Best 5-HTP Supplements of 2025

"I've used 5-HTP for years, and this product is the best. Taking it about 30 minutes before bed helps me fall asleep quickly. The quality is excellent, and it's very cost-effective. It also aids with appetite and anxiety, and I can take an extra capsule during the day without feeling drowsy."

"When I started taking Nutricost 5-HTP a few weeks ago, I noticed a significant improvement in my mood and sleep. It helps me feel more balanced and calm throughout the day, and I've experienced better sleep patterns. With 240 capsules in the bottle, it offers great value for such a high-quality, vegetarian supplement. I highly recommend it for anyone wanting to enhance their mental well-being and sleep quality."

"Initially skeptical about 5-HTP, I'm thrilled I gave it a shot. Since starting, I've felt much happier and less irritable. I take 100 mg in the morning after eating and another later if needed. It's hard to tell if the effects are from the supplement or placebo, but it works! Just a reminder: consult your doctor if you're on other medications, as it can affect your neuro-chemistry. Overall, a 10/10 experience!"

"This is my first review on Amazon, and I'm only writing it because this product worked astonishingly well. I initially sought it for my anxiety, and it delivered. I recommend taking 60mg instead of 100mg to avoid foggy cognition, and I found my mood improved significantly at this lower dose. Additionally, when combined with melatonin, the supplement was better absorbed and utilized by my body. Feel free to ask me about any synergistic combinations."

"I've been using this product for over a week, and I've already noticed improvements. I take it with GABA at night, and it has helped me stay asleep longer and fall back asleep more easily when I wake up. I plan to continue using it and believe it’s beneficial."

"After a month of use, I found this mix fantastic for my ADHD. I've gained more energy and lost 8 pounds without trying! My family even noticed me singing again. I’ve created a stack that works for me: Gotu Cola in the morning, True Focus after breakfast, and 5-HTP after dinner. It's life-changing!"

"I'm always searching for ways to streamline my supplements. This combination has truly made a difference in my mood and focus. I keep coming back for more!"

"After taking this for six months, I've noticed a significant change in my sharpness throughout the day. It's a great alternative for those wanting an edge without prescription medications."

"I started taking this with my morning medications and after a few weeks, my mood improved and I began to lose weight. I now sleep through the night and feel like it's given my body the boost it needed!"

"I've been using 5-HTP for about three years now and have never felt better. At 60 years old, I take two 100 mg tablets every night with magnesium and feel like I sleep like an infant. My mental health is steadier than ever, and I plan to stick with this product."

"After struggling with insomnia for years, I finally tried 5-HTP as a last resort. It took a month of taking 4-6 pills daily, but now I can sleep for 4-5 hours straight, which feels miraculous. It's the first thing that has actually worked for me!"

"As a retired healthcare provider, I can confidently say that this 5-HTP works effectively, even replacing previous prescription medications for my family member. This brand delivers excellent results, and we've switched to their products for other needs as well."

"I've been taking 5-HTP by the NOW brand for about six months at night. It really helps me relax and calms my nervous system. I notice a significant difference in my mood when I skip it. My thoughts feel calmer, too. I recommend this product after doing your research on what works best for your mental health."

"This is my first experience with 5-HTP for sleep, and I've noticed a remarkable improvement. My sleep onset is quicker, and I recall having vivid, memorable dreams. I’m not sure if the improvement is solely from this or from the GABA supplement I’m taking alongside it, but research indicates a combined effect. I did experience some mild stomach upset initially, but adjusting the dosage solved that issue."

"I’m thrilled with the Now Double Strength 5-HTP! The 200 mg per capsule is perfect for me, and the 120-capsule package offers excellent value. I initially wanted a time-released option but decided to try this based on positive reviews. Taking it after a meal works wonderfully for me, keeping me balanced and focused throughout the day. I highly recommend it!"

