Best L-Lysine Supplements of 2025

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 13, 2025

* We independently evaluate all recommended products and services. If you click on links we provide, we may receive compensation.

L-Lysine is an essential amino acid that helps the body produce proteins and supports the immune system. L-Lysine supplements are available in various forms, including capsules, tablets, and powders. These supplements are commonly used to prevent and treat cold sores caused by the herpes simplex virus. Additionally, L-Lysine supplements may improve athletic performance, reduce anxiety, and support bone health. It is important to consult with a healthcare provider before taking any new supplements, especially if you have a pre-existing medical condition or are taking medication.

At a Glance: Our Top Picks

NOW Supplements L-Lysine Hydrochloride 100 Tablets Cover #TOP 1
NOW Supplements L-Lysine Hydrochloride 100 Tablets
ftb score rating icon 9.8
Nature Made L-Lysine 1000mg Supplement Cover #TOP 2
Nature Made L-Lysine 1000mg Supplement
ftb score rating icon 9.7
Pure Encapsulations L-Lysine Capsules Cover #TOP 3
Pure Encapsulations L-Lysine Capsules
ftb score rating icon 9.5

Top 10 L-Lysine Supplements

#TOP 1

NOW Supplements L-Lysine Hydrochloride 100 Tablets

0113
Cream
NOW Supplements L-Lysine Hydrochloride 100 Tablets Cover
NOW Foods Supplements, (L-Lysine Hydrochloride) 1,000 mg, Double Strength, Amino Acid, 100 Tablets

Looking for a vegan-friendly L-Lysine supplement? NOW Supplements L-Lysine Hydrochloride provides you with a double-strength essential amino acid that supports collagen synthesis and is required for the maintenance of structural proteins such as collagen and elastin. With certifications such as non-GMO, nut-free, soy-free, and kosher, this product provides you with the necessary daily dose of Lysine. This GMP quality assured product is manufactured in the USA by a family-owned and operated company since 1968.

What We Like
Boosts immune system
Helps with cold sores
Easy to swallow
Good quality
Supports skin health
What We Don't Like
Large pill size
Possible stomach upset
#TOP 2

Nature Made L-Lysine 1000mg Supplement

Nature Made L-Lysine 1000mg Supplement Cover
Nature Made L-Lysine 1000 mg, Dietary Supplement, 60 Tablets, 60 Day Supply

Nature Made L-Lysine 1000mg Supplement is a dietary supplement that helps the body synthesize protein with just one convenient dose per day. This supplement provides 1000mg of one of the nine essential amino acids. L-Lysine is necessary for certain bodily functions and manufacturing body proteins. It aids in calcium absorption and collagen formation. Carnitine, an important energy-producing compound, is synthesized from lysine. Carnitine may help the body utilize fat more efficiently, and therefore may streamline the process of energy production. Adults take one tablet daily with water and a meal. Nature Made supplements are quality you can trust.

What We Like
High-quality ingredients
Convenient 60-day supply
Boosts overall wellness
Gluten-free and allergen-free
Easy to crush and swallow
What We Don't Like
Tablets are quite large
Potential mild side effects
#TOP 3

Pure Encapsulations L-Lysine Capsules

766298001685
Pure Encapsulations L-Lysine Capsules Cover
Pure Encapsulations L-Lysine - Essential Amino Acid Supplement for Immune Support & Gum, Lip Health* - with L-Lysine HCl - 90 Capsules

Pure Encapsulations L-Lysine Capsules are an amino acid supplement that provides essential nutrients to help maintain healthy immune function and gum health. With natural defense support, L-Lysine maintains healthy arginine production and supports the body's natural immune defenses. What makes this product stand out is its pure quality, using only premium ingredients sourced from trusted suppliers and free from wheat, eggs, tree nuts & peanuts, gluten, artificial colors, flavors & sweeteners, coatings and shellacs, GMOs, and unnecessary binders, fillers & preservatives.

What We Like
Helps with anxiety
Supports skin and collagen
Easy to swallow capsules
Cost-effective compared to prescriptions
Positive impact on mood and well-being
What We Don't Like
Occasional need to drink more water
#TOP 4

NOW L-Lysine Amino Acid 500mg, 250 Tablets

0102
White
NOW L-Lysine Amino Acid 500mg, 250 Tablets Cover
NOW L-Lysine 500 mg,250 Capsules

Get your essential amino acid L-Lysine from NOW Supplements, which cannot be produced by your body and must be obtained through your diet or supplementation. It supports the production of protein, hormones, enzymes, antibodies, and carnitine, as well as collagen which forms connective tissue such as skin, tendon, and bone. In addition, L-Lysine plays a crucial role in calcium absorption. This product is non-GMO, dairy-free, egg-free, gluten-free, nut-free, soy-free, vegan/vegetarian, and has been quality assured by GMP. It is packaged in the USA by a family owned and operated company since 1968.

