Best Probiotic Supplements of 2025

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 16, 2025

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Probiotic supplements are a popular choice for those looking to improve their gut health. These supplements contain live bacteria that can help balance the natural microbiome in the digestive system. They are available in various forms, including capsules, powders, and drinks, and can be taken daily to support digestive health, boost immunity, and improve nutrient absorption. Additionally, probiotics have been linked to reducing inflammation and improving mental health. It's important to note that not all probiotic supplements are created equal, so it's best to consult with a healthcare professional before starting a new regimen.

At a Glance: Our Top Picks

Physician's CHOICE Probiotics 60 Billion CFU Cover #TOP 1
Physician's CHOICE Probiotics 60 Billion CFU
ftb score rating icon 9.9
Nature's Bounty Acidophilus Probiotic Cover #TOP 2
Nature's Bounty Acidophilus Probiotic
ftb score rating icon 9.8
Probiotics for Women with Organic Prebiotics - 50 Billion CFU Cover #TOP 3
Probiotics for Women with Organic Prebiotics - 50 Billion CFU
ftb score rating icon 9.6

Top 10 Probiotic Supplements

#TOP 1

Physician's CHOICE Probiotics 60 Billion CFU

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Physician's CHOICE Probiotics 60 Billion CFU Cover
Physician's CHOICE Probiotics 60 Billion CFU - 10 Strains + Organic Prebiotics - Immune, Digestive & Gut Health - Supports Occasional Constipation, Diarrhea, Gas & Bloating - for Women & Men - 60ct

Physician's CHOICE Probiotics 60 Billion CFU is a high-quality probiotic supplement designed to support digestive health and gut health. With 10 diverse probiotic strains and organic prebiotics, this probiotic is expertly crafted to support occasional constipation, diarrhea, gas, and bloating. The probiotic is designed to survive the gut and maximize the colonization of its strains, thanks to its shelf-stable bottle, acid-resistant capsules, and 60 Billion Colony forming units (CFU). Backed by scientific research and 3rd-party tested for purity and potency, this probiotic is a great choice for those looking to support a diverse healthy microbiome.

What We Like
Effective digestive support
Contains organic prebiotics
Easy to swallow capsules
Non-GMO and third-party tested
Shelf-stable, no refrigeration needed
What We Don't Like
Some experience loose stools
#TOP 2

Nature's Bounty Acidophilus Probiotic

Nature's Bounty Acidophilus Probiotic Cover
Nature's Bounty Acidophilus Probiotic, Daily Probiotic Supplement, Supports Digestive Health, 1 Pack, 120 Tablets

Nature's Bounty Acidophilus Probiotic is a daily probiotic supplement that helps support digestive health. It contains 100 million active Lactobacillus Acidophilus cultures, is gluten, dairy, and wheat free, and is suitable for vegetarians. Customers have reported positive results, with many noting improved digestive health and fewer acid reflux symptoms. There are no reported side effects or aftertaste.

What We Like
Effective digestive health support
Gentle on the stomach
Convenient once-daily dosage
Value for money
No refrigeration needed
What We Don't Like
May vary in effectiveness
Price may be high for some

Probiotics for Women with Organic Prebiotics - 50 Billion CFU

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Probiotics for Women with Organic Prebiotics - 50 Billion CFU Cover
Physician's CHOICE Probiotics for Women - PH Balance, Digestive, UT, & Feminine Health - 50 Billion CFU - 6 Unique Strains for Her - Organic Prebiotics, Cranberry Extract+ - Women Probiotic - 30 CT

This probiotic is designed for feminine health and overall digestive health, with 6 diverse strains, D-Mannose, Pro-Cran, and organic prebiotics. It supports urinary tract health, occasional constipation, diarrhea, gas, and bloating. The probiotic is scientifically backed and designed to survive the gut. Each bottle is 3rd-party tested for purity and potency.

