Best Probiotic Enzyme Supplements of 2026

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 30, 2026

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Probiotic enzyme supplements are an increasingly popular way to support digestive health. These supplements contain live bacteria and enzymes that work together to improve the balance of gut flora and aid in the breakdown of food. Many people turn to probiotic enzyme supplements to help with digestive issues like bloating, constipation, and diarrhea. These supplements come in many different forms, including capsules, powders, and chewable tablets, and are available in a variety of strengths and formulations. Probiotic enzyme supplements are generally safe and well-tolerated, but it's always a good idea to talk to a healthcare professional before starting any new supplement regimen.

At a Glance: Our Top Picks

Physician's CHOICE Digestive Enzymes Cover #TOP 1
Physician's CHOICE Digestive Enzymes
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Zenwise Probiotic Digestive Multi Enzymes Cover #TOP 2
Zenwise Probiotic Digestive Multi Enzymes
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Physician's CHOICE Bloat & Gas Probiotic 5-in-1 Cover #TOP 3
Physician's CHOICE Bloat & Gas Probiotic 5-in-1
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Top 10 Probiotic Enzyme Supplements

Physician's CHOICE Digestive Enzymes

Physician's CHOICE Digestive Enzymes Cover
Physician's CHOICE Digestive Enzymes for Bloating & Digestion - 16 Enzymes with Organic Prebiotics & Probiotics for Gut & Digestive Health - Meal Time Discomfort Relief - Dual Action Support - 60 CT

Physician's CHOICE Enzymes is a powerful digestive health supplement designed to provide relief from mealtime discomfort. With 16 beneficial enzymes, it helps digest proteins, carbs, fruits, veggies, beans, dairy, and fats, making it suitable for all diets. The dual action approach combines digestive enzymes with prebiotics and probiotics to promote healthy digestion and gut function. The probiotics in this supplement are specially selected for their ability to survive the harsh gut environment, and the organic prebiotics fuel the growth of healthy bacteria in the gut. Crafted based on scientific research, Physician's CHOICE Enzymes are 3rd-party tested for purity and potency, ensuring a safety assured standard of quality. Take control of your digestive health with Physician's CHOICE Enzymes.

What We Like
Reduces bloating and discomfort
Improves digestion and regularity
Supports gut health
Easy to take capsules
Works for various digestive issues
What We Don't Like
Bottle runs out quickly
Results may take time

Zenwise Probiotic Digestive Multi Enzymes

ZNW00734
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Zenwise Probiotic Digestive Multi Enzymes Cover
Zenwise Health Digestive Enzymes for Gut Health & Bloating Relief - Multi Enzymes Digestion Supplement with Probiotics, Bromelain & Papaya for Digestive Health Support - Men & Women - 180 Count

Zenwise Health's Probiotic Digestive Multi Enzymes is a pre-meal plant-powered pill formulated to help women and men find relief from occasional bloating, gas, and discomfort. This advanced enzyme + prebiotic, probiotic non-GMO formula tackles hard-to-digest foods and is clinically proven to be reliably alive. It contains botanical bounty such as turmeric, ginger, green papaya, inulin, apple pectin, bladderwrack, fennel, and wakame to aid gut health and stomach comfort. Each bottle contains 180 capsules, and it is suggested to take one capsule before each meal.

What We Like
Reduces bloating and heaviness
Supports natural digestion
Easy to swallow capsules
No bad taste or odor
Effective for large meals
What We Don't Like
Bloating for some users
Packaging quantity discrepancy
#TOP 3

Physician's CHOICE Bloat & Gas Probiotic 5-in-1

Physician's CHOICE Bloat & Gas Probiotic 5-in-1 Cover
Physician's CHOICE Bloat & Gas Probiotic 5-in-1 Proactive Support + Daily Relief - Digestion & Gut Health- Herbals, Digestive Enzymes, Post & Prebiotics - Gas Relief for Adults - Women & Men - 30ct

The Physician's CHOICE Bloat Relief offers a powerful 5-in-1 formula that combines probiotics, prebiotics, postbiotics, digestive enzymes, and calming herbs—all in one daily capsule. This blend helps strengthen your gut lining and improves nutrient absorption, promoting overall digestive health. It provides dual-action relief by targeting the root causes of bloating and offering fast support during mealtime gas and discomfort. Thanks to its advanced capsule technology, the ingredients release slowly for maximum effectiveness in your stomach and colon. Plus, it includes enzymes that help break down hard-to-digest foods like carbs and dairy, making it easier for you to enjoy meals without worry. Scientific research backs this product, ensuring you get a trusted, effective supplement for everyday gut support.

