Best Prebiotic Probiotic Supplements of 2025

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 17, 2025

* We independently evaluate all recommended products and services. If you click on links we provide, we may receive compensation.

Prebiotic probiotic supplements are a popular dietary supplement that help to support a healthy gut. Prebiotics are a type of fiber that feed the good bacteria in the gut, while probiotics are live microorganisms that can improve digestion and boost the immune system. These supplements are available in various forms, including capsules, powders, and gummies, and can be taken daily to maintain a healthy gut microbiome. They are often recommended for those who suffer from digestive issues or who are looking to improve their overall health and wellness. With so many options available, it is important to choose a high-quality supplement that contains a variety of strains and is free from harmful additives.

At a Glance: Our Top Picks

Physician's CHOICE Probiotics 60 Billion CFU Cover #TOP 1
Physician's CHOICE Probiotics 60 Billion CFU
ftb score rating icon 9.8
Earth's Pearl Probiotics and Prebiotics for Gut Health Cover #TOP 2
Earth's Pearl Probiotics and Prebiotics for Gut Health
ftb score rating icon 9.7
Physician's CHOICE Prebiotic-Probiotic Cover #TOP 3
Physician's CHOICE Prebiotic-Probiotic
ftb score rating icon 9.5

Top 10 Prebiotic Probiotic Supplements

Physician's CHOICE Probiotics 60 Billion CFU

854226008582
Physician's CHOICE Probiotics 60 Billion CFU Cover
Physician's CHOICE Probiotics 60 Billion CFU - 10 Strains + Organic Prebiotics - Immune, Digestive & Gut Health - Supports Occasional Constipation, Diarrhea, Gas & Bloating - for Women & Men - 60ct

Physician's CHOICE Probiotics 60 Billion CFU is a high-quality probiotic supplement designed to support digestive health and gut health. With 10 diverse probiotic strains and organic prebiotics, this probiotic is expertly crafted to support occasional constipation, diarrhea, gas, and bloating. The probiotic is designed to survive the gut and maximize the colonization of its strains, thanks to its shelf-stable bottle, acid-resistant capsules, and 60 Billion Colony forming units (CFU). Backed by scientific research and 3rd-party tested for purity and potency, this probiotic is a great choice for those looking to support a diverse healthy microbiome.

What We Like
Significant digestive health improvement
Contains 60 billion CFUs
Includes organic prebiotics
Easy to swallow capsules
Non-GMO and shelf-stable
What We Don't Like
Some experience loose stools

Earth's Pearl Probiotics and Prebiotics for Gut Health

2Y-QD5M-UZ18
Yellow
Earth's Pearl Probiotics and Prebiotics for Gut Health Cover
Earth's Pearl Probiotic Pearls for Women and Men - Kids Probiotic with Prebiotic Fiber - Daily Probiotic for Women and Men - 60-Day Supply of Prebiotics and Probiotics for Women and Men Probiotic

Earth's Pearl Prebiotics and Probiotics for Women and Men are expertly formulated to support digestive health. The unique delivery system delivers 15 times more live bacteria directly to the intestinal tract, ensuring 1500% more effectiveness than other probiotics. The prebiotic fiber and probiotic blend nourishes existing good bacteria and provides additional beneficial bacteria for balanced protection and relief. The patented time-release formula provides relief and support throughout the entire day, and the innovative pearl shape makes them particularly easy to swallow. This 60-day supply of probiotic nutritional supplements is free from GMOs, gluten, and lactose and made in the USA.

