Best Acetaminophen for Arthritis of 2025

Bonnie Salem Avatar
Bonnie Salem
Last Updated: Jan 5, 2025

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Acetaminophen is a widely used medication for arthritis pain relief. It is a non-opioid pain reliever that works by blocking pain signals to the brain. Acetaminophen is available over-the-counter and is also found in many prescription medications. It is a popular choice for arthritis sufferers as it has fewer side effects compared to other pain relievers. However, it is important to note that acetaminophen should be taken in moderation and should not exceed the recommended dosage as it can cause liver damage. It is always best to consult with a healthcare provider before taking any medication for arthritis pain relief.

At a Glance: Our Top Picks

Amazon Basic Care Acetaminophen 650 mg Cover #TOP 1
Amazon Basic Care Acetaminophen 650 mg
ftb score rating icon 9.9
Timely-Extended Release Pain Relief Acetaminophen Tablet 650MG 400 Count Cover #TOP 2
Timely-Extended Release Pain Relief Acetaminophen Tablet 650MG 400 Count
ftb score rating icon 9.8
Rite Aid Acetaminophen 650mg Arthritis Caplets - 225 Count Cover #TOP 3
Rite Aid Acetaminophen 650mg Arthritis Caplets - 225 Count
ftb score rating icon 9.6

Top 10 Acetaminophen for Arthritis

Amazon Basic Care Acetaminophen 650 mg

Amazon Basic Care
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Amazon Basic Care Acetaminophen 650 mg Cover
Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, Arthritis Pain, 400 Count

Amazon Acetaminophen Pain Relief offers effective support for those dealing with minor arthritis pain. Each tablet contains 650 mg of acetaminophen, which is designed to relieve pain and reduce fever. This product is particularly useful for alleviating various discomforts, such as muscular aches, backaches, and menstrual cramps. Additionally, the extended-release formula ensures that you experience longer-lasting relief without the worry of taking multiple doses. Plus, it’s gluten-free and aspirin-free, making it a safe choice for many users. The child-resistant cap adds an extra layer of safety for households with children.

What We Like
Effective pain relief
Extended-release formula
Aspirin-free and gluten-free
Child-resistant cap
#TOP 2

Timely-Extended Release Pain Relief Acetaminophen Tablet 650MG 400 Count

TIME-CAP LABS, INC.
Timely-Extended Release Pain Relief Acetaminophen Tablet 650MG 400 Count Cover
TIME-CAP LABS, INC. Timely Acetaminophen 650 MG - 400 Caplets - Extended Release - Compared to Tylenol 8 HR Arthritis Pain Active Ingredient - Joint Pain Relief, Pain Reliever & Arthritis Pain Relief

Timely Pain Relief Acetaminophen Tablet 650MG 400 Count is the ideal over-the-counter medication for temporary relief of minor aches and pains, as well as reducing fever. Whether it's a headache, backache, toothache, the common cold, minor arthritis pain, muscular aches, or premenstrual and menstrual cramps, Timely Pain Relief can help. It's also perfect for reducing fever and providing long-term relief for minor arthritis pain. With 400 caplets, it's a great value and an easy way to be pain-free. These caplets are of the highest quality and provide the same efficacy as branded acetaminophen extended release. Keep a bottle in every medicine cabinet and first-aid kit to make sure your family is always prepared for pain relief.

What We Like
Relieves minor aches and pains
Reduces fever
High-quality at great prices
#TOP 3

Rite Aid Acetaminophen 650mg Arthritis Caplets - 225 Count

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225 Count
Rite Aid Acetaminophen 650mg Arthritis Caplets - 225 Count Cover
Rite Aid Acetaminophen 650mg Arthritis Extended Release Caplets - 225 Count

Rite Aid Acetaminophen 650mg Arthritis Caplets provide temporary relief from minor headaches, fever, and body aches associated with arthritis and joint pain. Each tablet contains aspirin-free, 650mg acetaminophen, making them ideal for menstrual, joint/muscle, and migraine relief. Easy-to-swallow caplets are perfect for use at home or on-the-go. The trusted brand since 1962, Rite Aid is committed to improving the health and wellness of its communities by offering quality products, services, and advice.

What We Like
Aspirin-free formula
Easy-to-swallow caplets
Effective for minor headaches, fever, and body aches
#TOP 4

Tylenol 8 Hour Arthritis Pain Relief Caplets, 100 ct

ASINPRILAK2754
100 Count
Tylenol 8 Hour Arthritis Pain Relief Caplets, 100 ct Cover
Tylenol 8 Hour Arthritis Pain Tablets with Acetaminophen for Joint Pain, 100 ct

Get fast-acting and temporary relief from minor arthritis and joint pain with Tylenol 8 Hour Arthritis Pain Extended-Release Caplets. With two effective layers of pain relief, each tablet contains 650mg of acetaminophen that provides relief for up to 8 hours. You can use it to alleviate minor aches, fever, and pains caused by arthritis or other conditions. This oral pain reliever has an excellent safety profile and can be used by adults 18 years and older. Tylenol is the #1 doctor recommended OTC brand for arthritis pain relief and pain and fever reduction.

