Best Multi-Enzyme Supplements of 2025

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 16, 2025

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Multi-enzyme supplements are dietary supplements that contain a combination of different enzymes that help to break down food molecules in the digestive system. These enzymes include proteases, amylases, and lipases, which are responsible for breaking down proteins, carbohydrates, and fats, respectively. Multi-enzyme supplements are often used to aid in digestion, alleviate symptoms of indigestion, and improve nutrient absorption. They are also popular among athletes and fitness enthusiasts as they can help to enhance protein synthesis and promote muscle growth. However, it is important to consult with a healthcare professional before incorporating multi-enzyme supplements into one's diet.

At a Glance: Our Top Picks

Zenwise Digestive Enzymes Cover #TOP 1
Zenwise Digestive Enzymes
ftb score rating icon 9.8
Physician's CHOICE Digestive Enzymes Cover #TOP 2
Physician's CHOICE Digestive Enzymes
ftb score rating icon 9.7
NOW Supplements Super Enzymes Cover #TOP 3
NOW Supplements Super Enzymes
ftb score rating icon 9.5

Top 10 Multi-Enzyme Supplements

#TOP 1

Zenwise Digestive Enzymes

Zenwise Digestive Enzymes Cover
Zenwise Health Digestive Enzymes for Gut Health - Probiotic Multi Enzymes with Prebiotics and Probiotics for Women and Men for Digestive Health and Bloating Relief, Daily Enzymes for Digestion -60 CT

Zenwise Enzymes is a convenient 3-in-1 gut support solution for digestive health and bloating relief. With its lab-proven multi-enzyme blend, it can help digest foods up to 39% more completely and 2 hours faster than your body can on its own. This makes it perfect for individuals following gluten-free, Keto, or Paleo diets, as well as those experiencing occasional bloating, gas, and discomfort from hard-to-digest foods. The product also contains a clinically proven DE111 probiotic, which guarantees to arrive alive and work within hours in the small intestine, where 90% of nutrient absorption occurs. Additionally, Zenwise Enzymes includes a variety of botanical ingredients like turmeric, ginger, and green papaya, which aid in gut health and stomach comfort. Taking just one capsule before each meal or drink can provide you with the digestive delight you've been seeking.

What We Like
Improves digestion
Reduces bloating
Helps with bowel movements
Easy to swallow
Effective during travel
What We Don't Like
May cause mild stomach discomfort
Requires taking with meals
#TOP 2

Physician's CHOICE Digestive Enzymes

Physician's CHOICE Digestive Enzymes Cover
Physician's CHOICE Digestive Enzymes - Multi Enzymes, Organic Prebiotics & Probiotics for Digestive Health & Gut Health - Meal Time Discomfort Relief & Bloating - Dual Action Approach - 60 CT

Physician's CHOICE Enzymes is a powerful digestive health supplement designed to provide relief from mealtime discomfort. With 16 beneficial enzymes, it helps digest proteins, carbs, fruits, veggies, beans, dairy, and fats, making it suitable for all diets. The dual action approach combines digestive enzymes with prebiotics and probiotics to promote healthy digestion and gut function. The probiotics in this supplement are specially selected for their ability to survive the harsh gut environment, and the organic prebiotics fuel the growth of healthy bacteria in the gut. Crafted based on scientific research, Physician's CHOICE Enzymes are 3rd-party tested for purity and potency, ensuring a safety assured standard of quality. Take control of your digestive health with Physician's CHOICE Enzymes.

What We Like
Effective for digestion
Affordable price
Helps reduce bloating
Natural ingredients
Quick relief after use
What We Don't Like
Herbal taste
May not help with bloating
#TOP 3

NOW Supplements Super Enzymes

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Beige W/Speckles
NOW Supplements Super Enzymes Cover
NOW Foods Supplements, Super Enzymes, Formulated with Bromelain, Ox Bile, Pancreatin and Papain,180 Capsules

NOW Supplements Super Enzymes is a comprehensive blend of enzymes that supports healthy digestion. Formulated with bromelain, ox bile, pancreatin and papain, Super Enzymes helps to optimize the breakdown of fats, carbohydrates and protein. It is Soy Free, Made without Gluten, Keto Friendly and GMP Quality Assured. Customers have reported that it helps with digestive issues, bloating, slow metabolism, and acid indigestion. It is easy to swallow and comes in capsule form.

