Best Diphenhydramine Allergy Medicine of 2026

Bonnie Salem Avatar
Bonnie Salem
Last Updated: Jan 16, 2026

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Diphenhydramine is an allergy medicine that is commonly used to relieve symptoms such as itching, sneezing, runny nose, and watery eyes. It is an antihistamine that works by blocking the effects of histamine, which is a substance that is released by the body in response to allergens. Diphenhydramine is available in both over-the-counter and prescription forms, and is commonly found in products such as Benadryl and Tylenol PM. While it is generally safe for most people to use, it can cause drowsiness and other side effects in some individuals. It is important to read the label and follow the instructions carefully when using diphenhydramine or any other medication.

At a Glance: Our Top Picks

Benadryl Ultratabs Allergy Relief Tablets, 100 ct Cover #TOP 1
Benadryl Ultratabs Allergy Relief Tablets, 100 ct
ftb score rating icon 9.8
Amazon Basic Care Allergy Relief Diphenhydramine HCl 25 mg Cover #TOP 2
Amazon Basic Care Allergy Relief Diphenhydramine HCl 25 mg
ftb score rating icon 9.7
Benadryl Extra Strength Allergy Relief 50 mg Tablets, 24 ct Cover #TOP 3
Benadryl Extra Strength Allergy Relief 50 mg Tablets, 24 ct
ftb score rating icon 9.5

Top 10 Diphenhydramine Allergy Medicine

Benadryl Ultratabs Allergy Relief Tablets, 100 ct

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Pink
Benadryl Ultratabs Allergy Relief Tablets, 100 ct Cover
Benadryl Ultratabs Allergy Medicine, 25 mg Diphenhydramine HCl Antihistamine Tablets For Cold & Allergy Relief of Symptoms Like Sneezing, Runny Nose, Itchy Eyes & Throat, Hay Fever, 100 Count Tablets

Benadryl Ultratabs Allergy Relief Tablets are a doctor-recommended solution for allergy and cold symptoms. With 25mg diphenhydramine HCl per tablet, it provides powerful relief for sneezing, runny nose, itchy throat, and watery eyes due to upper respiratory allergies or the common cold. This 100-count bottle is easy to swallow for adults and children aged six and up, making it a convenient solution for indoor and outdoor allergies.

What We Like
Effective allergy relief
Good value and price
Convenient bottle packaging
Versatile human and pet use
Reliable for runny nose

Amazon Basic Care Allergy Relief Diphenhydramine HCl 25 mg

Amazon Basic Care
Pink
400 Count
Amazon Basic Care Allergy Relief Diphenhydramine HCl 25 mg Cover
Amazon Basic Care Complete Allergy Relief, Diphenhydramine HCl 25 mg, Relieves Symptoms, Antihistamine Tablets, 400 Count

Amazon Basic Care Allergy Relief provides multi-symptom relief for hay fever and upper respiratory allergies. Each tablet contains 25 mg of diphenhydramine HCl, an antihistamine, which can alleviate symptoms such as runny nose, sneezing, itching of the nose or throat, and itchy, watery eyes. The powerful dose of allergy-fighting medicine relieves allergy symptoms for 4-6 hours. These mini-tabs are easy to swallow, making them ideal for travel. Nighttime allergy relief is also available to help you rest. Suitable for adults and children 6 years and older.

What We Like
Easy to swallow
Affordable price
Works like name brands
Effective for allergies
Usable for pets

Benadryl Extra Strength Allergy Relief 50 mg Tablets, 24 ct

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Benadryl Extra Strength Allergy Relief 50 mg Tablets, 24 ct Cover
Benadryl Extra Strength Allergy Relief Medicine, 50 mg Diphenhydramine HCl Antihistamine Tablets for Relief of Allergy Symptoms Due to Hay Fever or Other Upper Respiratory Allergies, 24 ct

Benadryl Allergy Relief Tablets offer a powerful solution for managing allergy symptoms. Each tablet contains 50 mg of diphenhydramine HCl, which helps reduce common issues like sneezing, runny nose, and itchy eyes caused by both indoor and outdoor allergies. This extra strength formula is effective against hay fever and symptoms related to the common cold, giving you quick relief when you need it most. The small, easy-to-take tablets are designed for adults and children 12 years and older, making it convenient to keep your allergies in check throughout the day.

