Best Acetaminophen for Fever of 2025

Bonnie Salem Avatar
Bonnie Salem
Last Updated: Jan 5, 2025

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Acetaminophen is a common over-the-counter medication used to relieve fever and pain. It is a safe and effective option for people of all ages, including children and pregnant women. Unlike other pain relievers, such as aspirin or ibuprofen, acetaminophen does not irritate the stomach or cause bleeding. It works by blocking the production of certain chemicals in the body that cause pain and fever. It is important to follow the recommended dosage instructions and not exceed the maximum daily limit to avoid potential liver damage. Acetaminophen is available in various forms, including tablets, capsules, and liquid, making it easy to use and convenient for on-the-go relief.

At a Glance: Our Top Picks

Amazon Basic Care Extra Strength Pain Relief Caplets Cover #TOP 1
Amazon Basic Care Extra Strength Pain Relief Caplets
ftb score rating icon 9.9
Tylenol Extra Strength Acetaminophen Rapid Release Gels, 100 ct Cover #TOP 2
Tylenol Extra Strength Acetaminophen Rapid Release Gels, 100 ct
ftb score rating icon 9.8
Tylenol Regular Strength Tablets Cover #TOP 3
Tylenol Regular Strength Tablets
ftb score rating icon 9.6

Top 10 Acetaminophen for Fever

#TOP 1

Amazon Basic Care Extra Strength Pain Relief Caplets

Amazon Basic Care
SB-123
White
500 Count
Amazon Basic Care Extra Strength Pain Relief Caplets Cover
Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 500 Count (Packaging may vary)

Amazon Basic Care Extra Strength Pain Relief Caplets contain Acetaminophen 500mg which is similar to Extra Strength Tylenol Caplets. It offers temporary relief for minor aches and pains caused by different factors such as toothache, headache, and backache. The product can also be used to reduce fever for adults and children aged 12 years and above. Pain can be caused by injury or illness, but the product can help ease the pain for a brief time or longer duration.

What We Like
Contains the same active ingredient as Extra Strength Tylenol Caplets
Temporarily relieves various types of pain
Can be used as a fever reducer
#TOP 2

Tylenol Extra Strength Acetaminophen Rapid Release Gels, 100 ct

JO48810
100 Count
Tylenol Extra Strength Acetaminophen Rapid Release Gels, 100 ct Cover
TENA Tylenol Extra Strength Acetaminophen Rapid Release Gels, Pain Reliever & Fever Reducer, 100 ct

Tylenol Extra Strength Acetaminophen Rapid Release Gels come in a 100-count bottle and are designed to provide fast relief from minor aches, pains, and fever. The unique laser-drilled holes in each gelcap quickly release 500mg of acetaminophen for extra strength pain relief. This oral pain reliever is suitable for adults and children aged 12 years and older and can be used to treat headaches, toothaches, backaches, cramps, and pain caused by the common cold.

What We Like
Fast-acting relief from minor aches and pains
Contains 500mg of acetaminophen for extra strength pain relief
Suitable for adults and children aged 12 years and older

Tylenol Regular Strength Tablets

300450496607
Tylenol Regular Strength Tablets Cover
Tylenol Regular Strength Tablets, Acetaminophen Pain Reliever & Fever Reducer, 100 ct

Tylenol Pain Reliever is a 100-count bottle of acetaminophen tablets that provides temporary relief of minor aches and pains, as well as helps reduce fever. Each tablet contains 325 mg of acetaminophen, which effectively relieves pain and has a great safety profile when used as directed. This pain reliever can be used by adults and children 6 years and older. It is ideal for alleviating common pain symptoms like headache, backache, toothache, menstrual cramps, and pain caused by the common cold. With Tylenol Pain Reliever, you can experience effective relief and get back to feeling your best. It is the #1 doctor recommended brand for pain relief and fever reduction.

What We Like
Temporary relief of aches and pains
Reduces fever
Excellent safety profile
#TOP 4

Tylenol Extra Strength Caplets

340200
White
Tylenol Extra Strength Caplets Cover
TENA Tylenol Extra Strength Caplets with 500 mg Acetaminophen, Pain Reliever and Fever Reducer for Headache, Backache, Toothache & Minor Arthritis Pain Relief, 100 Count

Tylenol Extra Strength Caplets are a pain reliever and fever reducer containing 500 mg acetaminophen for effective temporary relief of minor aches and pains. It is recommended for headaches, backaches, menstrual cramps, toothaches, and pain caused by the common cold. This extra strength acetaminophen pain reliever is safe when used as directed and can be used by adults and children who are 12 years and older. Tylenol is the #1 doctor recommended brand for pain relief and fever reduction.