"I’ve struggled with depression and anxiety since my brain injury at 10. After trying multiple prescriptions with no positive results, I found this 5-HTP Plus product. On the first day, I felt a noticeable improvement in my mood and energy. My coworkers even noticed a positive change in my demeanor! I still experience some anxiety, but this supplement has made it much easier to cope."

"As a 25-year-old dealing with anxiety and stress, I decided to try this 5-HTP supplement. Within 5-6 days, I felt a significant difference! My anxiety was more manageable, and I experienced better sleep. I appreciate that the ingredients are high-quality and easy to take. This product has truly helped me feel more in control of my mental health!"

"I have incorporated the DR EMIL NUTRITION 5-HTP Plus into my daily routine. It has truly become essential for me, promoting restorative sleep and improving my mood. The combination of SAM-e and Vitamin B6 is fantastic. Plus, it’s vegan-friendly! I wholeheartedly recommend this supplement to anyone looking to enhance their overall wellness."

"Pure Encapsulations 5-HTP 100 mg has been my go-to supplement for well-being. Its arrival was a relief during tough times, especially after a stressful experience with an Amazon return. I've turned back to this supplement, along with another, and it has truly provided comfort. I consistently recommend Pure Encapsulations for their commitment to high-quality products. Relying on their 5-HTP is a blessing, particularly when facing challenges."

"I can't believe how much better I feel now! After spending years on Zoloft and Lexapro with various side effects, I discovered this miracle pill. Just 50 mg in the morning has transformed my mood and energy. I wish I had known about this supplement sooner! It's worth every penny. I advise starting with 50 mg and gradually increasing if needed, but avoid mixing it with antidepressants to prevent serious complications."

"I've been using Pure 5-HTP at night along with GABA 750, and it has significantly improved my sleep quality. When I ran out and forgot to reorder, I quickly noticed my energy levels plummeting. Now, I'm on auto-ship because it seems to take some time to build up in my system. So, don’t give up after just a few days!"

"I read that GABA, B6, tryptophan, and magnesium help with sleep, so I decided to try it. Since starting this combination, I’ve noticed that I am sleeping more soundly."

"This product was just what I was looking for. I had previously bought the individual amino acids and minerals separately, but it was tricky to find the right dosage. After taking a chance on this product, I was amazed! It really works! I recommend taking it an hour before bed to feel sleepy. I also noticed a better attitude in the morning!"

"I've been using several Clean Nutra supplements for a few months and can definitely feel positive changes. Though I wish they offered 90-day bottles to cut down on plastic waste."

"I've added this supplement to my routine, and I've noticed deeper sleep and I feel great in the morning. I take it 30 minutes before bed, and I can feel it kick in quickly. While I've also increased my Vitamin D intake and started drinking yerba mate, I attribute the improved sleep directly to 5-HTP. I'm grateful for all the information available and the reviews that helped me make my purchase."

"For me, this product is a must-have! My anxiety levels have significantly decreased to virtually nothing since I started taking this supplement. After being on a pharmaceutical medication that I didn't like, I discovered 5-HTP through my husband, who heard about it from Joe Rogan. It didn't work for him, but once I tried it, I immediately knew it was the key for me."

"I've been using NOW Foods 5-HTP for a couple of months now, and I can honestly say it’s made a noticeable difference in my daily life. My mood feels more balanced, and I handle stress much better. I love that these capsules are vegan and made by a trusted brand. The 100 mg dosage is perfect for me, and the quality is consistent with every bottle. If you're looking for a natural way to support your neurotransmitters and improve well-being, I highly recommend giving this a try!"

"I've been using 5HTP for years and found this formulation at a much better price. After trying it last year, I've continued using it since. It’s very effective compared to the pills I was taking."

"This liquid HTP 5 formula seems to absorb quickly. It helps me induce sleep or just relax. I’ve noticed interesting dreams too. Overall, it’s great value for the money."

"I've struggled with sleep for years, especially due to perimenopause. Taking around 200mg two hours before bed really helps me get back to sleep after waking up. I find it much more effective than 5HTP pills. My only complaint is that it’s very expensive. I often need to buy it weekly."