Best Multi-Enzyme Supplement Tablets of 2026

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 4, 2025

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Multi-enzyme supplement tablets are a type of dietary supplement that contains a blend of different enzymes to aid in the digestion of food. These tablets are designed to support the body's natural digestive processes and can help to improve overall digestive health. They may be particularly useful for people who have difficulty digesting certain types of food, such as those with lactose intolerance or gluten sensitivity. Multi-enzyme supplements are available in a variety of formulations and may include enzymes such as amylase, protease, lipase, and lactase. They are generally safe and well-tolerated, but as with any dietary supplement, it is recommended to consult with a healthcare provider before use.

At a Glance: Our Top Picks

Puritans Pride Multi Enzyme Tablets Cover #TOP 1
Puritans Pride Multi Enzyme Tablets
ftb score rating icon 9.8
The Vitamin Shoppe Multi Enzyme Supplement (300 Tablets) Cover #TOP 2
The Vitamin Shoppe Multi Enzyme Supplement (300 Tablets)
ftb score rating icon 9.7
NOW Supplements Super Enzymes Digestive Support, 180 Tablets Cover #TOP 3
NOW Supplements Super Enzymes Digestive Support, 180 Tablets
ftb score rating icon 9.5

Top 10 Multi-Enzyme Supplement Tablets

#TOP 1

Puritans Pride Multi Enzyme Tablets

Puritan's Pride
10332
White
Puritans Pride Multi Enzyme Tablets Cover
Puritan's Pride Multi-Enzyme Formula, Digestive Aid for Proteins, Fats, and Carbohydrates, Dietary Supplement for Digestion and Healthy Gut Support, 50 Day Supply, 100 Easy to Swallow Coated Tablets

Puritans Pride Multi Enzyme Tablets are a type of multi-enzyme supplement designed to aid in the digestion of proteins, fats, and carbohydrates. With a package dimension of 1.98" L X 1.98" W X 4.17" H and made in the United States, this product is a convenient and reliable choice for those looking to improve their digestive health.

What We Like
Contains a blend of enzymes to aid in digestion of proteins, fats, and carbohydrates
Compact size makes it easy to take on the go
Reliable and made in the United States
#TOP 2

The Vitamin Shoppe Multi Enzyme Supplement (300 Tablets)

The Vitamin Shoppe Multi Enzyme Supplement (300 Tablets) Cover
Multi Enzyme - Helps Support The Digestion & Absorption of Protein, Carbs & Fat (300 Tablets) by The Vitamin Shoppe

The Vitamin Shoppe Multi Enzyme Supplement is a speciality protein tablet that supports the digestion and absorption of protein, carbs, and fat. It contains no yeast, wheat, gluten, soy, citrus, dairy, fish, artificial colors or flavors. With 150 servings, the recommended dosage is two (2) tablets after each meal, and it is advised not to take on an empty stomach. However, it is essential to consult a healthcare provider before using it if you are pregnant, nursing, taking any medication, or have any medical conditions.

What We Like
Supports digestion and absorption of protein, carbs, and fat
No harmful ingredients
Large number of servings (150)
#TOP 3

NOW Supplements Super Enzymes Digestive Support, 180 Tablets

2962
Tan W/Speckles
NOW Supplements Super Enzymes Digestive Support, 180 Tablets Cover
NOW Foods Supplements, Super Enzymes, Formulated with Bromelain, Ox Bile, Pancreatin and Papain, 180 Tablets

NOW Supplements Super Enzymes is a blend of enzymes that supports healthy digestion. The formula is designed to break down fats, carbs, and protein and optimize nutrient availability. The tablets are easy to swallow and are GMP Quality Assured. The product is packaged in the USA by a family-owned and operated company since 1968. Product Note: Customers are expected to be available during the product delivery to avoid melting or damage to the product.

