Best Vitamin D Supplements for Immune Support of 2025

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 9, 2025

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Vitamin D supplements are becoming increasingly popular for immune support due to their ability to strengthen the body's defenses against infections and illnesses. These supplements contain high levels of vitamin D, which is known to regulate the immune system and reduce inflammation. In addition, vitamin D is essential for bone health and can help prevent conditions such as osteoporosis. These supplements come in a variety of forms, including capsules, gummies, and liquids, and can be easily incorporated into a daily routine. However, it is important to consult with a healthcare provider before starting any new supplement regimen.

At a Glance: Our Top Picks

Nature Made Vitamin D3 1000 IU Cover #TOP 1
Nature Made Vitamin D3 1000 IU
ftb score rating icon 9.8
NatureWise Vitamin D3 5000iu, 200 Count Cover #TOP 2
NatureWise Vitamin D3 5000iu, 200 Count
ftb score rating icon 9.7
Sports Research Vitamin D3 5000IU (125mcg) Softgels Cover #TOP 3
Sports Research Vitamin D3 5000IU (125mcg) Softgels
ftb score rating icon 9.5

Top 10 Vitamin D Supplements for Immune Support

Nature Made Vitamin D3 1000 IU

Nature Made Vitamin D3 1000 IU Cover
Nature Made Vitamin D3 1000 IU (25 mcg), Dietary Supplement for Bone, Teeth, Muscle and Immune Health Support, 180 Softgels, 180 Day Supply

Nature Made Vitamin D3 offers essential support for your bones, teeth, muscles, and immune system. With a convenient 180 softgel supply, you can easily incorporate this supplement into your daily routine. Each softgel contains 25 mcg of Vitamin D3, which helps your body absorb calcium effectively, promoting overall health. By taking just one softgel daily with water and a meal, you ensure your body gets the nutrients it needs without any artificial flavors or colors. This trusted brand is the #1 pharmacist-recommended vitamin and supplement brand, making it a reliable choice for your health needs.

What We Like
Supports bone and teeth health
Boosts immune system function
Improves calcium absorption
Convenient 180-day supply

NatureWise Vitamin D3 5000iu, 200 Count

TB1250-120
Yellow
NatureWise Vitamin D3 5000iu, 200 Count Cover
NatureWise Vitamin D3 5000iu (125 mcg) 200-Day Supply for Immune Support, Healthy Muscle Function, and Bone Health - Non-GMO, Gluten Free in Organic Extra Virgin Olive Oil, (Mini Softgel), 200 Count

NatureWise Vitamin D3 Softgels are essential for healthy bones, teeth, muscle function, and immune system support. Many people lack enough Vitamin D, which is crucial for overall health. These gluten-free and non-GMO softgels are third-party tested for purity. Manufactured in the USA, they meet strict quality standards. Even if the softgels clump together in warm weather, it doesn't affect their quality. Simply shake the bottle to release the clumps.

What We Like
Essential for bone health
Gluten-free & non-GMO
Manufactured in the USA

Sports Research Vitamin D3 5000IU (125mcg) Softgels

Sports Research Vitamin D3 5000IU (125mcg) Softgels Cover
Sports Research Vitamin D3 5000 IU with Coconut MCT Oil - High Potency Vitamin D Supplement for Immune & Bone Support - Non-GMO Verified, Gluten & Soy Free – 125mcg, 360 Liquid Softgels

Sports Research Vitamin D3 5000IU (125mcg) Softgels are a high-potency Vitamin D supplement that helps maintain strong bones by supporting calcium metabolism and a healthy immune system. The product is Non-GMO Verified, gluten-free, and soy-free, and comes in 360 liquid softgels that are easy to swallow. The Vitamin D3 supplement is formulated with organic coconut oil to aid absorption and is made in cGMP compliant facilities in the United States.

What We Like
High-potency Vitamin D supplement
Non-GMO Verified, gluten-free, and soy-free
Formulated with organic coconut oil to aid absorption

Thorne Vitamin D3-5000IU Supplement - 60 Capsules

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Thorne Vitamin D3-5000IU Supplement - 60 Capsules Cover
THORNE Vitamin D-5000 - Vitamin D3 Supplement - Support Healthy Bones, Teeth, Muscles, Cardiovascular, and Immune Function - NSF Certified for Sport - Dairy-Free, Soy-Free - 60 Capsules

Thorne Vitamin D3-5000IU Supplement - 60 Capsules is the perfect vitamin D supplement for you. Vitamin D3 supports healthy bones, teeth, muscles, cardiovascular health, and immune function. It is more potent and better absorbed than vitamin D2. This supplement is NSF Certified for Sport and free from gluten, eggs, tree nuts, peanuts, dairy, soy, fish, or shellfish. Thorne is trusted by 100+ pro teams and is the only supplement manufacturer to collaborate with Mayo Clinic on wellness research and content. Thorne is also a proud partner of 11 U.S. Olympic Teams.

