Best L-Lysine Supplements of 2026

"I've added L-Lysine to my daily routine and have definitely noticed fewer cold sore outbreaks and a boost to my immune system. The tablets are gentle on my stomach, and my skin appears clearer and healthier. The only challenge is the large pill size, but I'll keep using it for the great results."

"As someone who takes multiple supplements, I chose this after researching the brand. NOW's L-Lysine offers excellent potency and value, making it one of the best options for daily use. The tablets are large but tasteless and odorless, and I haven't had any cold sore issues since starting them."

"For over a year, I've relied on NOW Foods L-Lysine 1,000 mg Double Strength to support my digestive and overall wellness. I trust the quality, and the supplement has been a solid addition to my health regimen. The pill size might be daunting for some, but the benefits are worth it."

"Since I started taking these, I've noticed far fewer cold sore outbreaks and an overall improvement in my immune health. I like that the tablets are easy to swallow, have no strange aftertaste, and contain clean, high-quality ingredients. The price is right and the dosage per pill means I don’t have to take more than one daily. Highly recommend for cold sore prevention and immune support!"

"I’ve always struggled with canker sores and cold sores, but after incorporating this supplement into my daily routine, I found real relief. Whenever I feel a sore coming on, I slightly adjust my dose and it helps tremendously. The value is great and I don’t notice any strong smell. Yes, the pills are pretty big, but crushing them up works well for me."

"I started using this during my workout periods and was amazed at the results—quick recovery, little to no muscle soreness, and no pain. The pill is on the larger side, but there’s no taste or smell, so it’s easy enough to manage. This product is truly incredible for muscle recovery!"

"I've made this supplement a consistent part of my routine because it helps support my immune system and keeps my lips and gums healthy. The capsules are vegan, hypoallergenic, and easy to take, which is great since I have dietary sensitivities."

"When I feel a cold coming on or get that tingle before a cold sore, I take these and notice quick relief. In my experience, they're effective for preventing cold sores and boosting immunity. Pure Encapsulations is a brand I trust for quality and thorough testing."

"After switching from large tablets to these capsules, I found them much easier to swallow and gentle on my stomach. As someone on multiple medications, this really helps reduce pill burden. The product is non-GMO, vegan, and made with carefully sourced ingredients, which gives me peace of mind."

"I've been using this supplement for almost a year, taking three pills a day, and haven't had a single cold sore in that time—even with all my usual triggers. When I did feel a tingle, it never turned into a full outbreak. There's only a faint garlic scent, which I don't mind at all."

"This product has truly been a life changer for me. I used to get bad cold sores every month, but after taking one tablet daily for a few months, the frequency and severity dropped dramatically. In my experience, it’s best to stick with it for a while to see real results."

"I started taking these for recurring canker sores and noticed a big reduction in both how often I get them and how painful they are. Plus, I’m bitten by mosquitoes much less now, possibly thanks to the garlic! The tablets do have a garlic smell, and taking three at once can be a lot, but the results are worth it."

"As someone prone to cold sores, I have to say this product is absolutely magical. If I sense a cold sore coming, I take three pills three times a day, and it stops it in its tracks. Since discovering these, I’ve only had a cold sore when I forgot them on vacation. My skin even looks clearer when I’m using them. I’ve tried over five types of L-lysine, and this is by far the best."

"I work closely with people daily, so I started taking this supplement two months ago. It has helped my immune defenses and seems to shorten sickness. I really feel it’s a great addition to my diet. Highly recommend for staying healthy!"

"I appreciate that this supplement combines lysine, vitamin C, garlic, zinc, and olive leaf extract—all great for immunity and even for keeping arteries healthy. I take one pill two or three times a day, spaced with meals. Good stuff, might even switch to a subscription."

"I appreciate that these capsules are easy to swallow and have made a noticeable difference for me. They've definitely helped a bunch."

"After using this supplement, I noticed improved immunity and felt more rested. I read about the brand and found their products to be high quality."

"These lysine capsules are my go-to for preventing cold sores. They're hard to find in capsule form at a good price, but these are convenient and much easier to digest than tablets. I keep coming back for more!"

"I've been using this L-Lysine supplement for several months, and the reduction in my cold sores has been amazing. The 1000mg tablets are easy to take, and I love that one bottle lasts for months. Solgar's reputation for quality is clear, and the tablets stay fresh thanks to the well-sealed bottle. I trust this brand for reliable results."

"As someone who needs lysine for overall health and to prevent canker sores, these vegan capsules have been a real lifesaver. I have a big family to care for, so the quantity is perfect. I've only had issues once, when my immune system was down, but otherwise, I haven't had any problems with canker sores since starting this."

"While I appreciate the high quality and potency of this brand, I do find the tablets a bit too big for easy swallowing. I'm on the lookout for a smaller or capsule alternative that would be easier to take, but the effectiveness of these tablets is undeniable."

"I've always been interested in simple wellness solutions, so I tried Nutricost L‑Lysine 1000 mg. After a few months, I can say it's a straightforward supplement with no unnecessary additives—just pure L-lysine in a clean capsule. I've noticed fewer cold sores and better immune resilience, especially when I'm stressed or traveling. The bottle is long-lasting and easy to fit into my daily routine. I recommend it if you want something plant-based for overall wellness, but don't expect miracle results overnight."

"I started using these L-Lysine capsules three years ago, and since then, my cystic acne has almost disappeared. My skin looks much healthier, and I rarely get breakouts now. The capsules are easy to swallow and don't have any unpleasant taste."

"The health benefits are great and the capsules aren't too big—they go down easily. 1000mg per serving is perfect for me, and I really appreciate the affordable price."

"I've found that taking this Lysine supplement speeds up healing for mouth sores and really helps with chapped lips. The 500mg tablets are so much easier to swallow than the larger ones, and I've never had any side effects."

"After suffering from cold sores for years, I started using Lysine based on a chemist's advice. Since adding it to my routine, the frequency and severity of my outbreaks have dropped dramatically, and even the scabs are less noticeable. I recommend it to anyone dealing with similar issues."

"I bought Lysine to see if it could help with my cracked lips, especially during Colorado winters. It worked perfectly—I haven't had any issues since I started taking it."

"I started using this supplement for my cold sores and was amazed at how quickly it worked. My healing time was cut in half—from 10 days to just 5. The pill doesn’t have any taste, which is great, and although it’s a bit big, I don’t have trouble swallowing it. Absolutely worth every penny!"

"After struggling with painful and frequent cold sores for years, I began taking 1000mg every morning. I haven’t had a single outbreak since. I’ve even recommended it to my family, and they’ve had the same success. Highly recommend this for anyone dealing with cold sores."

"This supplement is an easy way to support my diet. I just take one pill daily, and it really helped relieve my symptoms. Works exactly as described—thank you, I’ll be ordering again!"