What We Like
Comprehensive blend of enzymes that supports healthy digestion
Optimizes the breakdown of fats, carbohydrates, and protein
Easy to swallow tablet
GMP Quality Assured
Packaged in the USA by a family owned and operated company since 1968
#TOP 4

The Vitamin Shoppe Multi Enzyme

The Vitamin Shoppe Multi Enzyme Cover
Multi Enzyme - Helps Support The Digestion & Absorption of Protein, Carbs & Fat (100 Tablets) by The Vitamin Shoppe

The Vitamin Shoppe Multi Enzyme is a specialty protein tablet with carbohydrates that supports the digestion and absorption of protein, carbs, and fat. This multi-enzyme supplement is designed to help break down food more efficiently, making it easier for your body to absorb essential nutrients. It does not contain common allergens such as yeast, wheat, gluten, soy, citrus, dairy, fish, artificial colors, or flavors. With a recommended dosage of two tablets after each meal, this supplement can be easily incorporated into your daily routine. It is important to note that it should not be taken on an empty stomach. If you are pregnant, nursing, taking medication, or have any medical conditions, it is advised to consult with your healthcare provider before use. With 100 tablets per bottle, this product provides 50 servings, ensuring long-lasting support for your digestive health.

What We Like
Supports digestion and absorption
Allergen-free formula
Convenient dosage
#TOP 5

Multi Enzyme Supplement by The Vitamin Shoppe

1307284
1 Count (Pack of 1)
Multi Enzyme Supplement by The Vitamin Shoppe Cover
Multi Enzyme - Helps Support The Digestion & Absorption of Protein, Carbs & Fat (600 Tablets) by The Vitamin Shoppe

The Vitamin Shoppe Multi Enzyme is designed to enhance your digestion and nutrient absorption. This supplement helps break down proteins, carbohydrates, and fats, making it easier for your body to utilize essential nutrients. It's perfect for those who prioritize their overall wellness, allowing you to feel your best every day. Additionally, it's made without gluten, dairy, soy, nuts, or artificial additives, ensuring a clean option for your dietary needs. With these benefits, you can enjoy a more comfortable digestive experience while supporting your health goals.

What We Like
Supports nutrient absorption
Ideal for daily wellness
Free from common allergens
Enhances digestive comfort
#TOP 6

LightSpring Probiotic Digestive Tablets

LightSpring
LightSpring Probiotic Digestive Tablets Cover
Probiotic Multi-Enzyme Digestive Formula Tablets, 200 Count with Bundle Exclusive Better Ligth&Spring Guide

The LightSpring Probiotic Tablets are designed to enhance your digestive health. With 500 million CFUs of beneficial bacteria, these tablets help maintain a balanced gut, promoting regular digestion and reducing bloating. Being gluten-free and non-GMO, they cater to those with dietary sensitivities. Additionally, these probiotics support your immune system, helping to boost your defenses against infections. Easy to swallow, they can be taken with or without food, making them a convenient addition to your daily routine.

What We Like
Supports digestive balance
Gluten-free and non-GMO
Boosts immune system
Convenient daily use
#TOP 7

American Health Super Papaya Plus Digestive Enzyme Chewable Tablets

American Health Super Papaya Plus Digestive Enzyme Chewable Tablets Cover
American Health Super Papaya Enzyme Plus Chewable Tablets, Natural Papaya Flavor - Promotes Digestion & Nutrient Absorption, Contains Papain & Other Enzymes - 360 Count

American Health Super Papaya Plus Digestive Enzyme Chewable Tablets are a great-tasting, vegetarian formula that helps with digestion and nutrient absorption. It contains papain and other enzymes, as well as peppermint and chlorophyll to freshen breath and reduce bad taste. Customers have found it to be helpful with inefficient digestion, nausea, upset stomach, acid reflux, and digestion. It is gluten-free, wheat-free, lactose-free, egg-free, preservative-free, yeast-free, milk-free, soy-free, grapefruit-free, sodium-free, and artificial color-free.

What We Like
Helps with digestion and nutrient absorption
Contains papain and other enzymes
Peppermint and chlorophyll freshen breath and reduce bad taste
Gluten-free, wheat-free, lactose-free, egg-free, preservative-free, yeast-free, milk-free, soy-free, grapefruit-free, sodium-free, and artificial color-free
Great-tasting, vegetarian formula
#TOP 8

4 Top Care Probiotic Multi-Enzyme

4 Top Care
4TC-23-01
4 Top Care Probiotic Multi-Enzyme Cover
4 Top Care Daily Probiotic Multi-Enzyme Supplement Digestive Formula with Probiotic Acidophilus - Probiotics for Weight Management & Digestive Health & Gut Health for Men & Women 200 Tablets

Promote optimal digestion and gut health with 4 Top Care Digestive Health Supplement. This powerful blend of probiotics and digestive enzymes supports comprehensive digestive wellness. With ingredients like betaine hydrochloride, pancreatin, amylase, protease, bromelain, papain, pepsin, ox bile, lipase, cellulase, and lactobacillus acidophilus La-14, this supplement offers superior quality and reliability. Free from common allergens and harsh ingredients, it is suitable for everyone. With 200 tablets per bottle, it provides a long-term solution for ongoing digestive support.