What We Like
Reduces gas and bloating
Improves digestion
Alleviates sulfur burps
Balances vaginal health
Easy to swallow capsules
What We Don't Like
Price increases over time
May not work for everyone

Lovebug Toddler & Kids Probiotics

LOVEBUG
LBP20221
30 Pack (Pack of 1)
Lovebug Toddler & Kids Probiotics Cover
Lovebug Kids Probiotic Powder with Prebiotic Fiber - Toddler Immunity Support & Constipation Relief - USDA Organic Probiotics for Childrens Gut & Digestive Health (Ages 1-4) - 30 Pack (Unflavoured)

Lovebug Probiotics offers a specialized blend of 8 probiotic strains tailored for toddlers and young children aged 12 months to 4 years. The formulation aims to address digestive upsets, diarrhea, and constipation common in this age group. By providing 15 billion active cultures, including Lactobacillus GG, it supports digestive and immune health. Lovebug Probiotics is non-GMO, gluten-free, and free from artificial colors or flavors, ensuring a safe option for your child's well-being.

What We Like
Improves toddler digestion
Easy to mix and use
Gentle and allergen-free formula
Supports regularity and gut health
Kid-approved taste and texture
What We Don't Like
Slightly sweet flavor
Higher price point
#TOP 5

Jarrow Formulas Saccharomyces Boulardii + MOS Probiotics 90 Caps

Jarrow Formulas Saccharomyces Boulardii + MOS Probiotics 90 Caps Cover
Jarrow Formulas Saccharomyces Boulardii + MOS Probiotics for Digestive Health and Intestinal Tract Support - 5 Billion CFU Per Serving - 90 Delayed Release Caps - Probiotic + Prebiotic - 90 Servings

Jarrow Probiotics + Prebiotic offers a 90-day supply of digestive support with 90 veggie capsules. Each capsule contains 5 billion CFU of Saccharomyces boulardii, a probiotic yeast known to help maintain a healthy intestinal tract, especially for those needing extra support. It also includes MOS, a prebiotic that nourishes the good bacteria in your gut, promoting better digestion. The capsules are easy to take once daily, with or without food, fitting conveniently into your routine to help support overall gut health.

What We Like
Rapid intestinal relief
Supports gut health
Effective against C. Diff
Antibiotic resistant probiotic
Boosts immune function
#TOP 6

𝗪𝗜𝗡𝗡𝗘𝗥 Probiotics with Natural Lactase Enzyme and Prebiotic for Digestive Health

Nutrition Essentials
5440045
𝗪𝗜𝗡𝗡𝗘𝗥 Probiotics with Natural Lactase Enzyme and Prebiotic for Digestive Health Cover
Nutrition Essentials Probiotics for Women and Men - with Lactase Enzyme and Prebiotic Fiber for Digestive Health - 80 Percent + More Potent Supplement for Gut Health Support - Vegan Formula

𝗪𝗜𝗡𝗡𝗘𝗥 Probiotics use Bacillus Coagulans strain, which is supported by years of research and contains 900 billion CFU per bottle. The formula retains full potency until it reaches the intestines due to its dormancy in harsh conditions. It prolongs potency by up to 62% with FrostProtect bottle that shields from heat, light, and oxygen. The formula undergoes in-vitro pH testing to prevent stomach irritation, and it is suitable for vegans and vegetarians.

