Best Zinc Pyrithione Shampoo of 2025

Lisa Bechard Avatar
Lisa Bechard
Last Updated: Jan 17, 2025

* We independently evaluate all recommended products and services. If you click on links we provide, we may receive compensation.

Zinc Pyrithione Shampoo is a popular choice for those suffering from dandruff and other scalp conditions. This shampoo contains an active ingredient called zinc pyrithione, which is known for its anti-fungal and anti-bacterial properties. It helps to eliminate the fungus and bacteria that can cause dandruff, while also reducing inflammation and itching. Zinc Pyrithione Shampoo is gentle enough to use every day, and can help to restore a healthy balance to the scalp, leaving hair looking and feeling clean and refreshed.

At a Glance: Our Top Picks

DermaHarmony 2% Pyrithione Zinc Shampoo Bar Cover #TOP 1
DermaHarmony 2% Pyrithione Zinc Shampoo Bar
ftb score rating icon 9.8
Dove DermaCare Scalp Anti-Dandruff Shampoo Cover #TOP 2
Dove DermaCare Scalp Anti-Dandruff Shampoo
ftb score rating icon 9.7
Selsun Blue Itchy Dry Scalp Anti-dandruff Shampoo Cover #TOP 3
Selsun Blue Itchy Dry Scalp Anti-dandruff Shampoo
ftb score rating icon 9.5

Top 10 Zinc Pyrithione Shampoo

DermaHarmony 2% Pyrithione Zinc Shampoo Bar

SB-DH-ZNP
4 Ounce (Pack of 1)
DermaHarmony 2% Pyrithione Zinc Shampoo Bar Cover
Dermaharmony 2% Pyrithione Zinc Shampoo Bar for dandruff and seborrheic dermatitis - Peppermint (4 Oz)

DermaHarmony 2% Pyrithione Zinc Shampoo Bar is a soap-free bar derived from plant-based surfactants with no animal ingredients. It is 100% SLS free, scented with natural peppermint, and has a pH of 6. It is very mild to the skin and non-drying, and a single bar will last for months with daily use. It is ideal for relief or itching, redness, irritation, scaling and flaking associated seborrheic dermatitis and dandruff.

What We Like
Minimizes plastic waste
Effective against dandruff
Soothes itchy scalp
Long-lasting product
Great scent and lather
What We Don't Like
May strip hair color
Conditioner recommended after use

Dove DermaCare Scalp Anti-Dandruff Shampoo

00079400678881
White
Dove DermaCare Scalp Anti-Dandruff Shampoo Cover
Dove Damage Therapy Derma Shampoo Dryness + Itch for Flaky Scalp with Pyrithione Zinc and Coconut Oil 12 Fl Oz

Dove DermaCare Scalp Anti-Dandruff Shampoo is a mild, pH balanced formula that helps to gently care for hair. It is specifically designed to nourish the dry scalp and relieve it from itchy irritation. The indulgent coconut and shea butter scent gives a luxurious feel, and the active Pyrithione Zinc helps to effectively tackle dandruff and solve dryness and itch experienced by dandruff-prone scalp. It cleanses itchy and dry scalp while leaving hair flake free, smooth and less frizzy.

What We Like
Effective against dandruff
Subtle, pleasant scent
Leaves hair soft and shiny
Moisturizes scalp and hair
Thick and rich consistency
What We Don't Like
Unsealed bottles raise concerns
Price perceived as high
#TOP 3

Selsun Blue Itchy Dry Scalp Anti-dandruff Shampoo

16721731
Blue
Selsun Blue Itchy Dry Scalp Anti-dandruff Shampoo Cover
Selsun Blue Itchy Dry Scalp Anti-Dandruff Shampoo, 11 fl. oz., Extra-Hydrating Formula, Pyrithione Zinc 1%

Selsun Blue Itchy Dry Scalp Anti-dandruff Shampoo is a nourishing and moisturizing shampoo that helps control dandruff and nourish hair. It is formulated with Pyrithione Zinc 1% and is gentle enough for daily use. It helps prevent and eliminate itchy scalp and visible flakes associated with dandruff. It is suitable for all hair types and has a fresh scent.

