Best 5-HTP Supplements of 2026

"Since I started using this supplement, I've noticed my racing thoughts at night have decreased and my overall sleep quality has gotten better. The capsules don't leave any bad taste and actually help with my focus during the day. They're not the cheapest option, but I definitely feel like the results justify the cost."

"After about a week of taking Clean Neutroceuticals GABA 750mg, I felt more centered and focused, with less mental clutter. It doesn't make me tired, just gives me a steady sense of calm that makes it easier to finish what I start. I also like that the capsules are easy to swallow and have no weird fillers. For anyone who deals with stress or trouble concentrating, this has become one of my favorite tools for clarity and productivity."

"I take this blend in the evening and it gradually helps me relax before bed, especially when paired with my melatonin. My sleep has noticeably improved, and I find it helps me wind down without any grogginess."

"After taking this 5-HTP supplement daily for two months, I've noticed a remarkable improvement in my mood, decreased stress, and more restful sleep. When combined with magnesium glycinate, the results are even better. Both supplements are clean, vegan, and easy on my stomach. This pairing has become a staple in my wellness routine."

"Taking NOW Foods 5-HTP before bed has truly been a game-changer for my nightly routine. I fall asleep faster, feel more relaxed, and wake up refreshed—without the grogginess I get from other sleep aids. I also appreciate that it calms my mind and relieves evening stress. The bottle lasts a long time and offers great value."

"I started this supplement to boost my general well-being and quickly felt calmer, more centered, and in a better mood overall. It's become my go-to for natural neurotransmitter support, and I highly recommend it for both quality and effectiveness."

"I've found this 5-HTP supplement to be a fantastic value, especially considering the high potency and generous quantity. The capsules are easy to take, and I appreciate that they're non-GMO and gluten-free, which gives me confidence about their quality. I've noticed a clear improvement in my mood and sleep since starting this product. Nutricost has become a brand I trust, and I'll definitely be buying this bottle again."

"After doing some research, I realized that what I eat with 5-HTP makes a big difference in how it affects me. Taking it with a carb-rich snack gives me a noticeable energy boost for hours and helps my mood and productivity—it even contributed to me becoming employee of the month! Just a heads up: if I take it on an empty stomach, I feel pretty nauseous for a while, so I make sure to have a small snack. Sometimes I think the effects vary depending on the bottle, maybe due to storage or shipping, but overall when it works, it's a real game-changer for me."

"At first I was skeptical about 5-HTP, but since I started taking it, I've felt happier and less irritable. It's even made me walk with more confidence and better posture. I take a 100 mg pill in the morning after eating, and sometimes another in the afternoon if I need it. Whether it's placebo or not, the positive effect is real for me. I do advise anyone interested to start with a low dose and be cautious if on other medications, but for me, it's been a 10/10 experience."

"I've added this L-theanine supplement to my daily routine and it's been a huge help for promoting calm and focus. The effect is gentle but noticeable, and it's really enhanced my sense of well-being. No grogginess or dullness—just a clear, relaxed mind."

"As someone with a high-pressure job, this product is fantastic for taking the edge off without making me tired or unfocused. It's also helped me sleep better at night and get back to sleep if I wake up. I've bought it several times now and really appreciate the support it gives during stressful times."

"I've struggled with insomnia and racing thoughts for weeks, and nothing else—not even my prescription sleep aid—worked until I tried this. With just one or two chewables, I was finally able to fall asleep and stay asleep. The taste is pleasant and it's easy to take, though a bit pricey. It truly quiets my mind."

"I've found this supplement to be calming without making me tired. The unique blend, especially with htp5 and lion's mane, gives me a nice edge and a really clean feel."

"After events where I'm highly stimulated, I use this and notice it helps me recover and re-balance my brain chemistry. It's made a big difference in how I feel after busy days."

"For the past two weeks, this product has helped me sleep better with fewer interruptions at night. I'm also observing other potential benefits, like some relief in joint pain. I plan to purchase again to confirm the results."

