Best Capsule Enzyme Supplements of 2025

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 6, 2025

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Capsule enzyme supplements are a type of dietary supplement that contain enzymes to help the body break down and digest food more efficiently. These enzymes can help people who struggle with digestive issues or who want to improve their overall digestion. The supplements come in easy-to-swallow capsules and can be taken with meals or as directed by a healthcare professional. There are many different types of enzyme supplements available, each designed to target specific types of food or digestive issues. Overall, capsule enzyme supplements offer a convenient and effective way to support healthy digestion.

At a Glance: Our Top Picks

NOW Supplements Super Enzymes Cover #TOP 1
NOW Supplements Super Enzymes
ftb score rating icon 9.9
NatureBell Digestive Enzymes with Probiotics Cover #TOP 2
NatureBell Digestive Enzymes with Probiotics
ftb score rating icon 9.8
Source Naturals Essential Enzymes 500mg Cover #TOP 3
Source Naturals Essential Enzymes 500mg
ftb score rating icon 9.6

Top 10 Capsule Enzyme Supplements

NOW Supplements Super Enzymes

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Beige W/Speckles
NOW Supplements Super Enzymes Cover
NOW Foods Supplements, Super Enzymes, Formulated with Bromelain, Ox Bile, Pancreatin and Papain,180 Capsules

NOW Supplements Super Enzymes is a comprehensive blend of enzymes that supports healthy digestion. Formulated with bromelain, ox bile, pancreatin and papain, Super Enzymes helps to optimize the breakdown of fats, carbohydrates and protein. It is Soy Free, Made without Gluten, Keto Friendly and GMP Quality Assured. Customers have reported that it helps with digestive issues, bloating, slow metabolism, and acid indigestion. It is easy to swallow and comes in capsule form.

What We Like
Relieves digestive issues
Improves nutrient absorption
Recommended for pancreatic insufficiency
Easy-to-swallow capsules
Supports overall digestive health
#TOP 2

NatureBell Digestive Enzymes with Probiotics

BA-NB-DE240C
NatureBell Digestive Enzymes with Probiotics Cover
NatureBell Digestive Enzymes with Probiotics and Prebiotics, 240 Veggie Capsules | Gut & Digestive Health Support – 20 Enzyme & 5 Prebiotic Pancreatic Enzyme Complex | Non-GMO, Vegan Friendly

NatureBell Digestive Enzymes offers a comprehensive blend of digestive support in a convenient veggie capsule. With 240 capsules in a bottle, you can enjoy an 8-month supply, making it easy to incorporate into your daily routine. Each serving combines 20 digestive enzymes and 5 prebiotics, promoting better digestion and nutrient absorption. This unique formulation helps to alleviate bloating and supports overall gut health. Designed for both men and women, it aims to enhance your digestive balance and keep your gut flora thriving.

What We Like
Long-lasting 8-month supply
Supports digestion and nutrient absorption
Helps reduce bloating
Non-GMO and vegan-friendly
#TOP 3

Source Naturals Essential Enzymes 500mg

Source Naturals Essential Enzymes 500mg Cover
Source Naturals Essential Enzymes 500mg Bio-Aligned Multiple Enzyme Supplement Herbal Defense for Digestion, Gas, Constipation & Bloating Relief - Supports Immune System - 240 Capsules

Source Naturals Enzyme Supplement is a digestive aid that supports the body's natural digestive process, maximizing nutrient utilization while promoting digestive comfort. With 240 capsules per bottle, this product is a great value and each capsule should be taken with water at the beginning of each meal. This product is free of yeast, dairy, egg, gluten, soy, wheat, sugar, salt, preservatives, and artificial colors, flavors, and fragrances. Source Naturals has been a trusted brand for over 35 years, and this product is manufactured in the USA. Overall, Source Naturals Enzyme Supplement is a great choice for those looking to support their digestive health in a natural and effective way.