What We Like
Effective dandruff treatment
Gentle on skin and scalp
Quick results for cradle cap
Thick consistency, little needed
Aromatic and refreshing
What We Don't Like
New formula lacks lather
Availability issues in stores
#TOP 4

Zinc Shampoo for Dandruff Relief, 16oz

DHS
300960729165
Zinc Shampoo for Dandruff Relief, 16oz Cover
Zinc Shampoo, Dhs 16oz

DHS Zinc Shampoo is a dermatologist-recommended solution for fast relief from dandruff and seborrheic dermatitis flare-ups. The gentle and nourishing formula is soothing on your scalp and hair, contains 2% Zinc Pyrithione, is PABA-free and TEA Lauryl Sulfate-free. With instant relief from the first use, this unique formula leaves your hair soft and shiny with no more flakes. Use 3-4 times a week or as directed by your doctor, and pair with DHS Regular or Clear Shampoo on other days to maintain healthy hair.

What We Like
Effective for dandruff relief
Gentle on skin and scalp
Good lather and easy to rinse
Pleasant mild fragrance
Value for money
What We Don't Like
Medicinal smell
Conditioner not effective

Vanicream Medicated Dandruff Shampoo

345334206088
White
8 Fl Oz (Pack of 1)
Vanicream Medicated Dandruff Shampoo Cover
Vanicream Dandruff Shampoo – pH Balanced Mild Formula Effective For All Hair Types and Sensitive Scalps - Free of Fragrance, Lanolin, and Parabens – 8 Fl Oz

Vanicream Medicated Dandruff Shampoo is formulated with maximum over-the-counter strength for the control and reduction of the symptoms for dandruff and seborrheic dermatitis. It is free of proteins, sulfates, gluten, dyes, fragrance, masking fragrance, lanolin, parabens, and formaldehyde releasers. Customers have found it to be effective in relieving dry scalp, itchiness, and flaking, and have noted that it does not cause any reactions on sensitive skin. However, some customers have found that it can dry out their hair.

What We Like
Effective dandruff control
Fragrance-free formula
Moisturizes scalp
Gentle on sensitive skin
Thick and moisturizing texture
What We Don't Like
Doesn't rinse well
Leaves hair feeling sticky
#TOP 6

Dermaharmony 2% Pyrithione Zinc Shampoo Bar

4 Ounce (Pack of 1)
Dermaharmony 2% Pyrithione Zinc Shampoo Bar Cover
Dermaharmony 2% Pyrithione Zinc Shampoo Bar for dandruff and seborrheic dermatitis - Fragrance Free (4 Oz)

A solid shampoo bar that is 100% soap-free and uses 2% pyrithione zinc, argan oil, and oat flower to treat scalp issues. It is fragrance-free, free from sulfates, MPG, parabens, and PEG. The bar is very mild to the skin and non-drying, sulfate-free with a pH of 6, and has a dense luxurious lather in both hard and soft water. A single bar will last for months with daily use.

What We Like
Fragrance-free
Great lather
Soft, clean hair
Less itchiness
Eco-friendly alternative
What We Don't Like
May dry out hair
Addictive for scalp
#TOP 7

Noble Formula 2% Pyrithione Zinc Shampoo

8 Fl Oz (Pack of 1)
Noble Formula 2% Pyrithione Zinc Shampoo Cover
Noble Formula Shampoo with 2% Pyrithione Zinc (ZnP), 8 oz

Noble Formula Shampoo is specially designed for individuals dealing with psoriasis, eczema, or a sensitive scalp. With its 2% pyrithione zinc, this shampoo effectively addresses issues like itching, flaking, and irritation, providing much-needed relief. You can use it daily without worry, making it a convenient addition to your routine. Its powerful formula is the strongest non-prescription option available, ensuring you receive maximum benefits in managing your scalp health.

What We Like
Effective for scalp issues
No burning or irritation
Non-fragrant option
Helps control psoriasis and dandruff
Improves scalp condition over time
What We Don't Like
Runny consistency can waste product
May cause mild scalp itch
#TOP 8

Jupiter Anti Dandruff Shampoo

Jupiter Anti Dandruff Shampoo Cover
Jupiter Anti-Dandruff Shampoo, for Women & Men, Physician-Formulated for Flaky, Itchy, Oily, Dry Scalp, Vegan, Sulfate-Free, Color-Safe, & Paraben-Free, Anti-Dandruff Shampoo with Zinc, 9.5 fl oz

Jupiter Dandruff Shampoo is a sulfate-free and natural fragrance shampoo that is perfect for those who have dry, itchy, oily, and flaky scalp problems. The shampoo is formulated with Zinc Pyrithione, which is an active ingredient that effectively treats dandruff, irritation, dry scalp, and itchy scalp. It also helps to control excess sebum, clear buildup, and calm the scalp. Jupiter Dandruff Shampoo is safe for all hair types, including color and chemically-treated hair. It has been clinically tested to reduce hair breakage by 30%. The shampoo is formulated with natural and vegan ingredients, such as Coconut Oil, which moisturizes the scalp and hair, and Algae Extract, which hydrates the scalp with anti-aging properties. The shampoo has a spa-like scent that is refreshing and invigorating.