"I've struggled with hormonal acne since middle school and tried almost everything except Accutane. After using this product for about a month, I noticed a significant improvement in just a few weeks. My skin is the clearest it's been in years, and I'm definitely planning to repurchase!"

"I bought this for my daughter, who is 20, and she's seen a noticeable difference in her skin—less acne and much smoother texture."

"After trying countless products for my acne as a teenager, I started this supplement about six weeks ago. The results have been amazing—my skin looks better than ever, and even my acne marks are fading."

"After years of struggling with stress and sleep deprivation, I finally found something that works. I take Thorne’s 5-HTP before bed and now fall asleep quickly and wake up refreshed—no more snoozing my alarm. Even my boss has noticed my punctuality!"

"Tapering off Cymbalta was incredibly hard for me, but Thorne’s 5-HTP made a huge difference. It’s the best 5-HTP I’ve tried, probably thanks to the methylated B-6. My son also takes it for depression and anxiety—when he’s consistent, his mood is so much better."

"I’ve dealt with insomnia for years and tried everything—nothing worked until I tried this. With Thorne’s 5-HTP, I can sleep several hours straight and dream again. It’s a miracle for my sleep quality, though I wish it was less expensive since I go through bottles quickly."

"After adding this supplement to my daily routine, I've noticed a significant boost in my mood, reduced stress levels, and much better sleep. The combination of 5-HTP and SAM-e truly makes a difference for my overall well-being. I appreciate that the ingredients are natural and the labeling is transparent, which helps me trust what I'm taking. The capsules are easy to swallow and consistently deliver results. I feel confident recommending this to anyone seeking emotional and mental balance."

"Whenever I include these in my vitamin regimen, I get compliments on my appearance, especially my longer lashes and glowing skin. They've never upset my stomach, and there's no noticeable taste. I plan to resume taking them after my pregnancy, as I've clearly seen improvements in my skin and hair."

"I've struggled for years with depression and anxiety, trying various medications that often left me with insomnia and exhaustion. Since trying this product, I've experienced better energy, improved focus, and a more stable mood—even my coworkers and roommates have noticed the difference. I still have some tough days, but this supplement has made them much more manageable. I highly recommend it to anyone feeling overwhelmed by life's challenges."

"I purchased these for my elderly husband who was starting to forget things, and I’ve genuinely noticed his memory has sharpened. They’re easy to take, don’t taste bad, and aren’t too big. His health feels on track since starting this supplement—he’s now reminding me of things! I’m planning to try them myself because the improvement has been so clear."

"After dealing with memory issues in my 60s, I tried this supplement and within about a week and a half, the mental cloudiness lifted and I became much more aware of details again. I’d highly recommend this to anyone feeling forgetful."

"When I needed to cram for a major insurance exam, I was desperate for something to help my focus and memory. While I didn’t feel an instant rush, I ended up acing the test with a 94—the highest score the proctor had seen. Given my struggles with cognitive issues, I’m convinced this made a real difference. For the price, it’s worth a shot if you want to boost your memory."

"I've noticed that the liquid 5-HTP is more effective and faster-acting than capsules I've tried in the past. One dose helps me relax and fall asleep quickly, and the mild mint flavor makes it easy to take. I appreciate how easy it is to adjust the amount with the dropper, but I did feel a little queasy when I took too much, so following the directions is important."

"Because I have a circadian rhythm disorder and can't handle melatonin, this has been a game-changer for my nighttime routine. I started low and increased my dose, and felt the benefits on my sleep and mood almost immediately. It's helped me feel more productive and get outside each morning, and the flavor is pleasant. The dropper is convenient, even if the measurement markings aren't perfect."

"I was looking for something calming without making me groggy, and this is definitely it. Even though I'm not a mint fan, the taste is gentle and enjoyable. My sleep has improved and I don't feel drowsy the next day. I've been recommending it to my friends because it really works for me."