What We Like
One pill daily
Effective for digestion
Supports women's health
Good value for money
Natural ingredients
What We Don't Like
Absorption inconsistencies
Limited women's health benefits
#TOP 4

Garden of Life Dr. Formulated Probiotics for Women

Garden of Life Dr. Formulated Probiotics for Women Cover
Garden of Life Once Daily Dr. Formulated Probiotics for Women 50 Billion CFU 16 Probiotic Strains with Organic Prebiotics for Digestive, Vaginal & Immune Health, Dairy Free, Shelf Stable 30 Capsules

Garden of Life Dr. Formulated Probiotics for Women & Prebiotics is a 50 Billion CFU probiotic supplement specifically designed for women's daily digestive, vaginal, and immune health. It contains 16 probiotic strains that are shelf stable, gluten-free, dairy-free, and soy-free. It also contains organic prebiotic fiber to help feed good bacteria in the gut. Customers have reported feeling more energized and clear-headed after taking the product, as well as relief from bloating and other digestive issues.

What We Like
Improves digestion and gut health
Easy to take, one pill daily
Tailored formulation for women
Consistent results without side effects
Supports overall well-being
What We Don't Like
Plastic container size is excessive
#TOP 5

Nature's Bounty Ultra Strength Probiotic 10 Supplement

Nature's Bounty Ultra Strength Probiotic 10 Supplement Cover
Nature’s Bounty Probiotic 10, Ultra Strength Daily Probiotic Supplement, Support for Digestive, Immune and Upper Respiratory Health, 1 Pack, 30 Capsules

Boost your gut health and immune system with Nature's Bounty Ultra Strength Probiotic 10 Supplement. It contains 10 unique probiotic strains that supplement the natural diversity of your GI microbiome for overall wellness. Each capsule has 20 billion CFU of good bacteria that supports digestive health and maintains a healthy gut. The one-per-day formula is easy to follow and can be taken with a meal. This gluten-free probiotic supplement has been backed by 20 years of research and 50 years of quality, making it a reliable choice for your health needs.

What We Like
Effective for digestion
Helps maintain gut health
Affordable price
Multiple beneficial strains
Well-tolerated with food
What We Don't Like
May require dosage adjustments
Some may experience side effects
#TOP 6

NewRhythm Probiotics 50 Billion CFU 20 Strains

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NewRhythm Probiotics 50 Billion CFU 20 Strains Cover
NewRhythm Probiotics 50 Billion CFU 20 Strains, 60 Veggie Capsules, Targeted Release Technology, Stomach Acid Resistant, No Need for Refrigeration, Non-GMO, Gluten Free

NewRhythm Probiotics is a 100% natural, non-GMO, gluten-free probiotics supplement made in New York, USA. It features a targeted release formula with 50 billion living organisms per serving and 20 strains, including organic prebiotics fiber. This potent and pure formula supports the establishment and maintenance of favorable intestinal flora, providing powerful support for healthy digestion and balanced intestinal ecology. The capsules are scientifically backed and clinically proven to survive stomach acids and reach your intestinal track, thanks to the targeted release technology. The product is shelf-stable and doesn't require refrigeration, making it convenient for everyday use. Moreover, the product is independently tested in 3rd party labs in the USA, ensuring its quality and purity. If you are not completely satisfied with the product, you can take advantage of the 100% satisfaction guarantee within 30 days.

What We Like
Effective for chronic constipation
Improved digestive health
Stomach acid resistant capsules
No refrigeration required
Good value for money
What We Don't Like
Loose stools for some users
Dose adjustment needed
#TOP 7

OMOGS Probiotics 90 Billion CFUs 18 Strains

OMOGS-P-BLUE
OMOGS Probiotics 90 Billion CFUs 18 Strains Cover
OMOGS Probiotics 90 Billion CFUs 18 Strains,with 3 Organic Prebiotics & Vitamin C,Nutritional Supplement for Women,Men & Kids,Support Metabolism,Immunity and Digestive Health,Non-GMO, 90 Tablets

OMOGS Probiotics is a highly potent probiotic supplement that contains 90 billion CFUs, 18 clinically proven strains, and 3 organic prebiotics. It can help nourish and balance the beneficial bacteria in your digestive tract, support digestion and immune system, and relieve bloating and constipation. With its natural vegan and Non-GMO formula, OMOGS Probiotics is a safe and effective way to improve your gut health. Made in the USA and certified by GMP and third-party, OMOGS Probiotics guarantees quality, purity, and effectiveness.

