Best Multi-Enzyme Supplements for Immune Support of 2025

Body Ecology EcoOxyZyme is a multi-enzyme digestive supplement that supports gut health, immune system, and digestion. It helps maintain a healthy gut lining and inner ecosystem, restores gut balance by supporting the oxidative process in the digestive tract, and supports the immune system with the effects of ozone, peroxide, and other beneficial oxidants. Additionally, it helps keep the gut lining clean from microbes and protects the healthy community inside the gut. EcoOxyZyme is non-GMO, dairy-free, soy-free, gluten-free, vegan, paleo, and nut-free, ensuring quality and integrity.

Source Naturals Essential Enzymes Supplement is a bio-aligned multiple enzyme supplement that expertly formulated to break down multiple food groups, aiding the body's natural digestive process and maximizing the body's utilization of the nutrients in the diet by helping to break down foods into smaller components that can be absorbed. It is suggested to take 1 capsule with water at the beginning of each meal (or open capsule and sprinkle over food), but not on hot food, and not exceeding 6 capsules per day. This supplement is trusted for over 35 years, manufactured in the USA, and supports a strong immune system.

MaryRuth's Ultra Digestive Food Enzymes is a vegan supplement formulated to enable digestion, especially in those with digestive issues, amplifying nutrient absorption while reducing bloating, gas and abdominal pain. This extra strength blend of enzymes are formulated to help digest proteins, carbohydrates, fiber, fat, and lactose. It includes Protease, Amylase, Glucoamylase, Diastase, Invertase, Pectinase, Cellulase, Hemicellulase, Xylanase, Lipase, Lactase, Alpha-Galactosidase, and Beta-Glucanase. It is Non-GMO & Vegan, Dairy Free, Nut Free, Gluten & Wheat Free, Soy Free, Nightshade Free, Sugar Free, and contains Maltodextrin. Customers have reported that it works great and helps reduce bloating, gas, and abdominal pain.

Enzymedica Defense is a specialized enzyme formula designed to support your immune system. This powerful supplement helps purify your body by breaking down unwanted proteins and promoting healthy circulation. By assisting in removing proteins that don't belong in your bloodstream, Enzymedica Defense helps your immune system work at its best, especially when faced with environmental threats. With its fast-acting Thera-blend enzymes, this supplement provides targeted support throughout your digestive system. Take two capsules daily on an empty stomach for maximum benefits. Enzymedica is a trusted brand backed by rigorous science and research, giving you confidence in their supplements.

The WELMATE Probiotic Supplement offers essential support for your gut health and immune system. Each capsule contains Bifidobacterium longum, which helps improve digestion by breaking down food more effectively, allowing you to absorb more nutrients. This probiotic also promotes healthy skin by maintaining pH balance, resulting in a clearer complexion. Additionally, it strengthens your immune response by fostering beneficial microorganisms in your gut, helping to keep a healthy balance of good and bad bacteria. With this supplement, you can take a proactive approach to your overall well-being.

Zenwise Enzymes is a convenient 3-in-1 gut support solution for digestive health and bloating relief. With its lab-proven multi-enzyme blend, it can help digest foods up to 39% more completely and 2 hours faster than your body can on its own. This makes it perfect for individuals following gluten-free, Keto, or Paleo diets, as well as those experiencing occasional bloating, gas, and discomfort from hard-to-digest foods. The product also contains a clinically proven DE111 probiotic, which guarantees to arrive alive and work within hours in the small intestine, where 90% of nutrient absorption occurs. Additionally, Zenwise Enzymes includes a variety of botanical ingredients like turmeric, ginger, and green papaya, which aid in gut health and stomach comfort. Taking just one capsule before each meal or drink can provide you with the digestive delight you've been seeking.

Introducing CANLIST Probiotics, a high-quality probiotic supplement designed for both men and women. With 120 billion CFUs and 18 strains per capsule, it provides the highest number of CFUs and the richest strains possible. This powerful formula is enriched with natural plant-based digestive enzymes and water-soluble prebiotics fiber, which work together to reduce gas and bloating. In addition, CANLIST Probiotics support healthy digestion, boost the immune system, and promote optimal nutrient absorption. The shelf-stable and delayed-release technology ensures that the probiotics survive stomach acid and reach deep into the intestine. Made in the USA and tested for purity and potency, CANLIST Probiotics represent the highest standards in digestive and immune support.

LifeSeasons Digestivi-T is designed to enhance your digestive health by combining probiotics and enzymes that work in harmony to break down food. This support can help reduce bloating and make it easier for you to digest gluten and dairy. The ingredients are clinically tested, ensuring their effectiveness and safety for daily use. By taking just three capsules with your meals, you can experience improved comfort and overall well-being. This unique blend eliminates the need to purchase multiple supplements, making it a convenient and cost-effective choice for maintaining your digestive health.

Source Naturals Enzyme Supplement is a bio-aligned multiple enzyme supplement that aids in the body's natural digestive process. It expertly breaks down carbohydrates, protein, fat, and fiber, maximizing the body's utilization of nutrients in the diet. This supplement is suitable for vegetarians and does not contain common allergens such as yeast, dairy, gluten, or soy. With over 35 years of trust, Source Naturals is dedicated to supporting individual health potential. Manufactured in the USA, this supplement is a reliable choice for digestive health support.

Wholesome Wellness Digestive Enzymes is a plant-based, organic supplement that helps improve digestion and gut health. With a 1000 MG dose of clinical grade digestive enzymes and a 10 billion CFU 10 strain probiotic with prebiotics, this supplement provides relief from bloating, flatulence, fat, pancreatic, and bowel cleansing. The Advanced Multi Enzyme System helps digest a variety of foods, including fried, spicy, raw, processed food, dairy, protein, salts, carb / carbohydrate, vitamin and acidic diet fruits and veggies. The supplement also contains a powerful 10 billion CFU dose of 10 different probiotic strains clinically shown to enhance preventions & immune system response.