Best Vitamin B6 Supplements of 2026

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 20, 2026

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Vitamin B6 supplements are a popular choice for those looking to improve their overall health and wellbeing. This vitamin plays a key role in supporting a healthy metabolism, immune system, and nervous system. It can also help to reduce inflammation and support brain function. Vitamin B6 supplements are available in a variety of forms, including tablets, capsules, and gummies. They are an easy and convenient way to ensure that you are getting enough of this essential vitamin in your diet. It is important to speak with a healthcare professional before beginning any new supplement regimen.

At a Glance: Our Top Picks

Nature's Bounty Vitamin B6 Tablets Cover #TOP 1
Nature's Bounty Vitamin B6 Tablets
ftb score rating icon 9.9
ONNIT Alpha Brain Cover #TOP 2
ONNIT Alpha Brain
ftb score rating icon 9.8
NEURIVA ULTRA Brain Supplement Cover #TOP 3
NEURIVA ULTRA Brain Supplement
ftb score rating icon 9.6

Top 10 Vitamin B6 Supplements

#TOP 1

Nature's Bounty Vitamin B6 Tablets

Nature's Bounty Vitamin B6 Tablets Cover
Nature's Bounty Vitamin B6 100mg Tablets - Supports Energy Metabolism & Nervous System Health, 100 Ct

Nature's Bounty Vitamin B6 Tablets are an excellent choice for maintaining your energy levels throughout the day. These 100mg tablets support energy metabolism by converting food into fuel. They also play a crucial role in promoting cardiovascular and nervous system health. Moreover, they help maintain healthy amino acid levels and are suitable for vegetarians, gluten-free, non-GMO, and sugar-free. These tablets are the result of nearly 50 years of dedication to quality and scientific research by Nature's Bounty.

What We Like
Easy to swallow tablets
Noticeable energy boost
Trusted and reputable brand
Affordable price
Supports metabolism and immunity
What We Don't Like
Bottle packaging preference
Hard to measure effectiveness
#TOP 2

ONNIT Alpha Brain

OABPA
90 Count
ONNIT Alpha Brain Cover
ONNIT Alpha Brain® Nootropic Brain Supplement for Men and Women, IGEN™ Non-GMO Tested, Memory, Mental Clarity, Cognitive Support and Focus Capsules with L-Theanine and Vitamin B6 (90 Count)

Enhance your focus and cognitive speed with ONNIT Alpha Brain. This premium nootropic brain supplement is designed to combat occasional brain fog and boost concentration. Whether you're focusing on your career, academics, social life, or athletics, Alpha Brain is the ideal way to enhance your memory, mental speed, and focus for lasting mental clarity. Formulated with carefully selected ingredients including Cat's Claw Extract, Bacopa, Oat Straw, Huperzia Serrata, and our Focus and Flow Blends, Alpha Brain helps you realize your limitless potential. With no caffeine, dairy, nuts, or gluten, and being paleo and keto-friendly, these stimulant-free brain supplements are perfect to help reduce memory fog without worrying about afternoon crashes. Join the millions who have benefited from Alpha Brain since 2011, the market leader in nootropic brain boost.

What We Like
Improved focus and clarity
No jitters or overstimulation
Easy-to-swallow capsules
Consistent mental energy boost
Quality, well-known ingredients
What We Don't Like
Somewhat expensive
Contains maltodextrin
#TOP 3

NEURIVA ULTRA Brain Supplement

19657
Multi
NEURIVA ULTRA Brain Supplement Cover
NEURIVA Ultra Decaffeinated Clinically Tested Nootropic Brain Supplement for Mental Alertness, Memory, Focus & Concentration, Cognivive, Neurofactor, Phosphatidylserine, Vitamins B6 B12, 60 Capsules

Invest in your brain health with NEURIVA Brain Supplement. Formulated to support 7 indicators of brain health, NEURIVA Ultra contains clinically tested, naturally sourced ingredients like Cognivive, Neurofactor, and Phosphatidylserine, which work together to enhance cognitive function, memory, and focus. With Vitamin B6, B12, and folic acid, NEURIVA Ultra also helps support brain function. Plus, it's decaffeinated, sugar-free, vegetarian, and gluten-free. Experience a noticeable effect of mental alertness with Cognivive, a caffeine-free Alpinia galanga extract. NEURIVA Ultra is formulated with trustworthy ingredients and guaranteed for freshness, purity, and labeled potency, manufactured in a GMP-certified facility in the USA. Download the NEURIVA BRAIN GYM app from the App Store or Google Play to start assessing your skills and building your brain fitness routine.

