Best Natural Multi-Enzyme Supplements of 2025

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 4, 2025

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Natural multi-enzyme supplements are a blend of different enzymes that help in the digestion of various nutrients. These supplements are derived from natural sources and are designed to support digestive health. They contain a combination of enzymes like amylase, protease, lipase, and cellulase that help break down carbohydrates, proteins, fats, and fiber respectively. The enzymes in these supplements work together to improve nutrient absorption, reduce bloating, and promote overall digestive health. They are a safe and effective way to support digestive function and can be useful for people with digestive disorders or those looking to improve their gut health.

At a Glance: Our Top Picks

Source Naturals Essential Enzymes 500mg Cover #TOP 1
Source Naturals Essential Enzymes 500mg
ftb score rating icon 9.9
Natural Factors Multi Enzyme Vegetarian Formula Cover #TOP 2
Natural Factors Multi Enzyme Vegetarian Formula
ftb score rating icon 9.8
Source Naturals Essential Enzymes Cover #TOP 3
Source Naturals Essential Enzymes
ftb score rating icon 9.6

Top 9 Natural Multi-Enzyme Supplements

#TOP 1

Source Naturals Essential Enzymes 500mg

Source Naturals Essential Enzymes 500mg Cover
Source Naturals Essential Enzymes 500mg Bio-Aligned Multiple Enzyme Supplement Herbal Defense for Digestion, Gas, Constipation & Bloating Relief - Supports Immune System - 240 Capsules

Source Naturals Enzyme Supplement is a digestive aid that supports the body's natural digestive process, maximizing nutrient utilization while promoting digestive comfort. With 240 capsules per bottle, this product is a great value and each capsule should be taken with water at the beginning of each meal. This product is free of yeast, dairy, egg, gluten, soy, wheat, sugar, salt, preservatives, and artificial colors, flavors, and fragrances. Source Naturals has been a trusted brand for over 35 years, and this product is manufactured in the USA. Overall, Source Naturals Enzyme Supplement is a great choice for those looking to support their digestive health in a natural and effective way.

What We Like
Digestive aid
240 capsules per bottle
Free of common allergens
No preservatives or artificial ingredients
Trusted brand for over 35 years

Natural Factors Multi Enzyme Vegetarian Formula

Natural Factors Multi Enzyme Vegetarian Formula Cover
Natural Factors, High Potency Multi Enzyme Vegetarian Formula, Plant-Based Digestive Aid, 120 Capsules

Natural Factors Multi Enzyme Vegetarian Formula is a vegan blend that supports healthy digestion, breaks down proteins, carbs and fats, promotes healthy gut bacteria, and eases digestive discomfort. It replenishes the enzymes lost from foods during cooking and processing. It is non-GMO and free from dairy, gluten, artificial colors, preservatives, and sweeteners. You only need to take one capsule daily with food. The product is third-party certified and independently tested for over 800 contaminants using advanced technology to ensure purity and potency.

What We Like
Supports healthy digestion
Non-GMO and free from dairy, gluten, artificial colors, preservatives, and sweeteners
Replenishes enzymes lost from foods during cooking and processing
#TOP 3

Source Naturals Essential Enzymes

Source Naturals Essential Enzymes Cover
Source Naturals Essential Enzymes in Vegetarian Capsules, Digestive Aid* 500 Mg - 240 Capsules

Source Naturals Enzymes is an all-vegetarian, broad spectrum blend of digestive enzymes. Each vegetarian capsule contains 500 gm of these enzymes, making it a convenient and effective way to support your digestion. Simply take one capsule with water at the beginning of each meal, or sprinkle it over your food. This supplement is suitable for vegetarians and is free from yeast, dairy, egg, gluten, soy, wheat, sugar, starch, salt, preservatives, and artificial color, flavor, or fragrance. With over 40 years of trust, Source Naturals was created to promote optimal health for individuals. Manufactured in the USA, this product ensures quality and reliability.

