Best Lipase Enzyme Supplements of 2025

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Lipase enzyme supplements are designed to help individuals who struggle with breaking down fats in their diet. These supplements contain lipase enzymes that break down fats into smaller molecules that are easier to digest. They are especially beneficial for those with conditions such as cystic fibrosis, pancreatitis, and celiac disease. Lipase enzyme supplements come in various forms such as capsules, powders, and liquids. It is important to consult with a healthcare professional before taking any new supplements, especially if you have a medical condition or are taking medication.
At a Glance: Our Top Picks
Top 10 Lipase Enzyme Supplements
Integrative Therapeutics Lipase Concentrate-HP Enzyme Supplement - 90 Vegan Capsules
Integrative Therapeutics Lipase Concentrate-HP is a vegan enzyme supplement designed to support the digestion of fats in both acid and alkaline gastrointestinal conditions. It is pH-stable and effective in aiding the digestion of fats in the body. Suitable for both men and women, the supplement is keto and paleo-friendly, making it ideal for people with restricted diets.
Double Wood's VitaZyme Digestive Blend
Double Wood's VitaZyme Digestive Blend is a powerful 800mg blend of all 10 most essential digestive and pancreatic enzymes. It contains Amylase, Lipase, Bromelain, Lactase, Papain, Protease, Cellulase, Maltase, Invertase, and Glucoamylase to break down proteins, fats, and carbohydrates. It is Non-GMO, Gluten Free, and manufactured and tested for safety in the USA. Customers have reported improved digestion, bloating relief, and better absorption of nutrition.
Houston Enzymes Lypazyme
Houston Enzymes Lypazyme is a multi-enzyme supplement that supports the complete breakdown of triglyceride fats found in foods and supplements. With its combination of three different lipase enzymes, Lypazyme effectively breaks down food triglycerides into short-chain fatty acids. This makes it an excellent choice for individuals following high-fat diets such as the Ketogenic diet or taking fish oil supplements. One of the key benefits of Lypazyme is its ability to alleviate discomfort caused by slower stomach emptying, a common issue with high-fat diets. By using acid-stable lipase enzymes, Lypazyme starts the digestion process of triglyceride fats in the stomach, providing relief from bloating and discomfort. With Houston Enzymes Lypazyme, you can enjoy the convenience and benefits of a complete breakdown of triglyceride fats, making it an ideal choice for those on high-fat diets.
AST Enzymes Lipase-HP Plus
AST Enzymes Digestive Enzyme is a premium blend of high concentration lipase that supports fat digestion and maximizes the benefits of the food you eat. It promotes healthy cholesterol levels, cardiovascular health, gallbladder function, and nutrient absorption. Additionally, it includes essential enzymes that aid in the absorption of omega-3 and fish oil supplements. By assisting in the body's natural process of fat digestion and absorption, this formula ensures that you receive the maximum benefits from the foods you consume. Manufactured in the USA, this product is free of animal derivatives, dairy, yeast, fish or shellfish, peanuts, and tree nuts.
Vital Nutrients Pancreatic Enzymes 1000mg - Digestive Enzymes
Vital Nutrients Pancreatic Enzymes 1000mg is a digestive enzyme supplement that supports better absorption and digestion of protein, fats, and carbohydrates. The formula contains amylase, lipase, and protease to help break down food. It is free from gluten, dairy, soy, peanut, tree nut, egg, sugar, artificial colors, and more. Vital Nutrients is committed to producing high-quality supplements and tests every ingredient and batch above the industry standard.
AVVA Pharmа Micrazym
AVVA Pharmа Micrazym Pancreatic Enzymes is a highly effective multi-enzyme supplement that supports optimal digestion and nutrient absorption. With a high-strength formula containing lipase, protease, and amylase, these digestive enzymes break down fat molecules, proteins, and carbohydrates, allowing your body to get the most out of the foods you consume. The enteric coated micropellet technology ensures that the enzymes are protected from gastric acid, allowing them to reach the small intestine where they can be rapidly released and absorbed for prompt action. This pancreatic enzyme complex is formulated to comply with USP and European Pharmacopoeia standards, ensuring acid resistance, dissolution, and stability. In addition to supporting healthy digestion, Micrazym is also ultra-effective and economical, with one capsule replacing up to 5-15 tablets, saving you money. Order Micrazym today and enjoy the benefits of improved digestion and nutrient absorption.
