Best Probiotic Enzyme Supplements of 2025

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 17, 2025

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Probiotic enzyme supplements are an increasingly popular way to support digestive health. These supplements contain live bacteria and enzymes that work together to improve the balance of gut flora and aid in the breakdown of food. Many people turn to probiotic enzyme supplements to help with digestive issues like bloating, constipation, and diarrhea. These supplements come in many different forms, including capsules, powders, and chewable tablets, and are available in a variety of strengths and formulations. Probiotic enzyme supplements are generally safe and well-tolerated, but it's always a good idea to talk to a healthcare professional before starting any new supplement regimen.

At a Glance: Our Top Picks

Physician's CHOICE Digestive Enzymes Cover #TOP 1
Physician's CHOICE Digestive Enzymes
ftb score rating icon 9.9
Nature's Truth Probiotics with Enzymes Cover #TOP 2
Nature's Truth Probiotics with Enzymes
ftb score rating icon 9.8
Wholesome Wellness Digestive Enzymes Cover #TOP 3
Wholesome Wellness Digestive Enzymes
ftb score rating icon 9.6

Top 10 Probiotic Enzyme Supplements

Physician's CHOICE Digestive Enzymes

Physician's CHOICE Digestive Enzymes Cover
Physician's CHOICE Digestive Enzymes - Multi Enzymes, Organic Prebiotics & Probiotics for Digestive Health & Gut Health - Meal Time Discomfort Relief & Bloating - Dual Action Approach - 60 CT

Physician's CHOICE Enzymes is a powerful digestive health supplement designed to provide relief from mealtime discomfort. With 16 beneficial enzymes, it helps digest proteins, carbs, fruits, veggies, beans, dairy, and fats, making it suitable for all diets. The dual action approach combines digestive enzymes with prebiotics and probiotics to promote healthy digestion and gut function. The probiotics in this supplement are specially selected for their ability to survive the harsh gut environment, and the organic prebiotics fuel the growth of healthy bacteria in the gut. Crafted based on scientific research, Physician's CHOICE Enzymes are 3rd-party tested for purity and potency, ensuring a safety assured standard of quality. Take control of your digestive health with Physician's CHOICE Enzymes.

What We Like
Effective for digestion
Affordable compared to competitors
Quick relief from symptoms
Improves overall gastrointestinal health
What We Don't Like
Possible taste issues
May not eliminate bloating completely

Nature's Truth Probiotics with Enzymes

NT4400A
Nature's Truth Probiotics with Enzymes Cover
Nature's Truth Probiotics with Enzymes | 60 Capsules | Stomach Friendly for Men and Women | Non-GMO & Gluten Free Digestive Health Supplement

Nature's Truth Probiotics is a premium supplement that combines the power of prebiotics, probiotics, and multi-enzymes to support your overall wellness. With a potent formula that delivers 4 billion CFU per serving, these easy-to-take vegetarian capsules are designed to promote a healthy digestive system. The expertly crafted formula is backed by three generations of Vitamin Innovators, ensuring unrivaled quality. Nature's Truth Probiotics is naturally free of gluten, wheat, soy, artificial color, and flavoring, making it suitable for individuals with dietary restrictions. With its stomach-friendly formula, this supplement is suitable for both men and women, providing convenience and peace of mind for those looking to support their digestive health.

What We Like
Effective for gut health
Natural ingredients, no additives
Easy to swallow
Improves digestion
Good price point
What We Don't Like
Hard to find in stock

Wholesome Wellness Digestive Enzymes

digestive-enzymes
Green
Wholesome Wellness Digestive Enzymes Cover
Wholesome Wellness Digestive Enzymes 1000MG Plus Prebiotics & Probiotics Supplement, 180 Capsules, Organic Plant-Based Vegan Formula for Digestion & Lactose with Amylase & Bromelain,3-6 Months Supply

Wholesome Wellness Digestive Enzymes is a plant-based, organic supplement that helps improve digestion and gut health. With a 1000 MG dose of clinical grade digestive enzymes and a 10 billion CFU 10 strain probiotic with prebiotics, this supplement provides relief from bloating, flatulence, fat, pancreatic, and bowel cleansing. The Advanced Multi Enzyme System helps digest a variety of foods, including fried, spicy, raw, processed food, dairy, protein, salts, carb / carbohydrate, vitamin and acidic diet fruits and veggies. The supplement also contains a powerful 10 billion CFU dose of 10 different probiotic strains clinically shown to enhance preventions & immune system response.