What We Like
Effective pain relief and fever reduction
Can be used for a variety of minor aches and pains
Safe when used as directed

Tylenol Extra Strength Dissolve Packs with Acetaminophen, Berry, 32 Count

041532
Multi
32 Count
Tylenol Extra Strength Dissolve Packs with Acetaminophen, Berry, 32 Count Cover
Tylenol Extra Strength Dissolve Packs, 500 mg Acetaminophen Pain Reliever & Fever Reducer, On-The-Go Powder Packets for Minor Aches & Pains, Ibuprofen- & Aspirin-Free, Berry Flavor, 32 ct

Tylenol Extra Strength Dissolve Packs feature a great tasting Berry flavor and temporarily relieve minor aches and pains due to common cold, headache, backache, muscle aches, minor pain of arthritis, menstrual cramps, and toothache. Each packet contains 500 mg of acetaminophen, a pain reliever and fever reducer, and is both ibuprofen-free and aspirin-free. This portable pain medicine dissolves in seconds on the tongue with no water needed, and is safe for both adults and children 12 years of age and older. It's a convenient form to have on hand whenever pain hits.

What We Like
Great tasting Berry flavor
Temporarily relieves minor aches and pains
500 mg of acetaminophen, an effective pain reliever and fever reducer
Portable dissolving powder with no water needed
Safe for both adults and children 12 years of age and older
#TOP 6

Genexa Extra Strength Acetaminophen Pain & Fever Relief Caplets

0850015736124
Genexa Extra Strength Acetaminophen Pain & Fever Relief Caplets Cover
Genexa Clean Acetaminophen Extra Strength, Dye Free Pain Reliever & Fever Reducer, 0% Artificial Additives, Pain Relief for Headache, Backache, Toothache, & Minor Arthritis, 500mg, 100 Caplets

Genexa Pain Relief Caplets are formulated with the active ingredient Acetaminophen, 500 mg, which compares to the active ingredient of Extra Strength Tylenol Caplets. These caplets provide temporary relief for fever and minor aches and pains caused by various conditions such as headache, toothache, arthritis, backache, the common cold, and menstrual cramps. Suitable for adults and children 12 years and over, these caplets offer a convenient solution for pain relief. What sets Genexa Pain Relief Caplets apart is that they are made without artificial preservatives, artificial dyes, parabens, and common allergens, making them a safer choice for those with sensitivities. Plus, as a physician-formulated product, you can trust the quality and effectiveness of Genexa Pain Relief Caplets.

What We Like
Active ingredient: Acetaminophen
Temporarily reduces fever and relieves minor aches and pains
Suitable for adults and children 12 years and over
#TOP 7

Amazon Basic Care Children's Pain Reliever Oral Suspension Liquid

Amazon Basic Care
Bubblegum
4 Fl Oz (Pack of 1)
Amazon Basic Care Children's Pain Reliever Oral Suspension Liquid Cover
Amazon Basic Care Children's Pain Reliever Oral Suspension Liquid, Bubblegum Flavor, Acetaminophen 160 mg per 5 ml, Effective, Fever Reducer for Age 2-11 Years, Red, 4 fl oz (Pack of 1)

Amazon Basic Care Pain Reliever is a children's oral suspension liquid that provides fast and effective relief for kids aged 2 to 11 years. With its active ingredient, acetaminophen, it temporarily reduces fever and relieves minor aches and pains caused by common cold, headache, sore throat, and toothache. This bubble gum flavored pain reliever is not only safe for children but also gluten-free, alcohol-free, and free from aspirin and ibuprofen. The child-resistant safety cap and dosage cup included make it convenient and easy to administer. Amazon Basic Care Pain Reliever is the ideal choice for parents looking for a reliable and trusted pain and fever reducer for their children.

What We Like
Fast relief
Child-resistant safety cap
Gluten-free, alcohol-free
#TOP 8

Feverall Children Acetaminophen Suppositories

Feverall
White
Feverall Children Acetaminophen Suppositories Cover
Feverall Children Acetaminophen Suppositories 6 Rectal Suppositories 325mg Each Pain Reliever/Fever Reducer. Paraben Free, No Artificial Colors or Other preservatives. Ages 6-12 Years

Feverall Acetaminophen Suppositories are designed specifically for children aged 6 to 12. These doctor-recommended suppositories are effective in providing temporary relief from fever, minor aches, pains, and headaches. With six rectal suppositories, each containing 325mg of acetaminophen, you can easily manage your child's discomfort. They are free from parabens, preservatives, and artificial colors, ensuring a safer option for your little ones. You can administer one suppository every 4 to 6 hours, making it convenient for parents to help their children feel better without the worry of harmful additives.

