Best Probiotic Supplements for Immune Support of 2025

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 8, 2025

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Probiotic supplements are becoming increasingly popular as a means of supporting the immune system. These supplements contain live bacteria that are beneficial to the gut and can help to improve digestion and nutrient absorption. By promoting a healthy gut microbiome, probiotics can also boost the body's natural defenses against infection and disease. Some of the most popular probiotic supplements for immune support include Lactobacillus acidophilus, Bifidobacterium lactis, and Saccharomyces boulardii. These supplements are available in a variety of forms, including capsules, powders, and gummies, making them easy to incorporate into a daily routine.

At a Glance: Our Top Picks

Nature's Bounty Ultra Strength Probiotic 10 Supplement Cover #TOP 1
Nature's Bounty Ultra Strength Probiotic 10 Supplement
ftb score rating icon 9.9
Garden of Life Dr. Formulated Probiotics for Women Cover #TOP 2
Garden of Life Dr. Formulated Probiotics for Women
ftb score rating icon 9.8
OLLY Probiotic Gummy Cover #TOP 3
OLLY Probiotic Gummy
ftb score rating icon 9.6

Top 10 Probiotic Supplements for Immune Support

Nature's Bounty Ultra Strength Probiotic 10 Supplement

Nature's Bounty Ultra Strength Probiotic 10 Supplement Cover
Nature’s Bounty Probiotic 10, Ultra Strength Daily Probiotic Supplement, Support for Digestive, Immune and Upper Respiratory Health, 1 Pack, 30 Capsules

Boost your gut health and immune system with Nature's Bounty Ultra Strength Probiotic 10 Supplement. It contains 10 unique probiotic strains that supplement the natural diversity of your GI microbiome for overall wellness. Each capsule has 20 billion CFU of good bacteria that supports digestive health and maintains a healthy gut. The one-per-day formula is easy to follow and can be taken with a meal. This gluten-free probiotic supplement has been backed by 20 years of research and 50 years of quality, making it a reliable choice for your health needs.

What We Like
Contains 10 unique probiotic strains for overall wellness
Each capsule has 20 billion CFU of good bacteria to support digestive health
One-per-day formula is easy to follow and can be taken with a meal

Garden of Life Dr. Formulated Probiotics for Women

Garden of Life Dr. Formulated Probiotics for Women Cover
Garden of Life Once Daily Dr. Formulated Probiotics for Women 50 Billion CFU 16 Probiotic Strains with Organic Prebiotics for Digestive, Vaginal & Immune Health, Dairy Free, Shelf Stable 30 Capsules

Garden of Life Dr. Formulated Probiotics for Women & Prebiotics is a 50 Billion CFU probiotic supplement specifically designed for women's daily digestive, vaginal, and immune health. It contains 16 probiotic strains that are shelf stable, gluten-free, dairy-free, and soy-free. It also contains organic prebiotic fiber to help feed good bacteria in the gut. Customers have reported feeling more energized and clear-headed after taking the product, as well as relief from bloating and other digestive issues.

What We Like
Effective aid for bloating and bowel irregularities
Helps with weight management
Reduces bacterial infections

OLLY Probiotic Gummy

OLLY Probiotic Gummy Cover
OLLY Probiotic Gummy, 1 Billion CFUs, Immune and Digestive Support, Chewable Probiotic Supplement, Mango, 80 Count

OLLY Probiotic Mango Gummies are packed with one billion live cultures of bacillus coagulans, supporting your gut flora and immune system. These tasty gummies help keep your digestive tract healthy, making you feel your best. OLLY aims to simplify nutrition, ensuring you can easily maintain good health. Their gummy vitamins and supplements are not only effective but also enjoyable to consume, fitting seamlessly into your daily routine.

What We Like
1 Billion CFUs
Supports Gut Flora
Easy to Consume
#TOP 4

Culturelle Health & Wellness Daily Probiotic For Women & Men

049100363745
Natural
Culturelle Health & Wellness Daily Probiotic For Women & Men Cover
Culturelle Health & Wellness Daily Probiotic Supplement For Men & Women, Helps Support Your Immune System, Occasional Diarrhea, Gas & Bloating, 15 Billion CFUs, Non-GMO, 30 Count

Culturelle Health & Wellness Daily Probiotic For Women & Men is a probiotic supplement that supports your digestive health, natural immune defenses and restores the natural balance of good bacteria in your digestive tract. It is formulated with the #1 clinically studied probiotic strain, Lactobacillus rhamnosus (LGG) that has been proven to survive harsh stomach acids to reach the intestines where it is needed. The product contains 15 billion CFUs of probiotics per serving, which provides digestive and immune support. It is safe, backed by research and does not require refrigeration.

