Best Diphenhydramine Allergy Medicine of 2025

Bonnie Salem Avatar
Bonnie Salem
Last Updated: Jan 4, 2025

* We independently evaluate all recommended products and services. If you click on links we provide, we may receive compensation.

Diphenhydramine is an allergy medicine that is commonly used to relieve symptoms such as itching, sneezing, runny nose, and watery eyes. It is an antihistamine that works by blocking the effects of histamine, which is a substance that is released by the body in response to allergens. Diphenhydramine is available in both over-the-counter and prescription forms, and is commonly found in products such as Benadryl and Tylenol PM. While it is generally safe for most people to use, it can cause drowsiness and other side effects in some individuals. It is important to read the label and follow the instructions carefully when using diphenhydramine or any other medication.

At a Glance: Our Top Picks

Amazon Basic Care Allergy Relief Cover #TOP 1
Amazon Basic Care Allergy Relief
ftb score rating icon 9.8
Timely Allergy Relief Diphenhydramine 25 mg - TIME-CAP LABS Cover #TOP 2
Timely Allergy Relief Diphenhydramine 25 mg - TIME-CAP LABS
ftb score rating icon 9.7
Kirkland Signature Allergy Medicine Diphenhydramine HCI 25 mg - 600 Minitabs Cover #TOP 3
Kirkland Signature Allergy Medicine Diphenhydramine HCI 25 mg - 600 Minitabs
ftb score rating icon 9.5

Top 10 Diphenhydramine Allergy Medicine

Amazon Basic Care Allergy Relief

Amazon Basic Care
Pink
Amazon Basic Care Allergy Relief Cover
Amazon Basic Care Allergy Relief Diphenhydramine HCl 25 mg, Antihistamine Tablets for Symptoms Due to Hay Fever and Upper Respiratory Allergies, 100 Count

Basic Care Allergy Relief is an antihistamine tablet designed to provide temporary relief from various allergy symptoms. With its active ingredient, diphenhydramine HCl 25 mg, it effectively combats runny nose, sneezing, itching of the nose or throat, and itchy, watery eyes. It can also alleviate symptoms of the common cold, such as runny nose and sneezing. The mini-tabs are easy to swallow, ensuring a hassle-free experience. Additionally, Basic Care Allergy Relief offers nighttime allergy relief, allowing users to rest better. With its powerful allergy-fighting formula, this product from Amazon Basic Care is a convenient option for those seeking multi-symptom allergy relief.

What We Like
Effective relief from allergy symptoms
Easy-to-swallow mini-tabs
Nighttime allergy relief for better sleep
#TOP 2

Timely Allergy Relief Diphenhydramine 25 mg - TIME-CAP LABS

TIME-CAP LABS, INC.
TS0417-B700ML-M451
Timely Allergy Relief Diphenhydramine 25 mg - TIME-CAP LABS Cover
Timely Allergy Relief Diphenhydramine HCl 25 mg - 650 Caplets - Compared to Benadryl Allergy Ultratab - Antihistamine - Allergy Medication - Runny Nose Relief for Adults - Watery Eyes Treatment

Timely Allergy Relief is an effective solution for managing allergy symptoms and common cold discomfort. These caplets provide quick relief from hay fever symptoms like runny nose and watery eyes, helping you breathe easier and feel more comfortable. They're also beneficial for alleviating sneezing and throat irritation, so you can focus on your daily activities without interruption. Additionally, this medication is a cost-effective alternative to national brands, ensuring you get reliable relief without breaking the bank. Keep these convenient caplets in your first-aid kit for a dependable way to tackle allergies and colds.

What We Like
Quick allergy symptom relief
Helps with common cold symptoms
Cost-effective alternative
Convenient caplet form
#TOP 3

Kirkland Signature Allergy Medicine Diphenhydramine HCI 25 mg - 600 Minitabs

KIRKLAND
536099
Kirkland Signature Allergy Medicine Diphenhydramine HCI 25 mg - 600 Minitabs Cover
Kirkland Signature Allergy Medicine Diphenhydramine HCI 25 mg - 600 Minitabs - 2 Pack

Kirkland Signature Allergy Medicine Diphenhydramine HCI 25 mg - 600 Minitabs is an antihistamine that provides temporary relief from allergy symptoms such as sneezing, itching, watery eyes, and itching of the nose or throat. Additionally, it helps relieve symptoms from the common cold, such as runny nose and sneezing. This allergy medicine is perfect for those with hay fever and upper respiratory allergies. Users should avoid using any other products containing diphenhydramine, even those used on the skin.

