Best Gluten-Free 5-HTP Supplements of 2026

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 23, 2026

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Gluten-free 5-HTP supplements are a great option for individuals who are looking to improve their mood and reduce symptoms of anxiety and depression without consuming gluten. These supplements are made from the natural amino acid 5-HTP, which is a precursor to serotonin, a neurotransmitter that regulates mood and sleep. By increasing serotonin levels in the brain, 5-HTP supplements can help to alleviate symptoms of depression and anxiety. Additionally, these supplements are gluten-free, making them a safe and effective option for individuals with celiac disease or gluten intolerance. Overall, gluten-free 5-HTP supplements are a natural and safe way to support mental health and wellbeing.

At a Glance: Our Top Picks

Nutricost 5-HTP Supplement Cover #TOP 1
Nutricost 5-HTP Supplement
ftb score rating icon 9.8
Life Extension L-Theanine, 100mg, 60 Veg Capsules Cover #TOP 2
Life Extension L-Theanine, 100mg, 60 Veg Capsules
ftb score rating icon 9.7
Doctor's Best L-Theanine Cover #TOP 3
Doctor's Best L-Theanine
ftb score rating icon 9.5

Top 10 Gluten-Free 5-HTP Supplements

#TOP 1

Nutricost 5-HTP Supplement

NC-5HTP200-120C
Nutricost 5-HTP Supplement Cover
Nutricost 5-HTP 200mg, 120 Vegetarian Capsules (5-Hydroxytryptophan) - Non-GMO & Gluten Free

The Nutricost 5-HTP Supplement is a high-quality vegetarian and non-GMO supplement that contains 200mg of 5-HTP per capsule. With 120 servings per bottle, this supplement is perfect for those looking to supplement their needs. It is produced in a GMP-compliant and FDA-registered facility, and each batch is tested by independent, ISO-accredited laboratories. This supplement is great for those looking to improve their mood, sleep, and overall well-being.

What We Like
Noticeable mood improvement
Supports sleep quality
High value for price
Non-GMO and gluten-free
Easy to swallow capsules
#TOP 2

Life Extension L-Theanine, 100mg, 60 Veg Capsules

01683
Off White
Life Extension L-Theanine, 100mg, 60 Veg Capsules Cover
Life Extension L-Theanine, Amino Acid theanine, Calm, Relaxation, Mood, Gluten-Free, Non-GMO, Vegetarian, 200 mg, 60 Capsules

Life Extension L-Theanine promotes relaxation, calmness, and mood enhancement. Its main ingredient is an amino acid derived from tea that modulates the formation of neurotransmitters GABA, dopamine, and serotonin, which regulate mood and stress levels. Its calming effects encourage brainwave patterns similar to meditation and massage. The product is non-GMO, gluten-free and manufactured in the USA. It is developed using the latest scientific findings and formulated to achieve maximum bioavailability and efficacy.

What We Like
Promotes relaxation and calmness
Encourages brainwave patterns similar to meditation and massage
Non-GMO, gluten-free, and manufactured in the USA
#TOP 3

Doctor's Best L-Theanine

DRB-00197
No Color
Doctor's Best L-Theanine Cover
Doctor's Best L-Theanine Contains Suntheanine, Helps Reduce Stress & Sleep, Non-GMO, Gluten Free, Vegan, 150 mg (DRB-00197), 90 Count

Doctor's Best L-Theanine is a high-quality supplement that contains Suntheanine, a pure form of L-Theanine. L-Theanine is known for its ability to promote a healthy mood and a relaxed state while maintaining daytime alertness. This amino acid found naturally in tea supports relaxation, focus, and memory without causing drowsiness. It also supports brain health by enhancing cognitive performance and alertness. Additionally, L-Theanine may help improve the quality of sleep, concentration, and learning performance. With its ability to reduce stress and support mental tranquility, Doctor's Best L-Theanine is a great addition to your daily routine.

