Best Bacillus Subtilis Probiotic Supplements of 2025

Supersmart Bacillus Subtilis Probiotic is a clinically-tested and patented strain of probiotic that improves natural defenses. Medical professionals often recommend this probiotic supplement for digestive health and immune support. Each capsule is encapsulated using DR Caps, which are designed to withstand stomach acidity and ensure maximum absorption in the gut. With one capsule a day, you can conveniently enhance your natural defenses and protect against external attacks. Plus, Supersmart has a 100% satisfaction guarantee, showing their commitment to your well-being.

Microbiome Labs HU58 Probiotics are designed for both men and women to enhance your digestive health and immune system. These probiotics feature a powerful spore-based strain, Bacillus subtilis HU58, which helps maintain a healthy balance in your gut. You’ll benefit from its remarkable ability to survive harsh digestive conditions, ensuring that you receive the full advantages of the probiotics. Additionally, these capsules support digestion by boosting the production of essential fatty acids, helping your body break down food more effectively. Starting with a lower dosage allows your body to adjust gradually to these beneficial probiotics.

Klaire Labs Biospora Probiotic provides unique support for healthy gastrointestinal and immune function with its two powerful spore-forming probiotics, Bacillus coagulans and B. subtilis. Its unique blend is supplied in a base of plant cellulose, and requires no refrigeration. These spores withstand stomach acid and germinate in the small intestine within 6 hours of ingestion. Plus, it's free of common allergens and artificial colors, flavors or preservatives. Trusted by healthcare practitioners since 1969.

Bacillus Subtilis spore-based probiotic is a high-potency strain with prebiotic fiber that supports daily gut health and microbiome balance. It contains pure, high-quality Bacillus Subtilis spores that resist UV exposure, heat, and long storage times, ensuring maximum potency. The probiotic survives digestive acid and reaches the colon to provide relief from gas, bloating, irregularity, and other digestive symptoms. With added prebiotics such as Moringa and dandelion root, it helps feed good bacteria in the gut, promoting better digestion, energy, mood, and immunity. Safe for all ages and prepared in a top-quality lab with strict international standards.

Prioritize your gut health with Capsuline Advanced Probiotic. Its natural spore probiotic, DE111 Bacillus Subtilis, supports a healthy digestive system and promotes proper digestion. This shelf-stable probiotic supplement contains multiple probiotic strains, including Lactobacillus casei, Bifidobacterium longum, and Lactobacillus rhamnosus. It also boosts your immune system, thanks to its vegetarian and non-GMO formula.

Upgrade your gut health with The Inner Health Probiotic Supplement, an advanced formula consisting of Bacillus Subtilis, Bifidobacterium Longum, Lactobacillus Rhamnosus, Lactobacillus Plantarum, and Lactobacillus Acidophilus. With 120 capsules for a full 4-month supply, this USA-made product is free from artificial ingredients and suitable for vegetarians. Enjoy total peace of mind with the no-question money-back guarantee. Say goodbye to unexplained gut issues and improve your overall health with The Inner Health Probiotic Supplement.

Revive Herbs Advanced Probiotic is a high-quality probiotic supplement that offers numerous benefits to both women and men. With its clinically studied strain, DE111 (Bacillus subtilis), this probiotic is designed to support digestive and immune health. One of the standout features of this product is that it does not require refrigeration, making it convenient for travel and on-the-go use. Additionally, the spore-forming ability of DE111 allows it to survive stomach acid, ensuring that the probiotics reach their intended destination in the gut. The use of high-quality ingredients and the reasonable pricing of this product further instill trust in its quality. Lastly, the risk-free purchase policy with a 90-day return option gives consumers the confidence to try this probiotic without any hesitation.

SMNutrition Organic Probiotics are a powerful daily supplement for digestive health and immune support. With at least 70% of immune cells residing in the digestive tract, these probiotic gummies help maintain a healthy bacterial environment, crucial for a strong immune system. They contain DE111, a patented Bacillus subtilis probiotic that is reliable and can withstand high temperatures and stomach acid. Each serving of two gummies delivers 5 billion CFU, providing a potent dose of probiotics. These strawberry-flavored gummies are made from 100% organic ingredients, ensuring effectiveness, healthiness, and deliciousness. SMNutrition Organic Probiotics are also third-party tested, non-GMO, vegan, and free from common allergens. Enjoy the convenience of shelf-stable gummies that require no refrigeration and are manufactured to the highest quality standards.

Microbiome Labs MegaSporeBiotic is a daily use spore-based probiotic that promotes microbial diversity and maintains key health-promoting gut flora. Its DNA-verified Bacillus strains including bacillus subtilis and bacillus coagulans can survive harsh environments and colonize to support a healthy gut. It requires no refrigeration, making it a travel-friendly digestive probiotic supplement for adults, teens, and children age 5. Note that the packaging may vary as Microbiome Labs is rebranding through 2023.

MultiSpore® Plus Probiotic is designed to support your gut health with two powerful spore-forming bacteria, Bacillus Coagulans and Bacillus Subtilis. These strains thrive in your digestive system, boosting beneficial bacteria while reducing harmful ones. With 10 billion active organisms per serving, these heat-stable spores do not require refrigeration, making them easy to store. Additionally, the formula includes prebiotic inulin, which nourishes good bacteria, and a blend of digestive enzymes that help break down food for better nutrient absorption. This combination can enhance your overall digestive wellness.