Best Enzyme Supplements for Metabolism Support of 2025

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 6, 2025

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Enzyme supplements are becoming increasingly popular as a way to support metabolism. These supplements contain specific enzymes that help to break down carbohydrates, proteins, and fats, allowing the body to absorb nutrients more efficiently. By supporting the metabolism in this way, enzyme supplements can help to improve energy levels, support weight loss efforts, and promote overall digestive health. Some popular enzyme supplements include protease, amylase, and lipase, which are all essential for breaking down different types of nutrients. As always, it is important to talk to a healthcare professional before starting any new supplement regimen.

At a Glance: Our Top Picks

Pure Encapsulations CholestePure Cover #TOP 1
Pure Encapsulations CholestePure
ftb score rating icon 9.9
Love Wellness Boost & Reduce Kit Cover #TOP 2
Love Wellness Boost & Reduce Kit
ftb score rating icon 9.8
NaturalSlim Helpzymes Digestive Enzymes Cover #TOP 3
NaturalSlim Helpzymes Digestive Enzymes
ftb score rating icon 9.6

Top 7 Enzyme Supplements for Metabolism Support

#TOP 1

Pure Encapsulations CholestePure

Pure Encapsulations CholestePure Cover
Pure Encapsulations CholestePure | Supplement to Support Cardiovascular Health, Enzyme Function, and Lipid Metabolism* | 90 Capsules

Pure CholestePure is a multi-enzyme supplement designed to support cardiovascular health, enzyme function, and lipid metabolism. It contains a phytosterol complex with campesterol, stigmasterol, brassicasterol, and beta-sitosterol, which are known for their ability to maintain healthy enzyme function and support lipid metabolism. This supplement provides a convenient source of phytosterols without the extra calories found in margarines, spreads, or salad dressings. Pure CholestePure is made with premium ingredients sourced from trusted suppliers and is carefully manufactured and tested to ensure potency and purity. It is also free from wheat, eggs, tree nuts & peanuts, gluten, artificial colors, flavors & sweeteners, coatings and shellacs, GMOs, and unnecessary binders, fillers & preservatives.

What We Like
Cardiovascular support
Enzyme function maintenance
Lipid metabolism support
#TOP 2

Love Wellness Boost & Reduce Kit

LW-BOOSTDUO
Love Wellness Boost & Reduce Kit Cover
Love Wellness Bye Bye Bloat & Metabolove | Boost & Reduce Bundle | Metabolism Booster for Women Supplement | Digestive Enzymes for Gas & Bloating Relief | Combat Cravings & Boost Energy Supplement

The Love Wellness Kit is your Gut Health BFFs. This feel-good duo includes 1 bottle of Metabolove and 1 bottle of Bye Bye Bloat. Metabolove helps boost metabolism and reduces unwanted food cravings, while Bye Bye Bloat is designed to ease discomfort and promote healthy digestion. With organic ingredients like green tea, fennel, dandelion, and fenugreek, this kit provides a natural solution for bloating, gas relief, and digestive support. Take 2 Metabolove capsules in the morning to kickstart your metabolism, and 1-2 Bye Bye Bloat capsules after a meal or before bedtime to calm your stomach. Love yourself well with this expert-backed clean solution from Love Wellness.

What We Like
Gut Health Support
Boosts Metabolism
Eases Digestive Discomfort
#TOP 3

NaturalSlim Helpzymes Digestive Enzymes

HELPZYMES
NaturalSlim Helpzymes Digestive Enzymes Cover
NaturalSlim Helpzymes Digestive Enzymes - Superior Digestion Supplements for Gut Health, Bloating & Gas Relief - Amylase, Bromelain, Lipase, Protease & Pancreatin with Betaine HCL - 100 Caps (Solo)

NaturalSlim Helpzymes is designed to enhance your digestion and overall gut health. It helps break down food effectively, ensuring your body absorbs vital nutrients efficiently. By promoting better nutrient absorption, this supplement supports your digestive system in transforming food into usable energy. With its superior formula containing essential enzymes, it aids in boosting metabolism, which can lead to increased energy levels throughout your day. This powerful blend makes it easier for you to enjoy your meals without the discomfort of bloating or gas.

What We Like
Improved digestion
Enhanced nutrient absorption
Increased energy levels
Supports gut health

Digestive Support Enzymes

Digestive Support Enzymes Cover
MaryRuth Organics Gluten Enzymes Capsules | Up to 2 Month Supply | Enzyme Supplement for Gut Health Support | Gluten Digestion | & Nutrient Absorption | Vegan | Gluten Free | 60 Count

This supplement aids in the digestion of gluten, ultimately supporting gluten metabolism and immune function. It helps with occasional bloating, gas and discomfort that may be associated with digesting gluten. Encapsulated in vegan capsules, you can easily incorporate these into your routine.