What We Like
Easy to swallow
Effective for various needs
Long-time customer satisfaction
Interesting hinge lid design
Recommended by doctors
What We Don't Like
Possible side effects for some
#TOP 5

Bronson L-Lysine Defense Immune Support Complex

1147-90
Bronson L-Lysine Defense Immune Support Complex Cover
Bronson L-Lysine Defense Immune Support Complex 1500 MG L-Lysine Plus Olive Leaf, Garlic, Vitamin C and Zinc - Non-GMO, 90 Vegetarian Capsules

Bronson L-Lysine Defense Immune Support Complex is a non-GMO vegetarian capsule containing L-Lysine, Olive Leaf, Garlic, Vitamin C, and Zinc. L-Lysine helps to maintain healthy production of L-Arginine, support immune health, and maintain healthy lips. Olive Leaf and Garlic are natural immune support ingredients, and Vitamin C and Zinc help replenish the body with essential nutrients to maintain a healthy immune system. The product is tested in a cGMP registered facility in New York and has been trusted since 1960.

What We Like
Effective for mouth sores
Helps improve appetite
Easy to swallow
Supports immune system
Works against cold sores
What We Don't Like
Possible stomach discomfort if taken incorrectly
#TOP 6

Nutricost L-Lysine 1000mg, 500 Capsules

ZL00772
Nutricost L-Lysine 1000mg, 500 Capsules Cover
Nutricost L-Lysine 1000mg Per Serving, 250 Servings, 500 Capsules - Gluten Free, Non-GMO, 500mg Per Capsule

Nutricost's L-Lysine supplement contains 500mg of premium L-Lysine per capsule, providing a 1000mg serving. With 250 servings (500 capsules) of this essential amino acid, users can take 1-2 capsules per serving. The supplement is Non-GMO, Gluten-Free and made in a GMP compliant, FDA-registered facility.

What We Like
Easy to swallow capsules
No aftertaste
Good value in bulk
Recommended by dentist
What We Don't Like
Can cause intestinal backup
Some find hard to swallow
#TOP 7

THORNE Lysine 500mg Capsules

No Model
THORNE Lysine 500mg Capsules Cover
THORNE Lysine - Essential Amino Acid for Skin Health, Energy Production, and Immune Function - 500 mg - 60 Capsules

THORNE Lysine Capsules are packed with benefits for you. Firstly, they aid in wound healing by boosting collagen production in your skin. Secondly, they support your immune system, helping it stay strong and keeping your gum and lip tissues healthy. Thirdly, these capsules promote skin elasticity and calcium absorption for robust bones and teeth. Lastly, they are free from common allergens, making them suitable for many users.

What We Like
Great for immune support
Consistent quality
Reliable brand
Positive health results
Good price
What We Don't Like
Larger pill size
#TOP 8

Quantum Health SuperLysine+ Advanced Formula Immune Support Supplement|180 Tablets

F-SL180
Speckled Sand
Quantum Health SuperLysine+ Advanced Formula Immune Support Supplement|180 Tablets Cover
Quantum Health Super Lysine+ / Advanced Formula Lysine+ Immune Support with Vitamin C, Echinacea, Licorice, Propolis, Odorless Garlic (180 Tablets), Packaging may vary

Quantum Health SuperLysine+ Advanced Formula Immune Support Supplement is a powerful immune booster with ingredients like Vitamin C, Echinacea, Licorice, Propolis, and Odorless Garlic. It promotes collagen growth, supports lip health, and provides antioxidant support. The specially coated tablets are easy to swallow, and each bottle contains a full 60-day supply. It's an award-winning lysine power formula from a trusted leader in the natural products industry.

What We Like
Effective for cold sores
Boosts immune system
Easy to swallow
No significant side effects
Long-lasting results
What We Don't Like
Unpleasant taste and smell
Confusing dosage instructions
#TOP 9

Solgar L-Lysine 1000mg Tablets, 250 ct

E1702
Solgar L-Lysine 1000mg Tablets, 250 ct Cover
Solgar L-Lysine 1000 mg, 250 Tablets - Enhanced Absorption and Assimilation - Promotes Integrity of Skin and Lips - Collagen Support - Amino Acids - Non-GMO, Vegan, Gluten Free - 250 Servings

The Solgar L-Lysine 1000mg Tablets are an easy-to-take dietary supplement that promotes the integrity of skin and lips, and supports collagen production. The tablets contain Free Form L-Lysine for optimal absorption and assimilation, and are suitable for vegans, non-GMO, and certified gluten-free. L-Lysine is an essential amino acid that helps to maintain healthy skin tissue. This supplement is ideal for adults looking to support a healthy complexion and skin tissue.