What We Like
Digestive aid
240 capsules per bottle
Free of common allergens
No preservatives or artificial ingredients
Trusted brand for over 35 years

Wholesome Wellness Digestive Enzymes

digestive-enzymes
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Wholesome Wellness Digestive Enzymes Cover
Wholesome Wellness Digestive Enzymes 1000MG Plus Prebiotics & Probiotics Supplement, 180 Capsules, Organic Plant-Based Vegan Formula for Digestion & Lactose with Amylase & Bromelain,3-6 Months Supply

Wholesome Wellness Digestive Enzymes is a plant-based, organic supplement that helps improve digestion and gut health. With a 1000 MG dose of clinical grade digestive enzymes and a 10 billion CFU 10 strain probiotic with prebiotics, this supplement provides relief from bloating, flatulence, fat, pancreatic, and bowel cleansing. The Advanced Multi Enzyme System helps digest a variety of foods, including fried, spicy, raw, processed food, dairy, protein, salts, carb / carbohydrate, vitamin and acidic diet fruits and veggies. The supplement also contains a powerful 10 billion CFU dose of 10 different probiotic strains clinically shown to enhance preventions & immune system response.

What We Like
Relieves bloating and constipation
Plant-based vegan formula
Improves gut health
May enhance sleep, digestion, and energy

Complete Natural Products Organic Papaya Enzyme Capsules

Complete Natural Products Organic Papaya Enzyme Capsules Cover
Complete Natural Products Organic Papaya Enzymes & Papain Enzyme Capsules - 500mg 100 Pills, Organic Papaya Powder Digestive Super Fruit Capsules

Complete Natural Products Organic Papaya Enzyme Capsules are made in the USA and certified USDA Organic & OU Kosher. These veggie caps are vegan and non-GMO herbal supplements that contain natural papain enzymes from papaya. Papaya supplements are a great source of vitamins A, B, C, and K and are known as an excellent immunity booster. These capsules are high in fiber and water content, which help prevent constipation and promote a smooth bowel movement. The enzyme papain present in organic papaya powder is known to aid digestion by breaking down proteins. Therefore, a couple of capsules of papaya powder are often recommended as a home remedy for digestion-related problems and gut health.

What We Like
USDA Organic & OU Kosher certified
Vegan and non-GMO
High in fiber and water content
Contains natural papain enzymes from papaya
Great source of vitamins A, B, C, and K
#TOP 6

Horbäach Essential Digestive Enzymes

CL4401
Horbäach Essential Digestive Enzymes Cover
Horbäach Essential Digestive Enzymes | 100 Capsules | Enzyme Blend for Men & Women | Non-GMO & Gluten Free Supplement

Horbäach Digestive Enzymes offers a comprehensive blend of essential digestive enzymes, prebiotics, and probiotics in one convenient formula. This complex mix includes various enzymes like Protease and Lipase, which aid in breaking down different food types, helping you to digest your meals more effectively. The expertly crafted formula is designed with a focus on purity and potency, ensuring you receive high-quality ingredients for your digestive health. Plus, it is free from common allergens and artificial additives, making it a safe choice for everyone. Experience improved digestion and overall wellness with this reliable supplement.

What We Like
Comprehensive enzyme blend
Supports digestive health
High-quality, pure ingredients
Allergen-free formula
#TOP 7

NOW Optimal Digestive System Enzymes, 90 Veg Capsules

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NOW Optimal Digestive System Enzymes, 90 Veg Capsules Cover
NOW Foods Supplements, Optimal Digestive System, Full Spectrum Enzymes, 90 Veg Capsules

The NOW Optimal Digestive System Enzymes offer a blend of enzymes that will aid in the digestion of most foods, including beans and cruciferous vegetables. To maximize food utilization, it is recommended to take 2 capsules with or before each meal. This product is vegan/vegetarian, soy-free, keto-friendly and certified GMP assured. It is packaged in the USA by a family-owned company since 1968.

What We Like
Helps with bean and cabbage digestion
Offers a blend of enzymes for digestion of most foods
Vegan/vegetarian, soy-free, keto-friendly
#TOP 8

Nutricost Digestive Enzymes Supplement

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Nutricost Digestive Enzymes Supplement Cover
Nutricost Digestive Enzymes 620mg, 120 Capsules - Complete Digestive Enzyme Supplement

The Nutricost Digestive Enzymes Supplement is a complete full-spectrum high potency supplement that comes with 120 capsules per bottle. With just one capsule per serving, this supplement is designed to help you digest food efficiently. Made in a GMP compliant, FDA registered facility, it is non-GMO and 3rd party tested for safety and quality assurance.