What We Like
Fast-acting and temporary relief for minor arthritis and joint pain
Two effective layers of pain relief in each tablet
Relieves minor aches, fever, and pains caused by arthritis or other conditions
#TOP 5

TIME-CAP LABS Acetaminophen 650 MG

TIME-CAP LABS, INC.
TIME-CAP LABS Acetaminophen 650 MG Cover
TIME-CAP LABS, INC. Timely Acetaminophen 650 MG - 225 Caplets - Extended Release - Compared to Tylenol 8 HR Arthritis Pain Active Ingredient - Joint Pain Relief, Pain Reliever & Arthritis Pain Relief

TIME-CAP LABS Pain Relief offers effective relief for minor aches and pains, making it a great choice for headaches, backaches, and muscle discomfort. If you're battling a fever, this acetaminophen can help bring it down while easing associated aches. With 225 caplets in a bottle, you’ll have plenty on hand for your family's needs. This extended-release formula provides a convenient way to manage arthritis pain, allowing you to enjoy prolonged relief when taken as directed. It's a high-quality option that matches the efficacy of well-known brands.

What We Like
Effective for minor aches
Reduces fever quickly
Large quantity available
Convenient extended relief
Quality alternative to branded options
#TOP 6

Timely- Extended Release Pain Relief Acetaminophen Tablet 650MG 100 Count

TIME-CAP LABS, INC.
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Timely- Extended Release Pain Relief Acetaminophen Tablet 650MG 100 Count Cover
TIME-CAP LABS, INC. Timely Acetaminophen 650 MG - 100 Caplets - Extended Release - Compared to Tylenol 8 HR Arthritis Pain Active Ingredient - Joint Pain Relief, Pain Reliever & Arthritis Pain Relief

Timely- Acetaminophen Tablet is a high-quality pain relief medication that provides temporary relief for a variety of minor aches and pains. Whether you're dealing with a headache, toothache, backache, or the common cold, this acetaminophen tablet can help alleviate your discomfort. It also effectively reduces fever caused by minor pain of arthritis. With the same efficacy as branded acetaminophen extended release, Timely- Acetaminophen Tablet offers a cost-effective solution for your pain relief needs. With 100 caplets per bottle, it's a convenient choice to keep in your medicine cabinet or first-aid kit, ensuring long-term relief for the whole family. Take as directed on the bottle and experience the easy way to be pain-free.

What We Like
Relieves minor aches and pains
Reduces fever
High-quality at great prices
#TOP 7

Member's Mark Arthritis Pain Reliever Caplets

Hengulus
Pauline CY
Member's Mark Arthritis Pain Reliever Caplets Cover
Member's Mark - Arthritis Pain Reliever, Extended Release, Acetaminophen 650 mg, 400 Caplets

Relieve your minor arthritis pain with Member's Mark Acetaminophen Extended-Release Tablets 650 mg. This twin pack comes with two bottles of 200 caplets each, providing you with long-lasting relief from pain and fever. The caplets are designed to temporarily relieve minor arthritis pain and are easy to swallow.

What We Like
Extended-release formula for long-lasting relief
Easy-to-swallow caplets
Comes in a twin pack of 400 caplets
#TOP 8

Member's Mark Arthritis Pain Reliever

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Member's Mark Arthritis Pain Reliever Cover
Compare to Tylenol Arthritis Pain Active Ingredient. - Member's Mark - Arthritis Pain Reliever, Extended Release, Acetaminophen 650 mg, 400 CapletsQ

Introducing the Member's Mark Arthritis Pain Reliever, a powerful solution for those dealing with arthritis pain. With its extended-release formula and 650 mg strength, this acetaminophen-based pain reliever provides long-lasting relief for your arthritis symptoms. The 400 caplets in each bottle ensure you have an ample supply to manage your pain effectively. Say goodbye to the discomfort and inconvenience caused by arthritis with Member's Mark Arthritis Pain Reliever. Its extended-release feature ensures that you only need to take it once every 8 hours, giving you the convenience of lasting relief throughout the day. With its high strength of 650 mg, this pain reliever targets the source of your pain, providing you with the relief you need. Don't let arthritis hold you back - trust Member's Mark Arthritis Pain Reliever to help you live a pain-free life.