What We Like
Cost-efficient product
Improves gut health
Helps maintain regularity
Easy to swallow
No taste
What We Don't Like
Messy in storage containers
#TOP 8

Garden of Life Raw Probiotics for Women and Men Ultimate Care

Garden of Life Raw Probiotics for Women and Men Ultimate Care Cover
Raw Probiotics - 100 Billion CFU, Shelf Stable, 30 Capsules - For Men and Women, Digestive Enzymes, Clinically Studied Strains - by Garden of Life

Garden of Life Raw Probiotics for Women and Men Ultimate Care is a high-bifido formula with 100 billion CFU guaranteed and 34 probiotic strains from clinically studied species and Eastern European wild kefir culture, plus vitamins, minerals, raw fruits and veggies and enzymes. It includes a protein-digesting enzyme blend with digestive enzymes protease, acid protease, and protease S, to support healthy digestion and nutrient assimilation. It is third-party certified non-GMO and gluten-free, and is shelf stable, so no need to refrigerate.

What We Like
High potency (100 billion CFU)
Shelf-stable, no refrigeration needed
Clinically studied strains included
Improves digestive health
Contains digestive enzymes
What We Don't Like
Expensive product
Large plastic container waste

Garden of Life Men's Probiotic + Prebiotic Fiber

Garden of Life Men's Probiotic + Prebiotic Fiber Cover
Garden of Life Probiotics for Men Dr Formulated 50 Billion CFU 15 Probiotics for Digestive Health + Organic Prebiotic Fiber for Colon & Immune Support, Daily Gas Relief, Shelf Stable, 30 Capsules

Garden of Life Men's Probiotic + Prebiotic Fiber is a daily dietary supplement that provides 50 billion CFU and 15 probiotic strains for digestive and immune support. The once daily vegetarian capsule features Lactobacillus acidophilus and Bifidobacteria strains to alleviate occasional gas and discomfort by supporting colon health. The addition of organic prebiotic fiber to the supplement helps to maintain digestive balance and regularity in just one capsule a day, even in warmer climates. The product is free of gluten, dairy, soy, and genetically modified organisms, and manufactured following current good manufacturing practices.

What We Like
Effective digestion improvement
High CFU count
Doctor-formulated trust
Easy to swallow
Organic and non-GMO
What We Don't Like
Higher price point
Initial gas and bloating

Seed DS-01 Daily Synbiotic

SYN-AZ
Seed DS-01 Daily Synbiotic Cover
Seed DS-01 Daily Synbiotic - Prebiotic and Probiotic for Women & Men - Digestive Health, Gut Health, Immune Support, Bloating & Constipation Relief - Vegan & Shelf-Stable - 60 Capsules (30-Day Supply)

The Seed Daily Synbiotic combines prebiotics and probiotics to support your digestive and overall health. With 24 scientifically studied probiotic strains and a unique plant-based prebiotic capsule, it helps alleviate bloating and promotes regularity. This product is designed to ensure the probiotics survive digestion, delivering their benefits directly to your gut. Plus, it’s shelf-stable, meaning no refrigeration is needed, making it easy to incorporate into your daily routine.

What We Like
Effective results
Improved gut health
Easy to swallow
No unpleasant taste
Positive community reputation
What We Don't Like
Higher price point
Limited return policy
Buying Guide Image

How to Select Probiotic Supplements: The Comprehensive Guide

Introduction

Probiotics are live microorganisms that are believed to have health benefits when consumed in sufficient amounts. These beneficial bacteria can be found in fermented foods like yogurt and sauerkraut, as well as in supplement form. Probiotic supplements can help to restore the balance of bacteria in the gut, which can improve digestion and boost immune function. However, with so many options on the market, it can be overwhelming to choose the right probiotic supplement.