What We Like
Small, easy-to-swallow pills
Effective for gut health
Relieves IBS symptoms
Multiple probiotic strains
Good value for money
What We Don't Like
Small size can lead to mishaps

Physician's CHOICE Prebiotic-Probiotic

854226008612
Physician's CHOICE Prebiotic-Probiotic Cover
Physician's CHOICE Prebiotic-Probiotic - Multi-Strain Probiotics & Synergistic Prebiotics -Designed for Digestive Health, Supporting Gut Microbiome - Powerful PrePro for Gut Health - for Women & Men

Physician's CHOICE Gut Health is a prebiotic-probiotic combo designed to support digestive health and gut microbiome. It contains 250mg of Prebiotic Chicory Root Inulin, which helps promote a diverse and healthy microbiome. The combo also includes 10B CFU of 3 diverse Lactobacillus probiotic strains, expertly crafted to support occasional constipation, diarrhea, gas, and bloating. The probiotic is designed to survive the gut with the help of acid-resistant capsules and 10 billion colony forming units (CFU). Physician's CHOICE Gut Health is backed by science, with its formulation based on clinical research and reviewed by expert physicians. It is tested for purity and potency, and each bottle is manufactured in the USA using high-quality ingredients. Enjoy the convenience and benefits of supporting your gut health with Physician's CHOICE Gut Health.

What We Like
Improves gut health
Easy to take
No unpleasant odors
Visible skin improvement
Effective for digestion
What We Don't Like
Mixed effectiveness during illness

OMOGS Probiotics 90 Billion CFUs 18 Strains

OMOGS-P-BLUE
OMOGS Probiotics 90 Billion CFUs 18 Strains Cover
OMOGS Probiotics 90 Billion CFUs 18 Strains,with 3 Organic Prebiotics & Vitamin C,Nutritional Supplement for Women,Men & Kids,Support Metabolism,Immunity and Digestive Health,Non-GMO, 90 Tablets

OMOGS Probiotics is a highly potent probiotic supplement that contains 90 billion CFUs, 18 clinically proven strains, and 3 organic prebiotics. It can help nourish and balance the beneficial bacteria in your digestive tract, support digestion and immune system, and relieve bloating and constipation. With its natural vegan and Non-GMO formula, OMOGS Probiotics is a safe and effective way to improve your gut health. Made in the USA and certified by GMP and third-party, OMOGS Probiotics guarantees quality, purity, and effectiveness.

What We Like
Cost efficient
Improves gut health
Helps maintain regularity
No taste
Good CFU count
What We Don't Like
Slightly goopy in containers

VITALITOWN Probiotics 120 Billion CFUs

Vitalitown
120 Billion Cfus
VITALITOWN Probiotics 120 Billion CFUs Cover
VITALITOWN Probiotics 120 Billion CFUs | 36 Strains, with Prebiotics & Digestive Enzymes for Men Women | Shelf Stable | Digestive Health & Immune Support | Vegan, Non-GMO | 30 Delayed Release Veg Caps

VITALITOWN Probiotics is a high-quality probiotic supplement that provides 120 billion CFUs and 36 strains per capsule. It is specially formulated for both men and women, offering unsurpassed quality and value. The probiotics are vegan, non-GMO, and free from common allergens such as gluten, dairy, and soy. In addition to probiotics, this supplement also contains prebiotics and digestive enzymes. These three components work together to support healthy digestion, reduce gas and bloating, and boost the immune system. The probiotics are shelf-stable and feature delayed-release technology, ensuring their survival through stomach acid and effective delivery to the intestine. Made in the USA, VITALITOWN Probiotics adhere to the highest standards of purity and potency.

What We Like
Effective for digestive issues
High potency and value
Multiple beneficial strains
Convenient delayed release
No taste or smell
What We Don't Like
Results may vary for some

Probiotics for Women with Organic Prebiotics - 50 Billion CFU

8542260080566
Probiotics for Women with Organic Prebiotics - 50 Billion CFU Cover
Physician's CHOICE Probiotics for Women - PH Balance, Digestive, UT, & Feminine Health - 50 Billion CFU - 6 Unique Strains for Her - Organic Prebiotics, Cranberry Extract+ - Women Probiotic - 30 CT

This probiotic is designed for feminine health and overall digestive health, with 6 diverse strains, D-Mannose, Pro-Cran, and organic prebiotics. It supports urinary tract health, occasional constipation, diarrhea, gas, and bloating. The probiotic is scientifically backed and designed to survive the gut. Each bottle is 3rd-party tested for purity and potency.