What We Like
Improved digestive health
Relief from gastrointestinal discomfort
Enhanced food tolerance
Motivation for healthier lifestyle
Affordable price
What We Don't Like
Occasional broken tablets
Bottle coating with powder residue

Sunergetic 4-in-1 Probiotic Supplement

PROB-4IN1-60
Sunergetic 4-in-1 Probiotic Supplement Cover
Premium 4-in-1 Probiotic Prebiotic, Postbiotic & Digestive Enzymes for Men & Women – Supports Gut, Digestion & Immunity –Complete Gut Health with Pre, Post, Probiotics & Digestive Enzymes–60 Capsules

The Sunergetic Probiotic Blend is a comprehensive gut health supplement designed for both men and women. It features a unique combination of probiotics, prebiotics, postbiotics, and digestive enzymes to support healthy digestion and intestinal health. By taking just two capsules daily, you can help reduce occasional gas and bloating, promoting overall gut comfort. Additionally, this formula supports immune health and regularity, making it easier for you to maintain digestive balance without the need for refrigeration. Its scientifically backed strains ensure you receive powerful support for your gut microbiome.

What We Like
Improved digestive regularity
Reduces bloating
Helps curb sugar cravings
Easy to swallow capsules
Gut health support
What We Don't Like
Subtle results for some users
Limited weight loss effect
#TOP 8

NatureBell Probiotic 200 Billion CFU 40 Strains

NatureBell Probiotic 200 Billion CFU 40 Strains Cover
NatureBell Probiotic 200 Billion CFU – 40 Strains Per Serving | 240 Veggie Capsules with Prebiotics and Probiotics – Full Spectrum Complex with Enzymes – Daily Probiotics for Women & Men

The NatureBell 200B Probiotics offers a powerful blend designed to support your digestive health. Each serving provides 200 billion CFU with 40 different probiotic strains, helping to maintain a balanced gut flora for better digestion and overall wellness. This supplement also includes prebiotics and enzymes, which work together to nourish the good bacteria and aid in breaking down food efficiently, making digestion smoother. With 240 veggie capsules, you get a generous 120 servings, giving you long-lasting support. This formula is crafted for both men and women and combines natural fibers and enzymes like psyllium husk and bromelain to enhance your daily digestive routine.

What We Like
Easy to swallow capsules
Effective digestive support
Great value for money
High-quality probiotic strains
Versatile uses (yogurt, kvass)
What We Don't Like
Large pill size
Need two capsules for full benefit
#TOP 9

CANLIST Probiotics 120 Billion CFUs 18 Strains

Probiotics-1-1
Blue-1
CANLIST Probiotics 120 Billion CFUs 18 Strains Cover
CANLIST Probiotics 120 Billion CFUs 18 Strains, 3 Prebiotics & Digestive Enzymes for Men Women,Digestive & Immune Support,Shelf Stable Non-GMO 60 Capsules

Introducing CANLIST Probiotics, a high-quality probiotic supplement designed for both men and women. With 120 billion CFUs and 18 strains per capsule, it provides the highest number of CFUs and the richest strains possible. This powerful formula is enriched with natural plant-based digestive enzymes and water-soluble prebiotics fiber, which work together to reduce gas and bloating. In addition, CANLIST Probiotics support healthy digestion, boost the immune system, and promote optimal nutrient absorption. The shelf-stable and delayed-release technology ensures that the probiotics survive stomach acid and reach deep into the intestine. Made in the USA and tested for purity and potency, CANLIST Probiotics represent the highest standards in digestive and immune support.