What We Like
Amazing scent
Rich, luxurious lather
Moisturizing and gentle
Effective dandruff control
Color-safe formula
What We Don't Like
Requires a large amount
Possible scalp irritation
#TOP 9

True+Real Classic Clean Anti-Dandruff Shampoo

Light Blue
True+Real Classic Clean Anti-Dandruff Shampoo Cover
True+Real Classic Everyday Clean Anti-Dandruff Shampoo, Pyrithione Zinc 1%, Daily Use Scalp Care for All Hair Types, 14.2 Fl Oz, 1 pk

True+Real Classic Clean Dandruff Shampoo is a gentle, everyday use scalp care product formulated with Pyrithione Zinc 1%. It helps prevent recurrence of flaking and itching associated with dandruff, leaving hair soft and manageable. Shake well, wet hair throughly, massage into the scalp, repeat if desired or rinse clean for best results. Comparable to same ingredients as Head + Shoulders Classic Clean Daily Shampoo.

What We Like
Effective itch relief
Large bottle size
Woman-owned business
Good lather
Fragrance-free option
What We Don't Like
Strong scent
Can irritate eyes
#TOP 10

KAMEDIS Dandruff Therapy Shampoo

3PL-U-HC-1043
White
8 Ounce (Pack of 1)
KAMEDIS Dandruff Therapy Shampoo Cover
KAMEDIS Anti-Dandruff Therapy Shampoo. For Dry, Itchy, Flaky, Sensitive Scalp and Seborrheic Dermatitis. Contains 1% Zinc Pyrithione and Salicylic Acid. Hair & Head Treatment. Paraben Free. 6.7 Fl Oz.

KAMEDIS Dandruff Shampoo is a clinically proven shampoo that removes up to 100% of visible dandruff, providing quick and effective relief from itchy and flaky scalps. Made with 1.0% Zinc Pyrithione, it helps treat hair and skin with symptoms associated with dandruff including a flaky, scaly, itchy, irritated, and/or red scalp. This rich, lightly foaming shampoo soothes and purifies your scalp, providing relief for a red and itchy scalp caused by chronic scalp psoriasis symptoms, seborrheic dermatitis, and common dandruff. Additionally, the shampoo is formulated with purified botanicals that create natural, balanced healing, and the carefully selected botanicals are combined with Western technology to heal and relieve irritated skin in the short and long-term. Use KAMEDIS Dandruff Shampoo 3 times a week for the best results.

What We Like
Effective against itching and burning
Pleasant smell
Softens hair
Controls dandruff well
Little product needed
What We Don't Like
Somewhat expensive
Smaller bottle size
Buying Guide Image

Ready for the Course: How to Buy the Right Zinc Pyrithione Shampoo

The Benefits of Zinc Pyrithione Shampoo

If you're struggling with dandruff or an itchy, flaky scalp, you may find relief with a zinc pyrithione shampoo. This ingredient is a potent antifungal and antimicrobial agent that can help reduce the symptoms of seborrheic dermatitis, psoriasis, and other scalp conditions.

What to Look for in a Zinc Pyrithione Shampoo

When choosing a zinc pyrithione shampoo, there are a few key factors to consider:

  1. Concentration of Zinc Pyrithione: Look for a shampoo that contains at least 1% zinc pyrithione. This concentration has been shown to be effective in reducing dandruff and other scalp conditions.

  2. Other Active Ingredients: Some zinc pyrithione shampoos may contain additional active ingredients, such as salicylic acid or ketoconazole, that can further help with scalp irritation and inflammation.

  3. pH Level: The pH level of a shampoo can impact its effectiveness. Look for a shampoo with a pH level between 4.5 and 5.5, as this is the ideal range for maintaining a healthy scalp.

  4. Brand Reputation: It's important to choose a reputable brand that has a track record of producing high-quality, effective products.