What We Like
All-vegetarian blend
Convenient and effective
Suitable for vegetarians
#TOP 4

Zenwise Digestive Enzymes - Probiotic Multi Enzymes

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Zenwise Digestive Enzymes - Probiotic Multi Enzymes Cover
Zenwise Health Digestive Enzymes for Gut Health - Probiotic Multi Enzymes with Prebiotics and Probiotics for Women and Men for Digestive Health and Bloating Relief, Daily Enzymes for Digestion -100 CT

Zenwise Digestive Enzymes is a convenient 3-in-1 gut support solution that combines digestive enzymes, probiotics, and prebiotics. This powerful blend provides relief from occasional bloating, gas, and discomfort caused by hard-to-digest foods. The lab-proven multi-enzyme blend helps to digest foods more completely and faster than your body can on its own, making it perfect for those following gluten-free, Keto, or Paleo diets. The clinically proven DE111 probiotic is guaranteed to work in the small intestine, where 90% of nutrient absorption occurs. Additionally, Zenwise Digestive Enzymes contains a botanical bounty of ingredients such as turmeric, ginger, and green papaya, which aid in gut health and stomach comfort. With 100 capsules per bottle, it is recommended to take one capsule before each meal or drink for optimal digestive support.

What We Like
3-in-1 gut support
Digests food faster
Clinically proven probiotic

Wholesome Wellness Digestive Enzymes

digestive-enzymes
Green
Wholesome Wellness Digestive Enzymes Cover
Wholesome Wellness Digestive Enzymes 1000MG Plus Prebiotics & Probiotics Supplement, 180 Capsules, Organic Plant-Based Vegan Formula for Digestion & Lactose with Amylase & Bromelain,3-6 Months Supply

Wholesome Wellness Digestive Enzymes is a plant-based, organic supplement that helps improve digestion and gut health. With a 1000 MG dose of clinical grade digestive enzymes and a 10 billion CFU 10 strain probiotic with prebiotics, this supplement provides relief from bloating, flatulence, fat, pancreatic, and bowel cleansing. The Advanced Multi Enzyme System helps digest a variety of foods, including fried, spicy, raw, processed food, dairy, protein, salts, carb / carbohydrate, vitamin and acidic diet fruits and veggies. The supplement also contains a powerful 10 billion CFU dose of 10 different probiotic strains clinically shown to enhance preventions & immune system response.

What We Like
Relieves bloating and constipation
Plant-based vegan formula
Improves gut health
May enhance sleep, digestion, and energy
#TOP 6

FRISKA Mens Daily Digestive Enzyme and Probiotics Supplement

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FRISKA Mens Daily Digestive Enzyme and Probiotics Supplement Cover
FRISKA Men’s Daily Digestive Enzyme and Probiotics Supplement, Natural Support for Male Digestive Health, Bloating, Gas, Indigestion Relief, Supports Gut Health, Lactase and B-Vitamins, 30 Capsules

FRISKA Mens Daily Supplement is a powerful probiotic and digestive enzyme blend designed specifically for men. Enforced with lactase, it helps break down lactose sugar found in dairy products, making it ideal for those with lactose intolerance. The added B vitamins support brain and red blood cell function, promoting overall well-being. This supplement also includes digestive enzymes like amylase and lipase, as well as lactobacillus acidophilus probiotic, which provide relief from gut issues such as abdominal pain, bloating, and gas. By restoring gut health and maintaining healthy enzyme levels, FRISKA Mens Daily Supplement helps alleviate symptoms like diarrhea and bloating. Made from naturally sourced organic ingredients, this clean alternative is plant-based and easy to digest.

What We Like
Powerful probiotics
Enforced with lactase
Includes B vitamins
#TOP 7

Garden of Life 22 Digestive Enzymes for Women

Garden of Life 22 Digestive Enzymes for Women Cover
Garden of Life 22 Digestive Enzymes for Women with Bromelain, Papain, Lipase & Lactase Plus Probiotics & Vitamins B12, Biotin & Zinc – RAW Enzymes – Non-GMO, Gluten-Free, Vegetarian, 90 Capsules

Garden of Life 22 Digestive Enzymes for Women is a raw enzyme supplement designed to support the digestive and overall health needs of women with amplified potencies of carb-digesting enzymes. It has 22 digestive enzymes, probiotics, probiotic-created vitamins and minerals, and antioxidant enzymes to help process difficult-to-digest food and support colon, bone, and breast health, gut-related immunity, and digestion. The formula is Third-Party Non-GMO Project Verified, Certified Gluten-Free, Vegetarian, and Carbon Neutral.