What We Like
Extra strength formula
Relieves multiple allergy symptoms
Fast-acting antihistamine
Suitable for ages 12
#TOP 4

ValuMeds Allergy Medicine (600 Tablets)

60535-2
Pink
25 mg
ValuMeds Allergy Medicine (600 Tablets) Cover
ValuMeds Allergy Medicine Antihistamine, Diphenhydramine HCl 25 mg | Children and Adults | Relieve Itchy Eyes, Runny Nose, Sneezing (25 mg, 600)

ValuMeds Allergy Medicine is a powerful antihistamine that helps control coughs and runny noses for healthier breathing. It also reduces dry, itchy eyes, sneezing, and itchy noses and throats caused by allergies. This medicine can cause drowsiness, making it helpful for a better night's rest, but users should avoid driving after use. It's important to read the package for proper use and dosage instructions.

What We Like
Contains 600 tablets
Can help relieve allergy symptoms such as runny nose, itchy eyes, and sneezing
Causes drowsiness, aiding in better sleep

Benadryl Liqui-Gels Allergy Medicine & Cold Relief, Dye Free

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Benadryl Liqui-Gels Allergy Medicine & Cold Relief, Dye Free Cover
Benadryl Liqui-Gels Allergy Medicine, Dye-Free Liquid Gel Capsules with 25 mg of Diphenhydramine HCl Antihistamine for Relief of Allergy & Cold Symptoms Like Runny Nose & Sneezing, 24 ct

Benadryl Liqui-Gels Allergy Medicine & Cold Relief, Dye Free is a 24-count package of liquid capsules that provide effective relief from allergy symptoms such as sneezing, runny nose, itchy nose, itchy throat, itchy, watery eyes, and cold symptoms such as sneezing and runny nose. Free of dyes, it is safe for adults and children ages 6 and up to use. This antihistamine allergy medicine is effective for common allergens like pollen, dust mites, mold, and pet dander, and comes from a doctor-recommended brand.

What We Like
Effective relief from allergy and cold symptoms
Dye-free for safe use
Comes from a doctor-recommended brand
#TOP 6

Benadryl Children's Dye-Free Allergy Liquid, Bubble Gum, 4 fl. oz

493805
Clear
4 Fl Oz (Pack of 1)
Benadryl Children's Dye-Free Allergy Liquid, Bubble Gum, 4 fl. oz Cover
Children's Benadryl Dye-Free Allergy Relief Liquid + 12.5 mg Diphenhydramine HCl, Antihistamine Allergy Medicine for Kids Helps Relieve Runny Nose & Sneezing, Bubble Gum Flavor, 4 fl. oz

Benadryl Children's Dye-Free Allergy Liquid Medicine is a specially formulated antihistamine designed to temporarily relieve children's allergy symptoms caused by hay fever and other upper respiratory allergies. It contains diphenhydramine HCl that works to alleviate allergy symptoms including runny nose, sneezing, itching of nose or throat, and itchy, watery eyes. This allergy liquid medicine comes with a convenient dosing cup and a kid-friendly bubble gum flavor that your child will love.

What We Like
Convenient dosing cup
Kid-friendly bubble gum flavor
Alleviates allergy symptoms caused by hay fever and other upper respiratory allergies
#TOP 7

Benadryl Ultratabs 25 mg Allergy Relief Tablets

416436
24 Count
Benadryl Ultratabs 25 mg Allergy Relief Tablets Cover
Benadryl Ultratabs Allergy Relief Medicine, 25 mg Diphenhydramine HCl Antihistamine Tablets For Relief of Cold & Allergy Symptoms Like Sneezing, Runny Nose, & Itchy Eyes & Throat, 24 ct

Benadryl Allergy Relief is designed to help you manage common allergy symptoms like sneezing, runny nose, and itchy throat or eyes. These tablets contain diphenhydramine hydrochloride, an effective antihistamine that provides quick relief from hay fever and other upper respiratory issues caused by allergens such as pollen, dust, mold, and pet dander. Besides allergies, this medicine also tackles cold symptoms, offering a powerful formula that works when you need it most. Its convenient tablet form makes it easy for adults and children over 6 to get relief from multiple symptoms with just one pill.

What We Like
Effective allergy symptom relief
Contains diphenhydramine HCl
Also relieves cold symptoms
Works fast and conveniently
#TOP 8

Amazon Basic Care Children's Allergy Relief Oral Solution

Amazon Basic Care
4 Fl Oz (Pack of 1)
Amazon Basic Care Children's Allergy Relief Oral Solution Cover
Amazon Basic Care Children's Allergy Relief Oral Solution, Diphenhydramine HCl, Cherry Flavor, 4 fl oz (Pack of 1)

Amazon Basic Care Allergy Relief is a children's allergy medicine that provides temporary relief for a variety of allergy symptoms. It contains Diphenhydramine HCl, an antihistamine, which helps to alleviate sneezing, runny nose, itching of the nose or throat, and itchy, watery eyes. With its cherry flavor, kids will love taking this medicine. It offers 4-6 hours of allergy relief per dose, allowing your child to feel better throughout the day. The medicine is gluten-free and alcohol-free, making it safe for kids aged 6-11. Amazon Basic Care Allergy Relief is a trusted option for parents looking for an effective and convenient solution to their child's allergy symptoms.

