Best Acetaminophen for Migraine of 2025

Bonnie Salem Avatar
Bonnie Salem
Last Updated: Jan 5, 2025

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Acetaminophen is a commonly used over-the-counter medication for the relief of migraine headaches. It is a pain reliever that works by blocking the production of certain chemicals in the brain that cause pain and inflammation. Acetaminophen is available in various forms, including tablets, capsules, and liquid, and can be found under different brand names. It is important to follow the recommended dosage and not to exceed the maximum daily limit to prevent potential liver damage. Acetaminophen is a safe and effective option for the relief of mild to moderate migraine headaches.

At a Glance: Our Top Picks

Timely Extra Strength Headache Relief - Acetaminophen, Aspirin, Caffeine Cover #TOP 1
Timely Extra Strength Headache Relief - Acetaminophen, Aspirin, Caffeine
ftb score rating icon 9.8
Amazon Basic Care Migraine Relief Caplets Cover #TOP 2
Amazon Basic Care Migraine Relief Caplets
ftb score rating icon 9.7
GenCare Tension Headache Relief Pain Reliever (200 Caplets) Cover #TOP 3
GenCare Tension Headache Relief Pain Reliever (200 Caplets)
ftb score rating icon 9.5

Top 10 Acetaminophen for Migraine

#TOP 1

Timely Extra Strength Headache Relief - Acetaminophen, Aspirin, Caffeine

TIME-CAP LABS, INC.
TS0417-B700ML-M1690
Timely Extra Strength Headache Relief - Acetaminophen, Aspirin, Caffeine Cover
Timely Extra Strength Headache Relief - Acetaminophen with Aspirin & Caffeine (200 Caplets) - Headache, Migraine & Back and Body Pain & Muscle Aches - Compares to Excedrin Extra Strength - Made In USA

Timely Headache Relief combines Acetaminophen, Aspirin, and Caffeine for effective management of headaches and migraines. This unique trio works together to tackle various pain aspects, providing you with a powerful solution. You will appreciate the fast-acting relief that allows you to return to your daily activities without delay. Moreover, the inclusion of caffeine enhances the effectiveness of the pain relief, making it a useful option for those who need quick help. With 200 caplets in each bottle, it’s perfect for both home use and travel, ensuring you’re always prepared for discomfort.

What We Like
Fast-acting relief
Triple-action formula
Convenient for travel
Effective for various pains

Amazon Basic Care Migraine Relief Caplets

Amazon Basic Care
White
Amazon Basic Care Migraine Relief Caplets Cover
Amazon Basic Care Migraine Relief Acetaminophen, Aspirin (NSAID) and Caffeine Tablets, Pain Reliever/Pain Reliever Aid, 250mg, 200 Count (Packaging may vary)

Amazon Basic Care Migraine Relief Caplets contain acetaminophen, aspirin (NSAID), and caffeine to relieve migraine pain. These coated caplets are gluten-free and suitable for adults. They are designed to treat migraine headaches so you can get back to your normal activities. Each 2-caplet dose offers effective pain relief.

What We Like
Contains active ingredients found in Excedrin Migraine
Coated caplets are easy to swallow
Effective in treating migraine pain in adults
Gluten-free

GenCare Tension Headache Relief Pain Reliever (200 Caplets)

GenCare
GenCare Tension Headache Relief Pain Reliever (200 Caplets) Cover
GenCare - Tension Headache Relief Pain Reliever with Acetaminophen 500 mg & Caffeine 65 mg (200 Caplets) Best Value Bulk Extra Strength for Head, Migraine, Joint Pain & Body Ache Relief Medicine

GenCare Tension Headache Relief Pain Reliever provides extra strength relief for mild to severe headaches, tension pain, and muscle aches. Its potent combination of Acetaminophen (500mg) and Caffeine (65mg) also effectively relieves sore muscles, tooth aches, arthritis and joint pain. The caffeine content helps restore energy levels and focus for mental clarity. It comes in a 200 caplet bulk savings bottle for convenience and to keep your family's medicine cabinet fully stocked. It is suitable for adults and children 12 years and older.

