Best Vitamin B-Complex Supplements for Immune Support of 2026

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 20, 2026

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Vitamin B-complex supplements are a great way to boost the immune system and maintain overall health. These supplements contain a combination of essential B vitamins, including B1, B2, B3, B5, B6, B7, B9, and B12, which are crucial for proper body function. These vitamins work together to support the immune system, promote energy and metabolism, and aid in the production of red blood cells. Vitamin B-complex supplements are available in various forms, including capsules, tablets, and gummies. They are a convenient and easy way to ensure that your body is getting the essential vitamins it needs to stay healthy and strong.

At a Glance: Our Top Picks

Nature Made Super B Complex with Vitamin C, 140 Tablets Cover #TOP 1
Nature Made Super B Complex with Vitamin C, 140 Tablets
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Nature's Bounty Super B-Complex Tablets Cover #TOP 2
Nature's Bounty Super B-Complex Tablets
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NUTRAHARMONY Vitamin B Complex Cover #TOP 3
NUTRAHARMONY Vitamin B Complex
ftb score rating icon 9.6

Top 9 Vitamin B-Complex Supplements for Immune Support

Nature Made Super B Complex with Vitamin C, 140 Tablets

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Nature Made Super B Complex with Vitamin C, 140 Tablets Cover
Nature Made Super B Complex with Vitamin C & Folic Acid, B Complex Vitamins for Women and Men, Dietary Supplement for Immune Support, 140 Tablets, 140 Day Supply

Nature Made Super B Complex with Vitamin C and Folic Acid is a dietary supplement that offers 140 tablets for a 140-day supply. It is a gluten-free and vegan supplement that provides all 8 essential B vitamins, including folic acid and vitamin B12. This B-complex supplement helps support the immune system, a healthy brain and nervous system, and converts food into cellular energy. Adults can take one tablet daily with water and a meal. It is made in the USA with quality global ingredients and has no artificial colors, flavors, yeast, starch, or preservatives.

What We Like
All-in-one B vitamins
Includes Vitamin C and Folic Acid
Easy to swallow tablets
Long-lasting 140-day supply
Noticeable energy boost

Nature's Bounty Super B-Complex Tablets

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Nature's Bounty Super B-Complex Tablets Cover
Nature's Bounty Super B Complex Vitamins with Vitamin C & Folic Acid, Vitamins for Immune & Cellular Energy Support, 150 Tablets

Nature's Bounty Super B-Complex Tablets are a once-a-day multitasker designed to support overall health and wellbeing. With 150 coated tablets per bottle, this supplement contains key B vitamins that help with heart and nervous system health, aid in the conversion of food into fuel, and play an important role in energy metabolism. Vitamin C provides immune and antioxidant support, while Folic Acid helps with energy metabolism, and promotes the health of pregnant women. These tablets are vegetarian-friendly, non-GMO, and free of sugar, gluten, and lactose.

What We Like
Energy and focus boost
Easy to swallow tablets
Gentle on stomach
Great value, 150-count bottle
Vegetarian and allergen-free

NUTRAHARMONY Vitamin B Complex

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NUTRAHARMONY Vitamin B Complex Cover
Vitamin B Complex for Men & Women - Riboflavin B2, B12, B1, B3, B5, B6, B7, B8, B9 | Vitamin C, Choline, Inositol - B-Complex Supplement - Energy, Brain & Heart Support - Made in USA, 60 Vegan Caps

NUTRAHARMONY B Complex is a high-quality vitamin supplement that provides a full-spectrum of B-complex vitamins along with vitamin C, Choline, and Inositol. With a daily dose of 754 mg per serving, this B-complex supports energy, brain, and mood, while strengthening and maintaining the immune system. It also supports the work of the cardiovascular and nervous systems, making it a comprehensive health support. Made in the USA with care and love, these capsules are free from GMOs and artificial additives. If you're looking for a potent B-complex vitamin supplement that delivers results, NUTRAHARMONY B Complex is the one for you!