What We Like
Effective for digestion issues
Quick results after use
Plant-based, vegan formula
Convenient, easy-to-swallow capsules
Supports energy and immunity
What We Don't Like
Not as effective as some brands
Limited disclosure on ingredients
#TOP 4

Digestive Advantage IBS Probiotics for Digestive Health, 96ct Capsules

Reckitt
Digestive Advantage IBS Probiotics for Digestive Health, 96ct Capsules Cover
Digestive Advantage IBS Daily Probiotic Capsules for Digestive Health & Gut Health, Probiotics for Men and Women (96 Count Box) - Digestible Enzymes

Digestive Advantage IBS Probiotics is a daily probiotic and IBS capsules for men and women that can help lessen minor abdominal discomfort and occasional bloating while supporting digestive balance. Its patented BC30 probiotic can survive stomach acid 100X better and interact with intestinal cells to help support digestive and immune health. The capsules are GMO-free, vegetarian, and guaranteed for freshness, purity, and labeled potency. With continued use, it gives long-term digestive support and breaks down proteins, carbohydrates, and fats to aid in the digestive process.

What We Like
Easy to use
Effective for IBS relief
Improves digestive health
No significant side effects
Helps manage food sensitivities
What We Don't Like
Pricey for some
Requires consistent use
#TOP 5

Zenwise Digestive Enzymes

Zenwise Digestive Enzymes Cover
Zenwise Health Digestive Enzymes for Gut Health - Probiotic Multi Enzymes with Prebiotics and Probiotics for Women and Men for Digestive Health and Bloating Relief, Daily Enzymes for Digestion -60 CT

Zenwise Enzymes is a convenient 3-in-1 gut support solution for digestive health and bloating relief. With its lab-proven multi-enzyme blend, it can help digest foods up to 39% more completely and 2 hours faster than your body can on its own. This makes it perfect for individuals following gluten-free, Keto, or Paleo diets, as well as those experiencing occasional bloating, gas, and discomfort from hard-to-digest foods. The product also contains a clinically proven DE111 probiotic, which guarantees to arrive alive and work within hours in the small intestine, where 90% of nutrient absorption occurs. Additionally, Zenwise Enzymes includes a variety of botanical ingredients like turmeric, ginger, and green papaya, which aid in gut health and stomach comfort. Taking just one capsule before each meal or drink can provide you with the digestive delight you've been seeking.

What We Like
Improves digestion significantly
Reduces bloating and discomfort
Effective for trigger foods
Easy to swallow
Cost-effective compared to alternatives
What We Don't Like
Mild stomach discomfort reported
Requires intake before meals
#TOP 6

Carlyle Digestive Enzymes with 14 Probiotic Strains

CL4405
Carlyle Digestive Enzymes with 14 Probiotic Strains Cover
Carlyle Digestive Enzymes | with Probiotics & Prebiotics | 180 Capsules | Non-GMO and Gluten Free Supplement for Men & Women

Carlyle Digestive Enzymes with 14 Probiotic Strains is a non-GMO and gluten-free supplement that provides full-spectrum digestive support. It contains bromelain and comes in quick-release capsules that can be taken before or after meals. Customers have reported improved regularity and reduced bloating and stomach pain. Some customers have not seen the desired results.

What We Like
Gluten & dairy free
Effective for digestive issues
Cost-effective solution
Quick and accurate order fulfillment
Helps with IBS symptoms
What We Don't Like
Not the highest potency
#TOP 7

Life Extension Enhanced Super Digestive Enzymes & Probiotics

Life Extension Enhanced Super Digestive Enzymes & Probiotics Cover
Life Extension Enhanced Super Digestive Enzymes & Probiotics -Vegetarian-Friendly Digestive Health Formula For GI Balance - Plant-Based Diet Aid - Non-GMO - 60 Vegetarian Capsules

Life Extension Enhanced Super Digestive Enzymes & Probiotics is a vegetarian-friendly digestive health formula that helps promote digestive comfort and maintain a healthy microbiome. It contains ten types of digestive enzymes, including alpha galactosidase, protease 3.0, and lipase, as well as probiotic strand B. coagulans for comprehensive digestive support. This product is certified non-GMO and gluten-free, and is manufactured in the USA.

What We Like
Effective for bloating relief
Improves overall digestion
Contains probiotics
Recommended by health professionals
High-quality product
What We Don't Like
May cause stomach upset
Pricey compared to others

NatureBell Digestive Enzymes with Probiotics

BA-NB-DE240C
NatureBell Digestive Enzymes with Probiotics Cover
NatureBell Digestive Enzymes with Probiotics and Prebiotics, 240 Veggie Capsules | Gut & Digestive Health Support – 20 Enzyme & 5 Prebiotic Pancreatic Enzyme Complex | Non-GMO, Vegan Friendly

NatureBell Digestive Enzymes offers a comprehensive blend of digestive support in a convenient veggie capsule. With 240 capsules in a bottle, you can enjoy an 8-month supply, making it easy to incorporate into your daily routine. Each serving combines 20 digestive enzymes and 5 prebiotics, promoting better digestion and nutrient absorption. This unique formulation helps to alleviate bloating and supports overall gut health. Designed for both men and women, it aims to enhance your digestive balance and keep your gut flora thriving.