What We Like
Easy to take, one pill daily
Good for digestive health
Supports feminine wellness
Consistent results over time
Quality ingredients
What We Don't Like
Capsules may not absorb fully
Benefits may not last long

Amazon Solimo Probiotic Vegetarian Capsules

Amazon Basics
Amazon Solimo Probiotic Vegetarian Capsules Cover
Amazon Basics Probiotic 5 Billion CFU, 8 Probiotic strains with 60 mg Prebiotic Blend, 60 Count Vegetarian Capsules, 2 Month Supply, Supports Healthy Digestion (Previously Solimo)

Solimo Probiotic Vegetarian Capsules are designed to support healthy digestion with their 8-strain probiotic blend and 60 mg prebiotic blend. The capsules are vegetarian and come in a two-month supply with 60 capsules per bottle. Users are recommended to take one capsule daily during meals or as directed by a healthcare professional. The capsules are stored in a cool, dry place away from direct sunlight. Plus, Amazon provides a satisfaction guarantee and refund policy for up to a year after purchase.

What We Like
Affordable option
Effective for digestive health
No aftertaste
Easy to swallow capsules
Supports overall wellness
What We Don't Like
May cause initial gas and bloating
Capsules can be hard to swallow

Seed DS-01 Daily Synbiotic

SYN-AZ
Seed DS-01 Daily Synbiotic Cover
Seed DS-01 Daily Synbiotic - Prebiotic and Probiotic for Women & Men - Digestive Health, Gut Health, Immune Support, Bloating & Constipation Relief - Vegan & Shelf-Stable - 60 Capsules (30-Day Supply)

The Seed Daily Synbiotic combines prebiotics and probiotics to support your digestive and overall health. With 24 scientifically studied probiotic strains and a unique plant-based prebiotic capsule, it helps alleviate bloating and promotes regularity. This product is designed to ensure the probiotics survive digestion, delivering their benefits directly to your gut. Plus, it’s shelf-stable, meaning no refrigeration is needed, making it easy to incorporate into your daily routine.

What We Like
Effective results
Improved gut health
Easy to swallow
No unpleasant taste
Positive community reputation
What We Don't Like
Higher price point
Limited return policy
#TOP 9

SUPPLEMENTS STUDIO Probiotics with Digestive Enzymes and Prebiotic

SUPPLEMENTS STUDIO Probiotics with Digestive Enzymes and Prebiotic Cover
Probiotics with Digestive Enzymes and Prebiotic for Women and Men - 3-in-1 Vegan Probiotic Prebiotic Multi Enzyme Complex for Gut Health - Maximum Absorption Delayed-Release Capsules

Introducing SUPPLEMENTS STUDIO Probiotics, a 3-in-1 vegan probiotic prebiotic multi enzyme complex designed for both women and men. This powerful formula combines 10 strains of probiotics, a prebiotic from Jerusalem artichoke, and a blend of digestive enzymes for complete gut support. Encapsulated in acid-resistant delayed-release capsules, these probiotics survive stomach acid to reach the intestines for maximum absorption. The probiotics, prebiotic, and enzymes work together to promote regularity, improve nutrient absorption, aid digestion, and support overall gut health and immune function. With top-quality ingredients and complete transparency, this non-GMO supplement is free from fillers, preservatives, and artificial ingredients. It is shelf stable and does not require refrigeration. Manufactured in a GMP-certified facility in the USA, SUPPLEMENTS STUDIO Probiotics is backed by third-party testing and a 100% satisfaction guarantee.

