Best Gluten-Free Multi-Enzyme Supplements of 2026

NOW Supplements Super Enzymes is a comprehensive blend of enzymes that supports healthy digestion. Formulated with bromelain, ox bile, pancreatin and papain, Super Enzymes helps to optimize the breakdown of fats, carbohydrates and protein. It is Soy Free, Made without Gluten, Keto Friendly and GMP Quality Assured. Customers have reported that it helps with digestive issues, bloating, slow metabolism, and acid indigestion. It is easy to swallow and comes in capsule form.

Vital Nutrients Pancreatic Enzymes 1000mg is a digestive enzyme supplement that supports better absorption and digestion of protein, fats, and carbohydrates. The formula contains amylase, lipase, and protease to help break down food. It is free from gluten, dairy, soy, peanut, tree nut, egg, sugar, artificial colors, and more. Vital Nutrients is committed to producing high-quality supplements and tests every ingredient and batch above the industry standard.

Garden of Life Dr Formulated Digestive Enzymes with Papain, Bromelain, Lipase for Digestion & Nutrient Absorption is a full spectrum plant-based enzyme formula to aid the digestion of proteins, fats, and carbs. It is Certified Organic and Non-GMO, Gluten-Free, Vegan and Carbon Neutral. It comes in a tropical flavored, shelf stable tablet that is easy to take on the go.

Enzymedica GlutenEase is designed for those who struggle with gluten-heavy foods. It includes powerful enzymes that help break down gluten, making it easier for you to enjoy meals like bread and pasta without discomfort. The extra-strength formula features DPP-IV, which specifically targets gluten, reducing gas and bloating. Additionally, it efficiently processes both gluten and casein, ensuring that you can digest a variety of meals comfortably. With just one capsule per meal, this product offers a simple solution for managing gluten intolerance while being vegan and free from common allergens.

Sports Research Digestive Enzymes with Probiotics and Ginger is a plant-based supplement designed to help the body properly digest proteins, fats and carbohydrates, resulting in better nutrient absorption and less digestive discomfort. It is Non-GMO Project Verified, Vegan Certified and Gluten Free. Customers have reported positive results in their digestive system since taking this supplement.

Wholesome Wellness Digestive Enzymes is a plant-based, organic supplement that helps improve digestion and gut health. With a 1000 MG dose of clinical grade digestive enzymes and a 10 billion CFU 10 strain probiotic with prebiotics, this supplement provides relief from bloating, flatulence, fat, pancreatic, and bowel cleansing. The Advanced Multi Enzyme System helps digest a variety of foods, including fried, spicy, raw, processed food, dairy, protein, salts, carb / carbohydrate, vitamin and acidic diet fruits and veggies. The supplement also contains a powerful 10 billion CFU dose of 10 different probiotic strains clinically shown to enhance preventions & immune system response.

The Horbäach Digestive Enzymes supplement offers a unique vegetarian formula designed to support your digestion. It combines multiple plant-based enzymes like protease, papain, and bromelain to help break down proteins and improve nutrient absorption. This carefully crafted blend ensures you get a potent and pure product, reflecting Horbäach’s dedication to quality. With laboratory-tested ingredients, you can trust this supplement to deliver consistent results and support your digestive health effectively. If you're looking for a reliable way to aid digestion, this formula provides a convenient and powerful option.

MaryRuth's Ultra Digestive Food Enzymes is a vegan supplement formulated to enable digestion, especially in those with digestive issues, amplifying nutrient absorption while reducing bloating, gas and abdominal pain. This extra strength blend of enzymes are formulated to help digest proteins, carbohydrates, fiber, fat, and lactose. It includes Protease, Amylase, Glucoamylase, Diastase, Invertase, Pectinase, Cellulase, Hemicellulase, Xylanase, Lipase, Lactase, Alpha-Galactosidase, and Beta-Glucanase. It is Non-GMO & Vegan, Dairy Free, Nut Free, Gluten & Wheat Free, Soy Free, Nightshade Free, Sugar Free, and contains Maltodextrin. Customers have reported that it works great and helps reduce bloating, gas, and abdominal pain.

Enzymedica GlutenEase is designed to help you enjoy meals without the worry of hidden gluten or cross-contamination. With powerful enzymes that break down gluten and casein, this supplement helps prevent gas and bloating before they start. Its unique Thera-blend enzymes work effectively across different pH levels in your digestive system, ensuring quick relief and support. You only need one capsule to break down a significant amount of protein and carbohydrates, making it easy to incorporate into your daily routine. Plus, it’s free from common allergens and artificial ingredients, so you can feel good about what you're taking.

Life Extension Enhanced Super Digestive Enzymes & Probiotics is a vegetarian-friendly digestive health formula that helps promote digestive comfort and maintain a healthy microbiome. It contains ten types of digestive enzymes, including alpha galactosidase, protease 3.0, and lipase, as well as probiotic strand B. coagulans for comprehensive digestive support. This product is certified non-GMO and gluten-free, and is manufactured in the USA.