What We Like
Effective for digestion support
Reduces bloating and discomfort
Safe and affordable option
Full-spectrum enzyme blend
What We Don't Like
May cause evening discomfort
Effectiveness may diminish over time
#TOP 4

NatureBell Digestive Enzymes with Probiotics

BA-NB-DE240C
NatureBell Digestive Enzymes with Probiotics Cover
NatureBell Digestive Enzymes with Probiotics and Prebiotics, 240 Veggie Capsules | Gut & Digestive Health Support – 20 Enzyme & 5 Prebiotic Pancreatic Enzyme Complex | Non-GMO, Vegan Friendly

NatureBell Digestive Enzymes offers a comprehensive blend of digestive support in a convenient veggie capsule. With 240 capsules in a bottle, you can enjoy an 8-month supply, making it easy to incorporate into your daily routine. Each serving combines 20 digestive enzymes and 5 prebiotics, promoting better digestion and nutrient absorption. This unique formulation helps to alleviate bloating and supports overall gut health. Designed for both men and women, it aims to enhance your digestive balance and keep your gut flora thriving.

What We Like
Effective digestive aid
Improves digestion noticeably
Reduces bloating and discomfort
Convenient one-capsule dosage
Good value for the price
What We Don't Like
Strong odor of veggie capsules
No noticeable improvement for some
#TOP 5

NOW Supplements Super Enzymes Digestive Support, 180 Tablets

2962
Tan W/Speckles
NOW Supplements Super Enzymes Digestive Support, 180 Tablets Cover
NOW Foods Supplements, Super Enzymes, Formulated with Bromelain, Ox Bile, Pancreatin and Papain, 180 Tablets

NOW Supplements Super Enzymes is a blend of enzymes that supports healthy digestion. The formula is designed to break down fats, carbs, and protein and optimize nutrient availability. The tablets are easy to swallow and are GMP Quality Assured. The product is packaged in the USA by a family-owned and operated company since 1968. Product Note: Customers are expected to be available during the product delivery to avoid melting or damage to the product.

What We Like
Effective for digestive issues
Improves energy levels
Helps with food sensitivities
Contains ox bile for fat digestion
Affordable price
What We Don't Like
Large tablet size
Possible ingredient concerns
#TOP 6

Source Naturals Essential Enzymes

Source Naturals Essential Enzymes Cover
Source Naturals Essential Enzymes 500mg Bio-Aligned Multiple Supplement Herbal Defense for Digestion, Gas & Constipation Relief - Strong Immune System Support* - 120 Capsules

Source Naturals Essential Enzymes is a bio-aligned multiple supplement herbal defense for digestion, gas, and constipation relief. It helps the body breakdown proteins, fats, milk sugars, fiber and carbohydrates, and is ideal for those who are busy or eat out. Customers have reported that it helps to regulate their stomach, works great without a high price, and has helped them avoid GERD. It is a great supplement for anyone with GI issues or bodybuilders who are consuming a large amount of calories daily.

What We Like
Effective digestive aid
Helps with weight management
No bad taste or smell
Good for gas and bloating
Convenient dosage options
What We Don't Like
Possible issues with gastritis
#TOP 7

Wholesome Wellness Digestive Enzymes

digestive-enzymes
Green
Wholesome Wellness Digestive Enzymes Cover
Wholesome Wellness Digestive Enzymes 1000MG Plus Prebiotics & Probiotics Supplement, 180 Capsules, Organic Plant-Based Vegan Formula for Digestion & Lactose with Amylase & Bromelain,3-6 Months Supply

Wholesome Wellness Digestive Enzymes is a plant-based, organic supplement that helps improve digestion and gut health. With a 1000 MG dose of clinical grade digestive enzymes and a 10 billion CFU 10 strain probiotic with prebiotics, this supplement provides relief from bloating, flatulence, fat, pancreatic, and bowel cleansing. The Advanced Multi Enzyme System helps digest a variety of foods, including fried, spicy, raw, processed food, dairy, protein, salts, carb / carbohydrate, vitamin and acidic diet fruits and veggies. The supplement also contains a powerful 10 billion CFU dose of 10 different probiotic strains clinically shown to enhance preventions & immune system response.

What We Like
Life-changing digestive support
Effective absorption and nutrient support
Plant-based and vegan formula
Fast-acting results
Easy to swallow capsules
What We Don't Like
Not as effective for some users
Limited disclosure on ingredients
#TOP 8

Puritans Pride Multi Enzyme Tablets

Puritan's Pride
10332
White
Puritans Pride Multi Enzyme Tablets Cover
Puritan's Pride Multi-Enzyme Formula, Digestive Aid for Proteins, Fats, and Carbohydrates, Dietary Supplement for Digestion and Healthy Gut Support, 50 Day Supply, 100 Easy to Swallow Coated Tablets

Puritans Pride Multi Enzyme Tablets are a type of multi-enzyme supplement designed to aid in the digestion of proteins, fats, and carbohydrates. With a package dimension of 1.98" L X 1.98" W X 4.17" H and made in the United States, this product is a convenient and reliable choice for those looking to improve their digestive health.

