Best Acetaminophen for Muscle Pain of 2026

Tylenol Extra Strength Acetaminophen Rapid Release Gels come in a 100-count bottle and are designed to provide fast relief from minor aches, pains, and fever. The unique laser-drilled holes in each gelcap quickly release 500mg of acetaminophen for extra strength pain relief. This oral pain reliever is suitable for adults and children aged 12 years and older and can be used to treat headaches, toothaches, backaches, cramps, and pain caused by the common cold.

Get relief from minor aches and pains caused by muscle aches, joint pain, back pain, headache, toothache, the common cold, and menstrual cramps. Each extended-release tablet contains 650mg of acetaminophen and features two unique layers for effective pain relief that lasts up to 8 hours. These tablets reduce fever and have an excellent safety profile for adults and children over the age of 12. Tylenol is the #1 doctor recommended brand for pain relief and fever reduction.

Tylenol Pain Reliever is a 100-count bottle of acetaminophen tablets that provides temporary relief of minor aches and pains, as well as helps reduce fever. Each tablet contains 325 mg of acetaminophen, which effectively relieves pain and has a great safety profile when used as directed. This pain reliever can be used by adults and children 6 years and older. It is ideal for alleviating common pain symptoms like headache, backache, toothache, menstrual cramps, and pain caused by the common cold. With Tylenol Pain Reliever, you can experience effective relief and get back to feeling your best. It is the #1 doctor recommended brand for pain relief and fever reduction.

Tylenol Extra Strength Dissolve Packs feature a great tasting Berry flavor and temporarily relieve minor aches and pains due to common cold, headache, backache, muscle aches, minor pain of arthritis, menstrual cramps, and toothache. Each packet contains 500 mg of acetaminophen, a pain reliever and fever reducer, and is both ibuprofen-free and aspirin-free. This portable pain medicine dissolves in seconds on the tongue with no water needed, and is safe for both adults and children 12 years of age and older. It's a convenient form to have on hand whenever pain hits.

Advil Dual Action is a multi-symptom pain medication that provides relief for up to 8 hours. With a combination of ibuprofen and acetaminophen, it targets pain at the source and blocks pain signals. This pain medicine is great for headaches, toothaches, menstrual cramps, muscle pain, lower back pain, and minor aches and pains associated with arthritis. Additionally, the new packaging will feature 20% less plastic by 2022, keeping nearly 500,000 pounds of plastic out of landfills. With 216 caplets per box, Advil Dual Action is a convenient and effective solution for your pain relief needs.

GenCare Extra Strength Headache Relief Acetaminophen is a family-size pain relief bottle with 300 caplets for headaches, migraines, muscle aches, toothaches, menstrual cramps, arthritis, joint pain, and more. Each caplet contains 250mg of Acetaminophen, 250mg of Aspirin (NSAID), and 65mg of Caffeine that act fast to energize and restore mental focus. Adults and children over 12 can take 2 caplets every 6 hours not to exceed 8 caplets in 24 hours. GenCare offers a 100% satisfaction guarantee.

Excedrin Tension Headache Relief Caplets are an aspirin-free tension headache pain medicine that quickly relieves headaches and pain caused by tension and stress. The caplets combine acetaminophen with caffeine to deliver muscle ache, shoulder and neck pain relief, and temporarily relieve pain caused by headaches and muscle aches. The trusted formula effectively relieves tension-type headaches in convenient caplet form.

Excedrin PM Sleep Aid with Headache Relief Caplets provide temporary relief of pain associated with headaches and muscle aches accompanied by sleeplessness. This caffeine-free diphenhydramine, aspirin, and acetaminophen caplet is perfect for nighttime headache sufferers. Its triple action formula combines two effective pain relievers with a nighttime sleep-aid, helping you get to sleep faster. The pain reliever is available in convenient caplet form, ensuring effective headache and muscle pain relief whenever you need it.

GenCare Tension Headache Relief Pain Reliever provides extra strength relief for mild to severe headaches, tension pain, and muscle aches. Its potent combination of Acetaminophen (500mg) and Caffeine (65mg) also effectively relieves sore muscles, tooth aches, arthritis and joint pain. The caffeine content helps restore energy levels and focus for mental clarity. It comes in a 200 caplet bulk savings bottle for convenience and to keep your family's medicine cabinet fully stocked. It is suitable for adults and children 12 years and older.