What We Like
Provides temporary relief from allergy symptoms
Helps relieve symptoms from the common cold
Perfect for those with hay fever and upper respiratory allergies
#TOP 4

berkley jensen Allergy Relief Tablets

berkley jensen Allergy Relief Tablets Cover
berkley jensen Allergy Relief Tablets - 25mg Diphenhydramine HCI - Allergy Medicine to Temporary Relieve Sneezing, Watery Eyes, Runny Nose, Itchy Throat - Easy-Swallow, 400 Tablets (Pack of 1)

berkley jensen Allergy Tablets provide quick relief from common allergy symptoms like sneezing, itchy throat, and watery eyes, allowing you to carry on with your day without discomfort. The easy-to-swallow mini tablets make it simple for anyone to take their medication, especially those who struggle with larger pills. Each tablet contains a proper dose of 25mg Diphenhydramine HCl, effectively blocking the body’s histamine response to allergens. You have flexible dosing options, as you can take one or two tablets every four to six hours, ensuring your symptoms are managed throughout the day.

What We Like
Effective allergy symptom relief
Easy-to-swallow mini tablets
Properly dosed for effectiveness
Flexible dosing options
#TOP 5

Safrel Allergy Relief Medication Diphenhydramine HCl Caplets 25 mg (1000 Count)

009-01
Safrel Allergy Relief Medication Diphenhydramine HCl Caplets 25 mg (1000 Count) Cover
Safrel Allergy Relief Medication Diphenhydramine HCl Caplets 25 mg (1000 Count), Antihistamine Relieves Sneezing, Runny Nose, Hay Fever, Itchy Eyes and Throat, Seasonal Indoor & Outdoor Allergy Pills

Safrel Allergy Relief Medication is a powerful antihistamine that effectively treats indoor and outdoor allergies. With its active ingredient, Diphenhydramine HCl, this allergy relief medicine provides relief from symptoms such as runny nose, sneezing, itching of the nose or throat, and itchy, watery eyes caused by hay fever or other upper respiratory allergies. It also helps reduce sneezing and itchy noses and throats associated with the common cold. Safrel Allergy Relief Medication is suitable for adults and children 12 years and over, making it a convenient option for the whole family. Add it to your cart and experience the relief it offers.

What We Like
Effective allergy relief
Relieves symptoms of hay fever and the common cold
Convenient for adults and children 12 years and over

ValuMeds Allergy Medicine (600 Tablets)

60535-2
25 mg
ValuMeds Allergy Medicine (600 Tablets) Cover
ValuMeds Allergy Medicine Antihistamine, Diphenhydramine HCl 25 mg | Children and Adults | Relieve Itchy Eyes, Runny Nose, Sneezing (25 mg, 600)

ValuMeds Allergy Medicine is a powerful antihistamine that helps control coughs and runny noses for healthier breathing. It also reduces dry, itchy eyes, sneezing, and itchy noses and throats caused by allergies. This medicine can cause drowsiness, making it helpful for a better night's rest, but users should avoid driving after use. It's important to read the package for proper use and dosage instructions.

What We Like
Contains 600 tablets
Can help relieve allergy symptoms such as runny nose, itchy eyes, and sneezing
Causes drowsiness, aiding in better sleep
#TOP 7

GenCare Allergy Relief Medicine (600 Tablets)

GenCare
EB-002
GenCare Allergy Relief Medicine (600 Tablets) Cover
GenCare - Allergy Relief Medicine | Antihistamine Diphenhydramine 25mg (600 Tablets Per Bottle) Value Pack | Relieve for Itchy Eyes, Sneezing, Runny Nose | Seasonal or Indoor & Outdoor Allergies

GenCare Allergy Relief Medicine offers a bulk savings bottle with 600 easy-to-swallow tablets per bottle, perfect for families or people who suffer from chronic indoor and outdoor allergies. It provides fast relief from itchy, puffy, red or watery eyes, congestion, runny nose and sneezing. The antihistamine response may naturally cause drowsiness in both adults and kids, helping you fall asleep faster and stay asleep. Each tamper-proof bottle is backed up with a 100% satisfaction guarantee.

What We Like
600 easy-to-swallow tablets per bottle
Fast relief from various allergy symptoms
May help improve sleep quality
#TOP 8

Rite Aid Allergy Relief Tablets

011822303996
Rite Aid Allergy Relief Tablets Cover
Rite Aid Antihistamine Allergy Relief with Diphenhydramine | Allergy Medicine | Easy-to-Swallow Small Tablet Size Allergy Relief | Common Cold & Respiratory Allergy Medication (200 Count)

Rite Aid Allergy Relief is designed to combat various allergy symptoms, providing you with relief from sneezing, itchy eyes, and a runny nose. This product effectively tackles both indoor and outdoor allergens, such as pet dander and pollen, ensuring that you can enjoy your environment without discomfort. The small, easy-to-swallow tablets make taking your allergy medication convenient, allowing for quick relief from hay fever and cold symptoms. With a trusted brand since 1962, Rite Aid is committed to enhancing your health and wellness with quality products.

