Best Vitamin D Supplements for Immune Support of 2026

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 20, 2026

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Vitamin D supplements are becoming increasingly popular for immune support due to their ability to strengthen the body's defenses against infections and illnesses. These supplements contain high levels of vitamin D, which is known to regulate the immune system and reduce inflammation. In addition, vitamin D is essential for bone health and can help prevent conditions such as osteoporosis. These supplements come in a variety of forms, including capsules, gummies, and liquids, and can be easily incorporated into a daily routine. However, it is important to consult with a healthcare provider before starting any new supplement regimen.

At a Glance: Our Top Picks

NatureWise Vitamin D3 Softgels Cover #TOP 1
NatureWise Vitamin D3 Softgels
ftb score rating icon 9.8
Sports Research Vegan Vitamin D3+K2 with Organic Coconut Oil - 60 Softgels Cover #TOP 2
Sports Research Vegan Vitamin D3+K2 with Organic Coconut Oil - 60 Softgels
ftb score rating icon 9.7
Nature Made Vitamin D3 1000 IU Softgels Cover #TOP 3
Nature Made Vitamin D3 1000 IU Softgels
ftb score rating icon 9.5

Top 10 Vitamin D Supplements for Immune Support

NatureWise Vitamin D3 Softgels

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NatureWise Vitamin D3 Softgels Cover
NatureWise Vitamin D3 5000iu (125 mcg) 1 Year Supply for Immune Support, Healthy Muscle Function, and Bone Health - Non-GMO, Gluten Free in Organic Extra Virgin Olive Oil, (Mini Softgel), 360 Count

Get your daily dose of essential Vitamin D with NatureWise Vitamin D3 Softgels. Formulated with 5000IU of Vitamin D3 in certified organic olive oil, it supports healthy teeth and bones, immune function, and muscle function. The highest potency softgels are easy to swallow and more bioavailable than powdered or tablet forms. Gluten-free and non-GMO, it's third party tested for purity and potency. The product is suitable for those with darker skin, the elderly, overweight individuals, and those who spend a lot of time indoors.

What We Like
Easy to swallow softgels
High potency dosage
Non-GMO and gluten-free
Organic extra virgin olive oil
Long-lasting supply, good value

Sports Research Vegan Vitamin D3+K2 with Organic Coconut Oil - 60 Softgels

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Sports Research Vegan Vitamin D3+K2 with Organic Coconut Oil - 60 Softgels Cover
Sports Research® Vitamin D3 + K2 w/ Coconut Oil - Vegan Vitamin D 5000iu & Mk7 Vitamin K 100mcg for Bone & Immune Support - Vegan Certified · Non-GMO · Soy Free - 60 Softgels

Sports Research Vegan Vitamin D3+K2 with Organic Coconut Oil combines two essential vitamins to support bone and immune health. The new softgel shell, containing added turmeric root powder, helps protect the active ingredients inside against UV light. Vitamin D3 helps maintain strong bones and supports a healthy immune system, while Vitamin K2 ensures that calcium gets deposited in your bones where it's needed and protects arteries from calcification. This vegan formula uses patented plant-based forms of both vitamins and is free of soy, gluten, gelatin, and carrageenan. The easy-to-swallow softgels are of superior quality, third-party tested, and manufactured in cGMP compliant facilities in the U.S.

What We Like
Easy to swallow softgels
Vegan and clean ingredients
No aftertaste or odor
Combines D3 and K2
Trusted, reliable brand
#TOP 3

Nature Made Vitamin D3 1000 IU Softgels

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300 Count
Nature Made Vitamin D3 1000 IU Softgels Cover
Nature Made Vitamin D3 1000 IU (25 mcg), Vitamin D Supplement for Bone, Teeth, Muscle and Immune Health Support, 300 Softgels, 300 Day Supply

Nature Made Vitamin D3 1000 IU Softgels are an easy way to support your immune, muscle, teeth, and bone health. The supplement provides 25mcg of Vitamin D3, the body's preferred form of Vitamin D, per serving, improving calcium absorption and providing immune support. The gluten-free product is sourced from high-quality ingredients, and each 300-day supply bottle contains 300 softgels. Adults can take one softgel daily with water and a meal. The United States Pharmacopeia (USP) has verified this product, and it is the number one pharmacist-recommended vitamin and supplement brand.

