Best Enzyme Supplements for Immune Support of 2025

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 6, 2025

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Enzyme supplements are becoming increasingly popular for immune support. These supplements contain enzymes that help break down food and nutrients in the body, allowing the immune system to function more efficiently. Enzymes such as protease, amylase, and lipase can help to reduce inflammation, improve digestion, and boost overall immunity. Some enzyme supplements also contain probiotics, which can further enhance immune function by promoting the growth of beneficial gut bacteria. These supplements can be particularly helpful for those with digestive issues or weakened immune systems, but they should always be used in conjunction with a healthy diet and lifestyle.

At a Glance: Our Top Picks

Enzymedica Enzyme Defense Cover #TOP 1
Enzymedica Enzyme Defense
ftb score rating icon 9.8
Source Naturals Essential Enzymes Cover #TOP 2
Source Naturals Essential Enzymes
ftb score rating icon 9.7
MaryRuth's Ultra Digestive Food Enzymes Cover #TOP 3
MaryRuth's Ultra Digestive Food Enzymes
ftb score rating icon 9.5

Top 10 Enzyme Supplements for Immune Support

#TOP 1

Enzymedica Enzyme Defense

B00P9MZUMW
Brown
Enzymedica Enzyme Defense Cover
Enzymedica, Immune Defense, Regular Strength, Proteolytic Enzymes for Immune Support, 120 Count

Enzymedica Defense is a specialized enzyme formula designed to support your immune system. This powerful supplement helps purify your body by breaking down unwanted proteins and promoting healthy circulation. By assisting in removing proteins that don't belong in your bloodstream, Enzymedica Defense helps your immune system work at its best, especially when faced with environmental threats. With its fast-acting Thera-blend enzymes, this supplement provides targeted support throughout your digestive system. Take two capsules daily on an empty stomach for maximum benefits. Enzymedica is a trusted brand backed by rigorous science and research, giving you confidence in their supplements.

What We Like
Complete immune support
Promotes healthy immune function
Fast-acting enzyme support
#TOP 2

Source Naturals Essential Enzymes

Source Naturals Essential Enzymes Cover
Source Naturals Essential Enzymes 500mg Bio-Aligned Multiple Supplement Herbal Defense for Digestion, Gas & Constipation Relief - Strong Immune System Support* - 120 Capsules

Source Naturals Essential Enzymes is a bio-aligned multiple supplement herbal defense for digestion, gas, and constipation relief. It helps the body breakdown proteins, fats, milk sugars, fiber and carbohydrates, and is ideal for those who are busy or eat out. Customers have reported that it helps to regulate their stomach, works great without a high price, and has helped them avoid GERD. It is a great supplement for anyone with GI issues or bodybuilders who are consuming a large amount of calories daily.

What We Like
Strong immune system support
Aids in digestion, gas, and constipation relief
Helps break down proteins, fats, and carbs
No aftertaste and easy to swallow
Cost-effective

MaryRuth's Ultra Digestive Food Enzymes

MaryRuth's Ultra Digestive Food Enzymes Cover
MaryRuth Organics Ultra Digestive Enzymes Capsules | Up to 2 Month Supply | Supplement for Gut Health Support | Digestion & Immune Support with Amylase | Lipase & Lactase | Vegan | 60 Count

MaryRuth's Ultra Digestive Food Enzymes is a vegan supplement formulated to enable digestion, especially in those with digestive issues, amplifying nutrient absorption while reducing bloating, gas and abdominal pain. This extra strength blend of enzymes are formulated to help digest proteins, carbohydrates, fiber, fat, and lactose. It includes Protease, Amylase, Glucoamylase, Diastase, Invertase, Pectinase, Cellulase, Hemicellulase, Xylanase, Lipase, Lactase, Alpha-Galactosidase, and Beta-Glucanase. It is Non-GMO & Vegan, Dairy Free, Nut Free, Gluten & Wheat Free, Soy Free, Nightshade Free, Sugar Free, and contains Maltodextrin. Customers have reported that it works great and helps reduce bloating, gas, and abdominal pain.

