Best Chewable Multi-Enzyme Supplements of 2026

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 4, 2025

* We independently evaluate all recommended products and services. If you click on links we provide, we may receive compensation.

Chewable multi-enzyme supplements are a popular option for individuals looking to improve their digestive health. These supplements contain a blend of enzymes that help break down food and aid in the absorption of nutrients. They are available in a variety of flavors and are designed to be taken before or after meals. Many people appreciate the convenience of chewable supplements, as they can be easily taken on-the-go. Additionally, they may be a good option for individuals who struggle to swallow pills. Chewable multi-enzyme supplements can be found at many health food stores and online retailers.

At a Glance: Our Top Picks

American Health Chewable Multi-Enzymes, Original Papaya Cover #TOP 1
American Health Chewable Multi-Enzymes, Original Papaya
ftb score rating icon 9.9
NOW Papaya Enzyme with Mint and Chlorophyll, 180 Chewable Lozenges Cover #TOP 2
NOW Papaya Enzyme with Mint and Chlorophyll, 180 Chewable Lozenges
ftb score rating icon 9.8
Garden of Life Dr Formulated Digestive Enzymes Cover #TOP 3
Garden of Life Dr Formulated Digestive Enzymes
ftb score rating icon 9.6

Top 10 Chewable Multi-Enzyme Supplements

#TOP 1

American Health Chewable Multi-Enzymes, Original Papaya

American Health Chewable Multi-Enzymes, Original Papaya Cover
American Health Chewable Multi-Enzymes, Original Papaya, 250 Count

American Health Chewable Multi-Enzymes, Original Papaya supplement is designed to help with inefficient digestion and promote nutrient absorption. It is a 100% natural digestive enzyme that is useful for digestion-related issues. The vegetarian formula is great tasting and easy to consume.

What We Like
100% natural digestive enzyme
Helps with inefficient digestion
Promotes nutrient absorption
Vegetarian formula
Great tasting
#TOP 2

NOW Papaya Enzyme with Mint and Chlorophyll, 180 Chewable Lozenges

2970
NOW Papaya Enzyme with Mint and Chlorophyll, 180 Chewable Lozenges Cover
NOW Foods Supplements, Papaya Enzyme with Mint and Chlorophyll, Digestive Support*, 180 Chewable Lozenges

NOW Papaya Enzyme Lozenges are a refreshing way to support protein digestion after meals. With a delicious mint flavor and 40mg of papaya per lozenge, this tablet is perfect for freshening your breath. These lozenges are Non-GMO, Soy Free, Kosher, and Keto Friendly. Additionally, the NPA A-rated GMP certification ensures that every aspect of the NOW manufacturing process has been examined, including stability, potency, and product formulation. NOW Papaya Enzyme Lozenges are packaged in the USA by a family-owned and operated company since 1968.

What We Like
Refreshing mint flavor
Supports protein digestion
Non-GMO, Soy Free, Kosher, Keto Friendly
#TOP 3

Garden of Life Dr Formulated Digestive Enzymes

Garden of Life Dr Formulated Digestive Enzymes Cover
Garden of Life Dr Formulated Digestive Enzymes with Papain, Bromelain, Lipase for Digestion & Nutrient Absorption – Organic Digest+ - Vegan, Gluten-Free, Non-GMO, Tropical Fruit Flavor, 90 Chewables

Garden of Life Dr Formulated Digestive Enzymes with Papain, Bromelain, Lipase for Digestion & Nutrient Absorption is a full spectrum plant-based enzyme formula to aid the digestion of proteins, fats, and carbs. It is Certified Organic and Non-GMO, Gluten-Free, Vegan and Carbon Neutral. It comes in a tropical flavored, shelf stable tablet that is easy to take on the go.