What We Like
Contains the most clinically studied probiotic strain
Provides digestive and immune support
Does not require refrigeration
Safe and backed by research
#TOP 5

OLLY Multi + Probiotic Adult Multivitamin Gummy

1556436
OLLY Multi + Probiotic Adult Multivitamin Gummy Cover
Olly Multi + Probiotic Adult Multivitamin Gummy, 1 Billion CFUs, Digestive and Immune Support Chewable Supplement, 35 Day Supply (70 Gummies), Tropical Twist

OLLY Multi + Probiotic is a daily gummy vitamin for adults that provides essential nutrients to support overall health, plus a super boost of 1 billion CFUs of Probiotics to support your immune system and digestion. It contains a powerful combination of essential Vitamins and Minerals, including Biotin, for gut health. These gluten-free gummies are made with no artificial colors or flavors and come in a bright tropical fruit blend flavor.

What We Like
Provides essential nutrients for overall health
Contains 1 billion CFUs of Probiotics for immune system and digestion support
Gluten-free and made with no artificial colors or flavors
Easy to take - chew two gummies, no food or water needed
Mix and match with other OLLY gummies
#TOP 6

Physician's CHOICE Probiotics 60 Billion CFU

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Physician's CHOICE Probiotics 60 Billion CFU Cover
Physician's CHOICE Probiotics 60 Billion CFU - 10 Strains + Organic Prebiotics - Immune, Digestive & Gut Health - Supports Occasional Constipation, Diarrhea, Gas & Bloating - for Women & Men - 84ct

Physician's CHOICE Probiotics is designed to enhance your digestive and gut health. With 60 billion CFU and 10 diverse probiotic strains, this supplement helps maintain a balanced microbiome, which can be beneficial for occasional issues like constipation, diarrhea, gas, and bloating. The formulation includes organic prebiotics that work in harmony with the probiotics, ensuring they thrive in your gut. Plus, the product is crafted to survive stomach acidity, maximizing the benefits for your digestive system. With third-party testing for purity and potency, you can trust that you're choosing a quality supplement.

What We Like
Supports gut health
Contains organic prebiotics
Survives stomach acidity
Third-party tested
#TOP 7

Culturelle Women’s Healthy Balance Probiotic

049100400594
Culturelle Women’s Healthy Balance Probiotic Cover
Culturelle 4-in-1 Probiotics for Women, Daily Probiotic & Prebiotic Supplement to Support Vaginal Health, Digestive Health, Immune Health, Occasional Diarrhea, Gas & Bloating Relief, Non-GMO, 30 Count

Culturelle Women’s Healthy Balance Probiotic is a vegetarian probiotic supplement designed to support digestive, immune, and vaginal health. It is powered by 5 clinically proven probiotic strains, including Lactobacillus rhamnosus (LGG), which has been shown to survive harsh stomach acids to reach the intestines. It contains 15 billion CFUs of probiotics per capsule, making it a convenient daily option. This probiotic supplement is safe for pregnant women and does not require refrigeration.

What We Like
Contains clinically proven probiotic strains to support digestive, immune, and vaginal health
15 billion CFUs per capsule for convenience
Safe for pregnant women
Vegetarian and gluten-free
No refrigeration required

Primal Harvest Primal Immune Defense Supplement

Immune Defense
Primal Harvest Primal Immune Defense Supplement Cover
Primal Harvest Primal Immune Defense 10-in-1 Immune Defense Supplement: with 7 Billion CFU Probiotics, Zinc, Vitamins C, B6, D3, K2 - Immune Boosters for Adults 60 Capsules (1 Pack)

Primal Harvest Primal Immune Defense Supplement is a 3-step solution to boost your immune system, featuring high amounts of Vitamin D3, Vitamin C, Zinc, Vitamin B6, Prebiotics, Probiotics, and carefully chosen essential minerals. Besides aiding digestion, the powerful prebiotics and probiotics help maintain a strong immune response, and the product is gluten-free. The 90-day money-back policy ensures that you will be 100% satisfied with your purchase or get your money back. The product comes in a bottle with 60 capsules, providing you with the best possible immunity boost support.

