Best Multi-Enzyme Supplements for Immune Support of 2026

Introducing CANLIST Probiotics, a high-quality probiotic supplement designed for both men and women. With 120 billion CFUs and 18 strains per capsule, it provides the highest number of CFUs and the richest strains possible. This powerful formula is enriched with natural plant-based digestive enzymes and water-soluble prebiotics fiber, which work together to reduce gas and bloating. In addition, CANLIST Probiotics support healthy digestion, boost the immune system, and promote optimal nutrient absorption. The shelf-stable and delayed-release technology ensures that the probiotics survive stomach acid and reach deep into the intestine. Made in the USA and tested for purity and potency, CANLIST Probiotics represent the highest standards in digestive and immune support.

Snap Supplements Gut & Greens offers a powerful combo of probiotics, digestive enzymes, and superfood greens like Spirulina and Chlorella to help you maintain a balanced digestive system. This blend supports your gut by easing bloating and promoting a healthy microbiome, so you can feel comfortable and balanced. The organic Spirulina and Chlorella provide natural energy, aid detox, and boost your immune system, making it a great choice for daily wellness or travel. Taking this supplement daily with meals or after workouts can help you stay energized and support smooth digestion, fitting easily into your routine whether at home or on the go.

The Sunergetic Probiotic Blend is a comprehensive gut health supplement designed for both men and women. It features a unique combination of probiotics, prebiotics, postbiotics, and digestive enzymes to support healthy digestion and intestinal health. By taking just two capsules daily, you can help reduce occasional gas and bloating, promoting overall gut comfort. Additionally, this formula supports immune health and regularity, making it easier for you to maintain digestive balance without the need for refrigeration. Its scientifically backed strains ensure you receive powerful support for your gut microbiome.

Source Naturals Essential Enzymes Supplement is a bio-aligned multiple enzyme supplement that expertly formulated to break down multiple food groups, aiding the body's natural digestive process and maximizing the body's utilization of the nutrients in the diet by helping to break down foods into smaller components that can be absorbed. It is suggested to take 1 capsule with water at the beginning of each meal (or open capsule and sprinkle over food), but not on hot food, and not exceeding 6 capsules per day. This supplement is trusted for over 35 years, manufactured in the USA, and supports a strong immune system.

BIOptimizers MassZymes Enzymes is designed to support your digestion by delivering a strong blend of enzymes that help break down proteins, fats, and carbohydrates. This can reduce bloating and improve how well your body absorbs nutrients, helping you feel lighter and more energized throughout the day. If you’re active or an athlete, it also aids in faster muscle recovery by enhancing protein breakdown, so you can bounce back quicker from workouts. Additionally, this supplement supports your gut health and immune system by easing common digestive issues like gas and indigestion, keeping your digestive tract balanced and comfortable.

MaryRuth's Ultra Digestive Food Enzymes is a vegan supplement formulated to enable digestion, especially in those with digestive issues, amplifying nutrient absorption while reducing bloating, gas and abdominal pain. This extra strength blend of enzymes are formulated to help digest proteins, carbohydrates, fiber, fat, and lactose. It includes Protease, Amylase, Glucoamylase, Diastase, Invertase, Pectinase, Cellulase, Hemicellulase, Xylanase, Lipase, Lactase, Alpha-Galactosidase, and Beta-Glucanase. It is Non-GMO & Vegan, Dairy Free, Nut Free, Gluten & Wheat Free, Soy Free, Nightshade Free, Sugar Free, and contains Maltodextrin. Customers have reported that it works great and helps reduce bloating, gas, and abdominal pain.

Wholesome Wellness Digestive Enzymes is a plant-based, organic supplement that helps improve digestion and gut health. With a 1000 MG dose of clinical grade digestive enzymes and a 10 billion CFU 10 strain probiotic with prebiotics, this supplement provides relief from bloating, flatulence, fat, pancreatic, and bowel cleansing. The Advanced Multi Enzyme System helps digest a variety of foods, including fried, spicy, raw, processed food, dairy, protein, salts, carb / carbohydrate, vitamin and acidic diet fruits and veggies. The supplement also contains a powerful 10 billion CFU dose of 10 different probiotic strains clinically shown to enhance preventions & immune system response.

The Pure Encapsulations Betaine HCl Pepsin Digestive Enzyme supplement supports digestive function, nutrient absorption, and gut health. It contains Betaine HCL and pepsin, which are essential for food digestion and nutrient absorption. Betaine HCL also contributes to the acidic environment of the stomach, which is necessary for maintaining a healthy balance. The supplement is made with premium ingredients, and is free from common allergens, artificial colors, flavors, sweeteners, GMOs, and unnecessary fillers and preservatives.

Doctor's Best Proteolytic Enzymes is a potent formulation containing a broad spectrum of proteolytic enzymes (proteases) to support muscle, joint, and overall tissue health. It is vegetarian, gluten-free, and Non-GMO, and comes in a 90-count veggie capsule bottle. Customers have reported positive results in terms of relief from joint and muscle pain, as well as improved gut health.

Zenwise Women's Probiotics is a 3-in-1 digestive health solution that combines probiotics, prebiotics, and digestive enzymes. With clinically proven DE111 probiotic and a spore-forming probiotic blend, it supports vaginal health and overall women's health. The addition of digestive enzymes helps break down foods, reducing gas and discomfort. The multi-enzyme blend has been shown to digest foods, including fats, more effectively than the body can on its own. With 60 capsules, it is recommended to take 1 capsule before each meal or drink to replenish probiotics and experience digestive delight.