Best Enzyme Supplements of 2026

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 30, 2026

* We independently evaluate all recommended products and services. If you click on links we provide, we may receive compensation.

Enzyme supplements are becoming increasingly popular as people seek ways to support their digestive health. These supplements contain various enzymes that help break down food in the digestive system, making it easier for the body to absorb nutrients. Some of the most common enzymes found in these supplements include protease, amylase, and lipase. Protease helps break down proteins, amylase aids in the digestion of carbohydrates, and lipase helps break down fats. Enzyme supplements are available in various forms, including capsules, powders, and chewable tablets, and can be used to support overall digestive health or to address specific digestive issues.

At a Glance: Our Top Picks

Physician's CHOICE Digestive Enzymes Cover #TOP 1
Physician's CHOICE Digestive Enzymes
ftb score rating icon 9.9
Zenwise Probiotic Digestive Multi Enzymes Cover #TOP 2
Zenwise Probiotic Digestive Multi Enzymes
ftb score rating icon 9.8
NOW Supplements Super Enzymes Cover #TOP 3
NOW Supplements Super Enzymes
ftb score rating icon 9.6

Top 10 Enzyme Supplements

#TOP 1

Physician's CHOICE Digestive Enzymes

Physician's CHOICE Digestive Enzymes Cover
Physician's CHOICE Digestive Enzymes for Bloating & Digestion - 16 Enzymes with Organic Prebiotics & Probiotics for Gut & Digestive Health - Meal Time Discomfort Relief - Dual Action Support - 60 CT

Physician's CHOICE Enzymes is a powerful digestive health supplement designed to provide relief from mealtime discomfort. With 16 beneficial enzymes, it helps digest proteins, carbs, fruits, veggies, beans, dairy, and fats, making it suitable for all diets. The dual action approach combines digestive enzymes with prebiotics and probiotics to promote healthy digestion and gut function. The probiotics in this supplement are specially selected for their ability to survive the harsh gut environment, and the organic prebiotics fuel the growth of healthy bacteria in the gut. Crafted based on scientific research, Physician's CHOICE Enzymes are 3rd-party tested for purity and potency, ensuring a safety assured standard of quality. Take control of your digestive health with Physician's CHOICE Enzymes.

What We Like
Reduces bloating and discomfort
Improves digestion and regularity
Helps with IBS and lactose intolerance
Easy to take capsules
Includes prebiotics and probiotics
What We Don't Like
Results may take time
Bottle doesn't last long

Zenwise Probiotic Digestive Multi Enzymes

ZNW00734
Off-white
Zenwise Probiotic Digestive Multi Enzymes Cover
Zenwise Health Digestive Enzymes for Gut Health & Bloating Relief - Multi Enzymes Digestion Supplement with Probiotics, Bromelain & Papaya for Digestive Health Support - Men & Women - 180 Count

Zenwise Health's Probiotic Digestive Multi Enzymes is a pre-meal plant-powered pill formulated to help women and men find relief from occasional bloating, gas, and discomfort. This advanced enzyme + prebiotic, probiotic non-GMO formula tackles hard-to-digest foods and is clinically proven to be reliably alive. It contains botanical bounty such as turmeric, ginger, green papaya, inulin, apple pectin, bladderwrack, fennel, and wakame to aid gut health and stomach comfort. Each bottle contains 180 capsules, and it is suggested to take one capsule before each meal.

What We Like
Improved digestion
Reduced bloating
Easy to swallow
No unpleasant taste or smell
Effective with difficult foods
What We Don't Like
Possible initial gas
Occasional mismatch with gut flora
#TOP 3

NOW Supplements Super Enzymes

2964
Beige W/Speckles
NOW Supplements Super Enzymes Cover
NOW Foods Supplements, Super Enzymes, Formulated with Bromelain, Ox Bile, Pancreatin and Papain,180 Capsules

NOW Supplements Super Enzymes is a comprehensive blend of enzymes that supports healthy digestion. Formulated with bromelain, ox bile, pancreatin and papain, Super Enzymes helps to optimize the breakdown of fats, carbohydrates and protein. It is Soy Free, Made without Gluten, Keto Friendly and GMP Quality Assured. Customers have reported that it helps with digestive issues, bloating, slow metabolism, and acid indigestion. It is easy to swallow and comes in capsule form.

