Best Ibuprofen Acetaminophen of 2026

Bonnie Salem Avatar
Bonnie Salem
Last Updated: Jan 18, 2026

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Ibuprofen and Acetaminophen are two commonly used over-the-counter pain relievers. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation and pain. It is often used to treat headaches, menstrual cramps, toothaches, and arthritis. Acetaminophen is a pain reliever and fever reducer that is often used to treat minor aches and pains associated with colds, flu, and headaches. It is also commonly used to reduce fever. Both Ibuprofen and Acetaminophen are effective for pain relief, but they work differently and have different side effects. It is important to follow the recommended dosages and consult with a healthcare provider if necessary.

At a Glance: Our Top Picks

Tylenol Extra Strength Dissolve Packs with Acetaminophen, Berry, 32 Count Cover #TOP 1
Tylenol Extra Strength Dissolve Packs with Acetaminophen, Berry, 32 Count
ftb score rating icon 9.8
TENA Children's Tylenol Liquid Pain Relief Cover #TOP 2
TENA Children's Tylenol Liquid Pain Relief
ftb score rating icon 9.7
Advil Dual Action Coated Caplets Cover #TOP 3
Advil Dual Action Coated Caplets
ftb score rating icon 9.5

Top 9 Ibuprofen Acetaminophen

Tylenol Extra Strength Dissolve Packs with Acetaminophen, Berry, 32 Count

041532
Multi
32 Count
Tylenol Extra Strength Dissolve Packs with Acetaminophen, Berry, 32 Count Cover
Tylenol Extra Strength Dissolve Powder Packs, 500 mg Acetaminophen Pain Reliever & Fever Reducer Medicine, Fast Relief for Minor Aches & Pains, Ibuprofen- & Aspirin-Free, On-the-Go Berry Flavor, 32 Ct

Tylenol Extra Strength Dissolve Packs feature a great tasting Berry flavor and temporarily relieve minor aches and pains due to common cold, headache, backache, muscle aches, minor pain of arthritis, menstrual cramps, and toothache. Each packet contains 500 mg of acetaminophen, a pain reliever and fever reducer, and is both ibuprofen-free and aspirin-free. This portable pain medicine dissolves in seconds on the tongue with no water needed, and is safe for both adults and children 12 years of age and older. It's a convenient form to have on hand whenever pain hits.

What We Like
No water needed
Fast pain relief
Easy to carry
Gentle on stomach
Convenient single-dose packets

TENA Children's Tylenol Liquid Pain Relief

00300450166081
Cherry (Dye-free)
8 Ounce
TENA Children's Tylenol Liquid Pain Relief Cover
Children's Tylenol Liquid Pain Relief & Fever Medicine, Oral Suspension, Dye-Free, Acetaminophen, No Aspirin, No Ibuprofen, No High Fructose Corn Syrup; Cherry Flavor, 8 fl. oz.; Pack of 1

Tylenol Children's Pain Relief is a dye-free liquid medication designed to help your child feel better when they are in pain or have a fever. It temporarily alleviates minor aches from common illnesses like colds and flu, sore throats, and headaches. This gentle formula is suitable for kids aged 2-11 and starts working quickly, often within 15 minutes, to reduce fever. Each dose contains acetaminophen, making it a safe option for pain relief without the use of ibuprofen or aspirin. With its pleasant cherry flavor, your child may find it easier to take.

What We Like
Dye-free formula
Fast fever relief
Gentle on the stomach
Cherry flavor
Pediatrician recommended

Advil Dual Action Coated Caplets

F00573014786
Advil Dual Action Coated Caplets Cover
Advil Dual Action Coated Caplets, 125 Mg Ibuprofen and 250 Mg Acetaminophen per Dose (2 Dose Equivalent) for 8 Hour Pain Relief - 216 Count

Advil Dual Action is a multi-symptom pain medication that provides relief for up to 8 hours. With a combination of ibuprofen and acetaminophen, it targets pain at the source and blocks pain signals. This pain medicine is great for headaches, toothaches, menstrual cramps, muscle pain, lower back pain, and minor aches and pains associated with arthritis. Additionally, the new packaging will feature 20% less plastic by 2022, keeping nearly 500,000 pounds of plastic out of landfills. With 216 caplets per box, Advil Dual Action is a convenient and effective solution for your pain relief needs.