What We Like
Certified Organic and Non-GMO
Vegan and Carbon Neutral
Tropical flavored, shelf stable tablet
Helps with digestion after meals
Includes prebiotic fiber from Organic Acacia
#TOP 4

American Health Super Papaya Plus Digestive Enzyme Chewable Tablets

American Health Super Papaya Plus Digestive Enzyme Chewable Tablets Cover
American Health Super Papaya Enzyme Plus Chewable Tablets, Natural Papaya Flavor - Promotes Digestion & Nutrient Absorption, Contains Papain & Other Enzymes - 360 Count

American Health Super Papaya Plus Digestive Enzyme Chewable Tablets are a great-tasting, vegetarian formula that helps with digestion and nutrient absorption. It contains papain and other enzymes, as well as peppermint and chlorophyll to freshen breath and reduce bad taste. Customers have found it to be helpful with inefficient digestion, nausea, upset stomach, acid reflux, and digestion. It is gluten-free, wheat-free, lactose-free, egg-free, preservative-free, yeast-free, milk-free, soy-free, grapefruit-free, sodium-free, and artificial color-free.

What We Like
Helps with digestion and nutrient absorption
Contains papain and other enzymes
Peppermint and chlorophyll freshen breath and reduce bad taste
Gluten-free, wheat-free, lactose-free, egg-free, preservative-free, yeast-free, milk-free, soy-free, grapefruit-free, sodium-free, and artificial color-free
Great-tasting, vegetarian formula
#TOP 5

21st Century Papaya Enzyme Chewable Tablets

P0054
21st Century Papaya Enzyme Chewable Tablets Cover
21st Century Papaya Enzyme Chewable (100 Count), Papaya & Pineapple Digestive Enzymes for Gut Health, Tropical Flavor, Non-GMO, Gluten-Free, No Added Salt, Yeast, Artificial Flavors

21st Century Papaya Enzyme Chewable Tablets are a great way to support your digestive system. These chewable tablets are gluten-free, contain no added salt, yeast, preservatives, or artificial flavors, and are suitable for all stages. Customers have reported that the tablets taste good, work well, and are a great option for those with gastric bypass surgery.

What We Like
Gluten-free
No added salt, yeast, preservatives, or artificial flavors
Taste good and work well
#TOP 6

American Health Papaya Enzyme with Chlorophyll Chewable Tablets

American Health Papaya Enzyme with Chlorophyll Chewable Tablets Cover
American Health Papaya Enzyme with Chlorophyll Chewable Tablets - 600 Count (200 Total Servings)

American Health Papaya Enzyme with Chlorophyll Chewable Tablets is a great after meal supplement that helps promote nutrient absorption and freshens breath. It is gluten free and comes in a 600 count bottle. Customers have reported that it works great for settling their tummy and avoiding indigestion. It is also a natural papaya enzyme that can be used as a minty mouth freshener.

What We Like
Promotes nutrient absorption
Freshens breath
Gluten free
#TOP 7

NOW ChewyZymes

2957
Pink W/Speckles
NOW ChewyZymes Cover
NOW Foods Supplements, ChewyZymes, Broad Spectrum Chewable Enzymes, Berry Flavor, 90 Chewables

NOW Digestive Enzymes are designed to support optimal digestion of meals. With a broad spectrum of digestive enzymes, it helps break down carbohydrates, proteins, and fats into smaller, more easily absorbed nutrients. The natural berry flavor of the vegetarian chewable tablet makes it great for both adults and kids. This supplement is also Vegan/Vegetarian, Soy Free, Keto Friendly, Dairy Free. NOW Digestive Enzymes are GMP Quality Assured. It means that every aspect of the NOW manufacturing process has been examined, including laboratory/testing methods for stability, potency, and product formulation. Customers should be available during the product delivery to avoid melting or damage of the product caused by exposure to heat or sunlight.

What We Like
Broad spectrum enzymes
Natural berry flavor
Vegan/Vegetarian/Keto Friendly
#TOP 8

Klaire Labs Vital-Zymes Chewable Digestive Enzymes (180 Tablets)

Klaire Labs Vital-Zymes Chewable Digestive Enzymes (180 Tablets) Cover
Klaire Labs SFI Health Vital-Zymes Chewable Digestive Enzymes for Adults & Kids - Enzymes for Digestion - Cherry-Flavored - May Help Reduce Occasional Gas, Bloating & Indigestion (180 Chewables)

Klaire Labs Vital-Zymes Chewable Digestive Enzymes is a multi-enzyme complex that supports the breakdown of proteins, fats, carbs, sugars & fibers. It contains a full complement of enzymes that lend maximum support for breaking down foods, including serratia peptidase, DPP-IV activity, disaccharidases and more. It is naturally cherry flavored and sweetened with xylitol, which makes it a delicious choice for children or adults who have difficulty swallowing pills. The unique formula avoids fruit enzymes, porcine and other animal-derived enzymes, and excessive amounts of proteases that may irritate GI tissues. Trusted by healthcare practitioners since 1969.