What We Like
Improved digestion and gut health
Reduces gas and bloating
Supports fat and nutrient absorption
Affordable and reliable formula
Helps after gallbladder removal
What We Don't Like
Dosage experimentation may be needed
Long-term use safety uncertain
#TOP 4

NOW Foods Quercetin with Bromelain

3071
Lime Green/Yellow
NOW Foods Quercetin with Bromelain Cover
NOW Foods Supplements, Quercetin with Bromelain, Balanced Immune System*, 240 Veg Capsules

NOW Foods Quercetin Supplement is designed to support your immune system. Quercetin is a natural antioxidant that helps maintain healthy immune responses, especially during seasonal changes. By promoting normal respiratory function, it can assist you in breathing easier when environmental factors challenge your health. The addition of Bromelain enhances this effect, contributing to a balanced immune response. This product is also suitable for various dietary preferences, being vegan, non-GMO, and free from common allergens like gluten and dairy, making it a convenient choice for many users.

What We Like
Immune system support
Effective for allergies and sinus
Easy-to-swallow capsules
High quality and trustworthy brand
Good value, large bottle
What We Don't Like
Slight bottle smell
#TOP 5

Double Wood Nattokinase Supplement

Double Wood Nattokinase Supplement Cover
Nattokinase Supplement 4,000 FU Servings, 120 Capsules (Derived from Japanese Natto) Systemic Enzymes for Cardiovascular and Circulatory Support by Double Wood

Double Wood Nattokinase Supplement is a powerful systemic enzyme supplement that promotes cardiovascular and circulatory health. Derived from Japanese Natto, this supplement contains Nattokinase, which helps lower plasma levels of certain proteins that affect circulation. By doing so, it supports a healthy circulatory system. Research suggests that Nattokinase may also have a positive impact on cardiovascular health. With 120 capsules, each containing 200mg of Nattokinase, this two-month supply is ideal for long-term use. Manufactured and tested in the USA, this vegan-safe supplement is gluten-free and non-GMO, making it a reliable choice for those looking to support their cardiovascular and circulatory health.

What We Like
High quality supplement
Supports heart health
Easy to use
Reasonable price
Helps digestion
What We Don't Like
Slow cholesterol reduction
Effects not immediate
#TOP 6

Pure Encapsulations Digestive Enzymes Ultra

Pure Encapsulations Digestive Enzymes Ultra Cover
Pure Encapsulations Digestive Enzymes Ultra - Vegetarian Digestive Enzyme Supplement to Support Protein, Carb, Fiber, and Dairy Digestion* - 90 Capsules

Pure Encapsulations Digestive Enzymes Ultra is a multi-enzyme supplement that supports the break down of protein, carbohydrate, fiber, and dairy*, while promoting optimal nutrient bioavailability and absorption*. The supplement contains a broad profile of digestive enzymes, providing optimal activity across a wide pH range. Pure Encapsulations uses only premium ingredients, and the product is free from wheat, eggs, tree nuts & peanuts, gluten, artificial colors, flavors & sweeteners, coatings and shellacs, GMOs, and unnecessary binders, fillers & preservatives.

What We Like
Improved digestion and regularity
Reduces bloating and discomfort
Comprehensive enzyme blend
Vegetarian and allergen-free formula
Small, easy-to-swallow capsules
What We Don't Like
Somewhat pricey
#TOP 7

Dr. Berg's Gallbladder Formula

Dr. Berg's Gallbladder Formula Cover
Dr. Berg Gallbladder Formula Extra Strength - with Ox Bile Powder and Conjugated Bile Acid - Digestive Enzymes Proprietary Blend - Full 45-Day Supply - 90 Vegetable Capsules

Dr. Berg's Gallbladder Formula is a powerful enzymatic supplement designed to promote healthy levels of bile salts and a healthy flow of bile. It is made with state-of-the-art manufacturing facilities and high-quality ingredients sourced from domestic and international farms. It comes with a 30-day money-back guarantee and is suitable for keto dieters. Customers have reported relief from bloating, indigestion, abdominal swelling, and constipation.

What We Like
Improved fat digestion
Reduced bloating and discomfort
Quick relief after meals
Helps post-gallbladder removal
Natural ingredients
What We Don't Like
Occasional constipation
Possible batch inconsistency
#TOP 8

Physician's CHOICE Bloat & Gas Probiotic 5-in-1

Physician's CHOICE Bloat & Gas Probiotic 5-in-1 Cover
Physician's CHOICE Bloat & Gas Probiotic 5-in-1 Proactive Support + Daily Relief - Digestion & Gut Health- Herbals, Digestive Enzymes, Post & Prebiotics - Gas Relief for Adults - Women & Men - 30ct

The Physician's CHOICE Bloat Relief offers a powerful 5-in-1 formula that combines probiotics, prebiotics, postbiotics, digestive enzymes, and calming herbs—all in one daily capsule. This blend helps strengthen your gut lining and improves nutrient absorption, promoting overall digestive health. It provides dual-action relief by targeting the root causes of bloating and offering fast support during mealtime gas and discomfort. Thanks to its advanced capsule technology, the ingredients release slowly for maximum effectiveness in your stomach and colon. Plus, it includes enzymes that help break down hard-to-digest foods like carbs and dairy, making it easier for you to enjoy meals without worry. Scientific research backs this product, ensuring you get a trusted, effective supplement for everyday gut support.