What We Like
8 hour relief
Multi-symptom pain relief
Combination of ibuprofen and acetaminophen
Less plastic packaging

Tylenol Children's Chewables 160 mg

580828
Purple
24 Count
Tylenol Children's Chewables 160 mg Cover
Children's Tylenol Chewables with 160 mg Acetaminophen, Pain Reliever & Fever Reducer for Kids' Cold + Flu Symptoms, Headache, Sore Throat & Toothache, Aspirin-Free, Grape Flavor, 24 ct

Tylenol Kids Chewables offer effective relief for your child's minor aches, pains, and cold symptoms. Each chewable tablet contains 160 mg of acetaminophen, which helps reduce fever and alleviate discomfort from headaches, sore throats, and even toothaches. The kid-friendly grape flavor makes it easy for children aged 2 to 11 to take their medicine without fuss. Plus, this formula is free from ibuprofen and aspirin, ensuring a gentle option for their tummies while providing trusted relief. With over 60 years of reliability, Tylenol is the top choice for parents seeking pediatric pain and fever solutions.

What We Like
Easy for kids to chew
Good taste for children
Convenient for travel
No need for swallowing pills
Effective symptom relief

Tylenol Extra Strength Acetaminophen Caplets 500 mg

0800005
Red Box
Tylenol Extra Strength Acetaminophen Caplets 500 mg Cover
Tylenol Extra Strength Acetaminophen Caplets, 500 mg, Pain Relief & Fever Reducer for Headache, Backache, Toothache, Menstrual Cramps & Pain, Travel-Friendly Packaging, 2-Caplet Pouches, 50 Count

The Tylenol Extra Strength Pain Relief offers powerful 500 mg acetaminophen caplets that help you quickly ease common aches like headaches, back pain, toothaches, arthritis discomfort, and menstrual cramps. It also works to reduce fever, making it a versatile choice for adults and kids 12 and older. The medicine comes in handy travel-sized pouches, so you can carry it easily in your bag, at work, or in your first aid kit for relief anytime you need it. Plus, it provides fast, long-lasting comfort without ingredients like ibuprofen, aspirin, or caffeine, making it a safe option when used as directed.

What We Like
Fast, effective pain relief
Fever reduction
Convenient travel pouches
Long-lasting comfort
Safe formula without aspirin

A+Health Dual Action Pain Reliever

DualActionPainRelief
White
216 Count
A+Health Dual Action Pain Reliever Cover
A+Health Dual Action Acetaminophen 250 mg and Ibuprofen (NSAID) 125mg Pain Reliever Caplets, 216 Count

A+Health Pain Reliever combines two effective ingredients, Acetaminophen and Ibuprofen, to provide comprehensive pain relief. You can count on these caplets to ease various pains, including headaches, backaches, and menstrual cramps, for up to eight hours. The dual-action formula ensures that you get the benefits of both medications in just one caplet, making it convenient for your daily needs. For adults and children over 12, simply take two caplets every eight hours to manage your discomfort efficiently. With 216 caplets in each bottle, relief is always within reach.

What We Like
Effective dual-action formula
Up to 8 hours relief
Convenient dosage instructions
Large quantity per bottle

Genexa Children's Acetaminophen Pain and Fever Reducer

Blueberry
Pain & Fever 1 Pack
Genexa Children's Acetaminophen Pain and Fever Reducer Cover
Genexa Children's Clean Acetaminophen | Pediatrician Preferred Ingredients | Pain & Fever Reducer for Kids | Dye Free, 0% Artificial Additives | Ages 2-11, Delicious Organic Blueberry Liquid, 4 fl oz

Genexa Children's Acetaminophen Pain and Fever Reducer is an oral suspension medicine that temporarily reduces fever and relieves a range of cold and flu symptoms, including minor aches and pains, headache, and sore throat. It contains 160 milligrams of Acetaminophen per 5mL dose, which is effective in providing pain and fever symptom relief for children ages 2-11 years old. The product is made with delicious organic blueberry flavor and is free of artificial sweeteners, preservatives, dyes, parabens, common allergens, and alcohol. It is certified gluten-free, vegan, and non-GMO, making it safe when used as directed.