What We Like
Improved digestion and gut comfort
Regular bowel movements
Reduces gas and bloating
High CFU multi-strain formula
Easy to swallow capsules
What We Don't Like
May increase appetite for some
Personal results may vary

Wholesome Wellness Digestive Enzymes

digestive-enzymes
Green
Wholesome Wellness Digestive Enzymes Cover
Wholesome Wellness Digestive Enzymes 1000MG Plus Prebiotics & Probiotics Supplement, 180 Capsules, Organic Plant-Based Vegan Formula for Digestion & Lactose with Amylase & Bromelain,3-6 Months Supply

Wholesome Wellness Digestive Enzymes is a plant-based, organic supplement that helps improve digestion and gut health. With a 1000 MG dose of clinical grade digestive enzymes and a 10 billion CFU 10 strain probiotic with prebiotics, this supplement provides relief from bloating, flatulence, fat, pancreatic, and bowel cleansing. The Advanced Multi Enzyme System helps digest a variety of foods, including fried, spicy, raw, processed food, dairy, protein, salts, carb / carbohydrate, vitamin and acidic diet fruits and veggies. The supplement also contains a powerful 10 billion CFU dose of 10 different probiotic strains clinically shown to enhance preventions & immune system response.

What We Like
Improved digestion and gut comfort
Reduces bloating and stomach discomfort
Easy-to-swallow capsules
Plant-based and organic formula
Includes enzymes, prebiotics, probiotics
What We Don't Like
May not work for everyone
Buying Guide Image

Finding the Best Probiotic Enzyme Supplements for You

Introduction

Probiotics are live microorganisms that provide numerous health benefits when consumed in adequate amounts. Probiotic enzyme supplements, in particular, can help support a healthy digestive system and boost the body's natural ability to break down food. Choosing the right probiotic enzyme supplement, however, can be a daunting task given the vast array of options available on the market. In this article, we will provide some useful tips to help you make an informed decision.

Consider the strain of probiotics

Not all probiotics are created equal. Different strains of probiotics have different effects on the body, so it's important to choose a probiotic supplement that contains the right strain for your specific needs. For example, Lactobacillus and Bifidobacterium are two common strains of probiotics that are known for their ability to support digestive health.

Check the CFU count

CFU stands for colony-forming units, which is a measure of the number of viable bacteria in a probiotic supplement. In general, a probiotic supplement with a higher CFU count is more potent and effective. However, it's important to note that the optimal CFU count can vary depending on the specific strain of probiotics and the intended use of the supplement. As a general rule of thumb, a CFU count of at least 1 billion is considered adequate for most adults.

Look for third-party certifications

Third-party certifications, such as those from organizations like the International Probiotics Association (IPA), provide assurance that a probiotic supplement meets certain quality standards. These certifications can help ensure that the probiotic supplement you choose contains the right strain of probiotics at the appropriate CFU count.

Consider the form of the supplement

Probiotic supplements come in various forms, including capsules, powders, and liquids. The form of the supplement can affect how well it is absorbed by the body, so it's important to choose a form that is suitable for your needs. For example, capsules are convenient and easy to take, but they may not be as effective as powders or liquids at delivering the probiotics to the intestines.

Take other factors into account

In addition to the strain of probiotics, the CFU count, third-party certifications, and the form of the supplement, there are several other factors to consider when choosing a probiotic enzyme supplement. These include the price, the reputation of the manufacturer, and any potential side effects. By considering all of these factors, you can make an informed decision and choose a probiotic enzyme supplement that is right for you.

Conclusion

In conclusion, choosing the right probiotic enzyme supplement can provide numerous health benefits. By considering the strain of probiotics, the CFU count, third-party certifications, the form of the supplement, and other factors, you can make an informed decision and choose a supplement that is suitable for your needs.

Frequently Asked Questions (FAQs)

1. Is it good to take probiotics with enzymes?

Yes, taking probiotics with enzymes can be beneficial. Digestive enzymes help break down food while probiotics support the health of the gut microbiome. They have a complementary relationship and can support digestion, reduce bloating, and strengthen the immune system. Taking them together may maximize their impact.

2. What do enzymes and probiotics do for the body?

Enzymes break down complex nutrients into smaller particles, aiding digestion. Probiotics help maintain a balance between 'good' and 'bad' gut bacteria, supporting gut health. Together, they can improve digestive issues and promote overall digestive health.

3. Is it OK to take digestive enzymes every day?

Taking digestive enzyme supplements daily is generally safe and can improve digestion without side effects. However, it is advisable to inform a healthcare provider about their usage, especially if you plan to take them regularly. This way, you have professional guidance and support if needed.