What We Like
Great for skin health
Helps prevent canker sores
Good quality packaging
Non-GMO and gluten-free
Positive customer service experience
What We Don't Like
Tough to swallow at first
No recycling info on packaging
#TOP 10

Vimergy L-Lysine Capsules for Immune Support and Healthy Skin (270 Count)

LYSINE-270
Vimergy L-Lysine Capsules for Immune Support and Healthy Skin (270 Count) Cover
Vimergy L-Lysine – Promotes Healthy Skin, Hair, Nails & Joints* – Supports Healthy Metabolism* – Vegan, Non-GMO & Gluten-Free – 270 Capsules

Get the benefits of L-Lysine, an essential amino acid, with Vimergy's vegetarian capsules. Each capsule contains 500mg of L-Lysine HCl without any gelatin, citric acid, or gluten. L-Lysine is crucial for making collagen and elastin, promoting healthy skin, bone, and tissue. It also supports healthy fat metabolism by synthesizing carnitine. The vegetarian capsules help maintain a healthy immune system. With 270 servings, you can trust the purity of each capsule as it is Non-GMO, Kosher, and Vegan.

What We Like
Effective health benefits
Fast delivery
Easy to swallow
High-quality brand
Inexpensive option
What We Don't Like
May require higher dosages
Buying Guide Image

Basic Information to Help You Figure out the Best L-Lysine Supplements

Introduction

L-Lysine is an essential amino acid that is necessary for the proper growth and development of the human body. It is not naturally produced by the body, so it must be obtained through the diet or through supplements. Choosing the right L-Lysine supplement can be a daunting task, as there are many different options available on the market. In this article, we will discuss some key factors to consider when choosing an L-Lysine supplement.

The Importance of Purity and Quality

When it comes to choosing a supplement, purity and quality should be top priorities. The best L-Lysine supplements are made from high-quality, pure ingredients that have been carefully sourced and processed. Look for supplements that have been certified by third-party organizations, such as the United States Pharmacopeia (USP), to ensure that they meet strict quality standards.

Consider Your Needs

L-Lysine supplements come in a variety of forms, including tablets, capsules, and powders. The form that is right for you will depend on your individual needs and preferences. For example, if you have difficulty swallowing pills, a powder form may be easier to take. On the other hand, if you prefer the convenience of a pre-measured dose, capsules or tablets may be a better option.

Dosage and Frequency

When it comes to L-Lysine supplements, more is not always better. It is important to choose a supplement that provides the right dosage for your needs. The recommended daily allowance (RDA) for L-Lysine is 38 milligrams per kilogram of body weight. However, some people may benefit from higher doses, depending on their individual circumstances. Consult with your healthcare provider to determine the right dosage for you.

Additional Ingredients

Some L-Lysine supplements may contain additional ingredients, such as vitamins, minerals, or herbs. While these ingredients can be beneficial, it is important to carefully read the label to ensure that the supplement does not contain any potentially harmful additives. For example, some L-Lysine supplements may contain allergens, such as soy or gluten, so be sure to check for these if you have allergies or sensitivities.

Cost and Value

When it comes to choosing a L-Lysine supplement, it is important to consider both the cost and the value of the product. While it may be tempting to choose the cheapest option, this may not always be the best choice. High-quality L-Lysine supplements may be more expensive, but they can provide greater benefits and may be more effective in the long run. It is worth investing in a high-quality product to ensure that you are getting the maximum benefits from your L-Lysine supplement.

Conclusion

Choosing the right L-Lysine supplement can be a challenging task, but it is important to take the time to research and compare options to find the best product for your needs. Consider factors such as purity and quality, form and dosage, additional ingredients, and cost and value when making your decision. With the right L-Lysine supplement, you can support your body's growth and development and ensure that you are getting the essential nutrients that you need.

Frequently Asked Questions (FAQs)

1. What is the supplement L-lysine used for?

L-lysine is a supplement used to support the body's absorption of calcium and plays a crucial role in the formation of collagen, which is essential for bones and connective tissues like skin, tendons, and cartilage. While most people get enough lysine in their diet, supplementation can be beneficial in certain cases.

2. Is it OK to take L-lysine everyday?

Taking L-lysine orally is generally considered safe for most people when used in doses up to 3000 mg per day for up to one year. However, it can cause side effects such as stomach pain and diarrhea. It's important to consult with a healthcare professional before starting any new supplement regimen.

3. What are the side effects of taking L-lysine capsules?

Possible side effects of L-lysine capsules include diarrhea, cramps, abdominal pain, gallstones, nausea, and potential kidney issues. It's important to be aware of these potential side effects and consult with a healthcare professional if you experience any adverse reactions.

