Best Saccharomyces Boulardii Probiotic Supplements of 2026

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 27, 2026

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Saccharomyces Boulardii is a type of yeast that is commonly used in probiotic supplements to support digestive health. It has been shown to help alleviate diarrhea caused by antibiotics or other gastrointestinal issues. Additionally, it may help to prevent the growth of harmful bacteria in the gut and promote the growth of beneficial bacteria. Saccharomyces Boulardii probiotic supplements are available in a variety of forms, including capsules, powders, and chewable tablets, making it easy to incorporate into your daily routine. These supplements are a great option for anyone looking to improve their digestive health and support the overall health of their gut microbiome.

At a Glance: Our Top Picks

Florastor Daily Probiotic Supplement for Digestive and Immune Support (100 Capsules) Cover #TOP 1
Florastor Daily Probiotic Supplement for Digestive and Immune Support (100 Capsules)
ftb score rating icon 9.8
Florastor Probiotics, 20 Capsules Cover #TOP 2
Florastor Probiotics, 20 Capsules
ftb score rating icon 9.7
DrFormulas' Nexabiotic Multi Probiotic with Saccharomyces Boulardii, Lactobacillus Acidophilus, B. infantis, Prebiotic 60 Count Capsules Cover #TOP 3
DrFormulas' Nexabiotic Multi Probiotic with Saccharomyces Boulardii, Lactobacillus Acidophilus, B. infantis, Prebiotic 60 Count Capsules
ftb score rating icon 9.5

Top 6 Saccharomyces Boulardii Probiotic Supplements

Florastor Daily Probiotic Supplement for Digestive and Immune Support (100 Capsules)

76936
Florastor Daily Probiotic Supplement for Digestive and Immune Support (100 Capsules) Cover
Florastor Probiotics for Digestive and Immune Health, 100 Capsules, Probiotics for Women & Men, Helps Flush Out Bad Bacteria, Boosts The Good with Our Unique Strain Saccharomyces Boulardii

Florastor Daily Probiotic Supplement is a unique probiotic with Saccharomyces boulardii lyo CNCM I-745, which helps increase the natural flora in your digestive tract and supports overall health by strengthening your digestive balance and supporting a healthy immune system. It contains 250mg of a strong probiotic strain, providing increased intestinal coverage and protection. The patented freeze-drying process gives Florastor a three-year shelf life without refrigeration, making it perfect for travelers and those with active lifestyles. The supplement is vegetarian, gluten-free, and appropriate for lactose intolerance. Florastor is an effective probiotic supplement for those who want to live a healthy lifestyle.

What We Like
Effective with antibiotics
Improves digestive health
Reduces bloating and gas
Helps prevent C. diff
High quality ingredients
#TOP 2

Florastor Probiotics, 20 Capsules

76966
Florastor Probiotics, 20 Capsules Cover
Florastor Probiotics for Digestive & Immune Health, 20 Capsules, Probiotics for Women & Men, 1 Probiotic Worldwide, Flush Out Bad Bacteria & Boost The Good with Our Strain Saccharomyces boulardii

Florastor Probiotics Capsules are designed to support digestive and immune health. They help flush out bad bacteria, allowing good bacteria to thrive, thus improving digestion and providing immune support. With a unique strain of Saccharomyces boulardii, these probiotics have over 65 years of research backing their effectiveness. The product is antibiotic-resistant, protecting against various gastrointestinal issues, and can be taken alongside antibiotics. For convenience, take 2 capsules 1-2 times daily without the need for refrigeration. Florastor Probiotics Capsules are the top-selling probiotic worldwide in their class, suitable for vegetarians, gluten-free, and lactose intolerance-friendly.

What We Like
Dual action support
Unique strain
Antibiotic resistant
#TOP 3

DrFormulas' Nexabiotic Multi Probiotic with Saccharomyces Boulardii, Lactobacillus Acidophilus, B. infantis, Prebiotic 60 Count Capsules

Multi
DrFormulas' Nexabiotic Multi Probiotic with Saccharomyces Boulardii, Lactobacillus Acidophilus, B. infantis, Prebiotic 60 Count Capsules Cover
DrFormulas' Best Probiotics for Women & Men | Nexabiotic Multi Probiotic with Saccharomyces Boulardii, Lactobacillus Acidophilus, B. infantis, Prebiotic 60 Count Capsules (Not Pearls)

DrFormulas' Nexabiotic Multi Probiotic is an advanced and effective probiotic supplement that supports digestive health for men and women. The vegetarian plant-based Delayed Released Capsules ensure maximum probiotic efficacy with its 23 strain multi probiotic containing Saccharomyces boulardii, Lactobacillus acidophilus and 21 other probiotics with prebiotic. Each tiny easy to swallow capsule has 17.25 billion CFUs at the time of manufacture to support regular bowel movements. The diverse Hardy soil based probiotic organisms, Lactobacillus and Bifidobacterium species, diarrhea shortening Lactobacillus acidophilus and Saccharomyces boulardii probiotics provide a safe solution for the digestive health conscious. Made in the USA in a FDA inspected GMP NSF Facility.