4. Who shouldn't take digestive enzymes?

Digestive enzymes that break down carbohydrates into sugars are not recommended for diabetics, as well as pregnant or breastfeeding women. It is important to consult with a healthcare provider before taking any supplements, especially if you have specific health conditions.

5. What are the best digestive enzymes?

The three most common digestive enzymes are amylase, lipase, and protease. Amylase breaks down complex carbohydrates, lipase breaks down fats, and protease breaks down proteins. These enzymes play a crucial role in the digestion of different nutrients.

6. What are signs you need digestive enzymes?

Signs that you may need digestive enzymes include belly pain or cramps, bloating, diarrhea, gas, oily stools, and unexplained weight loss. If you experience these symptoms, it may be worth considering digestive enzyme supplementation to support your digestion.

Editor's Notes

During our probiotic enzyme supplement research, we found 24 probiotic enzyme supplement products and shortlisted 10 quality products. We collected and analyzed 651,691 customer reviews through our big data system to write the probiotic enzyme supplements list. We found that most customers choose probiotic enzyme supplements with an average price of $20.66.

The probiotic enzyme supplements are available for purchase. We have researched hundreds of brands and picked the top brands of probiotic enzyme supplements, including Physician's CHOICE, Zenwise Health, LOVEBUG, Jarrow Formulas, Nutrition Essentials. The seller of top 1 product has received honest feedback from 6,407 consumers with an average rating of 4.9.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.

Probiotic Enzyme Supplements Comparison Table

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Brand Physician's CHOICE Zenwise Health Physician's CHOICE LOVEBUG Jarrow Formulas Nutrition Essentials Sunergetic NatureBell CANLIST Wholesome Wellness
Unit Count 60.0 Count 180 Count 30.00 Count 1.9 Ounce 90.0 Count 60 Count 60 Count 240 Count 60 Count 180 Count
Item Form Capsule Capsule Capsule Powder Capsule Max Strength for Women and Men, with a gentle, pH neutral prebiotic blend. Capsule Capsule Capsule Capsule
Flavor Digestive Enzymes Unflavored - Ages 1 - 4 Unflavored Unflavored Unflavored Probiotics Original Unflavored
Product Benefits Digestive Health, Gut Health, Digestive Relief, Meal Time Relief Digestive Health, Indigestion Relief, Digestive Aid, Nutrient Absorption, Gut Health Support, Immune Support Digestive Health Support Digestive Health Support Digestive Health Support Digestive Health Support 4 in 1 probiotic supplement, bio complete 3, pre pro post biotics for women General Health Improve Digestive Pegularity * Support Immune System * Support Metabolism * Boost Nutrient Absorption * -
Primary Supplement Type Digestive Enzymes probiotics Probiotic Probiotic Vitamin Probiotic 4-in-1 Probiotics, Colon Health Daily Probiotic Capsules, Prebiotic Probiotic & Postbiotic with digestive enzymes, bio complete 3, pre pro post biotics for women - Probiotics -
Item Weight 0.18 Pounds 0.2 Pounds - 1.6 Ounces 3.36 ounces 0.15 Pounds - 4 Ounces 2.4 ounces 0.46 Pounds
Diet Type Vegan Vegetarian Vegan Gluten Free Vegan Gluten Free, Vegan - - - Vegan
Age Range (Description) Adult Adult Adult - - - - - Adult Adult
Special Ingredients - Probiotics, Bacillus Subtilus, Lactobasillus, Bromelain, Papaya, Lactase, Lipase, Prebioitic, Inulin - Acidophilus Saccharomyces boulardii, MOS Yeast Fraction Acidophilus - - - Probiotic
FTB Score
ftb score rating icon 9.9
ftb score rating icon 9.8
ftb score rating icon 9.6
ftb score rating icon 9.5
ftb score rating icon 9.5
ftb score rating icon 9.5
ftb score rating icon 9.3
ftb score rating icon 9.3
ftb score rating icon 9.1
ftb score rating icon 9.1
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