Best Gluten-Free Enzyme Supplements of 2025

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 6, 2025

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Gluten-free enzyme supplements are becoming increasingly popular among people who suffer from gluten intolerance or celiac disease. These supplements are designed to help the body break down gluten proteins in the digestive tract, which can alleviate symptoms such as bloating, gas, and diarrhea. They contain a blend of enzymes that target gluten specifically, including proteases and peptidases. Some gluten-free enzyme supplements also contain probiotics, which can help improve gut health and reduce inflammation. These supplements are available in various forms, including capsules and powders, and can be taken before or after meals. It is important to note that gluten-free enzyme supplements are not a substitute for a gluten-free diet, but can be a useful addition to help manage symptoms.

At a Glance: Our Top Picks

Digestive Support Enzymes Cover #TOP 1
Digestive Support Enzymes
ftb score rating icon 9.8
Garden of Life Dr Formulated Digestive Enzymes Cover #TOP 2
Garden of Life Dr Formulated Digestive Enzymes
ftb score rating icon 9.7
MRM Gluten-Aid Digestive Enzymes Cover #TOP 3
MRM Gluten-Aid Digestive Enzymes
ftb score rating icon 9.5

Top 10 Gluten-Free Enzyme Supplements

Digestive Support Enzymes

Digestive Support Enzymes Cover
MaryRuth Organics Gluten Enzymes Capsules | Up to 2 Month Supply | Enzyme Supplement for Gut Health Support | Gluten Digestion | & Nutrient Absorption | Vegan | Gluten Free | 60 Count

This supplement aids in the digestion of gluten, ultimately supporting gluten metabolism and immune function. It helps with occasional bloating, gas and discomfort that may be associated with digesting gluten. Encapsulated in vegan capsules, you can easily incorporate these into your routine.

What We Like
Supports digestive health
May alleviate occasional bloating, gas and discomfort
Vegan and Non-GMO

Garden of Life Dr Formulated Digestive Enzymes

Garden of Life Dr Formulated Digestive Enzymes Cover
Garden of Life Dr Formulated Digestive Enzymes with Papain, Bromelain, Lipase for Digestion & Nutrient Absorption – Organic Digest+ - Vegan, Gluten-Free, Non-GMO, Tropical Fruit Flavor, 90 Chewables

Garden of Life Dr Formulated Digestive Enzymes with Papain, Bromelain, Lipase for Digestion & Nutrient Absorption is a full spectrum plant-based enzyme formula to aid the digestion of proteins, fats, and carbs. It is Certified Organic and Non-GMO, Gluten-Free, Vegan and Carbon Neutral. It comes in a tropical flavored, shelf stable tablet that is easy to take on the go.

What We Like
Certified Organic and Non-GMO
Vegan and Carbon Neutral
Tropical flavored, shelf stable tablet
Helps with digestion after meals
Includes prebiotic fiber from Organic Acacia
#TOP 3

MRM Gluten-Aid Digestive Enzymes

MRM
31019
MRM Gluten-Aid Digestive Enzymes Cover
MRM Nutrition Gluten-Aid™ | Digestive enzymes | Gluten + Dairy Digestion | BIOCORE DPP-IV® | Gluten-Free | 60 Servings

MRM Gluten-Aid is specifically designed to help you better digest gluten and dairy, making it easier to enjoy these foods without discomfort. This supplement supports your body's ability to absorb essential nutrients found in gluten and dairy-rich foods, so you don't have to compromise on your diet. Simply take one capsule before meals containing grains or dairy to promote smoother digestion. Plus, you can feel confident knowing that this product is certified gluten-free, making it a safe choice for those with gluten sensitivities.

What We Like
Enhanced nutrient absorption
Supports digestive comfort
Convenient pre-meal use
Gluten-free certification
#TOP 4

Enzymedica GlutenEase Extra Strength

12010
Enzymedica GlutenEase Extra Strength Cover
Enzymedica, GlutenEase Extra Strength, Maximum Potency Digestive Enzymes, Supports Gluten & Casein Intolerance, 30 Count

Enzymedica GlutenEase is designed for those who struggle with gluten-heavy foods. It includes powerful enzymes that help break down gluten, making it easier for you to enjoy meals like bread and pasta without discomfort. The extra-strength formula features DPP-IV, which specifically targets gluten, reducing gas and bloating. Additionally, it efficiently processes both gluten and casein, ensuring that you can digest a variety of meals comfortably. With just one capsule per meal, this product offers a simple solution for managing gluten intolerance while being vegan and free from common allergens.

What We Like
Supports gluten digestion
Reduces gas and bloating
Easy one-capsule dosage
Vegan and allergen-free
#TOP 5

Doctor's Best Digestive Enzymes

DRB-00047
Doctor's Best Digestive Enzymes Cover
Doctor's Best Digestive Enzymes, Support Healthy Digestion, Optimal Intestinal Health, Non-GMO, Vegetarian, Gluten Free, 90VC

Doctor's Best Digestive Enzymes is a uniquely formulated, full-spectrum, high potency digestive enzyme blend created to complement and support the body's own digestive capacities. Each capsule provides the body with enzymes designed to optimally aid the digestion of fats, proteins and carbohydrates present in cooked and raw food. It also supplies the added support of alpha-galactosidase and beta-glucanase to break down vegetables, beans and grains, as well as glucoamylase and invertase to assist with the digestion of sugars. In addition, this complete formula contains friendly probiotic bacteria to uniquely promote optimal intestinal health.