What We Like
Effective for digestion
Minty taste
Good value for money
Easy to swallow
Helps with gas and discomfort
What We Don't Like
Thicker, uncoated tablets
Animal-sourced ingredient concern
#TOP 9

Standard Process Multizyme - Pancreas Support Capsules

Standard Process Multizyme - Pancreas Support Capsules Cover
Standard Process Multizyme - Whole Food Pancreas Support, Pancreatin Digestive Enzymes, Digestive Health and Pancreatic Enzymes with Cellulase, Papain, Amylase, Lipase and More - 150 Capsules

Standard Process Multizyme is a whole food pancreas support supplement that contains digestive enzymes like cellulase, papain, amylase, and lipase. These enzymes help in the gastric and intestinal phases of digestion and provide supplementary support to pancreatic function. The suggested use is one capsule per meal, or as directed. Standard Process is known for its high-quality, natural products.

What We Like
Reduces abdominal bloating
Improves digestion significantly
Allows natural body function
Effective for various digestion issues
Recommended by health professionals
What We Don't Like
Not the cheapest option
#TOP 10

The Vitamin Shoppe Multi Enzyme

The Vitamin Shoppe Multi Enzyme Cover
Multi Enzyme - Helps Support The Digestion & Absorption of Protein, Carbs & Fat (100 Tablets) by The Vitamin Shoppe

The Vitamin Shoppe Multi Enzyme is a specialty protein tablet with carbohydrates that supports the digestion and absorption of protein, carbs, and fat. This multi-enzyme supplement is designed to help break down food more efficiently, making it easier for your body to absorb essential nutrients. It does not contain common allergens such as yeast, wheat, gluten, soy, citrus, dairy, fish, artificial colors, or flavors. With a recommended dosage of two tablets after each meal, this supplement can be easily incorporated into your daily routine. It is important to note that it should not be taken on an empty stomach. If you are pregnant, nursing, taking medication, or have any medical conditions, it is advised to consult with your healthcare provider before use. With 100 tablets per bottle, this product provides 50 servings, ensuring long-lasting support for your digestive health.

What We Like
Effective for digestion
Helps with heartburn relief
Minty flavor
Concentrated ingredients
Good for overeating
What We Don't Like
Requires taking two pills
Size of a dime
Buying Guide Image

Learn More About Purchasing the Multi-Enzyme Supplements

Understanding Multi-Enzyme Supplements

Before deciding on a multi-enzyme supplement, it's important to understand what they are and what they do. Enzymes are proteins that help facilitate chemical reactions in the body. They are essential for many bodily functions, including digestion and metabolism. Multi-enzyme supplements contain a blend of different enzymes that can aid in the digestion of food.

Consider Your Needs

When choosing a multi-enzyme supplement, it's important to consider your individual needs. Are you looking to improve your digestion, or do you have a specific medical condition that requires additional enzymes? Your healthcare provider can help you determine the right type of enzymes and dosage for your needs.

Research the Brand

Not all multi-enzyme supplements are created equal. It's important to do your research and choose a reputable brand. Look for a brand that has been independently tested and certified for purity and potency. Additionally, read reviews from other customers to see how well the product has worked for them.

Understand the Ingredients

Make sure to carefully read the ingredient list on the label of the multi-enzyme supplement you're considering. Look for a blend of enzymes that will aid in the digestion of the types of food you typically eat. For example, if you eat a lot of dairy, look for a supplement that contains lactase.

Start Low and Go Slow

When starting a new supplement, it's always a good idea to start with a lower dosage and gradually increase as needed. This will help your body adjust to the new enzymes and reduce the risk of any adverse effects. It's also important to follow the recommended dosage on the label and not exceed the maximum daily amount.

Talk to Your Healthcare Provider

If you have any concerns or questions about taking a multi-enzyme supplement, it's important to consult with your healthcare provider. They can provide personalized advice and guidance based on your individual needs and medical history.

Conclusion

Choosing the right multi-enzyme supplement can provide numerous benefits for your digestion and overall health. By considering your individual needs, researching the brand, understanding the ingredients, starting low and going slow, and talking to your healthcare provider, you can make an informed decision and choose the best supplement for you.

