Best Natural 5-HTP Supplements of 2025

NatureWise 5-HTP Plus+ is a plant-based supplement that helps promote healthy eating habits, particularly carbs and sugars, which can aid in maintaining a healthy diet. It delivers a potent 200 mg dose of 5-HTP enhanced with vitamin B6 for better absorption and effectiveness. The delayed release capsules are easier on the stomach, minimizing discomfort that higher doses of 5-HTP can cause. Our supplement is naturally derived from the seeds of the Griffonia plant, and is non-GMO, gluten-free, vegan, and contains no artificial fillers. Some studies have suggested that 5-HTP may have a role in promoting a healthy weight by supporting cravings habits.

Nested Naturals Vegan 5-HTP 100mg Capsules are a great supplement to promote healthy serotonin levels, positive moods, and better sleep. By supporting healthy levels of serotonin, it helps improve the quality of sleep, and maintain a stable mood throughout the day. It is a socially conscious supplement that is vegan, non-GMO, gluten-free, soy-free, and allergen-free. Nested Naturals also provides a lifetime guarantee, ensuring that customers are satisfied with their purchase.

Best Naturals 5-HTP Capsules are a high-quality supplement designed to support relaxation and restful sleep. Each capsule contains 50 mg of 5-HTP, and the bottle comes with 120 capsules. These capsules have been 3rd party lab tested for purity and quality, ensuring that you are getting a safe and effective product. The Best Naturals 5-HTP Capsules are non-GMO and gluten-free, making them suitable for a variety of dietary needs. They are proudly made in the USA in a GMP compliant, FDA registered facility. Additionally, these capsules contain no artificial color, flavor, sweetener, or preservatives. They are also free from common allergens such as sugar, milk, corn, soy, egg, lactose, gluten, wheat, yeast, and fish. With these capsules, you can enjoy the convenience of a high-quality 5-HTP supplement that supports relaxation and restful sleep.

Triquetra Health’s Organic 5-HTP Capsules are a natural solution to promote a calm and relaxed mood, better quality sleep, and mental cognition. Derived from organic Griffonia Seeds and extracted using the purest water extraction method, this 5-HTP supplement has a 99% purity and concentration of 5-HTP, making it 10 times more potent than other leading 5-HTP products on Amazon. The formula is enhanced with vitamin B6 and organic Lions Mane, aiding in the 5-HTP to serotonin conversion process and cognition enhancement properties, respectively. Each serving of 2 capsules provides 200 mg of 5-HTP and 10 mg of Vitamin B6, clinically validated for effectiveness.

TWINLEAF 5-HTP Supplement is a mood-enhancing supplement made in the USA with a proprietary formula that combines natural compounds 5-HTP and L-tryptophan. The supplement promotes calmness, positive outlook, and energy while also enhancing focus and brain work. It contains no GMOs, gluten, artificial colors, or flavors and is vegan and cruelty-free. The supplement is produced with strict manufacturing control and the highest quality of ingredients from top American scientists and healthcare professionals.

Experience quality rest, improved mood and weight management with Wild & Organic 5-HTP Gummies. These blueberry-flavored chewable gummies contain 5-HTP 200mg, L-tryptophan, and calcium carbonate which may help support the production of serotonin and melatonin to improve sleep, boost mood and reduce stress. It may also aid in weight management by helping balance appetite and reducing excess cravings. The chewable gummies make it easy to take, even for those who have trouble swallowing large pills. And if you're not satisfied, the brand offers a customer satisfaction guarantee.

Clean Nutraceuticals CalmAgain is an advanced all-in-one supplement that combines GABA, L-Theanine, Ashwagandha, 5-HTP, L-Tryptophan, SAM-e, L-Glycine, Vitamin D3, Vitamin B6, Magnesium Glycinate, and L Tyrosine into one convenient solution. With larger dosages of GABA Powder (750mg), L-Theanine (200mg), and 5-HTP (200mg) than other supplements in the market, Clean CalmAgain is a powerful mood support and balance support complex. The product is perfect for those who are looking for a supplement that can help them manage stress, anxiety, and improve their overall mood. Clean CalmAgain is made with vetted and trusted ingredients and is proudly made in the USA in a registered and certified facility.

Dr. Emil 5-HTP Plus is designed to enhance your mood and reduce stress. With 200 mg of pure 5-HTP and 20 mg of SAMe, this supplement helps your body convert 5-HTP more effectively, which can lead to improved emotional well-being. The addition of Vitamin B6 is crucial as it supports this conversion process, ensuring you get the most out of the 5-HTP. This doctor-derived formula promotes a sense of calm and relaxation, making it a natural option for those seeking to manage stress levels without harsh chemicals.

Natural Factors Stress-Relax 5-HTP Caplets are designed to promote emotional well-being through positively affecting serotonin production. The time-release caplets minimize gastric discomfort and optimize absorption for better results. The program offers a comprehensive approach to stress reduction for a healthier, calmer life. The caplets are third-party certified, ensuring purity and potency. Take one caplet 2-3 times daily with meals, slowly increasing the dose over two weeks to minimize gastrointestinal side effects.

NUTRAHARMONY 5HTP Capsules offer a powerful blend designed to enhance your mood and support restful sleep. With 400mg of 5-HTP, this supplement helps you maintain a positive outlook and balance in your daily life. The unique formula also includes Ashwagandha and L-Theanine, which promote relaxation and cognitive function. Additionally, Vitamins B6 and D3 in the mix contribute to overall brain health. Made in the USA with high-quality, globally sourced ingredients, you can trust that each capsule is crafted for your well-being.