Best Acetaminophen for Muscle Pain of 2025

Bonnie Salem Avatar
Bonnie Salem
Last Updated: Jan 5, 2025

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Acetaminophen is a popular over-the-counter medication used to alleviate pain and reduce fever. It is commonly used to relieve muscle pain caused by exercise, injury, or chronic conditions such as arthritis. Acetaminophen is available in various forms including tablets, capsules, and liquid suspension. It is a safe and effective pain reliever when used as directed, but it is important to follow the recommended dosage to avoid potential liver damage. For those seeking relief from muscle pain, acetaminophen can provide a convenient and reliable solution.

At a Glance: Our Top Picks

Tylenol 8 Hour Muscle Aches & Pain Relief Tablets, 100 Count Cover #TOP 1
Tylenol 8 Hour Muscle Aches & Pain Relief Tablets, 100 Count
ftb score rating icon 9.9
Rite Aid Extra Strength Acetaminophen Caplets Cover #TOP 2
Rite Aid Extra Strength Acetaminophen Caplets
ftb score rating icon 9.8
Amazon Basic Care Acetaminophen Extended-Release Tablets Cover #TOP 3
Amazon Basic Care Acetaminophen Extended-Release Tablets
ftb score rating icon 9.6

Top 10 Acetaminophen for Muscle Pain

#TOP 1

Tylenol 8 Hour Muscle Aches & Pain Relief Tablets, 100 Count

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Tylenol 8 Hour Muscle Aches & Pain Relief Tablets, 100 Count Cover
Tylenol 8 Hour Muscle Aches & Pain Acetaminophen Tablets for Muscle & Joint Pain, 100 ct

Get relief from minor aches and pains caused by muscle aches, joint pain, back pain, headache, toothache, the common cold, and menstrual cramps. Each extended-release tablet contains 650mg of acetaminophen and features two unique layers for effective pain relief that lasts up to 8 hours. These tablets reduce fever and have an excellent safety profile for adults and children over the age of 12. Tylenol is the #1 doctor recommended brand for pain relief and fever reduction.

What We Like
Provides temporary relief for minor aches and pains
Features two unique layers for effective pain relief that lasts up to 8 hours
Reduces fever and has an excellent safety profile
#TOP 2

Rite Aid Extra Strength Acetaminophen Caplets

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Rite Aid Extra Strength Acetaminophen Caplets Cover
Rite Aid Extra Strength Acetaminophen, 500mg - 500 Caplets | Pain Reliever & Fever Reducer for Migraines, Joint Pain, Muscle or Back Pain, and Menstrual Pain

Rite Aid Extra Strength Acetaminophen Caplets are pain relievers and fever reducers that can help relieve migraines, menstrual pain, joint and muscle pain, and arthritis pain. It contains 500mg acetaminophen, an active ingredient that effectively reduces fever and pain. The caplets' shape makes them easy to swallow, and the medicine is aspirin-free, making it ideal for those with aspirin allergies or sensitivities. Rite Aid is a trusted brand that has been providing health and wellness products since 1962.

What We Like
Effective pain and fever relief
Easy to swallow
Aspirin-free
Trusted brand

Amazon Basic Care Acetaminophen Extended-Release Tablets

Amazon Basic Care
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Amazon Basic Care Acetaminophen Extended-Release Tablets Cover
Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, 100 Count (Packaging may vary)

Amazon Basic Care Acetaminophen Extended-Release Tablets, also known as Amazon Acetaminophen Tablets, are a safe and effective pain reliever and fever reducer. With its active ingredient, acetaminophen 650 mg, it provides up to 8 hours of relief, helping you get through the day. This medication is great for minor muscle aches and pains, backache, arthritis pain, toothache, premenstrual and menstrual cramps, headache, the common cold, and fever. It's suitable for adults and children 12 years and older. The child-resistant push and turn cap ensures safety. Plus, it's gluten-free and contains no aspirin. Take advantage of the convenience and reliability of Amazon Basic Care Acetaminophen Extended-Release Tablets for all your pain relief needs.

What We Like
8 hours relief
Safe and effective
Gluten-free

Advil Dual Action Back Pain Caplets - 144 Count

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Advil Dual Action Back Pain Caplets - 144 Count Cover
Advil Dual Action Back Pain Caplets Delivers 250mg Ibuprofen and 500mg Acetaminophen Per Dose for 8 Hours of Back Pain Relief - 144 Count

Advil Dual Action Back Pain Caplets provide 8 hours of back pain relief with a lower maximum daily dose of each medication. The medication contains 250mg Ibuprofen and 500mg Acetaminophen to fight back pain 2 ways. Acetaminophen blocks pain signals and ibuprofen targets pain caused by inflammation. It also provides relief for headache, toothache, menstrual cramp, muscle pain and lower back pain.