What We Like
Reduces gas and bloating
Improves digestion
Alleviates sulfur burps
Balances vaginal health
Easy to swallow capsules
What We Don't Like
Price increases over time
May not work for everyone

Lovebug Toddler & Kids Probiotics

LOVEBUG
LBP20221
30 Pack (Pack of 1)
Lovebug Toddler & Kids Probiotics Cover
Lovebug Kids Probiotic Powder with Prebiotic Fiber - Toddler Immunity Support & Constipation Relief - USDA Organic Probiotics for Childrens Gut & Digestive Health (Ages 1-4) - 30 Pack (Unflavoured)

Lovebug Probiotics offers a specialized blend of 8 probiotic strains tailored for toddlers and young children aged 12 months to 4 years. The formulation aims to address digestive upsets, diarrhea, and constipation common in this age group. By providing 15 billion active cultures, including Lactobacillus GG, it supports digestive and immune health. Lovebug Probiotics is non-GMO, gluten-free, and free from artificial colors or flavors, ensuring a safe option for your child's well-being.

What We Like
Improves toddler digestion
Easy to mix and use
Gentle and allergen-free formula
Supports regularity and gut health
Kid-approved taste and texture
What We Don't Like
Slightly sweet flavor
Higher price point
#TOP 10

Nutricost Bromelain 500mg, 120 Vegetarian Capsules

NTC234101
Nutricost Bromelain 500mg, 120 Vegetarian Capsules Cover
Nutricost Bromelain 500mg, 120 Vegetarian Capsules - Bromelain (1200 GDU), Non-GMO, Gluten Free

Get 120 servings of high-grade bromelain with Nutricost Bromelain 500mg. Each capsule contains 500mg of bromelain with 2,400 GDU per gram, ensuring you get the best quality. The product is non-GMO, vegetarian, gluten-free, and 3rd party tested. It is manufactured in a GMP compliant, FDA registered facility.

What We Like
Easy to swallow capsules
Helps with inflammation
Supports digestion and recovery
No stomach upset
Vegetarian and gluten free
What We Don't Like
Unpleasant capsule odor
Uncertain effectiveness for some
Buying Guide Image

How to Select Enzyme Supplements: The Comprehensive Guide

Introduction

Enzyme supplements are becoming increasingly popular among people looking for a natural and safe way to improve their health. From aiding digestion to helping with nutrient absorption, enzyme supplements can be an important part of any health regimen. But with so many different enzyme supplements available, it can be difficult to know which one is right for you. This article will help you decide which enzyme supplement is best for your needs.

Types of Enzyme Supplements

There are several different types of enzyme supplements available, and each type has its own unique benefits. Here’s a look at some of the most popular types of enzyme supplements:

  • Proteolytic Enzymes: Proteolytic enzymes, also called proteases, are enzymes that break down proteins. They can help with digestion and nutrient absorption, as well as reducing inflammation.

  • Lipases: Lipases are enzymes that break down fat. They can help with digestion, as well as reducing cholesterol levels and aiding in weight loss.

  • Amylases: Amylases are enzymes that break down carbohydrates. They can help with digestion and nutrient absorption, as well as providing energy.

  • Bromelain: Bromelain is an enzyme derived from pineapple that can help with digestion, reduce inflammation, and provide relief from allergies.

Factors to Consider When Choosing an Enzyme Supplement

When choosing an enzyme supplement, there are several factors to consider. Here are some important things to keep in mind when selecting the right enzyme supplement for you:

  • Quality: Quality is an important factor to consider when choosing an enzyme supplement. Look for products that are manufactured in an FDA-approved facility and that contain high-quality ingredients with no fillers or additives.

  • Dosage: The dosage of the enzyme supplement you choose should be based on your individual needs. It is important to consult with your doctor before beginning any supplement regimen to determine the right dosage for you.

  • Cost: Different enzyme supplements can vary widely in price. While it’s important to get the best quality product you can afford, it’s also important to be mindful of your budget.

Conclusion

Enzyme supplements can be a great way to improve your health naturally. When choosing an enzyme supplement, it’s important to consider factors such as quality, dosage, and cost. With a bit of research, you can find the right enzyme supplement for you and your needs.