What We Like
Effective digestive aid
Improves digestion noticeably
Reduces bloating and discomfort
Convenient one-capsule dosage
Good value for the price
What We Don't Like
Strong odor of veggie capsules
No noticeable improvement for some
#TOP 9

Dr. Vitamin Multi Enzymes & Probiotics

Dr. Vitamin Multi Enzymes & Probiotics Cover
Dr. Vitamin Multi Enzymes, Pre and Probiotics for Digestive Health | 18 Active Enzymes & 1.5 Billion CFU Probiotics for Women & Men | Digestive Enzymes w/Prebiotics for Bloating Relief | 60 Capsules

Dr. Vitamin Digestive Support is designed to enhance your digestive health with a powerful combination of enzymes, probiotics, and prebiotics. This supplement features 18 active enzymes that help break down proteins, fats, and carbohydrates, making digestion smoother and reducing discomfort after meals. It also includes 19 probiotic strains and prebiotics that work together to promote a balanced gut microbiome, which can boost your immune system. Plus, its vegan and hypoallergenic formula is free from common allergens, making it suitable for those with dietary restrictions. With easy-to-swallow capsules, you can enjoy comprehensive digestive support effortlessly.

What We Like
Improved digestion
Reduced bloating
Convenient capsule dosage
Natural ingredients
Supports gut health
What We Don't Like
Capsules may be large
Higher price point
#TOP 10

FRISKA Womens Daily Digestive Enzyme and Probiotics Supplement

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FRISKA Womens Daily Digestive Enzyme and Probiotics Supplement Cover
FRISKA Women’s Daily Digestive Enzyme and Probiotics Supplement, Advanced Natural Support for Female Digestive Health, Fights Bloating, Eases Digestion, Supports Nutrient Absorption, 30 Capsules

FRISKA Womens Daily Digestive Enzyme and Probiotics Supplement is a natural support for female digestion, immune and urinary health. This supplement contains powerful probiotics and digestive enzymes for gut health and gas relief, as well as Cranberry Extract, Biotin and Vitamin D for immune and vaginal health. The digestive enzymes and probiotics are enforced with essential botanicals to make this supplement perfect for women. Daily use of this supplement helps keep the female body and vaginal health in balance, while improving digestion for overall health. This natural supplement is made in the USA from the highest quality of naturally sourced ingredients, and is plant-based and easy to digest.

What We Like
Reduces bloating and fullness
Improves energy and mood
Includes beneficial vitamins
Easy to swallow
Positive long-term effects noted
What We Don't Like
Probiotic count may seem low
More marketing focus than substance
Buying Guide Image

Finding the Best Probiotic Enzyme Supplements for You

Introduction

Probiotics are live microorganisms that provide numerous health benefits when consumed in adequate amounts. Probiotic enzyme supplements, in particular, can help support a healthy digestive system and boost the body's natural ability to break down food. Choosing the right probiotic enzyme supplement, however, can be a daunting task given the vast array of options available on the market. In this article, we will provide some useful tips to help you make an informed decision.

Consider the strain of probiotics

Not all probiotics are created equal. Different strains of probiotics have different effects on the body, so it's important to choose a probiotic supplement that contains the right strain for your specific needs. For example, Lactobacillus and Bifidobacterium are two common strains of probiotics that are known for their ability to support digestive health.

Check the CFU count

CFU stands for colony-forming units, which is a measure of the number of viable bacteria in a probiotic supplement. In general, a probiotic supplement with a higher CFU count is more potent and effective. However, it's important to note that the optimal CFU count can vary depending on the specific strain of probiotics and the intended use of the supplement. As a general rule of thumb, a CFU count of at least 1 billion is considered adequate for most adults.

Look for third-party certifications

Third-party certifications, such as those from organizations like the International Probiotics Association (IPA), provide assurance that a probiotic supplement meets certain quality standards. These certifications can help ensure that the probiotic supplement you choose contains the right strain of probiotics at the appropriate CFU count.

Consider the form of the supplement

Probiotic supplements come in various forms, including capsules, powders, and liquids. The form of the supplement can affect how well it is absorbed by the body, so it's important to choose a form that is suitable for your needs. For example, capsules are convenient and easy to take, but they may not be as effective as powders or liquids at delivering the probiotics to the intestines.

Take other factors into account

In addition to the strain of probiotics, the CFU count, third-party certifications, and the form of the supplement, there are several other factors to consider when choosing a probiotic enzyme supplement. These include the price, the reputation of the manufacturer, and any potential side effects. By considering all of these factors, you can make an informed decision and choose a probiotic enzyme supplement that is right for you.

Conclusion

In conclusion, choosing the right probiotic enzyme supplement can provide numerous health benefits. By considering the strain of probiotics, the CFU count, third-party certifications, the form of the supplement, and other factors, you can make an informed decision and choose a supplement that is suitable for your needs.

