Best Enzyme Probiotic Supplements of 2026

The Physician's CHOICE Gut Bundle combines powerful probiotics with digestive enzymes to support your digestive health. The probiotics help balance your gut environment, which can ease common issues like constipation, diarrhea, gas, and bloating. With 60 billion CFU, these probiotics are built to survive your digestive tract and effectively colonize your gut. The digestive enzymes improve how your body breaks down food, allowing you to absorb more nutrients from your meals. Together, these ingredients promote smoother digestion, helping you feel more comfortable after eating and supporting a flatter stomach. It’s a simple, effective way to improve your gut health and overall wellness.

NATURE TARGET Women's Probiotics offers a comprehensive solution for gut health. With 100 Billion CFUs probiotics, digestive enzymes, prebiotics, and a women's health blend, it supports digestion, nutrient absorption, and gut flora balance. The probiotics aid in weight management by reducing gas, bloating, constipation, and diarrhea. Additionally, it promotes vaginal and urinary tract health through D-mannose, cranberry, and probiotics. The inclusion of skin and immune support ingredients like cranberry and multivitamins help combat aging and boost immune response.

Garden of Life Raw Probiotics for Women and Men Ultimate Care is a high-bifido formula with 100 billion CFU guaranteed and 34 probiotic strains from clinically studied species and Eastern European wild kefir culture, plus vitamins, minerals, raw fruits and veggies and enzymes. It includes a protein-digesting enzyme blend with digestive enzymes protease, acid protease, and protease S, to support healthy digestion and nutrient assimilation. It is third-party certified non-GMO and gluten-free, and is shelf stable, so no need to refrigerate.

Sports Research Probiotics, a 2-in-1 formula, offers 60 billion CFUs per capsule along with 60mg of fiber inulin for gut and digestive support. The enhanced formula combines 12 strains of probiotics for digestive enzyme and fatty acid production support. Its longer shelf life ensures freshness until the expiration date, delivering 60 billion CFUs for gut health. Encapsulated in a premium veggie capsule, it is vegan, non-GMO, and gluten-free, providing the benefits of probiotics without extra ingredients.

ZBiotics Pre-Alcohol Probiotic helps you feel better the morning after drinking by targeting the real cause of hangovers—the toxic byproduct acetaldehyde left in your gut. By taking one bottle before you start drinking, you enable a specially designed enzyme to break down this toxin, reducing discomfort the next day. This product is convenient as one bottle lasts all day, covering your drinking from morning through night without needing refrigeration. Plus, its TSA-friendly size makes it easy to bring along when you travel. With ZBiotics Pre-Alcohol Probiotic, you can enjoy social occasions while waking up feeling refreshed and ready.

Sports Research Probiotics is a 3-in-1 formula packed with 65 billion CFUs per capsule. Enhanced with Cranberry fruit and fiber inulin, it supports gut health and digestion. The blend of 16 strains of probiotics aids in digestive enzyme and fatty acid production. With a longer shelf life, you can enjoy the benefits until the expiration date. Encapsulated in a premium veggie capsule, it's vegan, non-GMO, and gluten-free, offering all the goodness without any unnecessary additives.