What We Like
23 strain multi probiotic with prebiotic
Vegetarian plant-based Delayed Released Capsules ensure maximum probiotic efficacy
Each tiny easy to swallow capsule has 17.25 billion CFUs at the time of manufacture to support regular bowel movements and digestive health for men and women
Diverse probiotic organisms provide safe solution for digestive health conscious
Made in the USA in a FDA inspected GMP NSF Facility
#TOP 4

Klaire Labs Saccharomyces Boulardii Probiotic Supplement

SFI Health
709616776063
Cream
Klaire Labs Saccharomyces Boulardii Probiotic Supplement Cover
SFI Health Klaire Labs Ther-Biotic Saccharomyces Boulardii Probiotics for Women & Men - S Boulardii Probiotics for Digestive Health & Immune Support - Supports Healthy Intestinal Flora (60 Capsules)

Klaire Labs Saccharomyces Boulardii is a probiotic supplement that helps support healthy yeast balance, immune and digestive health. This powerful yeast probiotic is acid-resistant, temperature tolerant, and hypoallergenic. It is free of the most common allergens and contains no artificial colors, flavors, or preservatives. The product is freeze-dried to maintain maximum strength and viability, and it is trusted by healthcare practitioners since 1969.

What We Like
Helps support healthy yeast balance, immune and digestive health
Acid-resistant and temperature tolerant
Hypoallergenic, free of common allergens and artificial ingredients
#TOP 5

Totaria Sugar Free 5-in-1 Probiotic Gummies

Totaria Sugar Free 5-in-1 Probiotic Gummies Cover
Totaria Sugar Free 5-in-1 Probiotic Prebiotic Postbiotic Gummy, 36 Strains Probiotics for Women Men with Digestive Enzymes, Peppermint, Complete Immune, Gut & Digestive Support, Vegan, 60 Counts

The Totaria Probiotic Gummies offer a powerful blend of 100 billion CFUs from over 35 probiotic strains that help balance your digestion and support your immune system. These probiotics are designed to survive stomach acid, working together with prebiotics and postbiotics to strengthen your gut health and overall wellness. The included digestive enzymes and traditional herbs like peppermint and ginger help ease bloating, gas, and constipation, making digestion smoother and more comfortable. Plus, the gummies promote healthier skin and boost your energy by supporting gut health and cellular function. These gummies are an easy and tasty way to improve your digestive and immune support daily.

What We Like
High-potency 100 billion CFUs
Prebiotics and postbiotics included
Digestive enzymes and herbs
Supports skin and energy
#TOP 6

Ancient Nutrition SBO Gut Restore 60 Ct

SPG5425
1 Count (Pack of 1)
Ancient Nutrition SBO Gut Restore 60 Ct Cover
Ancient Nutrition Probiotics, SBO Probiotics Gut Restore 60 Ct, Promotes Gut Health, Digestive and Immune Support, Gluten Free, Ancient Superfoods Blend, 25 Billion CFUs* Per Serving

Ancient Nutrition Gut Restore is a prebiotic supplement that promotes gut health, digestive and immune support. It contains a unique blend of shelf-stable probiotics, including Saccharomyces boulardii, Bacillus subtilis, Bacillus coagulans, and Bacillus clausii, providing 25 Billion CFUs per serving. The organic fermented botanical blend maximizes the benefits of a healthy diet. This product is formulated to support gut health, and 2 capsules daily can provide healthy digestive and immune system support. Ancient Nutrition Gut Restore is a super convenient way to support your body with the good bacteria it craves! Additionally, Ancient Nutrition guarantees your complete satisfaction, offering a refund within 60 days of purchase.

What We Like
Promotes gut health
25 Billion CFUs per serving
Digestive and immune support
Buying Guide Image

Frequently Asked Questions (FAQs)

1. What is Saccharomyces boulardii probiotic good for?

Saccharomyces boulardii probiotic is commonly used for treating and preventing diarrhea, including rotaviral diarrhea in children. It may also be used for other types of diarrhea, acne, and digestive tract infections that can lead to ulcers. However, scientific evidence supporting its other uses is limited.

2. Is it safe to take Saccharomyces boulardii daily?

Saccharomyces boulardii is generally considered safe for most adults when taken orally for up to 15 months. However, it may cause gas in some individuals. In rare cases, it can lead to fungal infections that may spread throughout the body. It is important to consult with a healthcare provider before starting Saccharomyces boulardii.

3. What are the disadvantages of Saccharomyces boulardii?

Saccharomyces boulardii has been associated with fungal infections in individuals with digestive tract diseases. It is important to consult with a healthcare provider before starting Saccharomyces boulardii, especially if you have a weakened immune system. This probiotic supplement should be used with caution in such cases.

4. Who should not take Saccharomyces boulardii?

Individuals who are taking antifungal medications such as clotrimazole, itraconazole, ketoconazole, miconazole, nystatin, or voriconazole should not take Saccharomyces boulardii. It is important to consult with a healthcare provider to determine if this probiotic supplement is suitable for you, especially if you are taking any of these medications.

Editor's Notes

During our saccharomyces boulardii probiotic supplement research, we found 24 saccharomyces boulardii probiotic supplement products and shortlisted 6 quality products. We collected and analyzed 165,812 customer reviews through our big data system to write the saccharomyces boulardii probiotic supplements list. We found that most customers choose saccharomyces boulardii probiotic supplements with an average price of $23.92.

The saccharomyces boulardii probiotic supplements are available for purchase. We have researched hundreds of brands and picked the top brands of saccharomyces boulardii probiotic supplements, including Florastor, DrFormulas, SFI Health, Totaria, Ancient Nutrition. The seller of top 1 product has received honest feedback from 384 consumers with an average rating of 4.7.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.