What We Like
Provides 8 hours of back pain relief
Fights back pain 2 ways with Ibuprofen and Acetaminophen
Relieves headache, toothache, menstrual cramp, muscle pain and lower back pain

GenCare Extra Strength Headache Relief Acetaminophen (300 Caplets)

GenCare
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GenCare Extra Strength Headache Relief Acetaminophen (300 Caplets) Cover
GenCare - Headache Relief Acetaminophen with Aspirin (NSAID) & Caffeine (300 Caplets) Value Pack | Head Pain, Muscle Aches, Back Pain & Body | Generic Excedrin Extra Strength

GenCare Extra Strength Headache Relief Acetaminophen is a family-size pain relief bottle with 300 caplets for headaches, migraines, muscle aches, toothaches, menstrual cramps, arthritis, joint pain, and more. Each caplet contains 250mg of Acetaminophen, 250mg of Aspirin (NSAID), and 65mg of Caffeine that act fast to energize and restore mental focus. Adults and children over 12 can take 2 caplets every 6 hours not to exceed 8 caplets in 24 hours. GenCare offers a 100% satisfaction guarantee.

What We Like
Acts fast with 65mg of caffeine to energize and restore mental focus
Bulk savings bottle with 300 caplets for family use
Helps with a variety of aches and pains
#TOP 6

Timely Extra Strength Headache Relief - Acetaminophen, Aspirin, Caffeine

TIME-CAP LABS, INC.
TS0417-B700ML-M1690
Timely Extra Strength Headache Relief - Acetaminophen, Aspirin, Caffeine Cover
Timely Extra Strength Headache Relief - Acetaminophen with Aspirin & Caffeine (200 Caplets) - Headache, Migraine & Back and Body Pain & Muscle Aches - Compares to Excedrin Extra Strength - Made In USA

Timely Headache Relief combines Acetaminophen, Aspirin, and Caffeine for effective management of headaches and migraines. This unique trio works together to tackle various pain aspects, providing you with a powerful solution. You will appreciate the fast-acting relief that allows you to return to your daily activities without delay. Moreover, the inclusion of caffeine enhances the effectiveness of the pain relief, making it a useful option for those who need quick help. With 200 caplets in each bottle, it’s perfect for both home use and travel, ensuring you’re always prepared for discomfort.

What We Like
Fast-acting relief
Triple-action formula
Convenient for travel
Effective for various pains
#TOP 7

Tylenol 8 Hour Arthritis Pain Caplets, 225 Count

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Tylenol 8 Hour Arthritis Pain Caplets, 225 Count Cover
Tylenol 8 Hour Arthritis Pain Relief Extended-Release Tablets, 650 mg Acetaminophen, Joint Pain Reliever & Fever Reducer Medicine, Oral Pain Reliever for Arthritis & Joint Pain, 225 Count

Get fast-acting and temporary relief of minor arthritis and joint pain in hands, wrists, knees, ankles, elbows, and feet with Tylenol 8 Hour Arthritis Pain Extended-Release Caplets. These oral pain relievers contain 650mg of acetaminophen that provides two layers of effective pain relief that lasts for up to 8 hours. These caplets can also relieve minor aches and pains, including muscle aches, backache, headache, toothache, the common cold, and menstrual cramps. The safety profile of these caplets is excellent for adults aged 18 years and older.

What We Like
Fast-acting and temporary relief of minor arthritis and joint pain
Two layers of effective pain relief that lasts up to 8 hours
Can also relieve minor aches and pains
Excellent safety profile for adults aged 18 years and older
#1 doctor recommended OTC brand for arthritis pain relief
#TOP 8

Tylenol 8 Hour Arthritis Pain Extended-Release Caplets

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24 Count
Tylenol 8 Hour Arthritis Pain Extended-Release Caplets Cover
Tylenol 8 Hour Arthritis Pain Relief Extended-Release Tablets, 650 mg Acetaminophen, Joint Pain Reliever & Fever Reducer Medicine, Oral Pain Reliever for Arthritis & Joint Pain, 24 Count

Tylenol 8 Hour Arthritis Pain Extended-Release Caplets provide fast-acting, temporary relief of minor arthritis and joint pain. It contains 650 mg of acetaminophen, which is a known pain reliever and fever reducer. The first layer acts fast and the second lasts up to 8 hours. It can be used by adults 18 years and older and is an excellent oral pain reliever for a variety of aches and pains, including arthritis, joint ache, knee pain, muscle aches, backache, headache, toothache, the common cold, and pre-menstrual and menstrual cramps.