What We Like
Non-GMO, Gluten Free, Soy Free, Vegetarian
Supports Protein Digestion
Supports Fat Digestion
Enhances Overall Health
#TOP 6

NOW Supplements Gluten Digest Veg Capsules

733739029591
NOW Supplements Gluten Digest Veg Capsules Cover
NOW Foods Supplements, Gluten Digest with BioCore®DPP IV, Gastrointestinal Support*, 60 Veg Capsules

NOW Supplements Gluten Digest Veg Capsules is a comprehensive enzyme blend designed to support gastrointestinal health and promote the complete digestion of cereal grains. It is specially formulated with BioCore DPP IV and can help you digest gluten and other cereal grains. It is Non-GMO, Kosher, Soy Free, Vegan/Vegetarian, and Keto Friendly. Additionally, it is packaged in the USA by a family-owned company since 1968 and is GMP Quality Assured.

What We Like
Helps support gastrointestinal health
Promotes complete digestion of cereal grains
Non-GMO, Kosher, Soy Free, Vegan/Vegetarian, and Keto Friendly

Horbäach Essential Digestive Enzymes

CL4401
Horbäach Essential Digestive Enzymes Cover
Horbäach Essential Digestive Enzymes | 100 Capsules | Enzyme Blend for Men & Women | Non-GMO & Gluten Free Supplement

Horbäach Digestive Enzymes offers a comprehensive blend of essential digestive enzymes, prebiotics, and probiotics in one convenient formula. This complex mix includes various enzymes like Protease and Lipase, which aid in breaking down different food types, helping you to digest your meals more effectively. The expertly crafted formula is designed with a focus on purity and potency, ensuring you receive high-quality ingredients for your digestive health. Plus, it is free from common allergens and artificial additives, making it a safe choice for everyone. Experience improved digestion and overall wellness with this reliable supplement.

What We Like
Comprehensive enzyme blend
Supports digestive health
High-quality, pure ingredients
Allergen-free formula
#TOP 8

Enzymedica GlutenEase Digestive Enzymes

26200-FFP
Enzymedica GlutenEase Digestive Enzymes Cover
Enzymedica GlutenEase, Digestive Enzymes for Food Intolerance, Support for Hidden Gluten & Cross-Contamination, Offers Fast Acting Gas & Bloating Relief, 60 Count (FFP)

Enzymedica GlutenEase is designed to help you enjoy meals without the worry of hidden gluten or cross-contamination. With powerful enzymes that break down gluten and casein, this supplement helps prevent gas and bloating before they start. Its unique Thera-blend enzymes work effectively across different pH levels in your digestive system, ensuring quick relief and support. You only need one capsule to break down a significant amount of protein and carbohydrates, making it easy to incorporate into your daily routine. Plus, it’s free from common allergens and artificial ingredients, so you can feel good about what you're taking.

What We Like
Reduces gas and bloating
Supports gluten digestion
Fast-acting relief
Allergen-free formula

Doctor's Best Proteolytic Enzymes

DRB-00184
Doctor's Best Proteolytic Enzymes Cover
Doctor's Best Proteolytic enzymes, Digestion, Muscle, Joint, Non-GMO, Gluten Free, Vegetarian, 90 Veggie Caps

Doctor's Best Proteolytic Enzymes is a potent formulation containing a broad spectrum of proteolytic enzymes (proteases) to support muscle, joint, and overall tissue health. It is vegetarian, gluten-free, and Non-GMO, and comes in a 90-count veggie capsule bottle. Customers have reported positive results in terms of relief from joint and muscle pain, as well as improved gut health.

What We Like
Effective in reducing arthritis pain
Supports digestion and gut health
Helps alleviate joint discomfort
#TOP 10

Pure Encapsulations Gluten/Dairy Digest

Pure Encapsulations Gluten/Dairy Digest Cover
Pure Encapsulations Gluten/Dairy Digest | Unique Mix of Enzymes to Support Healthy Gluten and Dairy Digestion* | 60 Capsules

Pure Gluten Digest is a multi-enzyme supplement that supports healthy digestion and gastrointestinal comfort. It contains the unique Tolerase G enzyme, which targets the breakdown of gluten, and may help to relieve occasional bloating or gas due to dairy consumption. The supplement is made with premium ingredients, free from common allergens and unnecessary additives. With Pure Gluten Digest, you can enjoy your favorite gluten and dairy-containing foods without worrying about digestive discomfort.

What We Like
Digestion support
Gastrointestinal comfort
Gastrointestinal health
Buying Guide Image

Frequently Asked Questions (FAQs)

1. What enzyme breaks down gluten?

DPP-IV is the enzyme that breaks down gluten, and the addition of this enzyme specifically can improve the digestion of gluten proteins for occasional exposures.

2. Do digestive enzymes work for gluten intolerance?

The truth is, digestive enzymes can make people feel better after eating gluten because they aid in the overall digestion of food. Digestive enzymes contain a combination of enzymes – and sometimes probiotics – that help breakdown food and provide digestion relief.

3. Are enzymes gluten free?

If bacteria grown on media that contain wheat, barley, or rye is used to produce enzymes, gluten may be present in an enzyme ingredient due to the lingering presence of growth media. If gluten is present in the growth media it may have been broken down into protein fragments.

Editor's Notes

During our gluten-free enzyme supplement research, we found 24 gluten-free enzyme supplement products and shortlisted 10 quality products. We collected and analyzed 104,686 customer reviews through our big data system to write the gluten-free enzyme supplements list. We found that most customers choose gluten-free enzyme supplements with an average price of $21.59.

The gluten-free enzyme supplements are available for purchase. We have researched hundreds of brands and picked the top brands of gluten-free enzyme supplements, including MaryRuth Organics, Garden of Life, MRM, Enzymedica, Doctor's BEST. The seller of top 1 product has received honest feedback from 4,591 consumers with an average rating of 4.9.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.