What We Like
Improved memory recall
Enhanced mental clarity
No caffeine jitters
Clinically tested ingredients
Easy daily dosage
What We Don't Like
Large capsule size
Higher price point
#TOP 4

ONNIT Alpha Brain Premium Nootropic Brain Supplement

30 Count
ONNIT Alpha Brain Premium Nootropic Brain Supplement Cover
ONNIT Alpha Brain® Nootropic Brain Supplement for Men and Women, IGEN™ Non-GMO Tested, Memory, Mental Clarity, Cognitive Support and Focus Capsules with L-Theanine and Vitamin B6, 30 Count

ONNIT Alpha Brain is a daily mind support supplement that helps enhance memory and cognitive speed. Its carefully selected ingredients include Cat's Claw Extract, Bacopa, Oat Straw, Huperzia Serrata, and Focus and Flow Blends. With Alpha Brain, you can boost your focus in your career, academics, social life, or athletics. It is stimulant-free, free of caffeine, dairy, nuts, or gluten. Alpha Brain has been a leading nootropic in the market since 2011.

What We Like
Enhanced focus and concentration
No jitters or energy crash
Improved mental clarity
Steady, long-lasting energy
Easy to take capsules
What We Don't Like
Mild nausea for some users
Occasional minor digestive discomfort
#TOP 5

Nature Made Vitamin B6 100mg, 100 Tablets

1285
White
Nature Made Vitamin B6 100mg, 100 Tablets Cover
Nature Made Vitamin B6 100mg, B6 Vitamins for Energy Metabolism Support, 100 Tablets, 100 Day Supply

Nature Made Vitamin B6 100mg supplement is a dietary supplement that supports energy metabolism and nervous system function. It contains 100 tablets, providing a 100-day supply. This B6 vitamin supplement also supports the production of neurotransmitters needed for mood health and proper red blood cell formation. The supplement is gluten-free and has no color added, no artificial flavors, and no preservatives. Adults can take one tablet daily with water and a meal. The product is USP verified and is the number one pharmacist recommended Vitamin & Supplement Brand.

What We Like
Improved energy and mood
Affordable price
High quality supplement
Trusted brand
What We Don't Like
Limited brand variety
#TOP 6

Best Naturals Vitamin B-6 25 Mg Tablets, 250 Count

817716011509
25 Mg
Best Naturals Vitamin B-6 25 Mg Tablets, 250 Count Cover
Best Naturals Vitamin B-6 25 Mg Tablets, 250 Count

Best Naturals Vitamin B-6 25 Mg Tablets are designed to support a healthy cardiovascular system, maintain a healthy homocysteine level and support nervous system function. These Vitamin B6 supplements are ideal for those who want to maintain good heart health and improve their nervous system function. The products are shipped in accordance with manufacturers' recommendations, ensuring that they are of the highest quality.

What We Like
Easy to swallow tablets
Supports energy and mood
Gentle on stomach
Good value for price
Trusted brand quality
What We Don't Like
Tablets lack identifying marks
#TOP 7

Pure Encapsulations P5P 50 Vitamin B6 Supplement

Pure Encapsulations P5P 50 Vitamin B6 Supplement Cover
Pure Encapsulations P5P 50 - Active Vitamin B6 - Supports Energy Metabolism & Brain Health* - Gluten Free & Non-GMO - 60 Capsules

Pure Encapsulations P5P 50 Vitamin B6 Supplement is a high-quality supplement that provides activated vitamin B6 in the form of Pyridoxal 5' phosphate (P5P). P5P is an essential coenzyme in the metabolism of carbohydrates, proteins, and the release of glycogen for energy production. It also helps maintain the balance of sodium and potassium to regulate body fluids and promote healthy nervous and musculoskeletal system function.

What We Like
High product quality
Minimal unnecessary ingredients
Supports nerve health
Improves sleep quality
Helps with B6 deficiency
What We Don't Like
Possible stomach discomfort
High dose sensitivity
#TOP 8

Nutricost Vitamin B6 Capsules

ZL08080
Nutricost Vitamin B6 Capsules Cover
Nutricost Vitamin B6 (Pyridoxine HCl) 100mg, 240 Capsules

Nutricost Vitamin B6 Capsules contain 100mg of Vitamin B6 (Pyridoxine HCl) per capsule, with 240 capsules in each bottle. Just one capsule per serving is required. The product is Non-GMO, Gluten-Free and has been 3rd Party Tested. It is made in a GMP Compliant, FDA Registered Facility, ensuring the highest quality standards.