4. What are the benefits of taking L-lysine 1000 mg daily?

Taking L-lysine 1000 mg daily may help prevent osteoporosis by aiding in calcium absorption, reducing calcium loss in urine. It may also support athletic performance by assisting in muscle recovery from stress. However, individual results may vary, and it's important to consult with a healthcare professional before starting any new supplement regimen.

5. What happens when you start taking lysine?

Lysine is an essential amino acid, and taking lysine supplements can have various benefits. These include improved blood sugar control, management of anxiety and stress, collagen formation, and wound healing. However, it's important to note that lysine cannot be produced by the body and must be obtained through diet or supplements.

6. What to avoid when taking lysine?

When taking lysine, it's important to inform your healthcare provider about all the medications you currently use or plan to use. Avoid taking lysine without medical advice if you are using calcium supplements or gastrointestinal medicines such as prucalopride or tegaserod.

7. Should you take L Lysine morning or night?

Research suggests that taking a L-Arginine and L-Lysine supplement before bed may increase growth hormone levels. However, it's important to consult with a healthcare professional for personalized advice on the timing and dosage of L-lysine supplementation.

Editor's Notes

During our l-lysine supplement research, we found 24 l-lysine supplement products and shortlisted 10 quality products. We collected and analyzed 342,327 customer reviews through our big data system to write the l-lysine supplements list. We found that most customers choose l-lysine supplements with an average price of $13.49.

The l-lysine supplements are available for purchase. We have researched hundreds of brands and picked the top brands of l-lysine supplements, including NOW Foods, Nature Made, Pure Encapsulations, Bronson, Nutricost. The seller of top 1 product has received honest feedback from 385 consumers with an average rating of 4.7.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.

L-Lysine Supplements Comparison Table

#TOP1
#TOP2
#TOP3
#TOP4
#TOP5
#TOP6
#TOP7
#TOP8
#TOP9
#TOP10
Brand NOW Foods Nature Made Pure Encapsulations NOW Foods Bronson Nutricost THORNE Quantum Health SOLGAR Vimergy
Flavor Unflavored Unflavored Unflavoured Unflavored Garlic Unflavored Unflavored No Flavour Unflavored Unflavored
Unit Count 100 Count 60 Count 90.00 Count 250 Count 90.0 Count 500 Count 60.0 Count 180 Count 250 Count 270.00 Count
Item Form Tablet Tablet Capsule Tablet Capsule Capsule Capsule Tablet Tablet Capsule
Item Weight 0.31 Pounds 4.64 ounces 0.18 Pounds 0.25 Kilograms - 14.8 Ounces 500 Milligrams 0.04 Pounds 1.5 Pounds 0.26 Kilograms
Product Benefits Immune Support Energy Management Hypoallergenic Immune Support Replenishing - Bone & Joint Support Immune Support, Lip Health, Collagen Growth, Cholesterol Management, Energy Management Blemishes Treatment Immune Support
Item dimensions L x W x H 2.5 x 2.5 x 4.44 inches 2 x 1 x 3 inches 3.9 x 2.1 x 2.1 inches 2.81 x 2.81 x 5.13 inches - - 2.09 x 2.09 x 3.72 inches 2.62 x 2.62 x 5 inches 3.36 x 3.36 x 6.06 inches 6.25 x 3 x 3 inches
Diet Type Vegetarian, Kosher, Vegan Plant Based - Gluten Free Gluten Free Gluten Free - Plant Based Gluten Free -
Special Ingredients Amino Acid, Collagen, L-Carnitine Amino Acid, Collagen - - Ascorbic Acid L-Lysine - Vitamin C (as Ascorbic Acid) 100 mg, Calcium (Dicalcium Phosphate, Calcium Stearate) 29 mg, L-Lysine (as L-Lysine Hydrochloride) 1,500 mg, Garlic Bulb (Allium Sativum) P.E. 3:1 Deodorized 3500 ppm Allicin 200 mg, Echinacea Whole Plant (Echinacea purpurea) P.E. 4:1 100 mg, Propolis P.E. 2:1 25 mg, Licorice Root (Glycyrrhiza Glabra) P.E. 4:1 15 mg, Cellulose, Stearic Acid, Silicon Dioxide, Sodium Hydroxycellulose, Cellulose Coating (HPMC), Natural Colorants. L-Lysine -
Age Range (Description) - - Adult Adult Adult Adult Adult - - Adult
Primary Supplement Type multivitamin Vitamin - Calcium - - - Vitamin C protein -
FTB Score
ftb score rating icon 9.8
ftb score rating icon 9.7
ftb score rating icon 9.5
ftb score rating icon 9.3
ftb score rating icon 9.1
ftb score rating icon 9.1
ftb score rating icon 9.1
ftb score rating icon 9.0
ftb score rating icon 8.9
ftb score rating icon 8.7
Where to Buy