Best Papaya Enzyme Supplements of 2026

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 30, 2026

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Papaya enzyme supplements are becoming increasingly popular due to their potential health benefits. Derived from the papaya fruit, these supplements contain natural enzymes that aid in digestion and promote a healthy gut. They may also help reduce inflammation, boost the immune system, and improve skin health. Papaya enzyme supplements come in various forms, including chewable tablets and capsules, making it easy to incorporate into a daily routine. As with any supplement, it is important to speak with a healthcare professional before taking to ensure it is safe and effective for individual needs.

At a Glance: Our Top Picks

Zenwise Probiotic Digestive Multi Enzymes Cover #TOP 1
Zenwise Probiotic Digestive Multi Enzymes
ftb score rating icon 9.9
American Health Chewable Multi-Enzymes, Original Papaya Cover #TOP 2
American Health Chewable Multi-Enzymes, Original Papaya
ftb score rating icon 9.8
American Health Papaya Enzyme with Chlorophyll Chewable Tablets Cover #TOP 3
American Health Papaya Enzyme with Chlorophyll Chewable Tablets
ftb score rating icon 9.6

Top 7 Papaya Enzyme Supplements

Zenwise Probiotic Digestive Multi Enzymes

ZNW00734
Off-white
Zenwise Probiotic Digestive Multi Enzymes Cover
Zenwise Health Digestive Enzymes for Gut Health & Bloating Relief - Multi Enzymes Digestion Supplement with Probiotics, Bromelain & Papaya for Digestive Health Support - Men & Women - 180 Count

Zenwise Health's Probiotic Digestive Multi Enzymes is a pre-meal plant-powered pill formulated to help women and men find relief from occasional bloating, gas, and discomfort. This advanced enzyme + prebiotic, probiotic non-GMO formula tackles hard-to-digest foods and is clinically proven to be reliably alive. It contains botanical bounty such as turmeric, ginger, green papaya, inulin, apple pectin, bladderwrack, fennel, and wakame to aid gut health and stomach comfort. Each bottle contains 180 capsules, and it is suggested to take one capsule before each meal.

What We Like
Reduces bloating and heaviness
Supports natural digestion
Easy to swallow capsules
No bad taste or odor
Effective for large meals

American Health Chewable Multi-Enzymes, Original Papaya

043562
Orange
American Health Chewable Multi-Enzymes, Original Papaya Cover
American Health Chewable Original Papaya Enzyme 250 Chwbls

American Health Chewable Multi-Enzymes, Original Papaya supplement is designed to help with inefficient digestion and promote nutrient absorption. It is a 100% natural digestive enzyme that is useful for digestion-related issues. The vegetarian formula is great tasting and easy to consume.

What We Like
Fast digestive relief
Pleasant, sweet taste
Gentle for family use
Reduces bloating and gas
Chewable and easy to take

American Health Papaya Enzyme with Chlorophyll Chewable Tablets

American Health Papaya Enzyme with Chlorophyll Chewable Tablets Cover
American Health Chewable Papaya Enzyme with Chlorophyll 600 Chwbls

American Health Papaya Enzyme with Chlorophyll Chewable Tablets is a great after meal supplement that helps promote nutrient absorption and freshens breath. It is gluten free and comes in a 600 count bottle. Customers have reported that it works great for settling their tummy and avoiding indigestion. It is also a natural papaya enzyme that can be used as a minty mouth freshener.

What We Like
Promotes nutrient absorption
Freshens breath
Gluten free

American Health Super Papaya Plus Digestive Enzyme Chewable Tablets

American Health Super Papaya Plus Digestive Enzyme Chewable Tablets Cover
American Health Products Super Papaya Enzyme Plus 360 Tablets

American Health Super Papaya Plus Digestive Enzyme Chewable Tablets are a great-tasting, vegetarian formula that helps with digestion and nutrient absorption. It contains papain and other enzymes, as well as peppermint and chlorophyll to freshen breath and reduce bad taste. Customers have found it to be helpful with inefficient digestion, nausea, upset stomach, acid reflux, and digestion. It is gluten-free, wheat-free, lactose-free, egg-free, preservative-free, yeast-free, milk-free, soy-free, grapefruit-free, sodium-free, and artificial color-free.