What We Like
Formulated to enable digestion, amplifying nutrient absorption
Extra strength blend of enzymes to help digest proteins, carbohydrates, fiber, fat, and lactose
Non-GMO & Vegan, Dairy Free, Nut Free, Gluten & Wheat Free, Soy Free, Nightshade Free, Sugar Free
#TOP 4

Enzymedica Enzyme Defense Extra Strength Supplement

29080
Enzymedica Enzyme Defense Extra Strength Supplement Cover
Enzymedica, Immune Defense, Extra Strength, Proteolytic Enzymes for 2X Immune & Respiratory Support, 90 Count

Enzymedica Enzyme Defense Extra Strength Supplement is an advanced dietary supplement that supports immune health and overall systemic health. The double potency formula provides complete enzyme support to build the body's defense against environmental threats. The supplement is certified non-GMO, vegan, kosher, and gluten-free. The Thera-blend enzymes cover the entire pH range of the human body. The supplement is made with the quality you expect from the digestion experts at Enzymedica.

What We Like
Double potency formula for healthy immune function and overall systemic health
Complete enzyme support for building the body's defense against environmental threats
Certified non-GMO, vegan, kosher, and gluten-free
#TOP 5

Source Naturals Essential Enzymes 500mg

Source Naturals Essential Enzymes 500mg Cover
Source Naturals Essential Enzymes 500mg Bio-Aligned Multiple Enzyme Supplement Herbal Defense for Digestion, Gas, Constipation & Bloating Relief - Supports Immune System* - 120 Vegetarian Capsules

Source Naturals Enzyme Supplement is a bio-aligned multiple enzyme supplement that aids in the body's natural digestive process. It expertly breaks down carbohydrates, protein, fat, and fiber, maximizing the body's utilization of nutrients in the diet. This supplement is suitable for vegetarians and does not contain common allergens such as yeast, dairy, gluten, or soy. With over 35 years of trust, Source Naturals is dedicated to supporting individual health potential. Manufactured in the USA, this supplement is a reliable choice for digestive health support.

What We Like
Digestive support
Vegetarian-friendly
No common allergens
#TOP 6

Digestive Advantage Lactose Defense Capsules

B075G6XMRZ
Digestive Advantage Lactose Defense Capsules Cover
Digestive Advantage Probiotics + Lactase Digestive Enzymes For Digestive Health, Daily Probiotics For Women Men Occasional Bloating, Lactose Breakdown, Minor Abdominal Discomfort, Immune Support, 96ct

Digestive Advantage Lactose Defense Capsules are a unique blend of probiotic and lactase enzymes designed to support digestive balance and relieve minor abdominal discomfort caused by lactose intolerance. With a clinically tested probiotic strain called BC30, these capsules can survive stomach acid better to reach your gut and help support digestive and immune health. The probiotic in these capsules can interact with intestinal cells to enhance your body's overall digestive and immune function. In addition, these capsules are GMO-Free, Dairy-Free, and Vegetarian, making them a trustworthy choice for daily lactose support. With a 96-day supply, Digestive Advantage Lactose Defense Capsules are a convenient and effective solution for anyone looking to improve their digestive health and manage lactose intolerance.

What We Like
Probiotic + lactase blend
Clinically tested probiotic strain
Digestive & immune health support
#TOP 7

Enzymedica SerraGold Serrapeptase Supplement

26301
Enzymedica SerraGold Serrapeptase Supplement Cover
Enzymedica, SerraGold, High-Potency Serrapeptase Enzyme Supplement, Supports Respiratory, Heart & Immune Function, 120 Count

Enzymedica SerraGold Supplement offers whole-body support for mobility, immunity, and heart health. Its high-potency serrapeptase works effectively without the need for enteric coating, making it gentle on your stomach. You can take it easily on an empty stomach, allowing the systemic enzymes to enter your bloodstream and reach targeted cells and tissues. This means you can enjoy the benefits beyond just digestion. With a focus on clean ingredients and scientific validation, this supplement simplifies maintaining your health and well-being.

What We Like
Whole-body support
Gentle on the stomach
Systemic enzyme benefits
Clean, effective ingredients
#TOP 8

WELMATE Bifidobacterium Probiotic Supplement

21J044
WELMATE Bifidobacterium Probiotic Supplement Cover
WELMATE Bifidobacterium | Probiotic Supplement | Supports Gut Health | Immune Support | Digestive Enzymes | Gluten Free | Vegan | Men & Womens Probiotic | Value Size | 200 Count

The WELMATE Probiotic Supplement offers essential support for your gut health and immune system. Each capsule contains Bifidobacterium longum, which helps improve digestion by breaking down food more effectively, allowing you to absorb more nutrients. This probiotic also promotes healthy skin by maintaining pH balance, resulting in a clearer complexion. Additionally, it strengthens your immune response by fostering beneficial microorganisms in your gut, helping to keep a healthy balance of good and bad bacteria. With this supplement, you can take a proactive approach to your overall well-being.