What We Like
Contains organic blueberry flavor
Free of artificial sweeteners, preservatives, dyes, parabens, common allergens, and alcohol
Certified gluten-free, vegan, and non-GMO
#TOP 8

Amazon Basic Care Infants' Pain & Fever Acetaminophen Suspension Liquid

Amazon Basic Care
76616
Dye-free Grape
2 Fl Oz (Pack of 1)
Amazon Basic Care Infants' Pain & Fever Acetaminophen Suspension Liquid Cover
Amazon Basic Care Infants' Pain & Fever, Acetaminophen 160 mg per 5 mL, Suspension Liquid, Dye-Free Grape Flavor, 2 fl oz (Pack of 1)

Amazon Basic Care Infants' Pain & Fever Acetaminophen Suspension Liquid is a grape-flavored oral suspension liquid formulated for children ages 2 to 3 years. It is a pain reliever and fever reducer that temporarily reduces fever and relieves minor aches and pains due to the common cold, flu, headache, sore throat, and toothache. This product is free from alcohol, aspirin, ibuprofen, gluten, and high fructose corn syrup. It also comes with an enclosed syringe for pediatrician's preferred dosing system.

What We Like
Grape-flavored oral suspension liquid
Temporarily reduces fever and relieves minor aches and pains
Free from alcohol, aspirin, ibuprofen, gluten, and high fructose corn syrup
#TOP 9

Amazon Basic Care Children's Pain & Fever Oral Suspension

Amazon Basic Care
TS0417-B700ML-M384
Grape
4 Fl Oz (Pack of 1)
Amazon Basic Care Children's Pain & Fever Oral Suspension Cover
Amazon Basic Care Children's Acetaminophen 160 mg per 5 mL Oral Suspension, Grape Flavor, Pain Reliever and Fever Reducer for Headache, Sore Throat and Toothache, 4 fl oz (Pack of 1)

Amazon Basic Care Children's Pain & Fever Oral Suspension is a grape flavored liquid medicine that temporarily reduces fever and relieves minor aches and pains due to conditions such as the common cold, flu, headache, sore throat and toothache. It contains acetaminophen 160 mg per 5 mL, is aspirin free, ibuprofen free, alcohol free, and gluten free. The child-resistant safety cap is designed to protect little ones.

What We Like
Contains acetaminophen 160 mg per 5 mL
Temporarily reduces fever and relieves minor aches and pains
Aspirin free, ibuprofen free, alcohol free, and gluten free
Buying Guide Image

Frequently Asked Questions (FAQs)

1. Is acetaminophen and ibuprofen the same thing?

They act differently in the body, though. Acetaminophen, which is packaged as Tylenol, relieves pain and reduces fever. Ibuprofen, popularly packaged as Advil or Motrin, is an anti-inflammatory medication that is used to treat moderate pain from conditions like arthritis and menstrual cramps.

2. Can I take acetaminophen and ibuprofen together?

You can take ibuprofen and acetaminophen at the same time. Just make sure to not take more than the recommended dose. Some people experience some stomach or abdominal pain when taking the two medications together. In this case, it's better to alternate when you take each medication.

3. How much ibuprofen and acetaminophen can I take together?

“The usual safe doses for ibuprofen is up to [a maximum of] 800 mg per dose every eight hours and acetaminophen 650 mg every six hours if taken together, assuming normal kidney and liver functions,” according to Dr. Massachi.

Editor's Notes

During our ibuprofen acetaminophen research, we found 24 ibuprofen acetaminophen products and shortlisted 9 quality products. We collected and analyzed 333,647 customer reviews through our big data system to write the ibuprofen acetaminophen list. We found that most customers choose ibuprofen acetaminophen with an average price of $10.97.

The ibuprofen acetaminophen are available for purchase. We have researched hundreds of brands and picked the top brands of ibuprofen acetaminophen, including Tylenol, Advil, A+Health, Genexa. The seller of top 1 product has received honest feedback from 384 consumers with an average rating of 4.7.

Written by
Bonnie Salem Avatar

Bonnie Salem is a stay-at-home mother with two-year-old twins and has spent almost half of her life surrounded by baby products. As a mother and a professional copywriter, she has an insightful and unique eye for researching products suitable for infants. Bonnie Salem is an expert in health and nutrition who lives with her family in New Jersey. She has over 15 years of working experience in an institute of medicine after graduating from the University of Toronto. She is highly interested in personal health and wellness.