What We Like
Complete full-spectrum high potency digestive enzyme supplement
120 capsules per bottle
Non-GMO and 3rd party tested

Vital Nutrients Pancreatic Enzymes 1000mg - Digestive Enzymes

Vital Nutrients Pancreatic Enzymes 1000mg - Digestive Enzymes Cover
Vital Nutrients Pancreatic Enzymes 1000mg (Full Strength) | Pancreatin Digestion Supplement with Protease, Amylase & Lipase | Digestive Enzymes | Gluten, Dairy, and Soy Free | 90 Capsules

Vital Nutrients Pancreatic Enzymes 1000mg is a digestive enzyme supplement that supports better absorption and digestion of protein, fats, and carbohydrates. The formula contains amylase, lipase, and protease to help break down food. It is free from gluten, dairy, soy, peanut, tree nut, egg, sugar, artificial colors, and more. Vital Nutrients is committed to producing high-quality supplements and tests every ingredient and batch above the industry standard.

What We Like
Supports better absorption and digestion of protein, fats, and carbohydrates
Contains amylase, lipase, and protease to help break down food
Free from gluten, dairy, soy, peanut, tree nut, egg, sugar, artificial colors, and more

Pure Encapsulations Digestive Enzymes Ultra

Pure Encapsulations Digestive Enzymes Ultra Cover
Pure Encapsulations Digestive Enzymes Ultra - Vegetarian Digestive Enzyme Supplement to Support Protein, Carb, Fiber, and Dairy Digestion* - 90 Capsules

Pure Encapsulations Digestive Enzymes Ultra is a multi-enzyme supplement that supports the break down of protein, carbohydrate, fiber, and dairy*, while promoting optimal nutrient bioavailability and absorption*. The supplement contains a broad profile of digestive enzymes, providing optimal activity across a wide pH range. Pure Encapsulations uses only premium ingredients, and the product is free from wheat, eggs, tree nuts & peanuts, gluten, artificial colors, flavors & sweeteners, coatings and shellacs, GMOs, and unnecessary binders, fillers & preservatives.

What We Like
Promotes optimal nutrient bioavailability and absorption*
Broad profile of digestive enzymes for optimal activity across a wide pH range
Pure quality - made with premium ingredients and free from unnecessary additives
Buying Guide Image

Frequently Asked Questions (FAQs)

1. What do enzyme capsules do?

People diagnosed with an enzyme insufficiency often need to take prescription digestive enzymes. These supplements help the body process food and absorb nutrients better.

2. What are the benefits of taking enzyme supplements?

Proteolytic enzymes have many important functions in the body, including helping break down food for energy, and are found in certain foods and supplements. Studies suggest that they can improve digestion, decrease inflammation, ease arthritis pain and possibly reduce symptoms related to IBS.

3. Why you shouldn't take digestive enzymes?

Digestive enzyme supplements also could interact with antacids and certain diabetes medications. They may cause side effects including abdominal pain, gas and diarrhea.

4. What are the 3 best digestive enzymes?

The most important can include protease to help break down proteins, lipase to help with fats, and amylase to help digest carbohydrates. We recommend supplements with at least three types of enzymes.

Editor's Notes

During our capsule enzyme supplement research, we found 24 capsule enzyme supplement products and shortlisted 10 quality products. We collected and analyzed 209,085 customer reviews through our big data system to write the capsule enzyme supplements list. We found that most customers choose capsule enzyme supplements with an average price of $20.44.

The capsule enzyme supplements are available for purchase. We have researched hundreds of brands and picked the top brands of capsule enzyme supplements, including NOW Foods, NatureBell, Source Naturals, Wholesome Wellness, Complete Natural Products. The seller of top 1 product has received honest feedback from 385 consumers with an average rating of 4.7.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.