What We Like
Potent and better absorbed than vitamin D2
NSF Certified for Sport
Free from gluten, eggs, tree nuts, peanuts, dairy, soy, fish, or shellfish
Trusted by 100+ pro teams and is the only supplement manufacturer to collaborate with Mayo Clinic on wellness research and content
Proud partner of 11 U.S. Olympic Teams

Vitafusion Vitamin D3 Gummy Vitamins, 150 Ct

1102134
Absolutely Orange
Vitafusion Vitamin D3 Gummy Vitamins, 150 Ct Cover
Vitafusion Vitamin D3 Gummy Vitamins for Bone and Immune System Support, Peach, Blackberry and Strawberry Flavored, 50 mcg Vitamin D, 75 Day Supply, 150 Count

Vitafusion Vitamin D3 Gummy Vitamins provide immune system support with 50mcg of Vitamin D per 2 gummy serving. The vitamins come in delicious peach and berry flavors, without artificial flavors or sweeteners, synthetic dyes, high fructose corn syrup, gluten, or dairy. The product has won the 2021 ChefsBest Excellence Award for its taste. As America's #1 gummy vitamin brand, Vitafusion delivers the best vitamin experience.

What We Like
Provides immune system support with Vitamin D
Delicious peach and berry flavors
No artificial flavors or sweeteners, synthetic dyes, high fructose corn syrup, gluten, or dairy
#TOP 6

Nature Made Extra Strength Vitamin D3 5000 IU Softgels

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180 Count
Nature Made Extra Strength Vitamin D3 5000 IU Softgels Cover
Nature Made Extra Strength Vitamin D3 5000 IU (125 mcg), Dietary Supplement for Bone, Teeth, Muscle and Immune Health Support, 180 Softgels, 180 Day Supply

Nature Made Extra Strength Vitamin D3 5000 IU Softgels is a dietary supplement that helps improve your bone, teeth, muscle, and immune health. It is a 180-count bottle that can supply you for 180 days. This high-dose Vitamin D3 product is for people with higher Vitamin D needs and/or deficiency, as determined by a healthcare professional. The supplement is sourced from high-quality ingredients and is gluten-free with no color or artificial flavors added. Its recommended dosage is one softgel daily with water and a meal.

What We Like
Improves bone, teeth, muscle, and immune health
180-day supply from a 180-count bottle
High-dose Vitamin D3 product for people who need it
#TOP 7

Nature’s Bounty Vitamin D3 1000 IU Softgels

Nature’s Bounty Vitamin D3 1000 IU Softgels Cover
Nature's Bounty Vitamin D3 1000 IU Softgels, Immune Support, Promotes Healthy Bones, 350 Ct

Nature’s Bounty Vitamin D3 1000 IU Softgels is a highly recommended Vitamin D supplement that provides numerous benefits. The Vitamin D3 in the supplement is a more potent version of Vitamin D, which is essential for immune support and promoting healthy bones. The softgels may assist the immune system by regulating T-lymphocytes and B-lymphocytes, which are important components of the adaptive immune response. Vitamin D3 also helps the body absorb calcium and support bone health in adults. It's known as the sunshine vitamin and can help adults who often miss out on sunlight exposure. The supplement is non-GMO, gluten-free, sugar-free, and contains no artificial colors or sweeteners.

What We Like
Promotes immune health
Supports bone health in adults
Contains a more potent version of Vitamin D
Non-GMO, gluten-free, sugar-free, and contains no artificial colors or sweeteners
Comes in 350 count softgels
#TOP 8

Nature's Bounty Vitamin D3 Softgels

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Multi
Nature's Bounty Vitamin D3 Softgels Cover
Nature's Bounty Vitamin D for Immune Support and Promotes Healthy Bones, 10000IU, Softgels, Multi-Color, 10,000 IU, 72 Count (Pack of 1)

Nature's Bounty D3 Softgels are the perfect supplement for your overall health. With 72-count, 10000IU Vitamin D3 Softgels, they provide immune support by helping to regulate T and B-lymphocytes. Vitamin D3 is a more potent form of Vitamin D. In addition to immune support, getting a sufficient amount of Vitamin D is critical to building and maintaining strong bones in adults. It is essential for calcium absorption to help support healthy bones. Nature's Bounty D3 Softgels supplement the Vitamin D your body needs for overall health. Vitamin D3 supplements by Nature's Bounty contain the same form of Vitamin D that is naturally formed in the body through exposure to sunshine, helping replicate the benefits of natural sunshine all year long. Nature's Bounty is committed to safety and purity in all our supplements. Our rapid release Vitamin D3 Softgels are non-GMO, gluten- and sugar-free, and contain no artificial colors or sweeteners.