What We Like
Supports gut health
Aids digestion
Promotes healthy skin
Strengthens immune system
#TOP 9

Enzyme Defense Pro Immunity Support Supplement

11-30020
Enzyme Defense Pro Immunity Support Supplement Cover
Enzyme Science Enzyme Defense Pro, 60 Capsules–Immunity Support Supplement – Formulated with Vitamin D3, L-Lysine, Calcium, and Protease–Enzyme Digestion Support –Immune System

Enzyme Defense Pro is a high-potency proteolytic formula that supports and promotes a healthy immune function, respiratory health, and sinus health. It contains proteolytic enzymes that help break down unwanted proteins while encouraging cellular repair and recovery. With Vitamin D3, L-lysine, and minerals, it helps eliminate excess mucus, promotes easy breathing, supports healthy circulation, and improves the body's natural recovery process. Enzyme Science is dedicated to providing optimal solutions for digestive health and wellness.

What We Like
Supports and promotes healthy immune function, respiratory health, and sinus health
Contains proteolytic enzymes that help break down unwanted proteins and encourage cellular repair and recovery
Helps eliminate excess mucus, promote easy breathing, and support healthy circulation
#TOP 10

Dr. Mercola Full Spectrum Enzymes Dietary Supplement

10242
Dr. Mercola Full Spectrum Enzymes Dietary Supplement Cover
Dr. Mercola Full Spectrum Enzymes, 30 Servings (90 Capsules), Dietary Supplement, Supports Immune and Digestive Health, Non-GMO

Dr. Mercola Full Spectrum Enzymes Dietary Supplement is formulated with 22 digestive enzymes, including four special blends to completely digest carbohydrates, fats, proteins, fibers, and more. It is gluten-free, GMO-free, and soy-free, making it safe for human consumption. The supplement is designed for real people's consumption and contains an appropriate allowance for enzyme deficiencies and loss of enzymes due to age to ensure effective digestion without waste. Each bottle contains 90 servings, and the product comes with a full 30-day money-back guarantee.

What We Like
Gluten-free, GMO-free, and soy-free
Formulated with 22 digestive enzymes
Contains an appropriate allowance for enzyme deficiencies and loss of enzymes due to age to ensure effective digestion without waste
Buying Guide Image

Frequently Asked Questions (FAQs)

1. Are enzyme supplements are helpful to the immune system?

Taking supplemental enzymes, particularly when eating foods that is greatly processed, cooked inappropriately or hard to digest, lessens the stress on the digestive system, bolsters the correct uptake of nutrients and makes a perfect environment for 70% of your immune system.

2. What enzymes help the immune system?

Adenosine deaminase is an enzyme that converts adenosine and deoxyadenosine to inosine and deoxyinosine, respectively. Adenosine deaminase deficiency (ADA) accounts for 20% of SCID cases, and is an autosomal recessive immune system deficiency which results in diminished or absent T, B, and NK cells.

3. What are the benefits of taking enzyme supplements?

Proteolytic enzymes have many important functions in the body, including helping break down food for energy, and are found in certain foods and supplements. Studies suggest that they can improve digestion, decrease inflammation, ease arthritis pain and possibly reduce symptoms related to IBS.

4. Is the immune system dependent on enzymes?

Enzymes are the catalysts in our bodies for biochemical reactions and play many roles in the immune system. More than 50% of our immune function is in the gut. That is why what you consume has such a large impact on your immune system.

Editor's Notes

During our enzyme supplement for immune support research, we found 24 enzyme supplement for immune support products and shortlisted 10 quality products. We collected and analyzed 84,180 customer reviews through our big data system to write the enzyme supplements for immune support list. We found that most customers choose enzyme supplements for immune support with an average price of $25.72.

The enzyme supplements for immune support are available for purchase. We have researched hundreds of brands and picked the top brands of enzyme supplements for immune support, including Enzymedica, Source Naturals, MaryRuth Organics, Digestive Advantage, WELMATE. The seller of top 1 product has received honest feedback from 940 consumers with an average rating of 4.9.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.