Frequently Asked Questions (FAQs)

1. What does multi enzyme do for your body?

Multi-enzyme supplements contain digestive enzymes that help break down and digest food. These enzymes are natural substances that the body needs to support the digestive process.

2. Do digestive enzyme supplements really work?

While digestive enzyme supplements are claimed to improve various abdominal symptoms and overall gut health, there is limited evidence to support these claims. For most people, there is little proof that digestive enzyme supplements provide significant benefits.

3. Is there a downside to taking digestive enzymes?

Some potential downsides of taking digestive enzyme supplements include upset stomach, stomach pains, cramping, diarrhea, nausea, gas, and bloating. It's important to be aware of these possible side effects.

4. What are the side effects of multi digestive enzymes?

The potential side effects of multi digestive enzymes may include gas, bloating, loose stools or diarrhea, constipation, nausea, stomach discomfort, greasy stools, and headaches.

5. When should I take multi enzyme?

It is recommended to take multi enzyme supplements along with food. In most cases, they should be taken in combination with specific foods to ensure they function properly.

6. Which enzyme is best for weight loss?

Lipase is an enzyme that may be beneficial for weight loss. Lipase supplements can help increase the amount of fat that the body metabolizes.

7. Who shouldn't take enzymes?

People with ulcers, those taking blood thinners or anti-inflammatories, or those undergoing surgery should avoid taking enzymes. Digestive enzymes that break down protein can potentially worsen ulcers and interfere with blood clotting.

8. What happens to your body when you start taking digestive enzymes?

When taking digestive enzymes, the body processes food more efficiently, receives more nutrition, and the gut may heal and eliminate inflammation and waste. There may also be a die-off of yeast, bacteria, and pathogens when using therapeutic formulas that contain high levels of protease.

Editor's Notes

During our multi-enzyme supplement research, we found 24 multi-enzyme supplement products and shortlisted 10 quality products. We collected and analyzed 523,220 customer reviews through our big data system to write the multi-enzyme supplements list. We found that most customers choose multi-enzyme supplements with an average price of $20.69.

The multi-enzyme supplements are available for purchase. We have researched hundreds of brands and picked the top brands of multi-enzyme supplements, including Zenwise Health, Physician's CHOICE, NOW Foods, NatureBell, Source Naturals. The seller of top 1 product has received honest feedback from 1,273 consumers with an average rating of 4.9.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.

Multi-Enzyme Supplements Comparison Table

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Brand Zenwise Health Physician's CHOICE NOW Foods NatureBell NOW Foods Source Naturals Wholesome Wellness Puritan's Pride Standard Process Inc. The Vitamin Shoppe
Unit Count 60.0 Count 60.0 Count 180 Count 240.0 Count 180 Count 120.00 Count 180 Count 100 Count 150.0 Count 100.0 Count
Item Form Capsule Capsule Capsule Capsule Tablet Capsule Capsule Tablet Capsule Tablet
Flavor Unflavored Digestive Enzymes Unflavored Digestive Enzymes with Prebiotics Unflavored Unflavored Unflavored Unflavored Unflavored -
Item Weight 0.06 Kilograms 0.18 Pounds 0.21 Pounds - 0.2 Kilograms 0.01 Pounds 0.46 Pounds 0.1 Grams 0.14 Kilograms 0.11 Kilograms
Product Benefits Immune Support, nutrient absorption, indigestion relief, Gut Health Support, digestive aid, Digestive Health Support Digestive Health, Gut Health, Digestive Relief, Meal Time Relief Healthy Digestion,Supports,Supports Healthy Digestion - Digestive Health Support Constipation Relief - Digestive Aid Digestive Health Support Digestive Health Support
Age Range (Description) Adult Adult - Adult - Adult Adult Adult Adult Child
Diet Type Vegan Vegan Keto, Gluten Free - Keto, Gluten Free Vegetarian Vegan Vegetarian - -
Item dimensions L x W x H - 2.31 x 2.31 x 4.5 inches 2.81 x 2.81 x 5.13 inches - 2.7 x 2.7 x 4.75 inches 2.21 x 2.21 x 3.94 inches - 1.98 x 1.98 x 4.17 inches - 2.4 x 2.4 x 4.4 inches
Primary Supplement Type Bromelain, Digestive Enzymes - protein - protein Enzymes - multivitamin - -
FTB Score
ftb score rating icon 9.8
ftb score rating icon 9.7
ftb score rating icon 9.5
ftb score rating icon 9.4
ftb score rating icon 9.2
ftb score rating icon 9.1
ftb score rating icon 9.1
ftb score rating icon 8.9
ftb score rating icon 8.7
ftb score rating icon 8.7
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