What We Like
Effective for digestion
Great taste
Convenient large bottle size
Fast relief from discomfort
Helps prevent GI issues
#TOP 5

21st Century Papaya Enzyme Chewable Tablets

P0054
No Color
21st Century Papaya Enzyme Chewable Tablets Cover
21st Century Papaya Enzyme Chewable (100 Count), Papaya & Pineapple Digestive Enzymes for Gut Health, Tropical Flavor, Non-GMO, Gluten-Free, No Added Salt, Artificial Flavors

21st Century Papaya Enzyme Chewable Tablets are a great way to support your digestive system. These chewable tablets are gluten-free, contain no added salt, yeast, preservatives, or artificial flavors, and are suitable for all stages. Customers have reported that the tablets taste good, work well, and are a great option for those with gastric bypass surgery.

What We Like
Gluten-free
No added salt, yeast, preservatives, or artificial flavors
Taste good and work well
#TOP 6

Clean Nutra Natto Serrapeptase Enzyme Supplement

Nattokinase
Natural
Clean Nutra Natto Serrapeptase Enzyme Supplement Cover
Clean Nutraceuticals Nattokinase 5000 FU Serrapeptase 120000 SPU Lumbrokinase Enzyme Supplement with Bromelain Papain Papaya Enzymes Rutin Extract Amla Magnesium Vitamin B6 & VIT C Capsules

Clean Nutra Natto Enzyme is a powerful enzyme supplement that combines Nattokinase, Serrapeptase, and Lumbrokinase to provide a potent blend of fibrinolytic enzymes. These enzymes are carefully selected to ensure each serving delivers 4000 units of Nattokinase, promoting healthy blood flow and cardiovascular health. The formula is enriched with Rutin and Papain, which further enhance its effectiveness. In addition to the enzymes, Clean Nutra Natto Enzyme is fortified with a range of nutritional ingredients including coq10, bromelain, calcium, sofora japonica, turmeric, Vitamin B6, Vitamin C, and papaya enzyme. This comprehensive blend supports overall health and well-being. Made in the USA with strict quality standards, Clean Nutra Natto Enzyme is easy to incorporate into your daily routine, providing you with the convenience and benefits of a superior enzyme supplement.

What We Like
Powerful fibrinolytic enzyme blend
Enriched with nutritional ingredients
Superior quality and made in the USA

Wholesome Wellness Digestive Enzymes

digestive-enzymes
Green
Wholesome Wellness Digestive Enzymes Cover
Wholesome Wellness Digestive Enzymes 1000MG Plus Prebiotics & Probiotics Supplement, 180 Capsules, Organic Plant-Based Vegan Formula for Digestion & Lactose with Amylase & Bromelain,3-6 Months Supply

Wholesome Wellness Digestive Enzymes is a plant-based, organic supplement that helps improve digestion and gut health. With a 1000 MG dose of clinical grade digestive enzymes and a 10 billion CFU 10 strain probiotic with prebiotics, this supplement provides relief from bloating, flatulence, fat, pancreatic, and bowel cleansing. The Advanced Multi Enzyme System helps digest a variety of foods, including fried, spicy, raw, processed food, dairy, protein, salts, carb / carbohydrate, vitamin and acidic diet fruits and veggies. The supplement also contains a powerful 10 billion CFU dose of 10 different probiotic strains clinically shown to enhance preventions & immune system response.