What We Like
Effective gut health improvement
One pill daily convenience
Vegan-friendly ingredients
Reduced digestive discomfort
Combines multiple benefits
What We Don't Like
Uncertain effectiveness for some
Possible side effects noted
#TOP 10

Garden of Life Men's Probiotic + Prebiotic Fiber

Garden of Life Men's Probiotic + Prebiotic Fiber Cover
Garden of Life Probiotics for Men Dr Formulated 50 Billion CFU 15 Probiotics for Digestive Health + Organic Prebiotic Fiber for Colon & Immune Support, Daily Gas Relief, Shelf Stable, 30 Capsules

Garden of Life Men's Probiotic + Prebiotic Fiber is a daily dietary supplement that provides 50 billion CFU and 15 probiotic strains for digestive and immune support. The once daily vegetarian capsule features Lactobacillus acidophilus and Bifidobacteria strains to alleviate occasional gas and discomfort by supporting colon health. The addition of organic prebiotic fiber to the supplement helps to maintain digestive balance and regularity in just one capsule a day, even in warmer climates. The product is free of gluten, dairy, soy, and genetically modified organisms, and manufactured following current good manufacturing practices.

What We Like
50 billion CFU per capsule
15 diverse probiotics
Doctor-formulated and trustworthy
Easy to swallow
Organic and non-GMO ingredients
What We Don't Like
Higher price point
Initial gas and bloating
Buying Guide Image

Tips for Choosing the Prebiotic Probiotic Supplements

Introduction

When it comes to maintaining a healthy gut, prebiotic and probiotic supplements can be incredibly beneficial. But with so many options on the market, choosing the right one can be overwhelming. In this article, we will discuss what prebiotics and probiotics are, their potential health benefits, and how to choose the right prebiotic and probiotic supplements for your needs.

What are Prebiotics and Probiotics?

Prebiotics and probiotics are two types of non-digestible compounds that can promote the growth of beneficial bacteria in the gut. Prebiotics are indigestible fibers that act as food for the beneficial bacteria in the gut, while probiotics are live microorganisms that can provide similar benefits.

Potential Health Benefits

While research on the health benefits of prebiotics and probiotics is ongoing, many studies have suggested that they can help support a healthy gut microbiome. A healthy gut microbiome is associated with a wide range of potential health benefits, including improved digestion, stronger immunity, and better overall health.

Choosing the Right Prebiotic and Probiotic Supplements

When choosing prebiotic and probiotic supplements, there are a few key factors to consider. First, it's important to choose a reputable brand that uses high-quality ingredients and follows good manufacturing practices. Second, look for a supplement that contains a diverse range of prebiotics and probiotics, as this can help support a healthy gut microbiome. Finally, consider your own needs and goals when choosing a supplement. For example, if you are looking to support your immune system, choose a supplement that contains probiotics that have been shown to support immune health.

Conclusion

In conclusion, prebiotic and probiotic supplements can be a great addition to a healthy diet and lifestyle. By choosing the right supplement and incorporating it into your routine, you can support a healthy gut microbiome and potentially enjoy a wide range of health benefits.

Frequently Asked Questions (FAQs)

1. Can you take prebiotics and probiotics together?

Yes, you can take prebiotics and probiotics together. This combination, known as microbiome therapy, helps strengthen and nourish the good bacteria in your gut. Prebiotic fibers feed and support probiotic bacteria, making them more effective.

2. Is there a prebiotic and probiotic in one supplement?

Yes, when prebiotics and probiotics are combined in a supplement, it is called a synbiotic. This combination helps ensure that the beneficial bacteria in the supplement can survive the acidic environment of the stomach and colonize the gut successfully.

3. Should I take my prebiotic with my probiotic?

It is recommended to space out your prebiotic and probiotic intake by around 10 to 15 minutes. Taking them too close together may result in early interaction in the stomach, leading to bloating. It is best to take the probiotic first on an empty stomach.

4. What are the signs you need prebiotics?

Signs that you may need prebiotics include bloating, cramping, digestive irregularity (diarrhea and/or constipation), gas, and indigestion. These symptoms may indicate an imbalance in your gut microbiome that can be addressed with prebiotic supplementation.

5. Who should not take prebiotics?

Prebiotics are not recommended for individuals with Small Intestinal Bacterial Overgrowth (SIBO) or FODMAPs intolerance. These conditions may be worsened by the consumption of prebiotic supplements.