What We Like
Promotes relaxation and a healthy mood
Enhances cognitive performance and alertness
Supports healthy stress response and memory
#TOP 4

CLEARSTEM MINDBODYSKIN Hormonal Acne Supplement

CLEARSTEM MINDBODYSKIN Hormonal Acne Supplement Cover
CLEARSTEM - MINDBODYSKIN Hormonal Acne Supplement (5-HTP) - Natural DIM Supplement - Skin Care Vitamins - Hormone Balance, Antioxidants - Gluten Free, Cruelty Free - 30 Servings, 90 Capsules

CLEARSTEM Acne Support is designed to help you manage acne naturally by targeting multiple causes at once. It works to calm and clear your skin by addressing oil production, digestion, detox, stress, PMS, and hormone balance. This supplement also supports your immune system, improves digestion, and aids liver function, which can help prevent future breakouts. With ingredients like DIM, vitamins, antioxidants, and digestive enzymes, it promotes overall skin health and hormone regulation. For best results, take 2-3 capsules with meals, and you may notice clearer skin within a week or two.

What We Like
Clearer, smoother skin
Helps reduce acne
Fades acne scars
Improvement for hormonal acne

Thorne 5-HTP - Serotonin Support for Sleep and Stress - 90 Capsules

SA503-R
Thorne 5-HTP - Serotonin Support for Sleep and Stress - 90 Capsules Cover
THORNE - 5-HTP (Formerly 5-Hydroxytryptophan) - Contains Vitamin B6 - Serotonin Support for Sleep and Stress Management* - Gluten, Dairy & Soy-Free - 90 Capsules

The Thorne 5-HTP supplement is a great addition to your daily routine. This supplement offers support for restful sleep, nutritional support for stress, helps decrease sugar cravings, and supports a healthy outlook. With Thorne being chosen by champions and trusted by 100+ pro teams, it's no wonder they are the only supplement manufacturer to collaborate with Mayo Clinic on wellness research and content. This supplement also offers hypoallergenic benefits and is perfect for adults looking for a natural solution to support their sleep and stress management.

What We Like
Improved sleep quality
Stress and mood support
No morning grogginess
High product purity
Trusted brand reputation
#TOP 6

NOW Supplements 5-HTP 100mg Veg Capsules

0106
Beige
NOW Supplements 5-HTP 100mg Veg Capsules Cover
NOW Supplements, 5-HTP (5-hydroxytryptophan) 100 mg, Neurotransmitter Support*, 120 Veg Capsules

Improve your mood and relaxation with the NOW Supplements 5-HTP 100mg Veg Capsules, which are vegan and support the production of serotonin in the brain and central nervous system. These capsules can impact sleep, mood, appetite, and body temperature. The Griffonia Simplicifolia extract in these capsules helps to extract the intermediate metabolite between the amino acid L-tryptophan and serotonin. The product is GMP Quality Assured, non-GMO, and packaged in the USA by a family-owned company since 1968.

What We Like
Improved mood balance
Supports restful sleep
Reduces stress and anxiety
Vegan-friendly ingredients
Gentle on the stomach
#TOP 7

RediCalm - Natural Stress Relief Supplement - Non-GMO, Vegan

RediCalm
748252215192
RediCalm - Natural Stress Relief Supplement - Non-GMO, Vegan Cover
RediCalm - Natural Stress Relief Supplement - Non-GMO, Vegan, Gluten-Free

Features
Made In The USA: Every Bottle Of RediCalm Is Bottled At An GMP-Certified Facility In New York.
Natural Ingredients: Each Of The 5 Natural Ingredients In The RediCalm Formula Has Been Scientifically Shown To Provide Relief From Stress.
Non-GMO Vegan Gluten-Free 30 Vegetable Capsules
#TOP 8

Horbaach 5HTP 200mg Capsules

CL3963
Horbaach 5HTP 200mg Capsules Cover
Horbäach 5HTP 200mg Supplement | 180 Capsules | 5 Hydroxytryptophan | Griffonia Simplicifolia | Extra Strength | Non-GMO, Gluten Free

Horbaach 5HTP Capsules is a high-strength supplement that provides maximum support for your well-being. Each serving delivers 200mg of 5-HTP, a nutrient produced in the body from L-Tryptophan. With quick-release capsules made from seed extract, this professionally crafted supplement ensures purity and potency. Horbaach, a trusted brand, guarantees laboratory tested, superior quality ingredients. The 5HTP Capsules are naturally free of gluten, wheat, yeast, milk, lactose, soy, artificial color, and flavor, making it suitable for those with dietary restrictions. Improve your overall health and experience the benefits of 5-HTP with Horbaach 5HTP Capsules.