What We Like
Cherry flavor kids love
4-6 hours of relief
Gluten-free and alcohol-free

Benadryl Allergy Plus Congestion Ultratabs

Benadryl Allergy Plus Congestion Ultratabs Cover
Benadryl Allergy Plus Congestion Ultratabs, Medicine with Diphenhydramine HCl Antihistamine & Phenylephrine HCl Nasal Decongestant, Allergy & Sinus Congestion Relief Tablets, 24 ct

Benadryl Allergy Ultratabs is a trusted allergy medicine that provides relief from both allergies and congestion. With a unique formula containing diphenhydramine HCl and phenylephrine HCl, these tablets effectively alleviate symptoms caused by hay fever and other upper respiratory allergies. You can count on Benadryl Allergy Ultratabs to dry runny and stuffy noses, allowing you to breathe better. It also temporarily relieves common cold symptoms such as sneezing and congestion. Each tablet contains 25 mg of diphenhydramine HCl and 10 mg of phenylephrine HCl, which work together to alleviate sinus congestion and allergy symptoms. Suitable for ages 12 and up, this doctor-recommended allergy medicine provides safe and effective relief from indoor and outdoor allergies, as well as congestion due to the common cold.

What We Like
Relieves allergies and congestion
Temporarily relieves common cold symptoms
Contains both antihistamine and nasal decongestant
#TOP 10

GenCare Allergy Relief Medicine (600 Tablets)

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GenCare Allergy Relief Medicine (600 Tablets) Cover
GenCare Allergy Relief Medicine – Bulk Value 600 Count Diphenhydramine 25mg – Antihistamines for Adults for Congestion, Sneezing, Runny Nose, Itchy Eyes & Throat – Pink Generic Benadryl Tablets 25 mg

GenCare Allergy Relief Medicine offers a bulk savings bottle with 600 easy-to-swallow tablets per bottle, perfect for families or people who suffer from chronic indoor and outdoor allergies. It provides fast relief from itchy, puffy, red or watery eyes, congestion, runny nose and sneezing. The antihistamine response may naturally cause drowsiness in both adults and kids, helping you fall asleep faster and stay asleep. Each tamper-proof bottle is backed up with a 100% satisfaction guarantee.

What We Like
600 easy-to-swallow tablets per bottle
Fast relief from various allergy symptoms
May help improve sleep quality
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Frequently Asked Questions (FAQs)

1. Is diphenhydramine the same as Claritin?

Benadryl, also known by its generic name diphenhydramine, is known as a first-generation antihistamine. This group of antihistamines are among the first drugs developed to treat allergy symptoms. Claritin, also known by its generic name loratadine, is classified as a second-generation antihistamine.

2. What are side effects of diphenhydramine?

Diphenhydramine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:. dry mouth, nose, and throat.drowsiness.dizziness.nausea.vomiting.loss of appetite.constipation.increased chest congestion.

3. What allergy meds contain diphenhydramine?

Other common OTC brands that include the antihistamine diphenhydramine include:. Banophen.Siladryl.Unisom.Benadryl-D Allergy Plus Sinus.Robitussin Severe Multi-Symptom Cough Cold + Flu Nighttime.Sudafed PE Day/Night Sinus Congestion.

4. Does diphenhydramine allergy make you sleepy?

1. About diphenhydramine. Diphenhydramine is an antihistamine medicine that relieves the symptoms of allergies. It's known as a drowsy (sedating) antihistamine and is more likely to make you feel sleepy than other antihistamines.

Editor's Notes

During our diphenhydramine allergy medicine research, we found 24 diphenhydramine allergy medicine products and shortlisted 10 quality products. We collected and analyzed 740,250 customer reviews through our big data system to write the diphenhydramine allergy medicine list. We found that most customers choose diphenhydramine allergy medicine with an average price of $8.15.

The diphenhydramine allergy medicine are available for purchase. We have researched hundreds of brands and picked the top brands of diphenhydramine allergy medicine, including Benadryl, ValuMeds, GenCare. The seller of top 1 product has received honest feedback from 384 consumers with an average rating of 4.7.

Written by
Bonnie Salem Avatar

Bonnie Salem is a stay-at-home mother with two-year-old twins and has spent almost half of her life surrounded by baby products. As a mother and a professional copywriter, she has an insightful and unique eye for researching products suitable for infants. Bonnie Salem is an expert in health and nutrition who lives with her family in New Jersey. She has over 15 years of working experience in an institute of medicine after graduating from the University of Toronto. She is highly interested in personal health and wellness.