What We Like
Easy to swallow capsules
Gentle on stomach
Consistent high quality
Affordable price
No aftertaste

Nature Made Extra Strength Vitamin D3 5000 IU Softgels

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180 Count
Nature Made Extra Strength Vitamin D3 5000 IU Softgels Cover
Nature Made Vitamin D3 5000 IU (125 mcg) Softgels, Extra Strength Vitamin D Supplement for Bone and Immune Health Support, 180 Count, 180 Day Supply

Nature Made Extra Strength Vitamin D3 5000 IU Softgels is a dietary supplement that helps improve your bone, teeth, muscle, and immune health. It is a 180-count bottle that can supply you for 180 days. This high-dose Vitamin D3 product is for people with higher Vitamin D needs and/or deficiency, as determined by a healthcare professional. The supplement is sourced from high-quality ingredients and is gluten-free with no color or artificial flavors added. Its recommended dosage is one softgel daily with water and a meal.

What We Like
High potency dosage
Easy-to-swallow softgels
Improved energy and mood
Supports immune and bone health
No artificial colors or preservatives
#TOP 5

Nature Made Vitamin D3 K2 Softgels

Nature Made Vitamin D3 K2 Softgels Cover
Nature Made Vitamin D3 K2 Supplement, 5000 IU (125 mcg) Vitamin D for Bone, Teeth, Muscle and Immune Support, 30 D3 and K2 Softgels, 30 Day Supply

Nature Made Vitamin D3 K2 Softgels provide 5000 IU (125 mcg) of Vitamin D and 100 mcg of Vitamin K2 for a 30-day supply. It supports bone, teeth, muscle and immune health. Vitamin K2 helps direct calcium to bones and supports healthy artery function. It is designed for those with higher Vitamin D needs and/or deficiency. Made in the USA with quality global ingredients, gluten-free, and no synthetic dyes or artificial flavors.

What We Like
Easy to swallow capsules
No aftertaste or burps
Helps maintain healthy vitamin D levels
Made in the USA
Good value for price

Thorne Vitamin D3-5000IU Supplement - 60 Capsules

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Thorne Vitamin D3-5000IU Supplement - 60 Capsules Cover
THORNE - Vitamin D-5000 - Vitamin D3 Supplement - Support Healthy Bones, Teeth, Muscles, Cardiovascular & Immune Function* - NSF Certified for Sport - Gluten-Free, Soy-Free - 60 Servings

Thorne Vitamin D3-5000IU Supplement - 60 Capsules is the perfect vitamin D supplement for you. Vitamin D3 supports healthy bones, teeth, muscles, cardiovascular health, and immune function. It is more potent and better absorbed than vitamin D2. This supplement is NSF Certified for Sport and free from gluten, eggs, tree nuts, peanuts, dairy, soy, fish, or shellfish. Thorne is trusted by 100+ pro teams and is the only supplement manufacturer to collaborate with Mayo Clinic on wellness research and content. Thorne is also a proud partner of 11 U.S. Olympic Teams.

What We Like
High potency (5,000 IU)
Pure formula, no fillers
Easy to swallow capsules
Noticeable energy and mood improvement
Trusted brand with NSF certification

Vitafusion Vitamin D3 Gummy Vitamins, 150 Ct

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Vitafusion Vitamin D3 Gummy Vitamins, 150 Ct Cover
vitafusion Vitamin D3 Gummies, Bone and Immune Support, Peach, Blackberry, Strawberry Flavored, 50 mcg D3 Gummy Vitamin Supplement, 75 Day Supply, 150 Count

Vitafusion Vitamin D3 Gummy Vitamins provide immune system support with 50mcg of Vitamin D per 2 gummy serving. The vitamins come in delicious peach and berry flavors, without artificial flavors or sweeteners, synthetic dyes, high fructose corn syrup, gluten, or dairy. The product has won the 2021 ChefsBest Excellence Award for its taste. As America's #1 gummy vitamin brand, Vitafusion delivers the best vitamin experience.