What We Like
Amplified potencies of carb-digesting enzymes to support your nutritional and digestive needs.
22 digestive enzymes, probiotics, probiotic-created vitamins and minerals, and antioxidant enzymes to help process difficult-to-digest food and support colon, bone, and breast health, gut-related immunity, and digestion.
Untreated, uncooked, and unaltered to preserve the high activity levels of essential enzymes.
#TOP 8

Enzymedica Digest Gold + ATPro

20210
Enzymedica Digest Gold + ATPro Cover
Enzymedica Digest Gold + ATPro Maximum Strength Digestive Enzymes | Prevents Bloating Gas & Indigestion, Natural Digestion Support, Multi Enzyme Amylase, Protease, Lipase & Lactase, 90 Capsules

Enzymedica Digestive Enzymes are designed to enhance your digestive health. These powerful capsules help break down fats, fibers, proteins, and carbohydrates, making it easier for your body to absorb nutrients. By speeding up the digestion process, you can enjoy meals without the discomfort of bloating or gas. This product also aims to alleviate occasional indigestion, providing you with relief when you need it most. With all-natural ingredients sourced from the best materials, you can trust what you're putting into your body for optimal digestive support.

What We Like
Supports nutrient absorption
Reduces bloating and gas
Alleviates occasional indigestion
All-natural ingredients
#TOP 9

Natures Wellness Digestive Enzymes Complete

No Model
Natures Wellness Digestive Enzymes Complete Cover
Digestive Enzymes Complete - Advanced Multi Enzyme Supplement for Better Digestion & Absorption. Help Gas Relief, Discomfort, Bloating, IBS, Gluten & Lactose Intolerance

Natures Wellness Enzyme Supplement is an advanced multi enzyme complex that helps improve digestion and absorption. With its broad spectrum blend of enzymes, it can effectively break down proteins, carbs, fats, sugars, wheat, dairy, grains, gluten, and lactose, allowing you to enjoy a variety of foods without fearing food intolerance. This supplement also aids in relieving inflammatory bowel discomfort, IBS, bloating, and gas, thanks to ingredients like protease, bromelain, and papain. Additionally, it promotes a healthy gut flora and supports natural intestinal flora and nutrient absorption with its natural prebiotic and probiotic balance. Made in the USA to the highest standards, this gluten-free and non-GMO supplement comes with a lifetime money-back guarantee, ensuring your satisfaction. Try Natures Wellness Enzyme Supplement risk-free today!

What We Like
Advanced Enzyme Formula
Broad Spectrum Blend
Natural Prebiotic & Probiotic Balance
Buying Guide Image

Frequently Asked Questions (FAQs)

1. How can I increase my enzymes naturally?

However, it is possible to replenish your enzyme levels through dietary changes. These may include eating more protein, chewing your food longer, taking digestive enzyme supplements and more. Additionally, certain foods, such as pineapple and papaya, are naturally rich in enzymes.

2. Are enzyme supplements good for you?

“Overall, a healthy person really doesn't need to take digestive enzyme supplements,” Denhard explains. “The best digestive enzymes are the ones our bodies make naturally, and they work best when you eat a whole food diet.”

3. What is multi enzyme good for?

This medication contains digestive enzymes, which are natural substances needed by the body to help break down and digest food. It is used when the pancreas cannot make or does not release enough digestive enzymes into the gut to digest the food.

4. Why you shouldn't take digestive enzymes?

Digestive enzyme supplements also could interact with antacids and certain diabetes medications. They may cause side effects including abdominal pain, gas and diarrhea.

Editor's Notes

During our natural multi-enzyme supplement research, we found 24 natural multi-enzyme supplement products and shortlisted 9 quality products. We collected and analyzed 445,520 customer reviews through our big data system to write the natural multi-enzyme supplements list. We found that most customers choose natural multi-enzyme supplements with an average price of $21.31.

The natural multi-enzyme supplements are available for purchase. We have researched hundreds of brands and picked the top brands of natural multi-enzyme supplements, including Source Naturals, Natural Factors, Zenwise Health, Wholesome Wellness, FR!SKA. The seller of top 1 product has received honest feedback from 4,354 consumers with an average rating of 4.9.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.