Best Diphenhydramine Acetaminophen of 2025

Bonnie Salem Avatar
Bonnie Salem
Last Updated: Jan 5, 2025

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Diphenhydramine Acetaminophen is a combination medication used to relieve pain, fever, and allergies. Diphenhydramine is an antihistamine that helps to reduce itching, sneezing, and runny nose, while acetaminophen is a pain reliever and fever reducer. This medication is commonly used to treat symptoms associated with colds, flu, and allergies. It is available in tablet form and should be taken as directed by a healthcare professional. Diphenhydramine Acetaminophen may cause drowsiness, so it is important to avoid driving or operating machinery until the individual knows how the medication affects them.

At a Glance: Our Top Picks

Right Remedies Extra Strength PM Pain Relief Cover #TOP 1
Right Remedies Extra Strength PM Pain Relief
ftb score rating icon 9.8
Rite Aid Pain Relief Acetaminophen PM Caplets Cover #TOP 2
Rite Aid Pain Relief Acetaminophen PM Caplets
ftb score rating icon 9.7
HealthA2Z® Extra Strength Pain Relief PM Caplets Cover #TOP 3
HealthA2Z® Extra Strength Pain Relief PM Caplets
ftb score rating icon 9.5

Top 10 Diphenhydramine Acetaminophen

Right Remedies Extra Strength PM Pain Relief

Right Remedies Extra Strength PM Pain Relief Cover
Right Remedies Extra Strength Pain Relief PM & Nighttime Sleep Aid Caplets,(300 count), Acetaminophen 500 mg & Diphenhydramine HCl 25 mg, Non-Habit Forming, Compare to Active ingredients of Tylenol PM

Right Remedies PM Pain Relief offers effective support for those struggling with minor aches and pains, thanks to its 500 mg of acetaminophen. This ingredient helps alleviate discomfort from common ailments like headaches and muscle aches. Additionally, it contains 25 mg of diphenhydramine HCl, which not only relieves pain but also aids in falling asleep quickly. The caplets are designed to be easy to swallow, making them convenient for nighttime use. With a formulation that mirrors the active ingredients found in Tylenol PM, you can trust this product for reliable relief.

What We Like
Effective pain relief
Helps with sleep
Easy to swallow
Non-habit forming

Rite Aid Pain Relief Acetaminophen PM Caplets

Rite Aid Pain Relief Acetaminophen PM Caplets Cover
Rite Aid Extra Strength Pain Relief Acetaminophen PM Caplets, 500mg Acetaminophen / 25mg Diphenhydramine - 300 Count - Nighttime Pain Reliever + Sleep Aid

Rite Aid Pain Relief PM is a trusted brand that offers a non-habit forming solution for pain relief and sleep aid. With its extra strength acetaminophen, it effectively reduces pain while the diphenhydramine HCI aids in getting a good night's sleep. Whether you're dealing with headaches, migraines, menstrual pain, or body aches, this aspirin-free medication provides relief. The 500mg of acetaminophen also helps to reduce fevers temporarily. Rite Aid Pain Relief PM is the perfect choice for those who want to wake up feeling refreshed and ready to take on the day.

What We Like
Non-habit forming
Nighttime sleep aid
Pain and fever relief
#TOP 3

HealthA2Z® Extra Strength Pain Relief PM Caplets

FP0658
HealthA2Z® Extra Strength Pain Relief PM Caplets Cover
HealthA2Z® Extra Strength Pain Relief PM| Acetaminophen 500mg | Diphenhydramine 25mg | Pain Reliever & Nighttime Sleep Aid | Non-Habit Forming (150 Count (Pack of 1))

HealthA2Z® Extra Strength Pain Relief PM Caplets help relieve muscle, joint, headache, and cramp quickly. It contains a gentle, non-habit-forming sleep aid to help you fall asleep and stay asleep. The product does not contain aspirin and is suitable for adults. The recommended dosage is 2 caplets at bedtime, not to exceed 2 caplets in 24 hours.

