Best Protein Enzyme Supplements of 2025

Doctor's Best Betaine HCI Pepsin & Gentian Bitters is a dietary supplement that aids in efficient digestion. It contains three nutritional factors - Betaine HCl, Pepsin, and Gentian Bitters - that work together to support the digestive process. Betaine HCl helps the stomach's digestive capacity, Pepsin is an enzyme that digests protein-containing foods, and Gentian Bitters optimizes the digestive capacity and tonifies the digestive tract. The supplement can prevent occasional gas and bloating when taken before a meal.

Get digestive support with NOW Supplements Pancreatin 10X 200mg, which contains naturally occurring protease, amylase, and lipase enzymes. It assists in the digestion of protein, fat, and carbohydrates, making it a great addition to your daily diet. This product is soy-free, nut-free, gluten-free, dairy-free, and egg-free, making it suitable for most dietary needs. NOW Supplements is a family-owned and operated company that has been in business since 1968, and their products are GMP quality assured. Customers should note that exposure to heat or sunlight can damage the product.

Pure Encapsulations Digestive Enzymes Ultra is a multi-enzyme supplement that supports the break down of protein, carbohydrate, fiber, and dairy*, while promoting optimal nutrient bioavailability and absorption*. The supplement contains a broad profile of digestive enzymes, providing optimal activity across a wide pH range. Pure Encapsulations uses only premium ingredients, and the product is free from wheat, eggs, tree nuts & peanuts, gluten, artificial colors, flavors & sweeteners, coatings and shellacs, GMOs, and unnecessary binders, fillers & preservatives.

NOW Betaine HCl Capsules provide essential digestive support with 648mg of HCl per capsule, helping you maintain optimal stomach conditions for digestion. Enhanced with pepsin, a natural protease, these capsules assist in breaking down proteins from your meals, making it easier for your body to absorb nutrients. The vegetarian formula is suitable for vegans and is crafted with an acid-stable protease, ensuring effective digestion without animal-derived ingredients. For best results, simply take 1-2 capsules at the start of each meal, avoiding use on an empty stomach.

NOW Supplements Super Enzymes is a comprehensive blend of enzymes that supports healthy digestion. Formulated with bromelain, ox bile, pancreatin and papain, Super Enzymes helps to optimize the breakdown of fats, carbohydrates and protein. It is Soy Free, Made without Gluten, Keto Friendly and GMP Quality Assured. Customers have reported that it helps with digestive issues, bloating, slow metabolism, and acid indigestion. It is easy to swallow and comes in capsule form.

NOW Dairy Digest Complete is a vegan/vegetarian, kosher, soy-free, keto-friendly supplement that aids in the digestion of dairy products. It combines lactase, proteases, and lipases to digest lactose, dairy proteins, and fats. This multi-enzyme supplement is GMP Quality Assured and packaged in the USA by a family-owned company.

Doctor's Best Proteolytic Enzymes is a potent formulation containing a broad spectrum of proteolytic enzymes (proteases) to support muscle, joint, and overall tissue health. It is vegetarian, gluten-free, and Non-GMO, and comes in a 90-count veggie capsule bottle. Customers have reported positive results in terms of relief from joint and muscle pain, as well as improved gut health.

Sports Research Digestive Enzymes with Probiotics and Ginger is a plant-based supplement designed to help the body properly digest proteins, fats and carbohydrates, resulting in better nutrient absorption and less digestive discomfort. It is Non-GMO Project Verified, Vegan Certified and Gluten Free. Customers have reported positive results in their digestive system since taking this supplement.

Physician's CHOICE Enzymes is a powerful digestive health supplement designed to provide relief from mealtime discomfort. With 16 beneficial enzymes, it helps digest proteins, carbs, fruits, veggies, beans, dairy, and fats, making it suitable for all diets. The dual action approach combines digestive enzymes with prebiotics and probiotics to promote healthy digestion and gut function. The probiotics in this supplement are specially selected for their ability to survive the harsh gut environment, and the organic prebiotics fuel the growth of healthy bacteria in the gut. Crafted based on scientific research, Physician's CHOICE Enzymes are 3rd-party tested for purity and potency, ensuring a safety assured standard of quality. Take control of your digestive health with Physician's CHOICE Enzymes.

Zenwise Health's Probiotic Digestive Multi Enzymes is a pre-meal plant-powered pill formulated to help women and men find relief from occasional bloating, gas, and discomfort. This advanced enzyme + prebiotic, probiotic non-GMO formula tackles hard-to-digest foods and is clinically proven to be reliably alive. It contains botanical bounty such as turmeric, ginger, green papaya, inulin, apple pectin, bladderwrack, fennel, and wakame to aid gut health and stomach comfort. Each bottle contains 180 capsules, and it is suggested to take one capsule before each meal.