What We Like
Increases energy levels
Supports cognitive function
Promotes hair growth
Gentle on stomach
Good value

Integrative Therapeutics - Active B-Complex

Integrative Therapeutics - Active B-Complex Cover
Integrative Therapeutics Active B-Complex - Cellular Energy, Immune Function & Heart Health Support with Vitamins B2, B6 & B12* - Made for Busy Lifestyles - Gluten-Free - 60 Capsules (30 Servings)

Integrative Therapeutics - Active B-Complex supplement provides all 8 B-vitamins in a high-potency blend containing the active forms of vitamins B2, B6, B12, and folate. It supports cellular energy production, metabolism of carbohydrates, proteins, and fats, and healthy brain function. Additionally, it plays essential roles in cell function, growth, and energy production, as well as the nervous system's synthesis of serotonin, dopamine, and GABA. This gluten-free and vegan formula is free of wheat, soy, dairy, and artificial colors, flavors, or preservatives.

What We Like
Consistent energy boost
Improved mental clarity
Bioavailable B vitamin forms
No stomach upset
Supports heart health

Super B-Complex - High Strength Methylated Tablets

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Igennus Super B-Complex Methylated B Vitamins, All Day Nutrient Delivery, Clean Label, MTHFR Supplement with Methylfolate & B12 Methylcobalamin, Vegan, Lab Verified, 60 Small Tablets

The Super B-Complex Tablets are a high strength, vegan and vegetarian-friendly dietary supplement that supports energy metabolism, immune and hormonal systems, homocysteine regulation, nutrient metabolism, heart function, and psychological function. These small tablets (9mm) deliver a sustained release of vitamins including Thiamine, Riboflavin-5-phosphate, Niacinamide, Calcium D-pantothenate, D-Biotin, and Pyridoxal-5-Phosphate. Additionally, the methylated vitamin forms of bioavailable folate as methylfolate and methylcobalamin (Vit B12) are used for immediate absorption. The twice daily dosing optimises B12 levels, providing all-day nutrient coverage. The tablets are GMP manufactured in the USA and MTHFR friendly (no synthetic folic acid).

What We Like
Methylated B vitamins
Noticeable energy boost
Gentle on stomach
Vegan and clean ingredients
Easy to swallow tablets
#TOP 6

Garden of Life Raw B Complex - Vitamin Code

Garden of Life Raw B Complex - Vitamin Code Cover
Garden of Life Vitamin B Complex, 120 Vegan Capsules, High Potency Vitamins for Energy & Metabolism with B6, Folate & B12 as Methylcobalamin Plus Probiotics

Garden of Life Raw B Complex - Vitamin Code is a high potency supplement that supports energy, metabolism, immune system, heart, and blood health. This B Complex supplement contains 8 whole food complexed B vitamins, raw probiotics, and enzymes that support healthy digestion. The supplement is vegan, gluten-free, kosher, and free from synthetic binders, fillers, and artificial additives.

What We Like
Whole food ingredients
Steady energy boost
No stomach discomfort
Easy to swallow
Improves mood and clarity

Thorne Stress B-Complex - 60 Capsules

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Thorne Stress B-Complex - 60 Capsules Cover
THORNE - Stress B-Complex - Vitamins B2, B6, B12 & Folate in Highly-Absorbable and Active Forms - Extra Vitamin B5 for Adrenal Support, Stress Management & Immune Function* - 60 Servings

Thorne Stress B-Complex is a gluten-free dietary supplement that supports stress management, adrenal and immune functions, and optimal wellness. With an optimal balance of essential B vitamins, including extra vitamin B5, it helps the body's natural ability to manage stress and promote healthy adrenal and immune functions. Each B vitamin works synergistically to support multiple functions throughout the body, such as healthy energy production, red blood cell formation, and neurological function. This supplement is free from gluten, eggs, tree nuts, peanuts, dairy, soy, fish, and shellfish.

What We Like
Supports stress management and immune function
Contains an optimal balance of essential B vitamins, including extra vitamin B5, to promote healthy adrenal function
Works synergistically to support multiple functions throughout the body
Gluten-free and free from common allergens
Trusted brand chosen by champions and trusted by 100+ pro teams

NatureWise Vitamin B Complex

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NatureWise Vitamin B Complex Cover
NatureWise Vitamin B Complex for Women and Men - with Folic Acid Biotin B1 B2 B3 B6 B12 - Support Cellular Energy & Mental Clarity - Gluten & Dairy Free, Non-GMO - 60 Softgels[2-Month Supply]

NatureWise B Complex provides a comprehensive blend of B vitamins essential for energy production, metabolism, and cognitive function. B vitamins support cellular energy production, helping you utilize carbohydrates, proteins, and fats for increased energy levels. Additionally, they play a crucial role in the nervous system, aiding in mental clarity, mood regulation, and memory enhancement. The softgels are gluten-free, dairy-free, and free from common allergens like wheat, eggs, and nuts. Manufactured in the USA with premium ingredients, NatureWise B Complex ensures quality and efficacy for your overall well-being.