Nature's Sunshine Hi Lipase Supplement
Nature's Sunshine Lipase is a dietary supplement designed to support your digestive health, especially in breaking down fats. It features a powerful blend of herbs traditionally known for aiding digestion. This product includes lipases, enzymes that help your body process dietary fats more effectively, which is especially beneficial if you struggle with lipid digestion. Additionally, it contains dandelion root extract, known for its cleansing and detoxifying properties, providing further digestive support. With daily use, you can enjoy the vitamins and herbs similar to those found in multivitamins, promoting overall well-being.
NOW Supplements Pancreatin 10X 200mg
Get digestive support with NOW Supplements Pancreatin 10X 200mg, which contains naturally occurring protease, amylase, and lipase enzymes. It assists in the digestion of protein, fat, and carbohydrates, making it a great addition to your daily diet. This product is soy-free, nut-free, gluten-free, dairy-free, and egg-free, making it suitable for most dietary needs. NOW Supplements is a family-owned and operated company that has been in business since 1968, and their products are GMP quality assured. Customers should note that exposure to heat or sunlight can damage the product.
Lipase Plus Digestive Enzyme by Dynamic Enzymes
Lipase Plus by Dynamic Enzymes is your go-to solution for tackling fatty food digestion. This powerful enzyme supplement efficiently breaks down a variety of fats, making it easier for you to enjoy everything from healthy avocados to rich burgers. If you're following a keto diet or have had your gallbladder removed, this product is especially beneficial, as it helps manage gas and bloating while digesting proteins and carbs. Additionally, Lipase Plus enhances the absorption of essential fatty acids, ensuring your body gets the vital nutrients it needs for optimal function.
Garden of Life Dr Formulated Digestive Enzymes
Garden of Life Dr Formulated Digestive Enzymes with Papain, Bromelain, Lipase for Digestion & Nutrient Absorption is a full spectrum plant-based enzyme formula to aid the digestion of proteins, fats, and carbs. It is Certified Organic and Non-GMO, Gluten-Free, Vegan and Carbon Neutral. It comes in a tropical flavored, shelf stable tablet that is easy to take on the go.
Frequently Asked Questions (FAQs)
1. What does lipase supplement do?
Lipase is a digestive enzyme that boosts the absorption of fat in your body by breaking it down into glycerol and free fatty acids ( 9 ). Some studies show that supplementing with lipase may decrease feelings of fullness ( 10 , 11 ).
2. Can I take lipase supplement?
Some people use lipase as a medicine. Since lipase breaks down fat into smaller pieces, it is possible that lipase supplements might make digestion easier. Lipase is used for indigestion (dyspepsia), heartburn, and other gastrointestinal problems, but there is no good scientific evidence to support these uses.
3. How do I get more lipase enzymes?
Avocados contain the digestive enzyme lipase, which breaks down fat molecules into smaller fatty acids and glycerol. Although lipase is made by the body, consuming avocados or taking a lipase supplement may ease digestion after a high-fat meal.
4. What is a good source of lipase?
So, a good source of lipase is pancreatic juice. Lipase helps in digestion of fats. Fats are broken down by lipases with the help of bile into di- and monoglycerides. Then Di and monoglycerides are broken down into fatty acids and glycerol by the action of lipases.
During our lipase enzyme supplement research, we found 24 lipase enzyme supplement products and shortlisted 10 quality products. We collected and analyzed 66,488 customer reviews through our big data system to write the lipase enzyme supplements list. We found that most customers choose lipase enzyme supplements with an average price of $21.99.
The lipase enzyme supplements are available for purchase. We have researched hundreds of brands and picked the top brands of lipase enzyme supplements, including Integrative Therapeutics, Double Wood Supplements, Houston Enzymes, AST Enzymes, Vital Nutrients. The seller of top 1 product has received honest feedback from 55,046 consumers with an average rating of 4.9.

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