What We Like
Extra strength relief for headaches, tension pain, and muscle aches
Effective for sore muscles, tooth aches, arthritis and joint pain
Helps restore energy levels and focus for mental clarity
Comes in a 200 caplet bulk savings bottle
100% customer satisfaction guarantee
#TOP 4

Timely Extra Strength Headache Relief

TIME-CAP LABS, INC.
Timely Extra Strength Headache Relief Cover
Timely Extra Strength Headache Relief - Acetaminophen with Aspirin & Caffeine (300 Caplets) - Headache, Migraine & Back and Body Pain & Muscle Aches - Compares to Excedrin Extra Strength - Made In USA

Timely Headache Relief combines Acetaminophen, Aspirin, and Caffeine for powerful headache management. This triple-action formula works together to target various aspects of your discomfort, providing you with effective relief. The inclusion of caffeine enhances its effectiveness, making it comparable to prescription options. Plus, you'll appreciate the quick action of Timely Headache Relief, allowing you to return to your daily activities without delay. With 300 caplets per bottle, it's a perfect staple for your medicine cabinet and convenient for travel, ensuring you have relief at your fingertips whenever you need it.

What We Like
Triple-action formula
Fast-acting relief
Convenient for travel
Effective for various pains
#TOP 5

Amazon Basic Care Migraine Relief Geltabs

Amazon Basic Care
Green
Amazon Basic Care Migraine Relief Geltabs Cover
Amazon Basic Care Migraine Relief Geltabs, Acetaminophen, Aspirin (NSAID) and Caffeine, 80 Count

Amazon Basic Care Migraine Relief Geltabs contain acetaminophen, aspirin, and caffeine to treat migraine pain. With just one dose, you can temporarily reduce headache pain caused by migraines and get back to enjoying life's special moments. These headache pain relief pills are also gluten-free and compare to the active ingredients of Excedrin Migraine Geltabs.

What We Like
Offers headache pain relief
Temporarily reduces headache pain caused by migraines with just one dose
Combines acetaminophen, aspirin, and caffeine to treat migraine pain
Gluten-free
#TOP 6

Rite Aid Extra Strength Acetaminophen Caplets

011822300230
Rite Aid Extra Strength Acetaminophen Caplets Cover
Rite Aid Extra Strength Acetaminophen, 500mg - 500 Caplets | Pain Reliever & Fever Reducer for Migraines, Joint Pain, Muscle or Back Pain, and Menstrual Pain

Rite Aid Extra Strength Acetaminophen Caplets are pain relievers and fever reducers that can help relieve migraines, menstrual pain, joint and muscle pain, and arthritis pain. It contains 500mg acetaminophen, an active ingredient that effectively reduces fever and pain. The caplets' shape makes them easy to swallow, and the medicine is aspirin-free, making it ideal for those with aspirin allergies or sensitivities. Rite Aid is a trusted brand that has been providing health and wellness products since 1962.

What We Like
Effective pain and fever relief
Easy to swallow
Aspirin-free
Trusted brand
#TOP 7

Rite Aid Extra Strength Pain Reliever - 100 Tablets

011822317283
Rite Aid Extra Strength Pain Reliever - 100 Tablets Cover
Rite Aid Extra Strength Pain Reliever, Acetaminophen 250mg, Aspirin 250mg, Caffeine 65mg – 100 Tablets | Pain Reliever/Fever Reducer | NSAID Anti-Inflammatory | Migraine Relief Products

Rite Aid Extra Strength Pain Reliever is a migraine relief medication that contains 250mg of acetaminophen, 250mg of aspirin, and 65mg of caffeine. This easy-to-swallow coated tablet is perfect for those with sensitivities or allergies to ibuprofen. Its caffeine content has been proven to help with migraines and tension headaches by opening the constricted blood vessels in your brain. The product is formulated to relieve pain, migraines, and tension headaches, making it a great alternative to the leading national brand. Since 1962, Rite Aid has been a trusted brand in providing customers with the best products, services, and advice for their everyday health and wellness needs.

What We Like
Extra strength formula for effective pain relief
Contains caffeine, which has been proven to help with migraines and tension headaches
Ibuprofen-free, making it a great alternative for those with sensitivities or allergies to ibuprofen
Easy-to-swallow coated tablet design
Trusted brand since 1962
#TOP 8

GoodSense Migraine Relief Caplets

PERRIGO716258
White
GoodSense Migraine Relief Caplets Cover
GoodSense Migraine Relief, Acetaminophen, Aspirin (NSAID) and Caffeine Tablets, Migraine Relief, 24 Count

GoodSense Migraine Relief Caplets contain acetaminophen, aspirin (NSAID) and caffeine, which effectively treat migraine pain. The coated caplets are easy to swallow. These caplets are specifically designed for adults and are gluten-free.