What We Like
Effective relief for minor arthritis and joint pain
Fast-acting and long-lasting
Can be used for a variety of aches and pains

Rite Aid Pain Relief Acetaminophen PM Caplets

Rite Aid Pain Relief Acetaminophen PM Caplets Cover
Rite Aid Extra Strength Pain Relief Acetaminophen PM Caplets, 500mg Acetaminophen / 25mg Diphenhydramine - 300 Count - Nighttime Pain Reliever + Sleep Aid

Rite Aid Pain Relief PM is a trusted brand that offers a non-habit forming solution for pain relief and sleep aid. With its extra strength acetaminophen, it effectively reduces pain while the diphenhydramine HCI aids in getting a good night's sleep. Whether you're dealing with headaches, migraines, menstrual pain, or body aches, this aspirin-free medication provides relief. The 500mg of acetaminophen also helps to reduce fevers temporarily. Rite Aid Pain Relief PM is the perfect choice for those who want to wake up feeling refreshed and ready to take on the day.

What We Like
Non-habit forming
Nighttime sleep aid
Pain and fever relief
#TOP 10

Rite Aid Extra Strength Acetaminophen Easy Tabs Tablets, 500 mg - 100 Count

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Rite Aid Extra Strength Acetaminophen Easy Tabs Tablets, 500 mg - 100 Count Cover
Rite Aid Extra Strength Acetaminophen Easy Tabs Tablets, 500 mg - 100 Count | Pain Reliever & Fever Reducer | Migraine Relief Products | Joint Pain Relief | Muscle Pain Relief | Menstrual Pain Relief

Rite Aid Acetaminophen is a trusted brand since 1962 that offers effective pain relief and fever reduction. With its extra strength formulation of 500mg, it compares to the active ingredient in Extra Strength Tylenol. The small tablets are easy to swallow, thanks to their sweet coating, making it convenient for use at home or on-the-go. Each gelcap contains 500mg of acetaminophen without any aspirin, making it ideal for those seeking arthritis pain relief, back pain relief, joint pain relief, or muscle pain relief. Rite Aid Acetaminophen is your go-to solution for minor headaches, migraines, muscular and body aches, and pains associated with arthritis and joint pain.

What We Like
Extra strength formulation
Easy to swallow tablets
No aspirin
Buying Guide Image

Frequently Asked Questions (FAQs)

1. Is acetaminophen good for muscle pain?

Its anti-inflammatory properties are better for muscle soreness and body aches that typically stem from inflammation. Acetaminophen (Tylenol). Some studies show that acetaminophen relieves cold symptoms and a sore throat better than ibuprofen or naproxen.

2. Is ibuprofen or acetaminophen better for muscle pain?

As you may have guessed from the descriptions above, acetaminophen is best used for fever, aches and pains, but will not be very helpful if the pain is due to inflammation. Ibuprofen is more helpful for these symptoms when inflammation is the cause.

3. Which painkiller is best for muscle aches?

Muscle ache or pulled/strained muscle. Ibuprofen typically works better for this kind of pain relief, due to the anti-inflammatory effects.

4. Is acetaminophen a muscle relaxant?

TYLENOL® Back Pain caplets contain effective pain relief plus a muscle relaxant to relieve and relax painful back muscles....Disponibile online presso.

Editor's Notes

During our acetaminophen for muscle pain research, we found 24 acetaminophen for muscle pain products and shortlisted 10 quality products. We collected and analyzed 173,196 customer reviews through our big data system to write the acetaminophen for muscle pain list. We found that most customers choose acetaminophen for muscle pain with an average price of $17.48.

The acetaminophen for muscle pain are available for purchase. We have researched hundreds of brands and picked the top brands of acetaminophen for muscle pain, including TENA, Rite Aid, Advil, GenCare, TIME-CAP LABS, INC.. The seller of top 1 product has received honest feedback from 385 consumers with an average rating of 4.7.

Written by
Bonnie Salem Avatar

Bonnie Salem is a stay-at-home mother with two-year-old twins and has spent almost half of her life surrounded by baby products. As a mother and a professional copywriter, she has an insightful and unique eye for researching products suitable for infants. Bonnie Salem is an expert in health and nutrition who lives with her family in New Jersey. She has over 15 years of working experience in an institute of medicine after graduating from the University of Toronto. She is highly interested in personal health and wellness.