Best Acetaminophen for Back Pain of 2026

Bonnie Salem Avatar
Bonnie Salem
Last Updated: Jan 18, 2026

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Acetaminophen is a common pain reliever used to treat back pain. It is available over-the-counter and is often used as a first-line treatment for mild to moderate pain. Acetaminophen works by blocking the production of certain chemicals in the body that cause pain and inflammation. It is generally considered safe when used as directed, but can cause liver damage if taken in large amounts or used for long periods of time. Acetaminophen is a popular choice for those looking for a non-steroidal option to manage back pain.

At a Glance: Our Top Picks

Tylenol 8 Hour Muscle Aches & Pain Relief Tablets, 100 Count Cover #TOP 1
Tylenol 8 Hour Muscle Aches & Pain Relief Tablets, 100 Count
ftb score rating icon 9.8
Advil Dual Action Coated Caplets Cover #TOP 2
Advil Dual Action Coated Caplets
ftb score rating icon 9.7
GenCare Extra Strength Headache Relief Acetaminophen (300 Caplets) Cover #TOP 3
GenCare Extra Strength Headache Relief Acetaminophen (300 Caplets)
ftb score rating icon 9.5

Top 6 Acetaminophen for Back Pain

Tylenol 8 Hour Muscle Aches & Pain Relief Tablets, 100 Count

493961
Multi
100 Count
Tylenol 8 Hour Muscle Aches & Pain Relief Tablets, 100 Count Cover
Tylenol 8 Hour Acetaminophen 650 mg Extended Release Caplets, Fast Acting Bi-Layer Design, Quick & Long Lasting Pain Relief for Muscle, Joint, Back & Arthritis Aches, Fever Reducer, 100 Count

Get relief from minor aches and pains caused by muscle aches, joint pain, back pain, headache, toothache, the common cold, and menstrual cramps. Each extended-release tablet contains 650mg of acetaminophen and features two unique layers for effective pain relief that lasts up to 8 hours. These tablets reduce fever and have an excellent safety profile for adults and children over the age of 12. Tylenol is the #1 doctor recommended brand for pain relief and fever reduction.

What We Like
Provides temporary relief for minor aches and pains
Features two unique layers for effective pain relief that lasts up to 8 hours
Reduces fever and has an excellent safety profile

Advil Dual Action Coated Caplets

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Advil Dual Action Coated Caplets Cover
Advil Dual Action Coated Caplets, 125 Mg Ibuprofen and 250 Mg Acetaminophen per Dose (2 Dose Equivalent) for 8 Hour Pain Relief - 216 Count

Advil Dual Action is a multi-symptom pain medication that provides relief for up to 8 hours. With a combination of ibuprofen and acetaminophen, it targets pain at the source and blocks pain signals. This pain medicine is great for headaches, toothaches, menstrual cramps, muscle pain, lower back pain, and minor aches and pains associated with arthritis. Additionally, the new packaging will feature 20% less plastic by 2022, keeping nearly 500,000 pounds of plastic out of landfills. With 216 caplets per box, Advil Dual Action is a convenient and effective solution for your pain relief needs.

What We Like
8 hour relief
Multi-symptom pain relief
Combination of ibuprofen and acetaminophen
Less plastic packaging

GenCare Extra Strength Headache Relief Acetaminophen (300 Caplets)

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GenCare Extra Strength Headache Relief Acetaminophen (300 Caplets) Cover
GenCare - Headache Relief Acetaminophen with Aspirin (NSAID) & Caffeine (300 Caplets) Value Pack | Head Pain, Muscle Aches, Back Pain & Body | Generic ExcedrEn Extra Strength

GenCare Extra Strength Headache Relief Acetaminophen is a family-size pain relief bottle with 300 caplets for headaches, migraines, muscle aches, toothaches, menstrual cramps, arthritis, joint pain, and more. Each caplet contains 250mg of Acetaminophen, 250mg of Aspirin (NSAID), and 65mg of Caffeine that act fast to energize and restore mental focus. Adults and children over 12 can take 2 caplets every 6 hours not to exceed 8 caplets in 24 hours. GenCare offers a 100% satisfaction guarantee.

What We Like
Acts fast with 65mg of caffeine to energize and restore mental focus
Bulk savings bottle with 300 caplets for family use
Helps with a variety of aches and pains

Amazon Basic Care Migraine Relief Caplets

Amazon Basic Care
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Amazon Basic Care Migraine Relief Caplets Cover
Amazon Basic Care Migraine Relief, Acetaminophen, Aspirin (NSAID) and Caffeine Tablets, Headache Pain Reliever/Pain Reliever Aid, 200 Count

Amazon Basic Care Migraine Relief Caplets contain acetaminophen, aspirin (NSAID), and caffeine to relieve migraine pain. These coated caplets are gluten-free and suitable for adults. They are designed to treat migraine headaches so you can get back to your normal activities. Each 2-caplet dose offers effective pain relief.