Consider the Type and Strains of Bacteria

Not all probiotics are created equal. Different strains of bacteria have different effects on the body, so it's important to choose a supplement that contains the right strains for your specific needs. For example, some probiotics are good for improving digestion, while others are better at boosting immune function. It's also important to consider the type of bacteria that the supplement contains. Some probiotics are made from bacteria, while others are made from yeast. Each type has its own set of benefits and drawbacks, so it's important to choose a supplement that aligns with your goals.

Check the CFUs

CFUs, or colony-forming units, refer to the number of live microorganisms in each serving of the probiotic supplement. The higher the CFUs, the more beneficial bacteria you're getting in each serving. However, it's important to note that more is not always better. Too many CFUs can lead to digestive discomfort, so it's important to find a balance that works for you. It's also worth noting that some studies have found that certain strains of bacteria are more effective at lower CFUs, so it's important to consider the specific strains as well.

Look for Third-Party Testing

Probiotic supplements are not regulated by the FDA, which means that companies can make claims about their products that are not backed by scientific evidence. To ensure that you're getting a high-quality product, look for supplements that have been tested by third-party organizations like NSF International or the USP (United States Pharmacopeia). These organizations test supplements to ensure that they contain the ingredients listed on the label and are free from contaminants.

Consider the Delivery Method

Probiotics are living organisms, which means they need to be kept alive in order to be effective. Different delivery methods can impact the viability of the bacteria, so it's important to consider how the supplement is delivered. Some probiotics come in capsule form, which can be less effective because the bacteria may not survive the journey through the digestive system. Other probiotics come in powder or liquid form, which may be more effective because the bacteria are delivered directly to the gut.

Consider the Price and Brand

Probiotic supplements can vary widely in price, from a few dollars to over a hundred dollars. While it's important to consider the price, it's also important to remember that you get what you pay for. Cheaper supplements may not contain the same high-quality ingredients as more expensive brands, so it's worth investing in a product that has a good reputation and a proven track record. It's also worth noting that certain brands may have more research backing up their claims, so it's worth doing your due diligence and researching the brand before making a purchase.

Conclusion

Choosing a probiotic supplement can be overwhelming, but with a little bit of research and consideration, you can find a product that meets your needs. Look for a supplement that contains the right strains of bacteria for your specific goals, has a reasonable number of CFUs, has been third-party tested, has a suitable delivery method, and comes from a reputable brand. With these factors in mind, you can choose a probiotic supplement that will help to restore the balance of bacteria in your gut and improve your overall health. Don't be afraid to ask your healthcare provider for recommendations or to do your own research to find the best product for you. Remember, it's always important to speak with a healthcare professional before starting any new supplement regimen.

Frequently Asked Questions (FAQs)

1. What are the signs you need probiotics?

Signs that you may need probiotics include brain fog, abdominal pain, chronic fatigue, sleep disturbances, mood disturbances, depression, or anxiety. Probiotics help in balancing the friendly bacteria in your digestive system, promoting overall gut health.

2. Is it good to take probiotic pills everyday?

Yes, it is generally safe and recommended to take probiotic supplements daily. Probiotics are natural supplements, not medications. While there may be a few exceptions, taking them daily helps maintain a healthy balance of beneficial bacteria in your gut, supporting digestive health.

3. Is there a downside to taking probiotics?

Probiotics are generally safe for most people, but some side effects may occur. The most common ones include temporary increase in gas, bloating, constipation, and thirst. Additionally, some individuals may react poorly to certain ingredients in probiotic supplements or naturally occurring amines in probiotic foods.

