Best Gluten-Free Multi-Enzyme Supplements of 2025

Ora Organic Multi-Enzyme Supplement is a plant-based, vegan, and gluten-free dietary supplement designed to help you ease common digestive issues such as bloating and occasional constipation. It contains 15 plant-based digestive enzymes that work together to facilitate complete digestion for all diets. The supplement also includes probiotics that promote a balanced gut microbiome, and phytase, a powerhouse digestive enzyme that supports nutrient absorption. The capsules are easy to swallow, convenient to take on-the-go, and come with a 60-day satisfaction guarantee.

This supplement aids in the digestion of gluten, ultimately supporting gluten metabolism and immune function. It helps with occasional bloating, gas and discomfort that may be associated with digesting gluten. Encapsulated in vegan capsules, you can easily incorporate these into your routine.

Doctor's Best Proteolytic Enzymes is a potent formulation containing a broad spectrum of proteolytic enzymes (proteases) to support muscle, joint, and overall tissue health. It is vegetarian, gluten-free, and Non-GMO, and comes in a 90-count veggie capsule bottle. Customers have reported positive results in terms of relief from joint and muscle pain, as well as improved gut health.

Garden of Life Dr Formulated Digestive Enzymes with Papain, Bromelain, Lipase for Digestion & Nutrient Absorption is a full spectrum plant-based enzyme formula to aid the digestion of proteins, fats, and carbs. It is Certified Organic and Non-GMO, Gluten-Free, Vegan and Carbon Neutral. It comes in a tropical flavored, shelf stable tablet that is easy to take on the go.

Experience the power of Carlyle Enzyme Blend, a premium multi-enzyme supplement designed to support your overall wellness. This potent complex features a blend of eight plant enzymes, including Papain, Bromelain, and Lactase, to provide you with maximum daily support. Carlyle, a trusted brand in the health industry, is committed to delivering honest and superior quality supplements for your healthy living journey. With Carlyle Enzyme Blend, you can enjoy the convenience of vegetarian capsules and the peace of mind knowing that it is free from gluten, wheat, yeast, milk, lactose, soy, artificial color, flavor, and preservatives. Take control of your well-being with Carlyle Enzyme Blend and experience the benefits it can bring to your daily life.

NOW Supplements Gluten Digest Veg Capsules is a comprehensive enzyme blend designed to support gastrointestinal health and promote the complete digestion of cereal grains. It is specially formulated with BioCore DPP IV and can help you digest gluten and other cereal grains. It is Non-GMO, Kosher, Soy Free, Vegan/Vegetarian, and Keto Friendly. Additionally, it is packaged in the USA by a family-owned company since 1968 and is GMP Quality Assured.

Nature's Truth Probiotics is a premium supplement that combines the power of prebiotics, probiotics, and multi-enzymes to support your overall wellness. With a potent formula that delivers 4 billion CFU per serving, these easy-to-take vegetarian capsules are designed to promote a healthy digestive system. The expertly crafted formula is backed by three generations of Vitamin Innovators, ensuring unrivaled quality. Nature's Truth Probiotics is naturally free of gluten, wheat, soy, artificial color, and flavoring, making it suitable for individuals with dietary restrictions. With its stomach-friendly formula, this supplement is suitable for both men and women, providing convenience and peace of mind for those looking to support their digestive health.

Enzymedica GlutenEase is designed for those who struggle with gluten-heavy foods. It includes powerful enzymes that help break down gluten, making it easier for you to enjoy meals like bread and pasta without discomfort. The extra-strength formula features DPP-IV, which specifically targets gluten, reducing gas and bloating. Additionally, it efficiently processes both gluten and casein, ensuring that you can digest a variety of meals comfortably. With just one capsule per meal, this product offers a simple solution for managing gluten intolerance while being vegan and free from common allergens.

Carlyle Digestive Enzymes with 14 Probiotic Strains is a non-GMO and gluten-free supplement that provides full-spectrum digestive support. It contains bromelain and comes in quick-release capsules that can be taken before or after meals. Customers have reported improved regularity and reduced bloating and stomach pain. Some customers have not seen the desired results.

NOW Supplements Super Enzymes is a comprehensive blend of enzymes that supports healthy digestion. Formulated with bromelain, ox bile, pancreatin and papain, Super Enzymes helps to optimize the breakdown of fats, carbohydrates and protein. It is Soy Free, Made without Gluten, Keto Friendly and GMP Quality Assured. Customers have reported that it helps with digestive issues, bloating, slow metabolism, and acid indigestion. It is easy to swallow and comes in capsule form.