What We Like
Optimal digestion support
Comprehensive digestive wellness
Superior quality and reliability
#TOP 9

Spring Valley Probiotic Digestive Tablets

Nick & Hannah
pro1
Spring Valley Probiotic Digestive Tablets Cover
Spring Valley Probiotic Multi-Enzyme Digestive Formula Tablets, 200 Count + 1 Spatula (Style Varies)

Spring Valley Probiotic Tablets offer a convenient way to support your digestive health. With a robust count of 200 tablets, you can easily incorporate them into your daily routine. These multi-enzyme supplements are designed to enhance digestion, helping you break down food more efficiently. This can lead to improved nutrient absorption, which is essential for overall wellness. Additionally, the inclusion of a spatula makes it easy to handle the tablets without mess, adding to the product's user-friendly design.

What We Like
Supports digestive health
200 tablets for long-lasting supply
Enhances nutrient absorption
Includes convenient spatula
#TOP 10

NaturesPlus Ultra-Zyme Enzyme Supplement

097467044524
NaturesPlus Ultra-Zyme Enzyme Supplement Cover
Natures Plus Ultra-Zyme - 90 Tablets - Enzyme Supplement to Support Healthy Digestion - Gluten Free - 45 Servings

NaturesPlus Ultra-Zyme is a gluten-free enzyme supplement that promotes healthy digestion by supporting the digestive enzymes naturally produced by the body. Its special coatings ensure optimal enzyme release, and it also contains acidophilus and glutamic acid. The formula is free of artificial colors and preservatives, and the state-of-the-art manufacturing facilities maintain adherence to FDA and NSF standards.

What We Like
Promotes healthy digestion
Special coatings ensure optimal enzyme release
Contains acidophilus and glutamic acid
Free of artificial colors and preservatives
Manufactured in state-of-the-art facilities adhering to FDA and NSF standards
Buying Guide Image

Frequently Asked Questions (FAQs)

1. What are multi digestive enzyme tablets for?

This medication contains digestive enzymes, which are natural substances needed by the body to help break down and digest food. It is used when the pancreas cannot make or does not release enough digestive enzymes into the gut to digest the food.

2. Do enzymes tablets work?

It's for this reason that digestive enzyme supplements have been getting attention lately—there is speculation that they boost those processes and help relieve symptoms of indigestion. But the clinical evidence shows that digestive enzymes are not effective at alleviating gas or bloating.

3. What are the benefits of taking enzyme supplements?

They might claim to:. support healthy digestion.optimize the breakdown of fats, carbohydrates, and protein.promote optimal nutrient absorption.reduce gas, bloating, indigestion, and constipation following meals.help your body process difficult-to-digest foods.support colon health.

4. When should I take multi enzyme?

For digestive purposes, it's best to take enzymes near the beginning of the meal. The goal is to maximize the amount of time the enzymes have in contact with the food. Can enzymes be taken with breakfast, and last all day? When you take enzymes with any meal, the enzymes churn with that meal in your stomach.

Editor's Notes

During our multi-enzyme supplement tablet research, we found 24 multi-enzyme supplement tablet products and shortlisted 10 quality products. We collected and analyzed 79,999 customer reviews through our big data system to write the multi-enzyme supplement tablets list. We found that most customers choose multi-enzyme supplement tablets with an average price of $22.88.

The multi-enzyme supplement tablets are available for purchase. We have researched hundreds of brands and picked the top brands of multi-enzyme supplement tablets, including Puritan's Pride, The Vitamin Shoppe, NOW Foods, LightSpring, American Health. The seller of top 1 product has received honest feedback from 385 consumers with an average rating of 4.7.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.