What We Like
Consistent nervous system support
Simple, minimal ingredients
Supports memory and brain function
Affordable and reliable
Prompt seller service
What We Don't Like
No immediate dramatic effects
Effectiveness hard to judge
#TOP 9

Nutricost P5P Vitamin B6 Supplement 50mg, 240 Capsules

NTC_P5P_50MG_240CAP
Nutricost P5P Vitamin B6 Supplement 50mg, 240 Capsules Cover
Nutricost P5P Vitamin B6 Supplement 50mg, 240 Capsules (Pyridoxal-5-Phosphate) - Vegetarian Friendly, Non-GMO, Gluten Free

Nutricost P5P Vitamin B6 Supplement offers 50mg of Pyridoxal-5-Phosphate per capsule with 240 servings per bottle. It is a vegetarian-friendly, non-GMO, and gluten-free supplement made in a GMP compliant, FDA registered facility. This supplement falls under the category of Vitamin B6 Supplements.

What We Like
Easy to swallow
Effective absorption
P-5-P active form
Good quality packaging
Works with other vitamins
What We Don't Like
Results may take time
#TOP 10

Bronson Vitamin B6 Supplement - 250 Tablets

Bronson Vitamin B6 Supplement - 250 Tablets Cover
Bronson Vitamin B6 100mg Premium Vitamin B6 Supplement, 250 Tablets

The Bronson Vitamin B6 Supplement is a premium quality supplement that promotes protein metabolism and immune function. Its superior quality is backed by laboratory tests and manufactured at a cGMP registered facility, making it a trusted choice since 1960. This supplement is suitable for adult use, comes in tablet form, and is unflavored.

What We Like
Improved energy levels
Supports brain function
Good value for price
No aftertaste
Easy to take
Buying Guide Image

Sorting Out the Vitamin B6 Supplements That Are Right for You

Introduction

When it comes to maintaining optimal health, choosing the right vitamin supplements can be a daunting task. With so many options on the market, it can be difficult to determine which supplements are the best for your needs. One such vitamin that is essential for good health is Vitamin B6, also known as pyridoxine. In this article, we will explore the importance of Vitamin B6 and provide some helpful tips for choosing the right Vitamin B6 supplements.

The Importance of Vitamin B6

Vitamin B6 is a water-soluble vitamin that plays a crucial role in many of the body's physiological processes. It is involved in the metabolism of proteins and carbohydrates, the production of red blood cells, and the functioning of the nervous and immune systems. A deficiency of Vitamin B6 can lead to a host of health problems, including anemia, dermatitis, and even depression.

Choosing the Right Vitamin B6 Supplement

When it comes to choosing a Vitamin B6 supplement, there are a few key factors to consider. First and foremost, it is important to select a supplement that is of high quality. This means looking for a supplement that is manufactured by a reputable company and has undergone thorough testing to ensure its purity and potency.

Another important factor to consider is the form of Vitamin B6 in the supplement. Vitamin B6 is available in several forms, including pyridoxine hydrochloride, pyridoxal-5-phosphate, and pyridoxamine. While all forms of Vitamin B6 are effective, some individuals may find that they respond better to certain forms. For example, pyridoxal-5-phosphate may be better absorbed by the body, making it a good option for individuals with certain health conditions.

In addition to the form of Vitamin B6, it is also important to consider the dosage. The recommended daily allowance (RDA) for Vitamin B6 varies depending on age and gender, but is generally between 1.3 and 2.0 milligrams per day. It is important to choose a supplement that provides the right dosage for your individual needs.

Finally, it is important to consult with a healthcare provider before starting any new supplement regimen. This is especially important for individuals who are pregnant, breastfeeding, or have any pre-existing health conditions. A healthcare provider can help you determine the right dosage and form of Vitamin B6 for your specific needs.

Conclusion

In conclusion, Vitamin B6 is an essential nutrient that plays a crucial role in many of the body's physiological processes. When choosing a Vitamin B6 supplement, it is important to consider factors such as quality, form, dosage, and the advice of a healthcare provider. By taking the time to select the right Vitamin B6 supplement, you can ensure that you are providing your body with the nutrients it needs to maintain good health.