What We Like
Supports digestive health
May alleviate occasional bloating, gas and discomfort
Vegan and Non-GMO
#TOP 5

Patient One GI-One Digestive Support

Patient One
Not Applicable
Patient One GI-One Digestive Support Cover
Patient One GI-One | Supplement to Support Food Metabolism and Nutrient Absorption* | with Digestive Enzyme Complex and More | 90 Capsules

Patient One Digestive Support is designed to enhance your gastrointestinal health and improve how your body processes food. It helps maintain a healthy balance of intestinal flora, promoting a well-functioning GI tract. This supplement also optimizes the metabolism of proteins and carbohydrates, which can ease discomfort from gas and bloating. With a broad spectrum of digestive enzymes, it aids in better nutrient absorption, ensuring you get the most from your meals. This clean and pure formula is suitable for both men and women, making it a great choice for anyone looking to support their digestive health.

What We Like
Supports gut health
Enhances nutrient absorption
Reduces gas and bloating
Hypoallergenic formula
#TOP 6

Patient One Digest-Plex Supplement

Patient One
Not Applicable
Patient One Digest-Plex Supplement Cover
Patient One Digest-Plex | Supplement to Support Gastric Comfort and Food Metabolism* | with Betaine, Papain, Bromelain and Pepsin | 120 Capsules

Patient One Digest-Plex is designed to enhance your digestion and nutrient absorption. It helps your body break down proteins and carbohydrates, making it easier for you to get the nutrients you need. If you often feel discomfort after meals, this supplement can soothe your stomach and reduce gas and bloating. With a blend of hydrochloric acid and digestive enzymes, it supports a healthy gut environment. Plus, its hypoallergenic formula ensures that you can use it without worrying about common allergens, making it a safe choice for many individuals.

What We Like
Supports digestion and nutrient absorption
Reduces gas and bloating
Hypoallergenic and safe formula
Promotes overall gut health
#TOP 7

Life Extension DAO Supplement

Off White
Life Extension DAO Supplement Cover
Life Extension Food Sensitivity Relief with Diamine Oxidase (DAO), Occasional Gas, Digestive Comfort, histamine Sensitivity, DAO Enzyme Supplement, Gluten Free, Non-GMO, Vegetarian, 60 Capsules

Life Extension DAO Relief offers a solution for those seeking comfort from occasional digestive issues caused by histamine-rich foods like cheese and cured meats. This supplement contains diamine oxidase, an enzyme that helps break down histamine in your gut, alleviating discomfort. Made from plant-based pea sprouts, this formula is suitable for vegetarians and avoids animal-derived enzymes. With a commitment to quality, the product is non-GMO and gluten-free, ensuring you receive a pure supplement. Enjoy a healthier lifestyle with scientifically-backed ingredients designed to support your digestive well-being.

What We Like
Gastrointestinal comfort
Plant-based ingredients
Non-GMO and gluten-free
Supports histamine breakdown
Buying Guide Image

Frequently Asked Questions (FAQs)

1. What enzymes help with metabolism?

Some enzymes help to break down large nutrient molecules, such as proteins, fats, and carbohydrates, into smaller molecules....Role of enzymes in metabolism.

2. Do digestive enzymes help metabolism?

Digestive enzymes serve as catalysts for your metabolism and can increase your body's rate of burn. They not only break down the food you eat but also help eliminate excess fat.

3. Can enzyme supplements help you lose weight?

Some studies have even found that taking digestive enzyme supplements actually causes weight gain. But the bottom line is that most research on the topic suggests that there are no real weight-loss benefits to taking enzyme supplements.

4. What enzymes help you lose weight?

Lipase is a digestive enzyme that boosts the absorption of fat in your body by breaking it down into glycerol and free fatty acids ( 9 ). Some studies show that supplementing with lipase may decrease feelings of fullness ( 10 , 11 ).

Editor's Notes

During our enzyme supplement for metabolism support research, we found 24 enzyme supplement for metabolism support products and shortlisted 7 quality products. We collected and analyzed 108,193 customer reviews through our big data system to write the enzyme supplements for metabolism support list. We found that most customers choose enzyme supplements for metabolism support with an average price of $21.95.

The enzyme supplements for metabolism support are available for purchase. We have researched hundreds of brands and picked the top brands of enzyme supplements for metabolism support, including Pure Encapsulations, Love Wellness, NaturalSlim, MaryRuth Organics, Patient One. The seller of top 1 product has received honest feedback from 55,046 consumers with an average rating of 4.9.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.