What We Like
Fast pain relief for muscle, joint, headache, and cramp
Non-habit-forming sleep aid to help you fall asleep and stay asleep
Does not contain aspirin
#TOP 4

Tylenol PM Extra Strength Pain Reliever & Sleep Aid Caplets

JJ-2404
100ct
Tylenol PM Extra Strength Pain Reliever & Sleep Aid Caplets Cover
Tylenol PM Extra Strength Nighttime Pain Reliever & Sleep Aid Caplets, 500 mg Acetaminophen & 25 mg Diphenhydramine HCl, Relief for Nighttime Aches & Pains, Non-Habit Forming, 100 ct

Tylenol PM Extra Strength Caplets Nighttime Pain Reliever & Non-Habit Forming Sleep Aid contains 25 mg diphenhydramine HCl and 500 mg acetaminophen per caplet. It effectively relieves nighttime pain and helps you fall asleep fast. This non-habit forming nighttime sleep aid and pain relief medicine is suitable for adults and children who are 12 years of age and older. Tylenol PM is the #1 doctor-recommended brand for pain relief and fever reduction, ensuring a better night's sleep for a better day ahead.

What We Like
Non-habit forming when used as directed
Effectively relieves nighttime pain and helps you fall asleep fast
Can be used by adults and children who are 12 years of age and older
#TOP 5

NUVICARE Extra Strength Pain Relief PM

NUVICARE
Blue
NUVICARE Extra Strength Pain Relief PM Cover
NUVICARE Extra Strength Pain Relief PM - Acetaminophen 500mg & Diphenhydramine 25mg - Compare to Tylenol PM Extra Strength Sleep Aid - Adult PM Pain Reliever for Nighttime Aches & Pains (100 Tablets)

NUVICARE Pain Relief PM offers effective nighttime relief from pain and discomfort. Each tablet contains 500mg of acetaminophen, which helps alleviate headaches, muscle aches, and arthritis pain that disrupt your sleep. Additionally, it includes 25mg of diphenhydramine, a compound that promotes relaxation and aids in restful sleep. This combination targets nighttime aches, ensuring you can manage pain and fever symptoms while enjoying a more peaceful night. With Nuvicare, you can wake up feeling refreshed and ready for the day ahead.

What We Like
Extra strength pain relief
Promotes restful sleep
Combines pain relief and relaxation
Quality manufacturing standards
#TOP 6

Tylenol PM Extra Strength Caplets

Tylenol PM Extra Strength Caplets Cover
Tylenol PM Extra Strength Nighttime Pain Reliever & Sleep Aid Caplets, 500 mg Acetaminophen & 25 mg Diphenhydramine HCl, Relief for Nighttime Aches & Pains, Non-Habit Forming, 50 ct

Tylenol PM Extra Strength Caplets is a nighttime pain reliever and sleep aid that provides minor pain relief and helps you fall asleep fast. With 25 mg of diphenhydramine HCl and 500 mg of acetaminophen per caplet, it effectively relieves nighttime pain and helps you get the sleep you need. This non-habit forming sleep aid is recommended by doctors and is suitable for adults and children aged 12 and older. With Tylenol PM Extra Strength Caplets, you can fall asleep quickly, stay asleep, and wake up refreshed, so you can be the best version of yourself every day.

What We Like
Fast pain relief
Non-habit forming
Recommended by doctors
#TOP 7

Rite Aid Extra Strength PM Pain Relief Gelcaps

556-31-UPCR
Rite Aid Extra Strength PM Pain Relief Gelcaps Cover
Rite Aid Extra Strength PM Pain Relief Gelcaps, 500 mg Acetaminophen / 25 mg Diphenhydramine - 80 Count | Nighttime PM Pain Reliever + Sleep Aid | Arthritis Pain Relief | Menstrual Pain Relief

Rite Aid Extra Strength PM Pain Relief Gelcaps is a non-habit forming, aspirin-free pain reliever with a nighttime sleep aid. Each gelcap contains acetaminophen extra strength 500mg and diphenhydramine HCI 25mg, offering relief from headaches, migraines, menstrual pain, muscular or body aches, and arthritis and/or joint pain. It is a trusted brand since 1962 and is formulated for those with aspirin allergies or sensitivities.

What We Like
Non-habit forming
A nighttime sleep aid
Aspirin-free
Offers relief from various types of pain
Trusted brand since 1962
#TOP 8

Timely Acetaminophen PM

TIME-CAP LABS, INC.
Timely Acetaminophen PM Cover
TIME-CAP LABS, INC. Timely Acetaminophen PM - Extra Strength PM - 400 Count - Compared to Tylenol PM Extra Strength - Pain Relief PM for a Good Night Sleep - Made in USA

Timely PM is a reliable and affordable pain reliever and nighttime sleep-aid offered by TIME-CAP LABS, INC. With its maximum strength formulation of acetaminophen 500mg and Diphenhydramine HCl 25mg, it provides fast and reliable relief from headaches and other minor aches and pains, allowing you to rest better at night. This non-habit forming pain relief is safe for regular use, giving you the confidence to take a dose without worrying about dependence. Timely PM offers National Brand Equivalency, ensuring the same efficacy as national brands at a lower cost. With 400 caplets per bottle, it is a must-have in every medicine cabinet for adults and children 12 years and over, providing long-term relief for the whole family.

