Best Vitamin B6 Enzyme Supplements of 2025

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 6, 2025

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Vitamin B6 enzyme supplements are a popular choice among individuals looking to support their overall health and wellbeing. These supplements contain pyridoxine, a form of vitamin B6 that is essential for the proper functioning of enzymes in the body. Vitamin B6 helps the body break down proteins, carbohydrates, and fats, and also plays a role in the production of red blood cells and neurotransmitters. As a result, taking a Vitamin B6 enzyme supplement may help support healthy brain function, improve mood, and boost energy levels. These supplements come in various forms such as capsules, tablets, and gummies, making them easy to incorporate into one's daily routine.

At a Glance: Our Top Picks

Clean Nutra Natto Serrapeptase Enzyme Supplement Cover #TOP 1
Clean Nutra Natto Serrapeptase Enzyme Supplement
ftb score rating icon 9.8
Nattokinase 2000 FU with CoQ10 Cover #TOP 2
Nattokinase 2000 FU with CoQ10
ftb score rating icon 9.7
TRIPLE 8 NUTRITION Nattokinase Enzyme Supplement Cover #TOP 3
TRIPLE 8 NUTRITION Nattokinase Enzyme Supplement
ftb score rating icon 9.5

Top 10 Vitamin B6 Enzyme Supplements

#TOP 1

Clean Nutra Natto Serrapeptase Enzyme Supplement

Nattokinase
Natural
Clean Nutra Natto Serrapeptase Enzyme Supplement Cover
Clean Nutraceuticals Nattokinase 4000 FU Serrapeptase 120000 SPU Lumbrokinase Enzyme Supplement with Bromelain Papain Papaya Enzymes Rutin Extract Amla Magnesium Vitamin B6 & VIT C Capsules

Clean Nutra Natto Enzyme is a powerful enzyme supplement that combines Nattokinase, Serrapeptase, and Lumbrokinase to provide a potent blend of fibrinolytic enzymes. These enzymes are carefully selected to ensure each serving delivers 4000 units of Nattokinase, promoting healthy blood flow and cardiovascular health. The formula is enriched with Rutin and Papain, which further enhance its effectiveness. In addition to the enzymes, Clean Nutra Natto Enzyme is fortified with a range of nutritional ingredients including coq10, bromelain, calcium, sofora japonica, turmeric, Vitamin B6, Vitamin C, and papaya enzyme. This comprehensive blend supports overall health and well-being. Made in the USA with strict quality standards, Clean Nutra Natto Enzyme is easy to incorporate into your daily routine, providing you with the convenience and benefits of a superior enzyme supplement.

What We Like
Powerful fibrinolytic enzyme blend
Enriched with nutritional ingredients
Superior quality and made in the USA
#TOP 2

Nattokinase 2000 FU with CoQ10

NutraPep
Nattokinase 2000 FU with CoQ10 Cover
Nattokinase 2000 FU Serrapeptase 240000 SPU Supplement - Enhanced with Coenzyme CoQ10 Vitamin B6 Vitamin C Black Pepper Extract - Nattokinase 400mg Capsule for Men Women

Nattokinase 2000 FU by NutraPep offers a convenient way to enjoy the health benefits of natto without the unpleasant taste or smell. Each capsule delivers 2000 FUs of this vital enzyme, promoting your overall well-being. Enhanced with 240,000 SPUs of Serrapeptase, this supplement supports your body’s natural processes. The combination of CoQ10, Vitamin B6, and Vitamin C, along with black pepper extract, boosts nutrient absorption and enhances antioxidant levels. This means you can feel energized and supported in your daily activities while following a vegan, gluten-free lifestyle.

What We Like
High enzyme content
Enhanced nutrient absorption
Supports energy levels
Vegan and gluten-free
#TOP 3

TRIPLE 8 NUTRITION Nattokinase Enzyme Supplement

TRIPLE 8 NUTRITION
TRIPLE 8 NUTRITION Nattokinase Enzyme Supplement Cover
TRIPLE 8 NUTRITION Nattokinase 4000 FU Serrapeptase 120000 SPU Lumbrokinase Enzyme Supplement with Bromelain Papain Papaya Enzymes Rutin Extract Amla Magnesium Vitamin B6 & VIT C Capsules

TRIPLE 8 NUTRITION Enzyme Blend is a powerful supplement designed to support your health. It features a unique combination of Nattokinase, Serrapeptase, and Lumbrokinase, which are known for their fibrinolytic properties, helping to maintain healthy circulation. This blend is enhanced with Rutin and Papain, increasing its effectiveness. Additionally, the product is packed with essential nutrients like Vitamin B6 and Vitamin C, offering a comprehensive health boost. With easy-to-measure servings in a user-friendly bottle, you can effortlessly incorporate this supplement into your daily routine for maximum benefit.