What We Like
Improved energy and focus
Easy to swallow softgels
High quality, trusted brand
No stomach upset
Comprehensive B vitamin blend
#TOP 9

vitafusion B-Complex Gummy Dietary Supplements

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vitafusion B-Complex Gummy Dietary Supplements, with 5 B Vitamins to Support Cellular Energy Production (1), Plus Vitamin C, Strawberry Flavor, 60 Count

Features
Each One-Gummy Serving Of These Vitamin B Supplements For Adults Provides 5 Essential B Vitamins To Support Cellular Energy Metabolism Plus Vitamin C For Immune Support (1)
60-Count Bottle Of Vitafusion B-Complex Gummy Vitamins With 5 Essential B Vitamins To Support Cellular Energy Production (1), Plus Vitamin C, In A Delicious Strawberry Flavor; 60-Day Supply
These Yummy Daily B Complex Vitamins Are Made With No High-Fructose Corn Syrup, No Artificial Sweeteners, No Gluten, And No Synthetic FD&C Dyes
These Vitamin B Complex Gummies Are Specially Formulated With 5 Essential B Vitamins Including Vitamin B-6, Vitamin B-12, Niacin, Biotin, And Folate; Plus Vitamin C
In Yummy Strawberry Flavor, These B-Complex Supplements For Adults Support Cellular Energy Production (1) And Are A Delicious Gummy Vitamin Alternative To Traditional Vitamin Pills That Can Be Hard To Swallow
Great Taste, High Quality; Vitafusion Adult Multivitamins And Dietary Supplements Are Lab Tested, Delicious, And Nutritious Gummy Vitamins
(1) These Statements Have Not Been Evaluated By The Food And Drug Administration; This Product Is Not Intended To Diagnose, Treat, Cure Or Prevent Any Disease
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Frequently Asked Questions (FAQs)

1. Does Vitamin B Complex help immune system?

Vitamin B complex helps to support a healthy immune system by supporting cell health, red blood cells, energy levels and cardiovascular health, among other functions. This means it's important to make sure you not only get enough vitamin B12, but vitamin B as a whole.

2. Which B vitamin helps the immune system?

Vitamin B6 is in charge of keeping the immune system strong, making new red blood cells, and transporting oxygen throughout the body. Vitamin B has also been shown to improve migraines. Foods rich in pyridoxine are chicken, salmon, tuna, leafy greens, and chickpeas.

3. What is Vitamin B Complex best for?

B vitamins play a vital role in maintaining good health and well-being. As the building blocks of a healthy body, B vitamins have a direct impact on your energy levels, brain function, and cell metabolism. Vitamin B complex may help prevent infections and help support or promote: cell health.

4. Who should not take Vit B complex?

High doses of nicotinic acid, a synthetic form of vitamin B-3, can raise blood sugar levels. This can interfere with diabetes medications. People with diabetes or high blood sugar should not take high doses of nicotinic acid (measuring 1,000 mg or more).

Editor's Notes

During our vitamin b-complex supplement for immune support research, we found 24 vitamin b-complex supplement for immune support products and shortlisted 9 quality products. We collected and analyzed 736,604 customer reviews through our big data system to write the vitamin b-complex supplements for immune support list. We found that most customers choose vitamin b-complex supplements for immune support with an average price of $21.71.

The vitamin b-complex supplements for immune support are available for purchase. We have researched hundreds of brands and picked the top brands of vitamin b-complex supplements for immune support, including Nature Made, Nature's Bounty, NUTRAHARMONY, Integrative Therapeutics, Igennus Healthcare Nutrition. The seller of top 1 product has received honest feedback from 384 consumers with an average rating of 4.7.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.