What We Like
Reliable Relief
Banish Pain and Sleep Well
Safe for Regular Use
#TOP 9

GeriCare Night-Time Pain Relief Caplets

224-05-HST
GeriCare Night-Time Pain Relief Caplets Cover
GeriCare Extra Strength Night-Time Acetaminophen 500 mg, Diphenhydramine HCI 25 mg Pain Medicine Caplets 50 Count (Pack of 1)

GeriCare Night-Time Relief offers a unique solution for pain and sleep disruption. With its dual-action formula, these caplets combine the pain relief of Acetaminophen and the calming effects of Diphenhydramine HCI. This means you can effectively manage discomfort while promoting better sleep. Specifically designed for nighttime, these caplets help you overcome pain that may keep you awake, ensuring a more restful night. Plus, their convenient caplet form makes it easy to take without any measuring or mixing, allowing you to focus on getting the relief and rest you need.

What We Like
Dual-action pain relief
Promotes restful sleep
Convenient caplet form
Trusted brand quality
#TOP 10

Cabinet PM Nighttime Pain Reliever

Blue
Cabinet PM Nighttime Pain Reliever Cover
Cabinet: Nighttime Pain Reliever and Sleep Aid for Headaches, Aches, and Pains | Acetaminophen 500mg, Diphenhydramine 25mg,120 Caplets (Refill)

Cabinet PM Sleep Aid is designed to help you enjoy a restful night by relieving headaches and other discomforts. By taking it an hour before bed, you can ease your pain and drift off to sleep more easily. With ingredients similar to those in Tylenol PM, this product provides effective relief while being environmentally conscious. Ideal for those occasional sleepless nights, it helps you fall asleep quickly and wake up refreshed. Plus, its third-party testing ensures quality, allowing you to trust what you’re taking for your health.

What We Like
Effective pain relief
Promotes restful sleep
Environmentally friendly packaging
Quality tested by third parties
Buying Guide Image

Frequently Asked Questions (FAQs)

1. Can I take diphenhydramine and acetaminophen together?

Acetaminophen and diphenhydramine is a combination medicine used to treat occasional insomnia associated with minor aches and pains. This medicine is not for use in treating sleeplessness without pain, or sleep problems that occur often.

2. What is diphenhydramine acetaminophen used for?

ACETAMINOPHEN; DIPHENHYDRAMINE (a set a MEE noe fen; dye fen HYE dra meen) is a pain reliever antihistamine combination. It is used to treat allergy symptoms like sore throat, runny nose, sneezing, and itching of the eyes, nose, and throat.

3. What pain reliever can I take with diphenhydramine?

Diphenhydramine and ibuprofen combination is used to relieve trouble sleeping caused by minor aches and pains. It also helps you fall asleep and stay asleep. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is used in this combination to relieve inflammation, swelling, and pain.

Editor's Notes

During our diphenhydramine acetaminophen research, we found 24 diphenhydramine acetaminophen products and shortlisted 10 quality products. We collected and analyzed 154,621 customer reviews through our big data system to write the diphenhydramine acetaminophen list. We found that most customers choose diphenhydramine acetaminophen with an average price of $13.11.

The diphenhydramine acetaminophen are available for purchase. We have researched hundreds of brands and picked the top brands of diphenhydramine acetaminophen, including RIGHT REMEDIES, Rite Aid, HealthA2Z, Tylenol, NUVICARE. The seller of top 1 product has received honest feedback from 559 consumers with an average rating of 4.8.

Written by
Bonnie Salem Avatar

Bonnie Salem is a stay-at-home mother with two-year-old twins and has spent almost half of her life surrounded by baby products. As a mother and a professional copywriter, she has an insightful and unique eye for researching products suitable for infants. Bonnie Salem is an expert in health and nutrition who lives with her family in New Jersey. She has over 15 years of working experience in an institute of medicine after graduating from the University of Toronto. She is highly interested in personal health and wellness.