Best Acetaminophen for Head of 2025

Bonnie Salem Avatar
Bonnie Salem
Last Updated: Jan 5, 2025

* We independently evaluate all recommended products and services. If you click on links we provide, we may receive compensation.

Acetaminophen is a widely used over-the-counter medication for relieving headaches. It is a pain reliever and fever reducer that is commonly found in many household medicine cabinets. Acetaminophen works by blocking the production of certain chemicals in the body that cause pain and inflammation. It is a safe and effective option for treating mild to moderate headaches, and is often the go-to choice for those who cannot take aspirin or ibuprofen due to allergies or other medical conditions. It is important to always follow the recommended dosage instructions and to consult a healthcare professional before taking any medication.

At a Glance: Our Top Picks

GenCare Extra Strength Headache Relief Acetaminophen (300 Caplets) Cover #TOP 1
GenCare Extra Strength Headache Relief Acetaminophen (300 Caplets)
ftb score rating icon 9.8
GenCare Tension Headache Relief Pain Reliever (200 Caplets) Cover #TOP 2
GenCare Tension Headache Relief Pain Reliever (200 Caplets)
ftb score rating icon 9.7
Excedrin Tension Headache Relief Caplets - 100 Count Cover #TOP 3
Excedrin Tension Headache Relief Caplets - 100 Count
ftb score rating icon 9.5

Top 6 Acetaminophen for Head

GenCare Extra Strength Headache Relief Acetaminophen (300 Caplets)

GenCare
EB-009
GenCare Extra Strength Headache Relief Acetaminophen (300 Caplets) Cover
GenCare - Headache Relief Acetaminophen with Aspirin (NSAID) & Caffeine (300 Caplets) Value Pack | Head Pain, Muscle Aches, Back Pain & Body | Generic Excedrin Extra Strength

GenCare Extra Strength Headache Relief Acetaminophen is a family-size pain relief bottle with 300 caplets for headaches, migraines, muscle aches, toothaches, menstrual cramps, arthritis, joint pain, and more. Each caplet contains 250mg of Acetaminophen, 250mg of Aspirin (NSAID), and 65mg of Caffeine that act fast to energize and restore mental focus. Adults and children over 12 can take 2 caplets every 6 hours not to exceed 8 caplets in 24 hours. GenCare offers a 100% satisfaction guarantee.

What We Like
Acts fast with 65mg of caffeine to energize and restore mental focus
Bulk savings bottle with 300 caplets for family use
Helps with a variety of aches and pains

GenCare Tension Headache Relief Pain Reliever (200 Caplets)

GenCare
GenCare Tension Headache Relief Pain Reliever (200 Caplets) Cover
GenCare - Tension Headache Relief Pain Reliever with Acetaminophen 500 mg & Caffeine 65 mg (200 Caplets) Best Value Bulk Extra Strength for Head, Migraine, Joint Pain & Body Ache Relief Medicine

GenCare Tension Headache Relief Pain Reliever provides extra strength relief for mild to severe headaches, tension pain, and muscle aches. Its potent combination of Acetaminophen (500mg) and Caffeine (65mg) also effectively relieves sore muscles, tooth aches, arthritis and joint pain. The caffeine content helps restore energy levels and focus for mental clarity. It comes in a 200 caplet bulk savings bottle for convenience and to keep your family's medicine cabinet fully stocked. It is suitable for adults and children 12 years and older.

What We Like
Extra strength relief for headaches, tension pain, and muscle aches
Effective for sore muscles, tooth aches, arthritis and joint pain
Helps restore energy levels and focus for mental clarity
Comes in a 200 caplet bulk savings bottle
100% customer satisfaction guarantee
#TOP 3

Excedrin Tension Headache Relief Caplets - 100 Count

204591
Excedrin Tension Headache Relief Caplets - 100 Count Cover
Excedrin Tension Headache Relief Caplets Without Aspirin for Head, Neck and Shoulder Pain Relief - 100 Count

Excedrin Tension Headache Relief Caplets are an aspirin-free tension headache pain medicine that quickly relieves headaches and pain caused by tension and stress. The caplets combine acetaminophen with caffeine to deliver muscle ache, shoulder and neck pain relief, and temporarily relieve pain caused by headaches and muscle aches. The trusted formula effectively relieves tension-type headaches in convenient caplet form.

What We Like
Quickly relieves headaches and pain caused by tension and stress
Combines acetaminophen with caffeine to deliver muscle ache, shoulder and neck pain relief
Effectively relieves tension-type headaches in convenient caplet form
#TOP 4

Timely Extra Strength Pain Reliever

TIME-CAP LABS, INC.
Timely Extra Strength Pain Reliever Cover
Timely - 200 Caplets - Tension Headache and Pain Reliever with Acetaminophen 500 mg and Caffeine 65 mg Extra Strength for Head, Neck, Shoulder and Body Pain Reliever, Aspirin Free - Made in USA

Timely Pain Reliever offers effective support for tension headaches with its 200 caplet supply, ensuring you always have relief on hand. This product features a unique double-action formula that combines acetaminophen and caffeine, providing comprehensive comfort and enhancing the relief experience. It's not just for headaches; you can also use it for pain related to colds, cramps, toothaches, arthritis, and muscle aches. With its powerful blend, you can trust that Timely will help you tackle various discomforts quickly and effectively.