What We Like
Extended-release formula
650 mg strength
400 caplets
#TOP 9

Tylenol 8 Hour Arthritis Pain Caplets, 225 Count

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Tylenol 8 Hour Arthritis Pain Caplets, 225 Count Cover
Tylenol 8 Hour Arthritis Pain Relief Extended-Release Tablets, 650 mg Acetaminophen, Joint Pain Reliever & Fever Reducer Medicine, Oral Pain Reliever for Arthritis & Joint Pain, 225 Count

Get fast-acting and temporary relief of minor arthritis and joint pain in hands, wrists, knees, ankles, elbows, and feet with Tylenol 8 Hour Arthritis Pain Extended-Release Caplets. These oral pain relievers contain 650mg of acetaminophen that provides two layers of effective pain relief that lasts for up to 8 hours. These caplets can also relieve minor aches and pains, including muscle aches, backache, headache, toothache, the common cold, and menstrual cramps. The safety profile of these caplets is excellent for adults aged 18 years and older.

What We Like
Fast-acting and temporary relief of minor arthritis and joint pain
Two layers of effective pain relief that lasts up to 8 hours
Can also relieve minor aches and pains
Excellent safety profile for adults aged 18 years and older
#1 doctor recommended OTC brand for arthritis pain relief
#TOP 10

Tylenol 8 Hour Arthritis Pain Extended-Release Caplets

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24 Count
Tylenol 8 Hour Arthritis Pain Extended-Release Caplets Cover
Tylenol 8 Hour Arthritis Pain Relief Extended-Release Tablets, 650 mg Acetaminophen, Joint Pain Reliever & Fever Reducer Medicine, Oral Pain Reliever for Arthritis & Joint Pain, 24 Count

Tylenol 8 Hour Arthritis Pain Extended-Release Caplets provide fast-acting, temporary relief of minor arthritis and joint pain. It contains 650 mg of acetaminophen, which is a known pain reliever and fever reducer. The first layer acts fast and the second lasts up to 8 hours. It can be used by adults 18 years and older and is an excellent oral pain reliever for a variety of aches and pains, including arthritis, joint ache, knee pain, muscle aches, backache, headache, toothache, the common cold, and pre-menstrual and menstrual cramps.

What We Like
Effective relief for minor arthritis and joint pain
Fast-acting and long-lasting
Can be used for a variety of aches and pains
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Frequently Asked Questions (FAQs)

1. Is acetaminophen good for arthritis?

THURSDAY, March 17, 2016 (HealthDay News) -- Acetaminophen -- commonly known as Tylenol in the United States -- isn't an effective choice for relieving osteoarthritis pain in the hip or knee, or for improving joint function, a new study finds.

2. Is acetaminophen better than ibuprofen for arthritis?

Is acetaminophen or ibuprofen better? Ibuprofen is more effective than acetaminophen for treating inflammation and chronic pain conditions. Ibuprofen is FDA-approved to treat osteoarthritis and rheumatoid arthritis whereas acetaminophen may be used off-label for these conditions.

3. Is there a difference between regular Tylenol and arthritis Tylenol?

What is the difference between Tylenol and Tylenol Arthritis? Regular Tylenol contains 325 mg of acetaminophen and lasts about four to six hours. Tylenol 8-Hour Arthritis Pain contains 650 mg of acetaminophen with a unique double-layer design. The first layer dissolves quickly to release 325 mg of acetaminophen.

4. Why is acetaminophen not effective in treating arthritis?

But as the study suggests, Tylenol isn't the best option. Acetaminophen isn't meant to treat inflammation. These drugs treat various aches (headache, muscle ache and toothache) and reduce fever, but they aren't anti-inflammatory. Acetaminophen pain relievers also can damage your liver if they are overused.

Editor's Notes

During our acetaminophen for arthritis research, we found 24 acetaminophen for arthritis products and shortlisted 10 quality products. We collected and analyzed 274,153 customer reviews through our big data system to write the acetaminophen for arthritis list. We found that most customers choose acetaminophen for arthritis with an average price of $17.38.

The acetaminophen for arthritis are available for purchase. We have researched hundreds of brands and picked the top brands of acetaminophen for arthritis, including TIME-CAP LABS, INC., Rite Aid, Tylenol, Hengulus, TENA. The seller of top 1 product has received honest feedback from 385 consumers with an average rating of 4.7.

Written by
Bonnie Salem Avatar

Bonnie Salem is a stay-at-home mother with two-year-old twins and has spent almost half of her life surrounded by baby products. As a mother and a professional copywriter, she has an insightful and unique eye for researching products suitable for infants. Bonnie Salem is an expert in health and nutrition who lives with her family in New Jersey. She has over 15 years of working experience in an institute of medicine after graduating from the University of Toronto. She is highly interested in personal health and wellness.