What We Like
Powerful enzyme blend
Nutrient-rich formula
Easy to use
High-quality standards
#TOP 4

FRISKA Mens Daily Digestive Enzyme and Probiotics Supplement

0850012288022
FRISKA Mens Daily Digestive Enzyme and Probiotics Supplement Cover
FRISKA Men’s Daily Digestive Enzyme and Probiotics Supplement, Natural Support for Male Digestive Health, Bloating, Gas, Indigestion Relief, Supports Gut Health, Lactase and B-Vitamins, 30 Capsules

FRISKA Mens Daily Supplement is a powerful probiotic and digestive enzyme blend designed specifically for men. Enforced with lactase, it helps break down lactose sugar found in dairy products, making it ideal for those with lactose intolerance. The added B vitamins support brain and red blood cell function, promoting overall well-being. This supplement also includes digestive enzymes like amylase and lipase, as well as lactobacillus acidophilus probiotic, which provide relief from gut issues such as abdominal pain, bloating, and gas. By restoring gut health and maintaining healthy enzyme levels, FRISKA Mens Daily Supplement helps alleviate symptoms like diarrhea and bloating. Made from naturally sourced organic ingredients, this clean alternative is plant-based and easy to digest.

What We Like
Powerful probiotics
Enforced with lactase
Includes B vitamins

MaryRuth's Ultra Digestive Food Enzymes

MaryRuth's Ultra Digestive Food Enzymes Cover
MaryRuth Organics Ultra Digestive Enzymes Capsules | Up to 2 Month Supply | Supplement for Gut Health Support | Digestion & Immune Support with Amylase | Lipase & Lactase | Vegan | 60 Count

MaryRuth's Ultra Digestive Food Enzymes is a vegan supplement formulated to enable digestion, especially in those with digestive issues, amplifying nutrient absorption while reducing bloating, gas and abdominal pain. This extra strength blend of enzymes are formulated to help digest proteins, carbohydrates, fiber, fat, and lactose. It includes Protease, Amylase, Glucoamylase, Diastase, Invertase, Pectinase, Cellulase, Hemicellulase, Xylanase, Lipase, Lactase, Alpha-Galactosidase, and Beta-Glucanase. It is Non-GMO & Vegan, Dairy Free, Nut Free, Gluten & Wheat Free, Soy Free, Nightshade Free, Sugar Free, and contains Maltodextrin. Customers have reported that it works great and helps reduce bloating, gas, and abdominal pain.

What We Like
Formulated to enable digestion, amplifying nutrient absorption
Extra strength blend of enzymes to help digest proteins, carbohydrates, fiber, fat, and lactose
Non-GMO & Vegan, Dairy Free, Nut Free, Gluten & Wheat Free, Soy Free, Nightshade Free, Sugar Free
#TOP 6

Nutra BioGenesis - PanZyme - Digestive Enzymes - 180 Capsules

812806102563
Nutra BioGenesis - PanZyme - Digestive Enzymes - 180 Capsules Cover
Nutra BioGenesis - PanZyme - B Vitamins, Betanine HCl, and Pancreatin as Digestive Enzymes for Digestive Health - 180 Capsules

Nutra BioGenesis - PanZyme is a multi-enzyme supplement designed to maintain proper digestion of nutrients obtained from food. The blend contains Pancreatin and Hydrochloric Acid which help to provide nutritive support for digestion and absorption within the stomach and small intestine. The supplement is also enriched with botanicals, Betaine HCl, and digestive enzymes to enhance nutrient absorption. Additionally, its powerful combination of Vitamin B6, Betaine HCl, Ammonium Chloride and Pancreatin 4x helps to support digestive health. It is 100% free of magnesium stearate and stearic acid.

What We Like
Contains Pancreatin and Hydrochloric Acid to help maintain proper digestion
Enriched with botanicals, Betaine HCl, and digestive enzymes for enhanced nutrient absorption
Provides a powerful combination of Vitamin B6, Betaine HCl, Ammonium Chloride and Pancreatin 4x to support digestive health
100% free of magnesium stearate and stearic acid
#TOP 7

hessrida Nattokinase & Serrapeptase Supplement

hessrida
Nattokinase-WB
White
hessrida Nattokinase & Serrapeptase Supplement Cover
hessrida Nattokinase 12,000 FU Serrapeptase 360,000 SPU Supplement, Enriched with Super Enzymes, Nutrient Blend & Inulin for Circulation, Digestion & Gut Support, 60 Capsules

The hessrida Enzyme Complex combines powerful enzymes to enhance your health. With 12,000 FU of nattokinase and 360,000 SPU of serrapeptase, this supplement supports your digestion, circulation, and detoxification needs. You can enjoy the benefits of these enzymes, which are known for their ability to promote overall wellness. Additionally, the formula includes essential nutrients like vitamin C and magnesium, ensuring you receive comprehensive support. Thanks to advanced delivery technology, the capsules protect the enzymes from stomach acid, maximizing their absorption in your intestines for optimal effectiveness.