What We Like
Generous supply of caplets
Double-action relief
Versatile pain relief
Powerful formula
#TOP 5

Safrel Tension Headache Relief Pain Reliever (200 Caplets)

105-02
Safrel Tension Headache Relief Pain Reliever (200 Caplets) Cover
Safrel - Tension Headache Relief Pain Reliever with Acetaminophen 500 mg and Caffeine 65 mg (200 Caplets) Value Pack | Extra Strength for Head and Body Aches | Generic Excedrin Tension Headache

Safrel Tension Headache Relief Pain Reliever offers extra strength headache and pain relief, including arthritis, toothaches, menstrual cramps, and joint pain. It contains Acetaminophen and Caffeine, which provide energy and restore mental focus. Each bottle contains 200 caplets, and it is suitable for adults and children 12 years and older. Safrel offers 100% satisfaction guarantee.

What We Like
Provides fast and complete relief from headaches and other aches/pain
Offers extra strength for head and body aches
Contains Acetaminophen and Caffeine, which provide energy and restore mental focus
#TOP 6

HealthA2Z® Tension Headache Relief

HealthA2Z® Tension Headache Relief Cover
HealthA2Z® Tension Headache Relief | Acetaminophen 500mg | Caffeine 65mg | Pain Reliever Aid | Aspirin Free (50 caplets (Pack of 1))

HealthA2Z Headache Relief is a powerful pain reliever that combines the benefits of Acetaminophen and Caffeine to provide fast relief for head, neck, and shoulder pain associated with tension and stress. As an aspirin-free product, it is gentler on your stomach compared to aspirin-based alternatives. The recommended dosage for adults is 2 caplets every 6 hours, with a maximum of 8 caplets in 24 hours. HealthA2Z Headache Relief is a convenient solution for anyone seeking quick and effective relief from tension headaches. With its unique combination of ingredients, it targets the root causes of tension headaches and provides fast and lasting relief. Say goodbye to the discomfort and inconvenience of tension headaches with HealthA2Z Headache Relief.

What We Like
Fast relief for tension headaches
Gentler on the stomach
Convenient dosage instructions
Buying Guide Image

Frequently Asked Questions (FAQs)

1. Does Tylenol help with head?

The good news is that you can treat most tension headaches with over-the-counter (OTC) pain relievers, such as acetaminophen (Tylenol) or nonsteroidal anti-inflammatories, such as aspirin, naproxen (Aleve), or ibuprofen (Advil, Motrin). You could also try a warm shower, a nap, or a light snack.

2. Is ibuprofen or acetaminophen better for headaches?

For most run-of-the-mill headaches, it's usually best to try acetaminophen (Tylenol and generic) first. It doesn't pose the risk of stomach bleeding and heart attack associated with the regular use of most nonsteroidal anti-inflammatory drugs (NSAIDs), a class of painkillers that includes ibuprofen (Advil and generic).

3. Does acetaminophen help with sinus pressure?

Pain caused by pressure buildup in the sinus cavities may be relieved with acetaminophen (Tylenol, others) or ibuprofen (Advil, Motrin IB, others).

4. Is Tylenol good for head cold?

Because it's a virus, a head cold can't be treated by antibiotics. Taking an acetaminophen (Tylenol) or ibuprofen (Advil, Motrin) will help reduce your fever and relieve muscle aches.

Editor's Notes

During our acetaminophen for head research, we found 24 acetaminophen for head products and shortlisted 6 quality products. We collected and analyzed 135,074 customer reviews through our big data system to write the acetaminophen for head list. We found that most customers choose acetaminophen for head with an average price of $11.85.

The acetaminophen for head are available for purchase. We have researched hundreds of brands and picked the top brands of acetaminophen for head, including GenCare, Excedrin, TIME-CAP LABS, INC., Safrel, HealthA2Z. The seller of top 1 product has received honest feedback from 1,252 consumers with an average rating of 4.9.

Written by
Bonnie Salem Avatar

Bonnie Salem is a stay-at-home mother with two-year-old twins and has spent almost half of her life surrounded by baby products. As a mother and a professional copywriter, she has an insightful and unique eye for researching products suitable for infants. Bonnie Salem is an expert in health and nutrition who lives with her family in New Jersey. She has over 15 years of working experience in an institute of medicine after graduating from the University of Toronto. She is highly interested in personal health and wellness.