What We Like
Effective fever and pain relief
Doctor recommended for children
Free from harmful additives
Convenient dosing schedule
#TOP 9

Tylenol Children's Chewables 160 mg

580828
Purple
Tylenol Children's Chewables 160 mg Cover
Children's Tylenol Chewables with 160 mg Acetaminophen, Pain Reliever & Fever Reducer for Kids' Cold + Flu Symptoms, Headache, Sore Throat & Toothache, Aspirin-Free, Grape Flavor, 24 ct

Tylenol Kids Chewables offer effective relief for your child's minor aches, pains, and cold symptoms. Each chewable tablet contains 160 mg of acetaminophen, which helps reduce fever and alleviate discomfort from headaches, sore throats, and even toothaches. The kid-friendly grape flavor makes it easy for children aged 2 to 11 to take their medicine without fuss. Plus, this formula is free from ibuprofen and aspirin, ensuring a gentle option for their tummies while providing trusted relief. With over 60 years of reliability, Tylenol is the top choice for parents seeking pediatric pain and fever solutions.

What We Like
Effective pain relief
Temporarily reduces fever
Kid-friendly grape flavor
Aspirin-free formula
Recommended by pediatricians
#TOP 10

Little Remedies Infant Fever & Pain Reliever

B005LF0R0W
Grape
2 Fl Oz (Pack of 1)
Little Remedies Infant Fever & Pain Reliever Cover
Little Remedies Baby Medicine, Infant Fever and Pain Relief with Acetaminophen, Berry Flavor, 2 Fl Oz

The Little Remedies Infant Fever & Pain Reliever is a natural berry flavored medicine that temporarily reduces fever and relieves minor aches and pains caused by cold, flu, viruses, headache, sore throat, or toothache. It contains Acetaminophen 160 mg, a pain reliever and fever reducer, and is free from alcohol, artificial dyes, gluten, and parabens. The Accusafe system ensures safe and accurate dosing, making it safe for use in children ages 2 years and up. This product is FSA- and HSA-eligible in the U.S.

What We Like
Contains natural berry flavor without high fructose corn syrup
Free from alcohol, artificial dyes, gluten, and parabens
Accusafe system ensures safe and accurate dosing
Buying Guide Image

Frequently Asked Questions (FAQs)

1. Which is better for fever acetaminophen or ibuprofen?

As you may have guessed from the descriptions above, acetaminophen is best used for fever, aches and pains, but will not be very helpful if the pain is due to inflammation. Ibuprofen is more helpful for these symptoms when inflammation is the cause. Inflammation examples include menstrual cramps and arthritis.

2. Can you take acetaminophen with a fever?

Rest and drink plenty of fluids. Medication isn't needed. Call the doctor if the fever is accompanied by a severe headache, stiff neck, shortness of breath, or other unusual signs or symptoms. If you're uncomfortable, take acetaminophen (Tylenol, others), ibuprofen (Advil, Motrin IB, others) or aspirin.

3. At what temperature should you give acetaminophen?

This step is recommended as the only treatment for fevers between 100 and 102 degrees Fahrenheit (37.8 to 39 degrees Celsius). For fevers exceeding 102 degrees Fahrenheit (39 degrees Celsius), you can give acetaminophen (Tylenol) or ibuprofen (Advil) - following package dosage charts.

4. How quickly does acetaminophen reduce fever?

The recommended dose of acetaminophen is listed in the table below. Two hours after acetaminophen is taken, it will usually reduce the fever by 2 to 3 degrees F. Repeated does of the drug are often necessary because the fever will go up and down until the illness runs its course.

Editor's Notes

During our acetaminophen for fever research, we found 24 acetaminophen for fever products and shortlisted 10 quality products. We collected and analyzed 884,730 customer reviews through our big data system to write the acetaminophen for fever list. We found that most customers choose acetaminophen for fever with an average price of $6.74.

The acetaminophen for fever are available for purchase. We have researched hundreds of brands and picked the top brands of acetaminophen for fever, including Tylenol, TENA, Genexa, Feverall, Little Remedies. The seller of top 1 product has received honest feedback from 385 consumers with an average rating of 4.7.

Written by
Bonnie Salem Avatar

Bonnie Salem is a stay-at-home mother with two-year-old twins and has spent almost half of her life surrounded by baby products. As a mother and a professional copywriter, she has an insightful and unique eye for researching products suitable for infants. Bonnie Salem is an expert in health and nutrition who lives with her family in New Jersey. She has over 15 years of working experience in an institute of medicine after graduating from the University of Toronto. She is highly interested in personal health and wellness.