issues at local stores
Buying Guide Image

How to Select Enzyme Supplements: The Comprehensive Guide

Introduction

Enzyme supplements are becoming increasingly popular among people looking for a natural and safe way to improve their health. From aiding digestion to helping with nutrient absorption, enzyme supplements can be an important part of any health regimen. But with so many different enzyme supplements available, it can be difficult to know which one is right for you. This article will help you decide which enzyme supplement is best for your needs.

Types of Enzyme Supplements

There are several different types of enzyme supplements available, and each type has its own unique benefits. Here’s a look at some of the most popular types of enzyme supplements:

  • Proteolytic Enzymes: Proteolytic enzymes, also called proteases, are enzymes that break down proteins. They can help with digestion and nutrient absorption, as well as reducing inflammation.

  • Lipases: Lipases are enzymes that break down fat. They can help with digestion, as well as reducing cholesterol levels and aiding in weight loss.

  • Amylases: Amylases are enzymes that break down carbohydrates. They can help with digestion and nutrient absorption, as well as providing energy.

  • Bromelain: Bromelain is an enzyme derived from pineapple that can help with digestion, reduce inflammation, and provide relief from allergies.

Factors to Consider When Choosing an Enzyme Supplement

When choosing an enzyme supplement, there are several factors to consider. Here are some important things to keep in mind when selecting the right enzyme supplement for you:

  • Quality: Quality is an important factor to consider when choosing an enzyme supplement. Look for products that are manufactured in an FDA-approved facility and that contain high-quality ingredients with no fillers or additives.

  • Dosage: The dosage of the enzyme supplement you choose should be based on your individual needs. It is important to consult with your doctor before beginning any supplement regimen to determine the right dosage for you.

  • Cost: Different enzyme supplements can vary widely in price. While it’s important to get the best quality product you can afford, it’s also important to be mindful of your budget.

Conclusion

Enzyme supplements can be a great way to improve your health naturally. When choosing an enzyme supplement, it’s important to consider factors such as quality, dosage, and cost. With a bit of research, you can find the right enzyme supplement for you and your needs.

Frequently Asked Questions (FAQs)

1. What are enzyme supplements for?

Enzyme supplements are commonly used to aid digestion and alleviate digestive issues such as acid reflux, gas, bloating, and diarrhea. These supplements often contain enzymes like amylase, lipase, protease, lactase, and alpha-galactosidase, which can help improve digestion in individuals with enzyme insufficiency.

2. Do enzymes flatten your stomach?

Enzyme supplements are not a magic solution for flattening your stomach or losing weight. While they can have an impact on the gut microbiome, studies have shown that taking digestive enzyme supplements may actually lead to weight gain instead. Therefore, relying solely on enzyme supplements for weight loss is not recommended.

3. Do digestive enzymes clean your gut?

Certain foods like pineapples, mangoes, honey, bananas, avocados, kimchi, and ginger naturally contain digestive enzymes. These enzymes are important for maintaining optimal gut health, digestion, and nutrient absorption. They play a crucial role in supporting a healthy gut environment.

4. Are there any negative effects of digestive enzymes?

While most people tolerate digestive enzymes well, taking a high dose or ignoring dosage recommendations can lead to side effects. Some common side effects of digestive enzymes include upset stomach, stomach pains, cramping, and diarrhea. It is important to follow the recommended dosage and consult a healthcare professional if you experience any adverse effects.

Editor's Notes

During our enzyme supplement research, we found 24 enzyme supplement products and shortlisted 10 quality products. We collected and analyzed 554,934 customer reviews through our big data system to write the enzyme supplements list. We found that most customers choose enzyme supplements with an average price of $20.26.

The enzyme supplements are available for purchase. We have researched hundreds of brands and picked the top brands of enzyme supplements, including NOW Foods, Physician's CHOICE, Zenwise Health, Source Naturals, Double Wood Supplements. The seller of top 1 product has received honest feedback from 385 consumers with an average rating of 4.7.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.

Enzyme Supplements Comparison Table

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Brand NOW Foods Physician's CHOICE Zenwise Health Source Naturals Double Wood Supplements NatureBell Sports Research Carlyle Wholesome Wellness American Health
Flavor Unflavored Digestive Enzymes Unflavored Unflavored Unflavored Digestive Enzymes with Prebiotics Unflavored Unflavored Unflavored Papaya
Unit Count 180 Count 60.0 Count 180 Count 120.00 Count 180.0 Count 240.0 Count 90.0 Count 180 Count 180 Count 360 Count
Item Form Capsule Capsule Capsule Capsule Capsule Capsule Capsule Capsule Capsule Tablet
Item Weight 0.21 Pounds 0.18 Pounds 0.2 Pounds 0.01 Pounds 0.13 Kilograms - 0.09 Kilograms - 0.46 Pounds 0.74 Pounds
Diet Type Keto, Gluten Free Vegan Vegetarian Vegetarian Gluten Free - Vegan - Vegan Gluten Free
Product Benefits Healthy Digestion,Supports,Supports Healthy Digestion Digestive Health, Gut Health, Digestive Relief, Meal Time Relief Intestinal Support, Gut Health Support, Digestive Aid, Immune Support, Nutrient Absorption, Digestive Health Support, Inflammation Management, Indigestion Relief Constipation Relief Gut Health Support, Digestive Health Support, Metabolism Management - Digestion Aid Digestive Health Support - Immune Support, Digestive Health Support
Item dimensions L x W x H 2.81 x 2.81 x 5.13 inches 2.31 x 2.31 x 4.5 inches - 2.21 x 2.21 x 3.94 inches 2.5 x 2.5 x 4.75 inches - 2.63 x 2.63 x 4.88 inches 2.75 x 2.75 x 4.75 inches - 3 x 3 x 5.25 inches
Age Range (Description) - Adult Adult Adult Adult Adult - Adult Adult -
Special Ingredients Digestive Enzymes - Probiotic, Bromelain, Papaya, Lactase, Lipase, Prebioitic, Inulin, Bacillus Subtilus, Lactobasillus, Prebiotic - Bromelain - Probiotic - Probiotic Bromelain
Primary Supplement Type protein - Bromelain, Digestive Enzymes Enzymes - - Digestive Enzymes - - multivitamin
FTB Score
ftb score rating icon 9.9
ftb score rating icon 9.8
ftb score rating icon 9.6
ftb score rating icon 9.6
ftb score rating icon 9.5
ftb score rating icon 9.3
ftb score rating icon 9.3
ftb score rating icon 9.2
ftb score rating icon 9.0
ftb score rating icon 8.8
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