What We Like
Supports digestion and circulation
High absorption technology
Includes essential nutrients
Non-GMO and vegan-friendly
#TOP 8

Nattokinase Enzyme Supplement by Ehvzno

Ehvzno
Nattokinase Enzyme Supplement by Ehvzno Cover
Nattokinase Supplement 4000 FU Serrapeptase 120000 SPU Lumbrokinase Enzyme Supplement with Bromelain Papain Papaya Enzymes Rutin Extract Amla Magnesium Vitamin B6 & VIT C Capsules

Ehvzno Nattokinase Enzymes offers a powerful blend of enzymes designed to support your health. With 4000 units of Nattokinase, along with Serrapeptase and Lumbrokinase, this supplement enhances your body's ability to break down fibrin and promote overall well-being. It also includes vital nutrients like CoQ10 and Vitamin C, which help boost your immune system and energy levels. The convenient packaging makes it easy to incorporate into your daily routine, ensuring you can easily access its numerous health benefits without hassle. Trust in this USA-made product for quality and effectiveness.

What We Like
Powerful enzyme blend
Includes essential nutrients
Convenient daily use
High-quality USA-made

BulkSupplements Papaya Powder

PAPYPWD
BulkSupplements Papaya Powder Cover
BulkSupplements.com Papaya Powder - Bone Marrow Supplements - Papaya Digestive Enzymes - Immune Boost - Organic Extracts (1 Kilogram - 2.2 lbs)

BulkSupplements Papaya Digestive Enzymes is a high-quality, pure and natural supplement that offers a range of benefits. Packed with antioxidants, it supports a healthy immune system and aids in digestion. The vitamins A and C in the papaya powder contribute to maintaining healthy skin, while the papain enzyme has anti-inflammatory effects and can improve skin elasticity. Additionally, the vitamin B6 in the papaya extract promotes heart health by supporting energy metabolism and reducing fatigue. This gluten-free and dairy-free supplement is manufactured according to cGMP Standards, ensuring the highest quality. With no fillers or additives, BulkSupplements Papaya Digestive Enzymes is a convenient way to enjoy all the benefits of papaya.

What We Like
Rich in antioxidants
Promotes healthy skin
Contributes to heart health
#TOP 10

Dr. Wolz Zell Oxygen Immunkomplex

Dr. Wolz
17US
Dr. Wolz Zell Oxygen Immunkomplex Cover
Dr. Wolz Zell Oxygen Immunkomplex, BioActive Yeast Enzyme Concentrate, Dietary Supplement, 8.5 oz, 2-Pack

Dr. Wolz Immunkomplex is a premium dietary supplement designed to support your immune system health. Packed with a blend of trace elements, including selenium, zinc, lycopene, and broad-spectrum vitamins, this formula helps fortify your immune system. By fighting oxidative stress with its natural antioxidants, it can also slow signs of aging and reduce the effects of damaging UV sun rays. In addition, it contains vitamins B2, B6, B12, niacin, and pantothenic acid to reduce fatigue and restore energy, making it ideal for those with a weakened immune system. Free of lactose, colorants, or preservatives, Dr. Wolz Immunkomplex is a broad-spectrum formula that supports your well-being inside and out.

What We Like
Premium immune support
Fights oxidative stress
Reduces fatigue, restores energy
Buying Guide Image

Frequently Asked Questions (FAQs)

1. What enzymes use vitamin B6?

Representatives of the PLP-binding folds of the five structural classes of vitamin B6 dependent enzymes — the aspartate aminotransferase family, the tryptophan synthase β family, the alanine racemase family, the d-amino acid family and the glycogen phosphorylase family — are shown in Figure 3.

2. What is the supplement B6 good for?

Vitamin B6 is needed for the proper function of sugars, fats, and proteins in the body. It's also necessary for the development of the brain, nerves, skin, and many other parts of the body. It's found in cereals, legumes, and eggs, and often used with other B vitamins in vitamin B complex products.

3. What is vitamin B6 coenzyme?

Vitamin B6, or pyridoxine, is a water-soluble vitamin found naturally in many foods, as well as added to foods and supplements. Pyridoxal 5' phosphate (PLP) is the active coenzyme form and most common measure of B6 blood levels in the body.

4. What is the best form of vitamin B6?

The richest sources of vitamin B6 include fish, beef liver and other organ meats, potatoes and other starchy vegetables, and fruit (other than citrus). In the United States, adults obtain most of their dietary vitamin B6 from fortified cereals, beef, poultry, starchy vegetables, and some non-citrus fruits [1,3,5].

Editor's Notes

During our vitamin b6 enzyme supplement research, we found 24 vitamin b6 enzyme supplement products and shortlisted 10 quality products. We collected and analyzed 21,050 customer reviews through our big data system to write the vitamin b6 enzyme supplements list. We found that most customers choose vitamin b6 enzyme supplements with an average price of $29.32.

The vitamin b6 enzyme supplements are available for purchase. We have researched hundreds of brands and picked the top brands of vitamin b6 enzyme supplements, including Clean Nutraceuticals, NutraPep, TRIPLE 8 NUTRITION, FR!SKA, MaryRuth Organics. The seller of top 1 product has received honest feedback from 7,345 consumers with an average rating of 4.8.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.