What We Like
Comparable to Excedrin Migraine
Affordable price point
Fast and dependable relief
Effective for headaches and sinus pain
Good value for money
#TOP 5

GenCare Tension Headache Relief Pain Reliever (200 Caplets)

GenCare Tension Headache Relief Pain Reliever (200 Caplets) Cover
GenCare - Tension Headache Relief Pain Reliever with Acetaminophen 500 mg & Caffeine 65 mg (200 Caplets) Best Value Bulk Extra Strength for Head, Migraine, Joint Pain & Body Ache Relief Medicine

GenCare Tension Headache Relief Pain Reliever provides extra strength relief for mild to severe headaches, tension pain, and muscle aches. Its potent combination of Acetaminophen (500mg) and Caffeine (65mg) also effectively relieves sore muscles, tooth aches, arthritis and joint pain. The caffeine content helps restore energy levels and focus for mental clarity. It comes in a 200 caplet bulk savings bottle for convenience and to keep your family's medicine cabinet fully stocked. It is suitable for adults and children 12 years and older.

What We Like
Extra strength relief for headaches, tension pain, and muscle aches
Effective for sore muscles, tooth aches, arthritis and joint pain
Helps restore energy levels and focus for mental clarity
Comes in a 200 caplet bulk savings bottle
100% customer satisfaction guarantee

Midol Menstrual Pain Relief Gelcaps - 24 Count

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Midol Menstrual Pain Relief Gelcaps - 24 Count Cover
Midol Complete Gelcaps 24ct: Midol Complete Menstrual Pain Relief Gelcaps with Acetaminophen for Menstrual Symptom, PMS Relief, and Period Cramp Relief - 24 Count (Packaging May Vary)

Midol Menstrual Pain Relief Gelcaps are designed to relieve menstrual symptoms, including period cramps, muscle aches, back pain, headache, fatigue, water weight gain and bloating. This pack contains 24 easy-to-take gelcaps that offer up to six hours of relief. The gelcaps contain acetaminophen, caffeine and pyrilamine maleate, and are recommended for adults and children 12 years and older.

What We Like
Fast pain relief
Easy to swallow
Effective for cramps
Helps with bloating
Multipurpose use
Buying Guide Image

Frequently Asked Questions (FAQs)

1. Does acetaminophen help with back pain?

During back-pain flare-ups, you may also need an over-the-counter pain reliever to help you through. Doctors often suggest you first try acetaminophen (Tylenol, others) because it is gentler on the stomach, even though NSAIDs tend to work better for back pain.

2. Which pain reliever is best for back aches?

Medicines. Ibuprofen (such as Advil or Motrin), available over-the-counter, is an excellent medication for the short-term treatment of low back pain. ... Acetaminophen (such as Tylenol) and naproxen sodium (Aleve) are also effective in relieving pain.

3. Is ibuprofen or acetaminophen better for back pain?

Some feel acetaminophen works better for them, whereas others find ibuprofen better relieves a headache. Muscle ache or pulled/strained muscle. Ibuprofen typically works better for this kind of pain relief, due to the anti-inflammatory effects.

4. Is acetaminophen a muscle relaxant?

TYLENOL® Back Pain caplets contain effective pain relief plus a muscle relaxant to relieve and relax painful back muscles....Disponibile online presso.

Editor's Notes

During our acetaminophen for back pain research, we found 24 acetaminophen for back pain products and shortlisted 6 quality products. We collected and analyzed 304,062 customer reviews through our big data system to write the acetaminophen for back pain list. We found that most customers choose acetaminophen for back pain with an average price of $14.67.

The acetaminophen for back pain are available for purchase. We have researched hundreds of brands and picked the top brands of acetaminophen for back pain, including Tylenol, Advil, GenCare, Midol. The seller of top 1 product has received honest feedback from 384 consumers with an average rating of 4.7.

Written by
Bonnie Salem Avatar

Bonnie Salem is a stay-at-home mother with two-year-old twins and has spent almost half of her life surrounded by baby products. As a mother and a professional copywriter, she has an insightful and unique eye for researching products suitable for infants. Bonnie Salem is an expert in health and nutrition who lives with her family in New Jersey. She has over 15 years of working experience in an institute of medicine after graduating from the University of Toronto. She is highly interested in personal health and wellness.