What We Like
Contains effective active ingredients for migraine pain relief
Easy-to-swallow coated caplets
Designed specifically for adults
Gluten-free
#TOP 9

Excedrin Migraine Relief Caplets - 24ct

300672039248
Excedrin Migraine Relief Caplets - 24ct Cover
Excedrin Migraine Relief Caplets to Alleviate Migraine Symptoms - 24 count

Excedrin Migraine Relief Caplets come in a bottle of 24 and offer effective migraine headache pain relief. The triple action formula, which combines acetaminophen, aspirin, and caffeine, acts as a migraine headache pain reliever, relieves sensitivity to light and sound, and nausea. These caplets come in a convenient form, and for some, provide relief in just 30 minutes.

What We Like
Provides effective relief for migraine headache pain
Combines acetaminophen, aspirin, and caffeine for a powerful triple action formula
Relieves sensitivity to light and sound, and nausea
#TOP 10

GenCare Extra Strength Headache Relief Acetaminophen (300 Caplets)

GenCare
EB-009
GenCare Extra Strength Headache Relief Acetaminophen (300 Caplets) Cover
GenCare - Headache Relief Acetaminophen with Aspirin (NSAID) & Caffeine (300 Caplets) Value Pack | Head Pain, Muscle Aches, Back Pain & Body | Generic Excedrin Extra Strength

GenCare Extra Strength Headache Relief Acetaminophen is a family-size pain relief bottle with 300 caplets for headaches, migraines, muscle aches, toothaches, menstrual cramps, arthritis, joint pain, and more. Each caplet contains 250mg of Acetaminophen, 250mg of Aspirin (NSAID), and 65mg of Caffeine that act fast to energize and restore mental focus. Adults and children over 12 can take 2 caplets every 6 hours not to exceed 8 caplets in 24 hours. GenCare offers a 100% satisfaction guarantee.

What We Like
Acts fast with 65mg of caffeine to energize and restore mental focus
Bulk savings bottle with 300 caplets for family use
Helps with a variety of aches and pains
Buying Guide Image

Frequently Asked Questions (FAQs)

1. Is acetaminophen good for migraines?

People can also choose to take aspirin or acetaminophen (Tylenol) for migraines, but since the mechanism of a migraine headache involves inflammation and Tylenol doesn't have the anti-inflammatory properties, it's less effective in this case.

2. How much acetaminophen can I take for migraines?

The standard adult dose for Tylenol is two 325 mg capsules every 4 to 6 hours, not to exceed 10 tablets in 24 hours. 3 The maximum daily amount of acetaminophen should not exceed 4,000 mg. Like all medication, take it as directed by your healthcare provider or as instructed on the package.

3. Which painkiller is best for migraine?

Many people who have migraines find that over-the-counter painkillers, such as paracetamol, aspirin and ibuprofen, can help to reduce their symptoms. They tend to be most effective if taken at the first signs of a migraine attack, as this gives them time to absorb into your bloodstream and ease your symptoms.

4. Does acetaminophen make migraines worse?

Simple pain relievers. Common pain relievers such as aspirin and acetaminophen (Tylenol, others) may contribute to medication overuse headaches — especially if you exceed the recommended daily dosages.

Editor's Notes

During our acetaminophen for migraine research, we found 24 acetaminophen for migraine products and shortlisted 10 quality products. We collected and analyzed 125,367 customer reviews through our big data system to write the acetaminophen for migraine list. We found that most customers choose acetaminophen for migraine with an average price of $8.81.

The acetaminophen for migraine are available for purchase. We have researched hundreds of brands and picked the top brands of acetaminophen for migraine, including TIME-CAP LABS, INC., GenCare, Rite Aid, GoodSense, Excedrin. The seller of top 1 product has received honest feedback from 4,707 consumers with an average rating of 4.9.

Written by
Bonnie Salem Avatar

Bonnie Salem is a stay-at-home mother with two-year-old twins and has spent almost half of her life surrounded by baby products. As a mother and a professional copywriter, she has an insightful and unique eye for researching products suitable for infants. Bonnie Salem is an expert in health and nutrition who lives with her family in New Jersey. She has over 15 years of working experience in an institute of medicine after graduating from the University of Toronto. She is highly interested in personal health and wellness.