What We Like
Provides immune system support with Vitamin D
Delicious peach and berry flavors
No artificial flavors or sweeteners, synthetic dyes, high fructose corn syrup, gluten, or dairy
#TOP 8

Nature Made Vitamin D3 2000 IU Softgels

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Nature Made Vitamin D3 2000 IU Softgels Cover
Nature Made Vitamin D3 2000 IU (50 mcg), Vitamin D Supplement for Bone, Teeth, Muscle and Immune Health Support, 250 Softgels, 250 Day Supply

Nature Made Vitamin D3 2000 IU Softgels is a supplement that supports the health of the immune system, muscles, teeth, and bones. It contains 250 softgels for a 250-day supply, with each softgel providing 50mcg of Vitamin D3, which is the most preferred form of Vitamin D in the body. The supplement helps improve calcium absorption and sourced from high-quality ingredients that are gluten-free and without added colors or artificial flavors. Adults can take one softgel daily with water and a meal.

What We Like
Provides support for the immune system, muscles, teeth, and bones
Contains 250 softgels for a 250-day supply
Improves calcium absorption with 50mcg of Vitamin D3 per softgel
#TOP 9

Bronson Vitamin D3 10,000 IU - 1 Year Supply

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Bronson Vitamin D3 10,000 IU - 1 Year Supply Cover
Bronson Vitamin D3 10,000iu (250mcg) 1 Year Supply for Healthy Muscle Function and Immune Support, Non-GMO, 360 Tablets

Bronson Vitamin D3 offers 10,000 IU of D3 per tablet, providing a 1-year supply in one bottle. The supplement supports healthy immune function by replenishing Vitamin D levels, which can be disrupted if outdoor time is limited. It is laboratory tested and GMO-free, gluten-free, and soy-free. Bronson's products are manufactured in their state-of-the-art facility that complies with the most current regulations to ensure purity, potency, and integrity. Bronson Vitamins has been trusted by medical professionals since 1960.

What We Like
Provides a 1-year supply of Vitamin D3
Supports healthy immune function by replenishing Vitamin D levels
Manufactured in a state-of-the-art facility that complies with current regulations
#TOP 10

Metagenics Vitamin D3 10,000 IU with Vitamin K2 - 60 Count

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Metagenics Vitamin D3 10,000 IU with Vitamin K2 - 60 Count Cover
Metagenics Vitamin D3 + K - for Artery Health, Immune Support, Bone & Heart Health* - Vitamin D with MK-7 (Vitamin K2) - Non-GMO - Gluten-Free - 60 Softgels - 10,000 IU

Metagenics Vitamin D3 10,000 IU with Vitamin K2 is a bioactive vitamin D supplement designed for patients with increased nutritional needs for vitamin D. It promotes healthy bone formation and mineralization, as well as supports immune and cardiovascular health. Additionally, this product is non-GMO and gluten-free.

What We Like
High-potency vitamin D supplement with vitamin K for increased nutritional needs
Promotes healthy bone formation and mineralization
Supports immune and cardiovascular health
Non-GMO and gluten-free
60-Day Satisfaction Guarantee
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Frequently Asked Questions (FAQs)

1. Which vitamin D is best for immune system?

Researchers say vitamin D3 bolsters the immune system better than vitamin D2. This goes against previous research that rated both forms of vitamin D about the same. Experts say you can obtain a sufficient amount of vitamin D by being out in the sun for up to 30 minutes.

2. Does vitamin D activate the immune system?

Scientists have found that vitamin D is crucial to activating our immune defenses and that without sufficient intake of the vitamin - the killer cells of the immune system -- T cells -- will not be able to react to and fight off serious infections in the body.

3. How much vitamin D should I take for immune system?

The current recommendations suggest consuming 400–800 IU (10–20 mcg) of vitamin D per day. However, people who need more vitamin D can safely consume 1,000–4,000 IU (25–100 mcg) daily.

4. What is vitamin D's role in the immune system?

The active form of vitamin D tempers the damaging inflammatory response of some white blood cells, while it also boosts immune cells' production of microbe-fighting proteins.

Editor's Notes

During our vitamin d supplement for immune support research, we found 24 vitamin d supplement for immune support products and shortlisted 10 quality products. We collected and analyzed 1,922,434 customer reviews through our big data system to write the vitamin d supplements for immune support list. We found that most customers choose vitamin d supplements for immune support with an average price of $17.59.

The vitamin d supplements for immune support are available for purchase. We have researched hundreds of brands and picked the top brands of vitamin d supplements for immune support, including NatureWise, Sports Research, Nature Made, THORNE, Vitafusion. The seller of top 1 product has received honest feedback from 384 consumers with an average rating of 4.7.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.