6. What are the signs you need probiotics?

Signs that you may need probiotics include brain fog, abdominal pain, chronic fatigue, sleep disturbances, and mood disturbances like depression or anxiety. Probiotics can help restore the balance of friendly bacteria in your digestive system.

7. Should you take prebiotics and probiotics at night or in the morning?

The ideal time to take probiotics is right before bed. This is because the gut is relatively inactive during sleep, allowing the probiotics to have a better chance of surviving and colonizing the gut. Taking prebiotics and probiotics at night can support the effectiveness of the supplements.

Editor's Notes

During our prebiotic probiotic supplement research, we found 24 prebiotic probiotic supplement products and shortlisted 10 quality products. We collected and analyzed 916,401 customer reviews through our big data system to write the prebiotic probiotic supplements list. We found that most customers choose prebiotic probiotic supplements with an average price of $22.40.

The prebiotic probiotic supplements are available for purchase. We have researched hundreds of brands and picked the top brands of prebiotic probiotic supplements, including Physician's CHOICE, Earth's Pearl, OMOGS, Vitalitown, Seed. The seller of top 1 product has received honest feedback from 8,333 consumers with an average rating of 4.9.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.

Prebiotic Probiotic Supplements Comparison Table

#TOP1
#TOP2
#TOP3
#TOP4
#TOP5
#TOP6
#TOP7
#TOP8
#TOP9
#TOP10
Brand Physician's CHOICE Earth's Pearl Physician's CHOICE OMOGS Vitalitown Physician's CHOICE Amazon Basics Seed SUPPLEMENTS STUDIO Garden of Life
Unit Count 60 Count 60.00 Count 30 Count 90.0 Count 30 Count 30 Count 60 Count 60.00 Count 60 Count 30 Count
Item Form Capsule Tablet Capsule Tablet Capsule Capsule Capsule Capsule Capsule Capsule
Product Benefits Digestive Health Support, Gut Health, Occasional Constipation, Diarrhea, Gas & Bloating Cholesterol Management, Digestive Health Support, Energy Management, Immune Support, Stomach Health Support Gut Health Support Immune Support, Gut Health Support, Digestive Health Support Boost the Immune System*, Relieve Gas and Bloating*, Support Digestive Health*, Improve Nutrient Absorption*, Regulate & Support Mood Levels* Feminine Health, Gas & Bloating, Digestive Health Support, Gut Health, Occasional Constipation & Diarrhea Digestion,Supports Healthy Digestion Formulated to support digestive health, gut health, skin health, heart health, immune health, gut barrier integrity, and gut microbial balance. Immune Support, Digestive system support, Supports Healthy bacteria Immune Support, Digestive Health Support
Age Range (Description) Adult Kid, Adult Adult Kid; Adult - Adult Adult Adult Adult -
Flavor 60B Probiotic Unflavored Pre-Pro - Unflavored Women's Probiotic - - Unflavored Unflavored
Item dimensions L x W x H 3 x 3 x 5.5 inches 3.5 x 1.7 x 1.7 inches - - 2.1 x 2.1 x 3.93 inches 2.21 x 2.21 x 3.82 inches 2 x 2 x 3.5 inches - 2 x 2 x 4.3 inches 2.32 x 2.32 x 4.63 inches
Item Weight - 0.09 Pounds 0.15 Pounds 0.09 Kilograms 0.05 Pounds 0.15 Pounds - - 0.15 Pounds 0.16 Pounds
Package Information Bottle Bottle Bottle Bottle - - - Bottle Bottle -
Diet Type Vegan - Vegan - Vegan Gluten Free - - - Gluten Free
FTB Score
ftb score rating icon 9.8
ftb score rating icon 9.7
ftb score rating icon 9.5
ftb score rating icon 9.5
ftb score rating icon 9.3
ftb score rating icon 9.3
ftb score rating icon 9.1
ftb score rating icon 9.0
ftb score rating icon 9.0
ftb score rating icon 8.9
Where to Buy