What We Like
Immune support
Year-round support
Non-GMO

Nature Made Super D Immune Complex

HL000117
White
Nature Made Super D Immune Complex Cover
Nature Made Super Vitamin D Immune Complex, Vitamin D3, Selenium, Copper and Zinc Supplements for Immune Support, 70 Tablets, 70 Day Supply

Nature Made Immune Support offers a comprehensive blend of nutrients designed to enhance your immune system. Each bottle contains 70 tablets, providing a two-month supply. The formula includes a significant dose of Vitamin D3, which is crucial for immune function, along with Selenium, Zinc, and Copper for added antioxidant benefits. Taking just one tablet daily with a meal and water makes it easy to incorporate into your routine. Plus, these gluten-free tablets are made with high-quality ingredients, ensuring you receive effective support without artificial flavors.

What We Like
Immune system enhancement
High-quality, gluten-free ingredients
Convenient one-tablet daily dosage
Comprehensive nutrient blend

Livingood Daily Vitamin D with K2, 60 Capsules

Livingood Daily Vitamin D with K2, 60 Capsules Cover
Livingood Daily Vitamin D3 K2 4000 IU Supplement, 9-in-1 Dietary Supplement for Immune Support - Made with Vitamins D, A, E, K2, Zinc, Magnesium & Probiotic Blend for Maximum Absorption - 60 Capsules

Livingood Daily D3K2 is a 9-in-1 formula vitamin D supplement that provides a complete immune-boost. It contains superior D3K2 vitamins, loaded with magnesium, zinc, ALA, probiotic blend, and MCT oil from COCONUT. This vitamin D supplement is perfect for VEGETARIAN, KETO & PALEO types of diets, and is free from GMOs, gluten, soy, corn & fillers. Its Vit D3 (cholecalciferol) content is the safest and most beneficial form of the D vitamin forms. Together with zinc, vitamin D facilitates normal immune system function. Our vitamin D3 with K2 supplement is a good source of vitamin D when you don't get enough sun! Vitamin D with K2 helps regulate the absorption of calcium for bone development. Vitamin D and K are necessary for strong bones and muscles and they also help prevent the weakening of bones.

What We Like
9-in-1 formula
Perfect for vegetarian, keto & paleo
Immune health booster
Strengthens bones
Money-back guarantee
Buying Guide Image

Frequently Asked Questions (FAQs)

1. Which vitamin D is best for immune system?

Researchers say vitamin D3 bolsters the immune system better than vitamin D2. This goes against previous research that rated both forms of vitamin D about the same. Experts say you can obtain a sufficient amount of vitamin D by being out in the sun for up to 30 minutes.

2. Does vitamin D activate the immune system?

Scientists have found that vitamin D is crucial to activating our immune defenses and that without sufficient intake of the vitamin - the killer cells of the immune system -- T cells -- will not be able to react to and fight off serious infections in the body.

3. How much vitamin D should I take for immune system?

The current recommendations suggest consuming 400–800 IU (10–20 mcg) of vitamin D per day. However, people who need more vitamin D can safely consume 1,000–4,000 IU (25–100 mcg) daily.

4. What is vitamin D's role in the immune system?

The active form of vitamin D tempers the damaging inflammatory response of some white blood cells, while it also boosts immune cells' production of microbe-fighting proteins.

Editor's Notes

During our vitamin d supplement for immune support research, we found 24 vitamin d supplement for immune support products and shortlisted 10 quality products. We collected and analyzed 1,832,894 customer reviews through our big data system to write the vitamin d supplements for immune support list. We found that most customers choose vitamin d supplements for immune support with an average price of $11.23.

The vitamin d supplements for immune support are available for purchase. We have researched hundreds of brands and picked the top brands of vitamin d supplements for immune support, including Nature Made, NatureWise, Sports Research, THORNE, Vitafusion. The seller of top 1 product has received honest feedback from 385 consumers with an average rating of 4.7.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.