Best Papain Enzyme Supplements of 2025

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Papain enzyme supplements are derived from the papaya fruit and are known for their digestive benefits. These supplements contain papain, a proteolytic enzyme that breaks down proteins in the digestive system, making it easier for the body to absorb nutrients. Papain enzyme supplements are commonly used to alleviate digestive issues such as bloating, gas, and constipation. They are also believed to have anti-inflammatory properties and may aid in wound healing. These supplements come in various forms, including capsules, tablets, and powders, and can be found at most health food stores.
At a Glance: Our Top Picks
Top 10 Papain Enzyme Supplements
American Health Super Papaya Plus Digestive Enzyme Chewable Tablets
American Health Super Papaya Plus Digestive Enzyme Chewable Tablets are a great-tasting, vegetarian formula that helps with digestion and nutrient absorption. It contains papain and other enzymes, as well as peppermint and chlorophyll to freshen breath and reduce bad taste. Customers have found it to be helpful with inefficient digestion, nausea, upset stomach, acid reflux, and digestion. It is gluten-free, wheat-free, lactose-free, egg-free, preservative-free, yeast-free, milk-free, soy-free, grapefruit-free, sodium-free, and artificial color-free.
Complete Natural Products Organic Papaya Enzyme Capsules
Complete Natural Products Organic Papaya Enzyme Capsules are made in the USA and certified USDA Organic & OU Kosher. These veggie caps are vegan and non-GMO herbal supplements that contain natural papain enzymes from papaya. Papaya supplements are a great source of vitamins A, B, C, and K and are known as an excellent immunity booster. These capsules are high in fiber and water content, which help prevent constipation and promote a smooth bowel movement. The enzyme papain present in organic papaya powder is known to aid digestion by breaking down proteins. Therefore, a couple of capsules of papaya powder are often recommended as a home remedy for digestion-related problems and gut health.
NOW Supplements Super Enzymes
NOW Supplements Super Enzymes is a comprehensive blend of enzymes that supports healthy digestion. Formulated with bromelain, ox bile, pancreatin and papain, Super Enzymes helps to optimize the breakdown of fats, carbohydrates and protein. It is Soy Free, Made without Gluten, Keto Friendly and GMP Quality Assured. Customers have reported that it helps with digestive issues, bloating, slow metabolism, and acid indigestion. It is easy to swallow and comes in capsule form.
Swanson Papain Papaya Enzyme 90 Veg Capsules
Swanson Papain Papaya Enzyme is a protein-digesting enzyme that provides additional digestive support at mealtimes. It is a sugar-free alternative for protein digestion support, making it a convenient option for those looking to support their digestive health. With its vegetarian formula, it caters to individuals following a vegetarian lifestyle. This enzyme supplement, formulated according to GMP guidelines, offers a reliable option for maintaining digestive wellness. Swanson Papain Papaya Enzyme is a must-have for anyone seeking to improve their protein digestion and overall digestive health.
NusaPure Papaya Papain Enzyme
NusaPure Papaya Papain Enzyme is a powerful digestive health supplement that offers 900mg of papain per serving. It is non-GMO, gluten-free, and vegan/vegetarian friendly. It is manufactured in the USA in a cGMP registered facility and is crafted with high quality, clean, and non-GMO ingredients. Customers have reported positive results in terms of digestive health support, as well as improved blood sugar levels and weight loss. However, some customers have reported feeling sick after taking the product.
Garden of Life Dr Formulated Digestive Enzymes
Garden of Life Dr Formulated Digestive Enzymes with Papain, Bromelain, Lipase for Digestion & Nutrient Absorption is a full spectrum plant-based enzyme formula to aid the digestion of proteins, fats, and carbs. It is Certified Organic and Non-GMO, Gluten-Free, Vegan and Carbon Neutral. It comes in a tropical flavored, shelf stable tablet that is easy to take on the go.
NOW Plant Enzymes Supplement
NOW Plant Enzymes is a blend of enzymes that helps to support proper digestion by breaking down fats, fiber, proteins, and carbohydrates, optimizing nutrient availability in the food you eat. The product is vegan, Non-GMO, Soy Free, and Kosher certified. Moreover, the GMP quality assured certification ensures that every aspect of the NOW manufacturing process has been examined, including laboratory/testing methods for potency, stability, and product formulation. It is a plant-based enzyme supplement for people who want to maintain healthy digestion.
Double Wood's VitaZyme Digestive Blend
Double Wood's VitaZyme Digestive Blend is a powerful 800mg blend of all 10 most essential digestive and pancreatic enzymes. It contains Amylase, Lipase, Bromelain, Lactase, Papain, Protease, Cellulase, Maltase, Invertase, and Glucoamylase to break down proteins, fats, and carbohydrates. It is Non-GMO, Gluten Free, and manufactured and tested for safety in the USA. Customers have reported improved digestion, bloating relief, and better absorption of nutrition.
Carlyle Plant Enzymes
Experience the power of Carlyle Enzyme Blend, a premium multi-enzyme supplement designed to support your overall wellness. This potent complex features a blend of eight plant enzymes, including Papain, Bromelain, and Lactase, to provide you with maximum daily support. Carlyle, a trusted brand in the health industry, is committed to delivering honest and superior quality supplements for your healthy living journey. With Carlyle Enzyme Blend, you can enjoy the convenience of vegetarian capsules and the peace of mind knowing that it is free from gluten, wheat, yeast, milk, lactose, soy, artificial color, flavor, and preservatives. Take control of your well-being with Carlyle Enzyme Blend and experience the benefits it can bring to your daily life.
Wonder Labs Proteolytic Enzymes with Digestive Enzymes
Wonder Laboratories Proteolytic Enzymes with Digestive Enzymes supports your body's natural response to inflammation, immune function, and digestive health. It contains Bromelain, Lipase, Trypsin, Papain, Pancreatin, Chymotrypsin, Protease, and Amylase. The organic sources of digestive enzymes are well-formulated for your digestive system. The product is made and packaged in the USA by a family-owned company since 1962.
Frequently Asked Questions (FAQs)
1. What is papain enzyme used for?
It is a protease, meaning it breaks down proteins. Papain contains substances that might help fight infection and heal wounds. People use papain for dental cavities, shingles, parasite infections, jellyfish stings, wound healing, and many other conditions, but there is no good scientific evidence to support these uses.
2. What are the benefits of taking papaya enzymes?
Derived from unripe papayas, papain is a strong digestive aid. It is an enzyme that works by breaking down proteins, which helps the gut soak up more nutrients. Papain may provide safe symptom relief to people with celiac disease, IBS, and indigestion. Papaya enzyme is also an anti-inflammatory and antioxidant.
3. Can I take papaya enzyme everyday?
Papaya leaf extract is possibly safe when taken as medicine for up to 5 days. Side effects might include nausea and vomiting. The unripe papaya fruit is possibly unsafe. Unripe papaya fruit contains papaya latex, which contains an enzyme called papain.
During our papain enzyme supplement research, we found 24 papain enzyme supplement products and shortlisted 10 quality products. We collected and analyzed 170,698 customer reviews through our big data system to write the papain enzyme supplements list. We found that most customers choose papain enzyme supplements with an average price of $18.05.
The papain enzyme supplements are available for purchase. We have researched hundreds of brands and picked the top brands of papain enzyme supplements, including American Health, Complete Natural Products, NOW Foods, Swanson, NusaPure. The seller of top 1 product has received honest feedback from 385 consumers with an average rating of 4.7.

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