Frequently Asked Questions (FAQs)

1. What are the benefits of taking vitamin B6?

Taking vitamin B6 can provide several benefits, including preventing and treating anemia, improving mood, promoting brain health, easing nausea during pregnancy, protecting the heart, reducing the risk of cancer, and lowering the risk of eye disease.

2. Is it OK to take vitamin B6 everyday?

Taking vitamin B6 through food is generally safe, even in excessive amounts. When used as a supplement in appropriate doses, vitamin B6 is likely safe. However, taking too much vitamin B6 from supplements can lead to lack of muscle control or coordination of voluntary movements (ataxia). It is important to follow the recommended dosage guidelines.

3. Who Cannot take vitamin B6?

It is important to consult with a doctor before taking vitamin B6 supplements, especially if you have heart disease, kidney disease, or if you are pregnant or breastfeeding. The doctor can determine the appropriate dosage and ensure it is safe for you to take.

4. Is B6 good for energy or sleep?

Vitamin B6 plays a vital role in various bodily activities, including immunological health, cognitive growth, and function. Some studies have shown that vitamin B6 may aid sleep and influence dreams. However, it is recommended to consult with a doctor before taking any supplements, including vitamin B6.

5. Does vitamin B6 help with belly fat?

Vitamin B6 assists the body in breaking down proteins, fats, and carbohydrates, making it easier to convert food into energy. It can also boost metabolism, allowing for faster and more efficient calorie and fat burning. However, it's important to note that vitamin B6 alone is not a solution for weight loss and should be part of a comprehensive approach to a healthy lifestyle.

6. What are the symptoms of low B6?

Low levels of vitamin B6 can lead to various symptoms, including skin rashes, cracked lip corners, a glossy tongue, mood changes, impaired immune function, tiredness, nerve pain, seizures, and elevated homocysteine levels. If you experience these symptoms, it is advisable to consult with a healthcare professional.

7. Can too much vitamin B6 cause weight gain?

Taking B vitamins, including vitamin B6, alone will not cause weight gain. In fact, most people do not consume enough vitamins and minerals necessary for overall health, metabolism, and longevity. It is important to maintain a balanced diet and lifestyle for optimal weight management.

8. Does B6 cause anxiety?

Vitamin B6 plays a role in the production of a chemical messenger that helps inhibit impulses in the brain. Some studies have linked this calming effect to reduced anxiety. However, it is important to consult with a healthcare professional for personalized advice on managing anxiety.

Editor's Notes

During our vitamin b6 supplement research, we found 24 vitamin b6 supplement products and shortlisted 10 quality products. We collected and analyzed 484,935 customer reviews through our big data system to write the vitamin b6 supplements list. We found that most customers choose vitamin b6 supplements with an average price of $13.29.

The vitamin b6 supplements are available for purchase. We have researched hundreds of brands and picked the top brands of vitamin b6 supplements, including Nature's Bounty, ONNIT, NEURIVA, Nature Made, Best Naturals. The seller of top 1 product has received honest feedback from 384 consumers with an average rating of 4.7.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.

Vitamin B6 Supplements Comparison Table

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#TOP10
Brand Nature's Bounty ONNIT NEURIVA ONNIT Nature Made Best Naturals Pure Encapsulations Nutricost Nutricost Bronson
Item Form Tablet Capsule Capsule Capsule Tablet Tablet Capsule Capsule Capsule Tablet
Primary Supplement Type Vitamin B6 Vitamin B6 - Vitamin-b Vitamin B6 Vitamin B6 Vitamin-b Vitamin B6 Vitamin B6 Vitamin-b
Flavor Unflavored Unflavored - Unflavored Unflavored Unflavored Unflavored Unflavored Unflavored Unflavored
Diet Type Gluten Free Vegan - Gluten Free Gluten Free Vegetarian Gluten Free Gluten Free Gluten Free -
FTB Score
ftb score rating icon 9.9
ftb score rating icon 9.8
ftb score rating icon 9.6
ftb score rating icon 9.5
ftb score rating icon 9.5
ftb score rating icon 9.5
ftb score rating icon 9.5
ftb score rating icon 9.3
ftb score rating icon 9.2
ftb score rating icon 9.2
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