Best Softgel Probiotic Supplements of 2025

Nature's Way Probiotic Pearls Acidophilus is a daily probiotic formula that contains 2 strains and 1 billion cultures in a convenient, once-daily softgel. It helps protect against occasional bloating, constipation, and digestive discomfort while promoting digestive balance, immune, and colon health. The small probiotic pearls are easy to swallow and perfect for taking anywhere and everywhere, with no refrigeration required.

SHO Balance Prebiotics & Probiotics Supplement is a vegan, dairy-free, and gluten-free supplement for digestive health, gut health, and weight management. It contains 100 billion CFU of Lactobacillus Casei K-1 from Japan, prebiotics supplement Fructooligosaccharides (FOS), spirulina, flaxseed oil, and olive oil for maximum synergistic anti-inflammation plus detox effects. The kit includes a patented daily-tracking, 1-click dispenser and 30 days supply of prebiotics and probiotics. It is easy to swallow with a small size, and each SPHERI-GEL contains 50 billion probiotic CFU.

Nature's Way Probiotic Pearls Complete is a digestive supplement formulated with six probiotic strains to support digestive balance, colon health and protect against occasional bloating, constipation and digestive discomfort. It provides 2 strains of Lactobacilli and 4 strains of Bifidobacteria to help promote digestive balance, colon health and support immune health. The small pearls are easy to swallow and don't need refrigeration. These softgels don't contain salt, wheat, or artificial colors.

Nature's Way Probiotic Pearls Women's is a daily probiotic supplement designed to support vaginal, urinary tract and digestive health. With 1 billion live probiotic cultures, active Lactobacilli cultures and a triple-layer coating, these small pearls are easy to swallow and don't require refrigeration. Made with gluten-free and wholesome ingredients, this supplement is a convenient and reliable choice for women's health. Nature's Way is a trusted partner that offers digestive support for a healthy lifestyle.

Nature's Way Probiotic Pearls is a daily supplement designed for adults aged 50+ to support digestive balance, colon health, and immune health. It contains 1 billion live probiotic cultures per serving and 4 strains of Bifidobacteria. The triple-layer softgel protects probiotics from heat, air, and stomach acid to maximize survivability, helping to protect against bloating, constipation, and digestive discomfort. The product does not require refrigeration.

Nature's Way Probiotic Pearls for Women is a daily probiotic designed to support digestive and vaginal health. It contains 1 billion live probiotic cultures with Lactobacillus strains to promote healthy digestive balance, immune health, and urinary tract health. The small pearls are easy to swallow and do not require refrigeration. They are also gluten-free and free of yeast-derived ingredients, wheat, dairy, and artificial colors. The triple-layer softgel protects the probiotics from heat, air, moisture, and stomach acid to ensure maximum survival and delivery to the intestine. This probiotic also helps protect against occasional bloating, constipation, and digestive discomfort.

Nature's Way Probiotic Pearls Elite is a reliable acidophilus supplement that delivers 5 billion probiotics to support digestive, immune, and colon health. It protects against occasional bloating, constipation, and digestive discomfort with its advanced triple-layer coating that protects each pearl from heat, air, moisture, and stomach acid. Nature's Way Probiotic Pearls Elite is an extra strength formula that offers 5x the potency of Probiotic Pearls Acidophilus. It does not require refrigeration.

Primadophilus Probiotic Pearls by Nature's Way is a daily probiotic containing 4 strains to support digestive balance and immune function. The inclusion of Lactobacillus reuteri helps promote healthy gut flora, while Lactobacilli and Bifidobacterium strains benefit the small and large intestines. You can easily take one softgel daily, with or without food. This probiotic is free from salt, soy, wheat, and artificial colors, making it suitable for many. Nature's Way emphasizes natural solutions, offering quality vitamins and supplements to support your journey to wellness.

The Osumex Gut Support Probiotic is designed to enhance your digestive health quickly and effectively. With 17 active probiotic strains, it helps alleviate bloating and irregular bowel movements, giving you immediate relief. This gluten-free and vegetarian formula caters to various dietary needs, ensuring you can support your gut health without compromise. The convenient vegetable softgels are easy to swallow, making it simple to integrate into your daily routine. By promoting long-term gut wellness, this supplement not only aids digestion but also boosts your immune function, energy levels, and overall mood.

OLLY Happy Hoo-Ha Probiotic is a specially formulated supplement designed to support vaginal health and pH balance for women or people with vaginas. With a blend of two probiotic strains, Lactobacillus acidophilus La-14 and Lactobacillus rhamnosus HN001, this product helps restore and maintain a healthy balance of good bacteria, promoting overall vaginal health. By taking one capsule daily with water, you can easily incorporate this convenient supplement into your self-care routine. OLLY Happy Hoo-Ha Probiotic is vegetarian, free of synthetic flavors and colors, and provides 10 billion CFU per serving. Say goodbye to taboo topics and hello to a happier, healthier you with OLLY Happy Hoo-Ha Probiotic.