How to Use Zinc Pyrithione Shampoo

To get the most out of your zinc pyrithione shampoo, follow these tips:

  1. Wet your hair thoroughly before applying the shampoo.

  2. Massage the shampoo into your scalp, focusing on areas that are particularly itchy or flaky.

  3. Leave the shampoo on your scalp for at least 3-5 minutes to allow the active ingredients to work.

  4. Rinse the shampoo out thoroughly, making sure to remove all traces of product from your scalp.

  5. Use the shampoo regularly, at least 2-3 times per week, to maintain a healthy scalp.

Conclusion

If you're struggling with scalp irritation, a zinc pyrithione shampoo may be just what you need. Look for a shampoo with at least 1% zinc pyrithione, additional active ingredients, a pH level between 4.5 and 5.5, and a reputable brand. Follow the tips for use, and soon you'll be enjoying a healthier, happier scalp.

Frequently Asked Questions (FAQs)

1. Is Zinc Pyrithione shampoo good for hair?

Yes, Zinc Pyrithione shampoo is good for hair. It helps improve the health of the scalp, which in turn benefits the hair. It can effectively treat issues like dandruff, itchiness, acne, and scalp psoriasis by targeting the yeast/fungus causing the problem.

2. What does Zinc Pyrithione do in shampoo?

Zinc Pyrithione is an active ingredient commonly found in anti-dandruff shampoos. It has antifungal, antibacterial, and antimicrobial properties, which help eliminate fungus, bacteria, and microorganisms that contribute to an itchy, flaky scalp. To use it, follow the instructions on the bottle and apply it to a wet scalp.

3. Which is better, ketoconazole or Zinc Pyrithione shampoo?

Ketoconazole is an anti-fungal used to treat fungal infections like dandruff, while Zinc Pyrithione is an anti-bacterial and antifungal substance that helps with Seborrhoeic Dermatitis. Both have their benefits, and some dandruff-curing cleansers, like Clear, use Zinc Pyrithione in their formula.

4. What are the side effects of pyrithione zinc?

Some possible side effects of pyrithione zinc include allergic reactions like rash, hives, itching, red or swollen skin, blisters, or peeling. Other signs may include difficulty breathing, talking, or swallowing, tightness in the chest or throat, wheezing, or swelling of the mouth, face, lips, tongue, or throat. If you experience any of these symptoms, seek medical attention.

5. How long should pyrithione zinc be left in the hair?

When using nonprescription antiseborrheic shampoos containing pyrithione zinc, such as Head & Shoulders or Nizoral, it is recommended to rub the shampoo into the wet scalp, rinse, and then reapply for 3 to 5 minutes before the final rinse.

6. What are the disadvantages of ketoconazole and zinc pyrithione shampoo?

Ketoconazole shampoo may cause permed hair to lose its curl and, in rare cases, it can result in hair loss. If you notice any hair loss, it is recommended to consult with a doctor.

Editor's Notes

During our zinc pyrithione shampoo research, we found 48 zinc pyrithione shampoo products and shortlisted 10 quality products. We collected and analyzed 106,604 customer reviews through our big data system to write the zinc pyrithione shampoo list. We found that most customers choose zinc pyrithione shampoo with an average price of $19.61.

The zinc pyrithione shampoo are available for purchase. We have researched hundreds of brands and picked the top brands of zinc pyrithione shampoo, including Dermaharmony, Dove, Selsun Blue, DHS, Vanicream. The seller of top 1 product has received honest feedback from 363 consumers with an average rating of 4.9.

Written by
Lisa Bechard Avatar

Lisa Bechard is a skin therapist with 12 years of working experience in the beauty industry and also an experienced beauty writer who has expertise in skincare, medical aesthetics and cosmetic surgery, and wellness. Her writing skills are excellent and all her content is very persuasive and insightful.

Zinc Pyrithione Shampoo Comparison Table

#TOP1
#TOP2
#TOP3
#TOP4
#TOP5
#TOP6
#TOP7
#TOP8
#TOP9
#TOP10
Brand Dermaharmony Dove Selsun Blue DHS Vanicream Dermaharmony Noble Formula Jupiter True+Real KAMEDIS
Item Form Bar Liquid Liquid Liquid Liquid Bar Liquid Cream Gel Cream
Hair Type All Normal Dry Oily All All All,Dry Normal All All
Age Range (Description) Adult Adult Adult Adult Adult Adult Adult Adult Adult 3 Years and Older
Scent Peppermint Fragranced Fresh Mild Botanical Unscented Unscented - Fresh Unscented Floral
FTB Score
ftb score rating icon 9.8
ftb score rating icon 9.7
ftb score rating icon 9.5
ftb score rating icon 9.5
ftb score rating icon 9.4
ftb score rating icon 9.2
ftb score rating icon 9.0
ftb score rating icon 9.0
ftb score rating icon 8.8
ftb score rating icon 8.8
Where to Buy