What We Like
Extra strength
Quick-release capsules
Trusted brand

DR EMIL NUTRITION 200 MG 5-HTP Plus Formula

850002956207
No Color
DR EMIL NUTRITION 200 MG 5-HTP Plus Formula Cover
DR. EMIL NUTRITION 200 MG 5-HTP Plus with SAM-e to Maintain Normal Healthy Sleep and Create a Sense of Wellbeing - 5HTP Supplement with Vitamin B6-60 Vegan Capsules, 30 Servings

The DR EMIL NUTRITION 200 MG 5-HTP Plus Formula is a natural supplement that supports mood, stress, and sleep. This formula contains 200mg of pure 5-HTP supplemented with 20mg of SAMe and 20mg of L Tryptophan to optimize 5-HTP conversion and support stress levels in the body. It also contains vitamin B6 for improved 5-HTP conversion. Vitamin B6 has been shown to aid 5-HTP conversion, and this formula has enough to ensure efficacy. This product is vegan and promotes calm and relaxation, making it a natural way to support a calm and relaxed mood by supporting 5-HTP conversion in the body.

What We Like
Mood and stress improvement
Better sleep quality
Natural, high-quality ingredients
Easy-to-swallow capsules
Visible skin and hair benefits
#TOP 10

5HTP Liquid Drops for Mood, Sleep, and Relaxation

DW5HTP
2 Fl Oz (Pack of 1)
5HTP Liquid Drops for Mood, Sleep, and Relaxation Cover
5HTP Liquid Drops - More Absorbable and Effective Than 5 HTP Capsules (60 Servings of 50mg 99%+ 5-HTP) Serotonin Supplement for Mood, Sleep, and Relaxation by Double Wood

Double Wood's 5HTP Liquid Drops are a unique and effective serotonin supplement that is more absorbable than encapsulated 5 HTP products. With over 99% 5-HTP, Double Wood offers the first maximum absorption 5 HTP drops. This product may help support mood and nighttime relaxation. A bottle contains 60 servings of our 5 HTP supplement per bottle in a convenient dropped format, which is a two-month supply. The 5 HTP drops capsules are manufactured and tested in the USA, Gluten-Free, and Non-GMO.

What We Like
Fast-acting sleep support
Mild, pleasant mint flavor
Adjustable dosage dropper
Improves mood and relaxation
No grogginess or drowsiness
Buying Guide Image

Frequently Asked Questions (FAQs)

1. Who should not take 5-HTP?

People with high blood pressure or diabetes should talk to their doctor before taking 5-HTP. If you take antidepressants, you should not take 5-HTP (see "Possible Interactions" section). People with liver disease, pregnant women, and women who are breastfeeding should not take 5-HTP.

2. Is Natrol 5-HTP gluten free?

Natrol 5-HTP TR is 100% vegetarian and has a controlled delivery system that releases 5-HTP slowly and then steadily over a period of 15 hours. No yeast, wheat, corn, milk, egg, soy, glutens, artificial colors or flavors, added sugar, starch or preservatives.

3. When should you not take 5-HTP?

Do not take 5-HTP if you're taking other medications that increase serotonin levels, such as antidepressants like SSRIs and MAO inhibitors. Use caution when taking carbidopa, a medication for Parkinson's disease. 5-HTP is not recommended for people with Down syndrome, as it has been linked to seizures.

Editor's Notes

During our gluten-free 5-htp supplement research, we found 24 gluten-free 5-htp supplement products and shortlisted 10 quality products. We collected and analyzed 387,527 customer reviews through our big data system to write the gluten-free 5-htp supplements list. We found that most customers choose gluten-free 5-htp supplements with an average price of $21.28.

The gluten-free 5-htp supplements are available for purchase. We have researched hundreds of brands and picked the top brands of gluten-free 5-htp supplements, including Nutricost, Life Extension, Doctor's BEST, CLEARSTEM, THORNE. The seller of top 1 product has received honest feedback from 33,435 consumers with an average rating of 4.9.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.