Frequently Asked Questions (FAQs)

1. What are enzyme supplements for?

Enzyme supplements are commonly used to aid digestion and alleviate digestive issues such as acid reflux, gas, bloating, and diarrhea. These supplements often contain enzymes like amylase, lipase, protease, lactase, and alpha-galactosidase, which can help improve digestion in individuals with enzyme insufficiency.

2. Do enzymes flatten your stomach?

Enzyme supplements are not a magic solution for flattening your stomach or losing weight. While they can have an impact on the gut microbiome, studies have shown that taking digestive enzyme supplements may actually lead to weight gain instead. Therefore, relying solely on enzyme supplements for weight loss is not recommended.

3. Do digestive enzymes clean your gut?

Certain foods like pineapples, mangoes, honey, bananas, avocados, kimchi, and ginger naturally contain digestive enzymes. These enzymes are important for maintaining optimal gut health, digestion, and nutrient absorption. They play a crucial role in supporting a healthy gut environment.

4. Are there any negative effects of digestive enzymes?

While most people tolerate digestive enzymes well, taking a high dose or ignoring dosage recommendations can lead to side effects. Some common side effects of digestive enzymes include upset stomach, stomach pains, cramping, and diarrhea. It is important to follow the recommended dosage and consult a healthcare professional if you experience any adverse effects.

Editor's Notes

During our enzyme supplement research, we found 24 enzyme supplement products and shortlisted 10 quality products. We collected and analyzed 662,528 customer reviews through our big data system to write the enzyme supplements list. We found that most customers choose enzyme supplements with an average price of $20.49.

The enzyme supplements are available for purchase. We have researched hundreds of brands and picked the top brands of enzyme supplements, including Physician's CHOICE, Zenwise Health, NOW Foods, Double Wood Supplements, Pure Encapsulations. The seller of top 1 product has received honest feedback from 6,407 consumers with an average rating of 4.9.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.

Enzyme Supplements Comparison Table

#TOP1
#TOP2
#TOP3
#TOP4
#TOP5
#TOP6
#TOP7
#TOP8
#TOP9
#TOP10
Brand Physician's CHOICE Zenwise Health NOW Foods NOW Foods Double Wood Supplements Pure Encapsulations Dr. Berg Nutritionals Physician's CHOICE LOVEBUG Nutricost
Item Form Capsule Capsule Capsule Capsule Capsule Capsule Capsule Capsule Powder Capsule
Diet Type Vegan Vegetarian Keto Halal, Kosher, Vegan, Vegetarian Gluten Free, Vegan Vegetarian Keto Vegan Gluten Free Vegetarian
Flavor Digestive Enzymes Unflavored Unflavored Unflavored Unflavored Unflavored Unflavored - Ages 1 - 4 Pineapple
Primary Supplement Type Digestive Enzymes probiotics protein Quercetin Nattokinase Enzyme Blend - Probiotic Probiotic Non-specific
Unit Count 60.0 Count 180 Count 180 Count - 120 Count 90 Count 90 Count 30.00 Count 1.9 Ounce 120 Count
Product Benefits Digestive Health, Gut Health, Digestive Relief, Meal Time Relief Digestive Health, Indigestion Relief, Digestive Aid, Nutrient Absorption, Gut Health Support, Immune Support Healthy Digestion,Supports,Supports Healthy Digestion - Heart Health Support,Circulation Support,Vascular Health Support Metabolism Management Metabolism Management Digestive Health Support Digestive Health Support gluten free
Item Weight 0.18 Pounds 0.2 Pounds 0.21 Pounds - 0.09 Pounds 0.09 Pounds 3.2 ounces - 1.6 Ounces 0.31 Pounds
Age Range (Description) Adult Adult - - - Adult Adult Adult - Adult
Item dimensions L x W x H 2.31 x 2.31 x 4.5 inches - 2.81 x 2.81 x 5.13 inches - 2 x 2 x 3.5 inches 3.4 x 1.9 x 1.2 inches - - 3.63 x 2 x 4.44 inches -
Special Ingredients - Probiotics, Bacillus Subtilus, Lactobasillus, Bromelain, Papaya, Lactase, Lipase, Prebioitic, Inulin Digestive Enzymes - Nattokinase - - - Acidophilus Bromelain
FTB Score
ftb score rating icon 9.9
ftb score rating icon 9.8
ftb score rating icon 9.6
ftb score rating icon 9.4
ftb score rating icon 9.4
ftb score rating icon 9.3
ftb score rating icon 9.3
ftb score rating icon 9.2
ftb score rating icon 9.1
ftb score rating icon 9.0
Where to Buy