4. Should I take probiotics in the morning or at night?

It is recommended to take probiotics in the morning, as stomach acid production is typically at its lowest during this time. This allows the probiotics to reach the small and large intestines before breakfast. However, consistency is key, so taking them at the same time each day is more important than the specific time of day.

5. What are the side effects of taking probiotics?

Possible side effects of taking probiotics include allergic reactions, mild stomach upset, diarrhea, flatulence, and bloating during the initial days of use. It's important to note that certain individuals, such as those with a weakened immune system or at risk of infection, should exercise caution when using probiotic supplements.

6. When should probiotics not be used?

Probiotics are generally considered safe, but there are some situations where caution should be exercised. Individuals with a weakened immune system due to illness or medication may be at risk of getting sick from probiotics. Additionally, since probiotics are classified as dietary supplements, not drugs, their efficacy and safety may vary.

Editor's Notes

During our probiotic supplement research, we found 24 probiotic supplement products and shortlisted 10 quality products. We collected and analyzed 1,478,804 customer reviews through our big data system to write the probiotic supplements list. We found that most customers choose probiotic supplements with an average price of $16.91.

The probiotic supplements are available for purchase. We have researched hundreds of brands and picked the top brands of probiotic supplements, including Physician's CHOICE, Nature's Bounty, Garden of Life, NewRhythm, OMOGS. The seller of top 1 product has received honest feedback from 8,314 consumers with an average rating of 4.9.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.

Probiotic Supplements Comparison Table

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Brand Physician's CHOICE Nature's Bounty Physician's CHOICE Garden of Life Nature's Bounty NewRhythm OMOGS Garden of Life Garden of Life Seed
Unit Count 60 Count 120 Count 30 Count 30 Count 30 Count 60.0 Count 90.0 Count 30 Count 30 Count 60.00 Count
Item Form Capsule Tablet Capsule Capsule Capsule Capsule Tablet Capsule Capsule Capsule
Product Benefits Digestive Health Support, Gut Health, Occasional Constipation, Diarrhea, Gas & Bloating Digestive Health Support Feminine Health, Gas & Bloating, Digestive Health Support, Gut Health, Occasional Constipation & Diarrhea Digestive Health Support Immune Support Immune Support, Digestive Health Support, Improves Stomach Health Immune Support, Gut Health Support, Digestive Health Support Digestive Health Support Immune Support, Digestive Health Support Formulated to support digestive health, gut health, skin health, heart health, immune health, gut barrier integrity, and gut microbial balance.
Flavor 60B Probiotic Unflavored Women's Probiotic Unflavored Unflavored Unflavored - Unflavored Unflavored -
Item dimensions L x W x H 3 x 3 x 5.5 inches 1.9 x 2 x 4.1 inches 2.21 x 2.21 x 3.82 inches 2.32 x 2.32 x 4.63 inches 3 x 2.38 x 3.31 inches 2.1 x 2.1 x 3.93 inches - 2.32 x 2.32 x 4.63 inches 2.32 x 2.32 x 4.63 inches -
Diet Type Vegan Gluten Free Gluten Free Gluten Free Gluten Free Gluten Free - Gluten Free Gluten Free -
Item Weight - 0.02 Pounds 0.15 Pounds 0.16 Pounds 2.08 ounces 0.13 Pounds 0.09 Kilograms 2.8 Ounces 0.16 Pounds -
Special Ingredients - Acidophilus Acidophilus Acidophilus proprietary probiotic blend Probiotic Probiotic, Prebiotic Probiotic, Acidophilus Acidophilus -
Primary Supplement Type - Probiotic - Prebiotic & Probiotic Supplement Probiotic probiotic - Probiotic & Enzyme Supplement Prebiotic & Probiotic Supplement -
FTB Score
ftb score rating icon 9.9
ftb score rating icon 9.8
ftb score rating icon 9.6
ftb score rating icon 9.5
ftb score rating icon 9.5
ftb score rating icon 9.4
ftb score rating icon 9.3
ftb score rating icon 9.2
ftb score rating icon 9.1
ftb score rating icon 8.9
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