What We Like
Improved digestion and gut comfort
Reduces bloating and stomach discomfort
Easy-to-swallow capsules
Plant-based and organic formula
Includes enzymes, prebiotics, probiotics
Buying Guide Image

Learn More About Purchasing the Papaya Enzyme Supplements

Benefits of Papaya Enzyme Supplements

Some potential benefits of taking papaya enzyme supplements include:

  • Improved digestion: Papain and chymopapain are both enzymes that help break down proteins in the stomach, making it easier for the body to digest food.
  • Reduced inflammation: Papaya enzymes have been shown to have anti-inflammatory effects, which can help with conditions like arthritis and inflammatory bowel disease.
  • Better absorption of nutrients: By helping to break down proteins in the stomach, papaya enzymes can improve the body's ability to absorb nutrients from food.
  • Other potential benefits: Some people also take papaya enzyme supplements for their potential benefits on the skin, immune system, and cardiovascular health.

Types of Papaya Enzyme Supplements

There are several different types of papaya enzyme supplements on the market, including:

  • Capsules: These are the most common type of papaya enzyme supplement. They typically contain powdered papaya enzymes in a gel capsule.
  • Tablets: Some papaya enzyme supplements come in tablet form, which may be easier to swallow for some people.
  • Powder: Papaya enzyme powder can be mixed with water or added to food. This is a good option for people who don't like taking capsules or tablets.

How to Choose a Papaya Enzyme Supplement

When shopping for a papaya enzyme supplement, there are a few key things to consider:

  • Quality: Look for a papaya enzyme supplement that is made from high-quality ingredients and is free from additives and fillers.
  • Dosage: Pay attention to the recommended dosage on the supplement label, and make sure to follow it closely.
  • Form: Choose a papaya enzyme supplement that comes in a form that is convenient and easy for you to take.
  • Price: Compare prices from different brands to find a papaya enzyme supplement that fits your budget.

Conclusion

Papaya enzyme supplements are a convenient and effective way to support digestive health and reduce inflammation. By considering factors like quality, dosage, form, and price, you can find the right papaya enzyme supplement for your needs.

Frequently Asked Questions (FAQs)

1. What is papaya enzyme pills good for?

Papaya enzyme pills, derived from unripe papayas, contain an enzyme called papain. This enzyme helps in breaking down proteins, aiding digestion, and allowing the gut to absorb more nutrients. It may provide relief for individuals with celiac disease, IBS, and indigestion. Additionally, papaya enzyme is known for its anti-inflammatory and antioxidant properties.

2. Is it safe to take papaya enzymes?

While papaya enzymes can be safe when used appropriately, it is important to be cautious. Large amounts of papain, found in unripe papaya fruit, can potentially damage the esophagus. When applied topically, ripe papaya fruit is generally safe for up to 10 days, but unripe papaya fruit application may be unsafe for the skin.

3. When should you take papaya enzyme?

The suggested use for papaya enzyme is to chew three tablets following a meal, one to three times daily. Alternatively, you can dissolve one or two tablets in the mouth as needed.

4. How many papaya enzyme pills should I take?

For adults, the recommended dosage is to chew three tablets of papaya enzyme following meals.

5. Is it okay to take papaya enzymes everyday?

While papaya enzymes can be beneficial, it is important not to overdo it. Consuming excessive amounts of papain, especially in supplement form, may have harmful effects, particularly on the esophagus. It is advisable to consume papaya enzymes in moderation and consult with a healthcare professional if necessary.

6. Who shouldn't take papaya enzymes?

Individuals allergic to latex or papaya should avoid using papain. Topical application of papain may cause allergic reactions, blisters, and skin irritation. It is also important to use caution if you have diabetes, hypoglycemia, or are taking medications or natural remedies that lower blood sugar, as papain may lower blood sugar levels.

Editor's Notes

During our papaya enzyme supplement research, we found 24 papaya enzyme supplement products and shortlisted 7 quality products. We collected and analyzed 723,672 customer reviews through our big data system to write the papaya enzyme supplements list. We found that most customers choose papaya enzyme supplements with an average price of $21.46.

The papaya enzyme supplements are available for purchase. We have researched hundreds of brands and picked the top brands of papaya enzyme supplements, including Zenwise Health, American Health, 21st Century, Clean Nutraceuticals, Wholesome Wellness. The seller of top 1 product has received honest feedback from 795 consumers with an average rating of 4.9.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.