What We Like
Multi-symptom relief
Controls indoor and outdoor allergies
Easy-to-swallow tablets
Trusted brand since 1962
#TOP 9

Kirkland Signature Diphenhydramine 25mg

Kirkland Signature Diphenhydramine 25mg Cover
KirkIand Signature Allergy Medicine Diphenhydramine HCI 25 Mg, 600 Minitabs + STS Sticker.

Kirkland Allergy Medicine offers effective relief from allergy symptoms with its active ingredient, Diphenhydramine HCI, at a strength of 25 mg. This antihistamine helps alleviate sneezing, runny nose, and itchy eyes, making it a great choice for those suffering from seasonal allergies. With 600 minitabs in one package, you’ll have plenty on hand for when you need them. Plus, it’s an FSA eligible item, allowing you to use your flexible spending account for purchase, adding convenience to your health care shopping.

What We Like
Effective allergy relief
Large quantity of tablets
FSA eligible for savings
Easy to swallow minitabs
#TOP 10

MedPlus Allergy Relief Tablets, 25 mg

MedPlus
DH-76EB-6N7V
Pink
MedPlus Allergy Relief Tablets, 25 mg Cover
MedPlus Allergy Relief Medicine, 25 mg, 600 Tablets | Diphenhydramine Hcl | Antihistamine | Relief for Indoor & Outdoor Allergies, Pink

MedPlus Allergy Relief is a powerful antihistamine that offers fast relief from a variety of allergy symptoms. Each tablet contains 25 mg of Diphenhydramine HCl, which can help alleviate itchy, puffy, or watery eyes caused by allergens like pollen, pet dander, and dust. Additionally, this medicine can ease congestion associated with both allergies and colds, making it a versatile choice for indoor and outdoor discomfort. With a bulk supply of 600 tablets, you’ll enjoy the convenience of having allergy relief on hand whenever you need it.

What We Like
Proudly made in the USA
Fast relief for allergy symptoms
Helps with congestion relief
Large 600 tablet supply
100% satisfaction guarantee
Buying Guide Image

Frequently Asked Questions (FAQs)

1. Is diphenhydramine the same as Claritin?

Benadryl, also known by its generic name diphenhydramine, is known as a first-generation antihistamine. This group of antihistamines are among the first drugs developed to treat allergy symptoms. Claritin, also known by its generic name loratadine, is classified as a second-generation antihistamine.

2. What are side effects of diphenhydramine?

Diphenhydramine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:. dry mouth, nose, and throat.drowsiness.dizziness.nausea.vomiting.loss of appetite.constipation.increased chest congestion.

3. What allergy meds contain diphenhydramine?

Other common OTC brands that include the antihistamine diphenhydramine include:. Banophen.Siladryl.Unisom.Benadryl-D Allergy Plus Sinus.Robitussin Severe Multi-Symptom Cough Cold + Flu Nighttime.Sudafed PE Day/Night Sinus Congestion.

4. Does diphenhydramine allergy make you sleepy?

1. About diphenhydramine. Diphenhydramine is an antihistamine medicine that relieves the symptoms of allergies. It's known as a drowsy (sedating) antihistamine and is more likely to make you feel sleepy than other antihistamines.

Editor's Notes

During our diphenhydramine allergy medicine research, we found 24 diphenhydramine allergy medicine products and shortlisted 10 quality products. We collected and analyzed 423,499 customer reviews through our big data system to write the diphenhydramine allergy medicine list. We found that most customers choose diphenhydramine allergy medicine with an average price of $7.18.

The diphenhydramine allergy medicine are available for purchase. We have researched hundreds of brands and picked the top brands of diphenhydramine allergy medicine, including TIME-CAP LABS, INC., KIRKLAND, berkley jensen, Safrel, ValuMeds. The seller of top 1 product has received honest feedback from 385 consumers with an average rating of 4.7.

Written by
Bonnie Salem Avatar

Bonnie Salem is a stay-at-home mother with two-year-old twins and has spent almost half of her life surrounded by baby products. As a mother and a professional copywriter, she has an insightful and unique eye for researching products suitable for infants. Bonnie Salem is an expert in health and nutrition who lives with her family in New Jersey. She has over 15 years of working experience in an institute of medicine after graduating from the University of Toronto. She is highly interested in personal health and wellness.