What We Like
Contains a full range of enzymes needed for optimal digestion
Naturally cherry flavored and sweetened with xylitol, making it a delicious choice for children or adults who have difficulty swallowing pills
Avoids fruit enzymes, porcine and other animal-derived enzymes, and excessive amounts of proteases that may irritate GI tissues
#TOP 9

American Health Super Papaya Enzyme Chewables

American Health Super Papaya Enzyme Chewables Cover
American Health Super Papaya Enzyme Plus Chewable Tablets, Natural Peppermint Flavor - Promotes Digestion & Nutrient Absorption, Contains Papain & Other Enzymes - 90 Count, 30 Total Servings

American Health Papaya Enzyme offers advanced digestive support through naturally-sourced enzymes. These chewable tablets help your body absorb nutrients effectively, making them beneficial for digesting proteins, carbohydrates, and fats. Enjoying these tasty wafers after meals can enhance your digestive comfort. Additionally, the peppermint flavor not only freshens your breath but also masks any unpleasant aftertaste. With no GMOs or artificial ingredients, this product is a convenient and health-conscious choice for anyone seeking to improve their digestion.

What We Like
Natural digestive support
Enhances nutrient absorption
Tasty and convenient
Freshens breath
Non-GMO and allergen-free
#TOP 10

Carlyle Papaya Enzyme Chewable Tablets

CL4387
Carlyle Papaya Enzyme Chewable Tablets Cover
Carlyle Papaya Enzyme Chewable Tablets | Vegetarian, Non-GMO, Gluten Free Formula | Tropical Flavor

Carlyle Papaya Enzyme Chewable Tablets are a vegetarian, non-GMO, gluten-free formula with a tropical flavor. This precise blend of enzymes Protease, Amylase, Bromelain, & Lipase helps to reap the nutritional benefits of Papaya fruit. Customers have found it to be helpful for stomach upsets, heartburn, indigestion, and constipation. It is also great for rabbits!

What We Like
Vegetarian, Non-GMO, Gluten Free Formula
Tasty Tropical Chewable Tablets
Helpful for Stomach Upsets, Heartburn, Indigestion, and Constipation
Buying Guide Image

Frequently Asked Questions (FAQs)

1. What do chewable enzymes do?

Assist in the breakdown of protein into constituent amino acids. Support maximum calcium, magnesium, iron, and other mineral absorption. Help to activate pancreatic enzymes. Maintain healthy gastrointestinal microbe balance and immunity.

2. Are there chewable digestive enzymes?

ChewyZymes is a broad spectrum digestive enzyme formulation in a natural berry-flavored, vegetarian chewable tablet for adults and children. It is designed to support optimal digestion of meals. * Digestive enzymes are essential to the body's absorption and full use of food.

3. What is multi enzyme good for?

This medication contains digestive enzymes, which are natural substances needed by the body to help break down and digest food. It is used when the pancreas cannot make or does not release enough digestive enzymes into the gut to digest the food.

4. Is it good to take enzyme supplements?

“Overall, a healthy person really doesn't need to take digestive enzyme supplements,” Denhard explains. “The best digestive enzymes are the ones our bodies make naturally, and they work best when you eat a whole food diet.”

Editor's Notes

During our chewable multi-enzyme supplement research, we found 24 chewable multi-enzyme supplement products and shortlisted 10 quality products. We collected and analyzed 195,289 customer reviews through our big data system to write the chewable multi-enzyme supplements list. We found that most customers choose chewable multi-enzyme supplements with an average price of $15.20.

The chewable multi-enzyme supplements are available for purchase. We have researched hundreds of brands and picked the top brands of chewable multi-enzyme supplements, including American Health, NOW Foods, Garden of Life, 21st Century, Klaire Labs. The seller of top 1 product has received honest feedback from 385 consumers with an average rating of 4.7.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.