What We Like
Contains a high amount of essential vitamins and minerals to support your immune system and energy levels.
Powerful prebiotics and probiotics help maintain a strong immune response and aid digestion.
Gluten-free and comes with a 90-day money-back policy to ensure customer satisfaction.

VITALITOWN Probiotics 120 Billion CFUs

Vitalitown
120 Billion Cfus
VITALITOWN Probiotics 120 Billion CFUs Cover
VITALITOWN Probiotics 120 Billion CFUs | 36 Strains, with Prebiotics & Digestive Enzymes for Men Women | Shelf Stable | Digestive Health & Immune Support | Vegan, Non-GMO | 30 Delayed Release Veg Caps

VITALITOWN Probiotics is a high-quality probiotic supplement that provides 120 billion CFUs and 36 strains per capsule. It is specially formulated for both men and women, offering unsurpassed quality and value. The probiotics are vegan, non-GMO, and free from common allergens such as gluten, dairy, and soy. In addition to probiotics, this supplement also contains prebiotics and digestive enzymes. These three components work together to support healthy digestion, reduce gas and bloating, and boost the immune system. The probiotics are shelf-stable and feature delayed-release technology, ensuring their survival through stomach acid and effective delivery to the intestine. Made in the USA, VITALITOWN Probiotics adhere to the highest standards of purity and potency.

What We Like
120 Billion CFUs & 36 Strains
Vegan, Non-GMO
Digestive & Immune Support
#TOP 10

Nature's Nutrition Probiotic 80 Billion CFU

NNProbioticUltra
Nature's Nutrition Probiotic 80 Billion CFU Cover
Probiotic Supplement 80 Billion CFU + Prebiotics, Acidophilus Probiotic Supports Immune System & Digestive Health, Supports Occasional Constipation, Supplement for Women Feminine Health - 120 Capsules

Nature's Nutrition Probiotic is designed to enhance your digestive health with a potent blend of 80 billion CFU, including Lactobacillus acidophilus. This probiotic formula not only aids in maintaining a balanced gut flora but also improves nutrient absorption, which can lead to better overall health. Additionally, it supports your immune system, helping you stay strong and healthy. Specifically formulated for women, this supplement promotes healthy vaginal flora, ensuring comfort and hygiene. You can trust this non-GMO, artificial ingredient-free formula to support your wellness needs without compromise.

What We Like
Supports digestive health
Boosts immune system
Formulated for women's health
Non-GMO and pure
Buying Guide Image

Frequently Asked Questions (FAQs)

1. What is the best probiotic to boost immune system?

Probiotics may help support our immune system. High-quality studies suggest that the Lactobacillus rhamnosus, LGG®, Lactobacillus paracasei, L. CASEI 431® and Bifidobacterium, BB-12® strains (hereafter referred to by use of the trademarks LGG®, L.

2. Do probiotics help boost immune system?

Probiotics may help give your immune system a boost and inhibit the growth of harmful gut bacteria ( 34 ). Also, some probiotics have been shown to promote the production of natural antibodies in the body. They may also boost immune cells like the IgA-producing cells, T lymphocytes and natural killer cells ( 35 , 36 ).

3. Are probiotics good for weak immune system?

When the gut becomes unbalanced with unhealthy levels of certain bacteria, probiotics can help restore the balance. They've been shown to secrete protective substances, which may turn on the immune system and prevent pathogens from taking hold and creating major disease.

4. Who should not take probiotics?

Some reports have linked probiotics to serious infections and other side effects. The people most likely to have trouble are those with immune system problems, people who've had surgery, and others who are critically ill. Don't take probiotics if you have any of those issues.

Editor's Notes

During our probiotic supplement for immune support research, we found 24 probiotic supplement for immune support products and shortlisted 10 quality products. We collected and analyzed 938,331 customer reviews through our big data system to write the probiotic supplements for immune support list. We found that most customers choose probiotic supplements for immune support with an average price of $19.73.

The probiotic supplements for immune support are available for purchase. We have researched hundreds of brands and picked the top brands of probiotic supplements for immune support, including Nature's Bounty, Garden of Life, OLLY, Culturelle, Physician's CHOICE. The seller of top 1 product has received honest feedback from 385 consumers with an average rating of 4.7.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.