Frequently Asked Questions (FAQs)

1. Is it good to take probiotics with enzymes?

Yes, taking probiotics with enzymes can be beneficial. Digestive enzymes help break down food while probiotics support the health of the gut microbiome. They have a complementary relationship and can support digestion, reduce bloating, and strengthen the immune system. Taking them together may maximize their impact.

2. What do enzymes and probiotics do for the body?

Enzymes break down complex nutrients into smaller particles, aiding digestion. Probiotics help maintain a balance between 'good' and 'bad' gut bacteria, supporting gut health. Together, they can improve digestive issues and promote overall digestive health.

3. Is it OK to take digestive enzymes every day?

Taking digestive enzyme supplements daily is generally safe and can improve digestion without side effects. However, it is advisable to inform a healthcare provider about their usage, especially if you plan to take them regularly. This way, you have professional guidance and support if needed.

4. Who shouldn't take digestive enzymes?

Digestive enzymes that break down carbohydrates into sugars are not recommended for diabetics, as well as pregnant or breastfeeding women. It is important to consult with a healthcare provider before taking any supplements, especially if you have specific health conditions.

5. What are the best digestive enzymes?

The three most common digestive enzymes are amylase, lipase, and protease. Amylase breaks down complex carbohydrates, lipase breaks down fats, and protease breaks down proteins. These enzymes play a crucial role in the digestion of different nutrients.

6. What are signs you need digestive enzymes?

Signs that you may need digestive enzymes include belly pain or cramps, bloating, diarrhea, gas, oily stools, and unexplained weight loss. If you experience these symptoms, it may be worth considering digestive enzyme supplementation to support your digestion.

Editor's Notes

During our probiotic enzyme supplement research, we found 24 probiotic enzyme supplement products and shortlisted 10 quality products. We collected and analyzed 413,712 customer reviews through our big data system to write the probiotic enzyme supplements list. We found that most customers choose probiotic enzyme supplements with an average price of $20.20.

The probiotic enzyme supplements are available for purchase. We have researched hundreds of brands and picked the top brands of probiotic enzyme supplements, including Physician's CHOICE, Nature's Truth, Wholesome Wellness, Reckitt, Zenwise Health. The seller of top 1 product has received honest feedback from 8,333 consumers with an average rating of 4.9.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.

Probiotic Enzyme Supplements Comparison Table

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Brand Physician's CHOICE Nature's Truth Wholesome Wellness Reckitt Zenwise Health Carlyle Life Extension NatureBell DR VITAMIN SOLUTIONS FR!SKA
Unit Count 60.0 Count 60.0 Count 180 Count 96.00 Count 60.0 Count 180 Count 60 Count 240.0 Count 60 Count 30.00 Count
Item Form Capsule Capsule Capsule Capsule Capsule Capsule Capsule Capsule Capsule Capsule
Flavor Digestive Enzymes - Unflavored Unflavored Unflavored Unflavored Unflavored Digestive Enzymes with Prebiotics Unflavored Woman
Product Benefits Digestive Health, Gut Health, Digestive Relief, Meal Time Relief Digestive Health Support - Digestive Health Support Immune Support, nutrient absorption, indigestion relief, Gut Health Support, digestive aid, Digestive Health Support Digestive Health Support Helps your body absorb nutrients from the food you eat, Vegetarian and non-GMO formula, 10-enzyme blend targets plant-based foods plus proteins, fats & carbs, Promotes optimal digestion, especially for those on plant-based diets - Digestive Health Support Bone Support, Nail and Hair Health, Digestive Support, Bloating Relief, Digestive Balance
Age Range (Description) Adult Adult Adult - Adult Adult - Adult Adult Adult
Item Weight 0.18 Pounds 3.1 Ounces 0.46 Pounds 2.08 Ounces 0.06 Kilograms - 0.14 Pounds - - 0.31 Pounds
Package Information Bottle Bottle Bottle - - Bottle - Bottle Bottle Bottle
Item dimensions L x W x H 2.31 x 2.31 x 4.5 inches 2.03 x 2.03 x 4.31 inches - 2.01 x 4.25 x 6.42 inches - 2.75 x 2.75 x 4.75 inches 2 x 2 x 3.6 inches - 2.03 x 2.03 x 3.97 inches -
Diet Type Vegan - Vegan Vegetarian Vegan - Vegetarian - - Vegetarian
FTB Score
ftb score rating icon 9.9
ftb score rating icon 9.8
ftb score rating icon 9.6
ftb score rating icon 9.6
ftb score rating icon 9.4
ftb score rating icon 9.2
ftb score rating icon 9.1
ftb score rating icon 9.0
ftb score rating icon 8.9
ftb score rating icon 8.8
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