Best Diphenhydramine Ibuprofen of 2025

Bonnie Salem Avatar
Bonnie Salem
Last Updated: Jan 5, 2025

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Diphenhydramine Ibuprofen is a combination medication that is commonly used to treat pain, fever, and inflammation. It is made up of two active ingredients, diphenhydramine and ibuprofen, which work together to provide powerful relief from a variety of symptoms. Diphenhydramine is an antihistamine that helps to reduce inflammation and swelling, while ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works to block the production of certain chemicals in the body that cause pain and fever. Together, these two ingredients make Diphenhydramine Ibuprofen a highly effective medication for treating a wide range of conditions, including headaches, menstrual cramps, arthritis, and more.

At a Glance: Our Top Picks

Amazon Basic Care Ibuprofen PM, Pain Reliever/Nighttime Sleep-Aid, 120 Count Cover #TOP 1
Amazon Basic Care Ibuprofen PM, Pain Reliever/Nighttime Sleep-Aid, 120 Count
ftb score rating icon 9.8
Advil Pain Reliever and Fever Reducer, Ibuprofen 200mg for Pain Relief - 300 Count Cover #TOP 2
Advil Pain Reliever and Fever Reducer, Ibuprofen 200mg for Pain Relief - 300 Count
ftb score rating icon 9.7
Advil PM Pain Reliever & Sleep Aid Cover #TOP 3
Advil PM Pain Reliever & Sleep Aid
ftb score rating icon 9.5

Top 10 Diphenhydramine Ibuprofen

Amazon Basic Care Ibuprofen PM, Pain Reliever/Nighttime Sleep-Aid, 120 Count

Amazon Basic Care
Amazon Basic Care Ibuprofen PM, Pain Reliever/Nighttime Sleep-Aid, 120 Count Cover
Amazon Basic Care Ibuprofen PM, Ibuprofen 200 mg and Diphenhydramine Citrate 38 mg Tablets, Pain Reliever and Nighttime Sleep-Aid, 120 Count (Packaging may vary)

Amazon Basic Care Ibuprofen PM is a pain reliever (NSAID) and nighttime sleep-aid. It contains ibuprofen 200 mg and diphenhydramine citrate 38 mg, providing relief of occasional sleeplessness when associated with minor aches and pains. This product is intended for adults and children 12 years and over, and is gluten free.

What We Like
Combines pain relief and nighttime sleep-aid
Contains ibuprofen 200 mg and diphenhydramine citrate 38 mg
Relieves occasional sleeplessness when associated with minor aches and pains
Suitable for adults and children 12 years and over
Gluten free
#TOP 2

Advil Pain Reliever and Fever Reducer, Ibuprofen 200mg for Pain Relief - 300 Count

F00573171754
2 Piece Set
Advil Pain Reliever and Fever Reducer, Ibuprofen 200mg for Pain Relief - 300 Count Cover
Advil Pain Reliever and Fever Reducer, Ibuprofen 200mg for Pain Relief - 300 Count, Advil PM Pain Reliever and Nighttime Sleep Aid, Ibuprofen for Pain Relief and Diphenhydramine Citrate - 2 Count

Advil Pain Reliever and Fever Reducer is a coated ibuprofen 200mg pain reliever that can provide relief for back pain, headaches, arthritis, and other types of pain. The bottle contains 300 coated tablets, which are easy to swallow and can last for up to 6 hours. The packaging now features 20% less plastic to reduce plastic waste. In addition, the Advil PM Pain Reliever and Nighttime Sleep Aid Caplets can provide restful sleep and relief for headaches, arthritis pain, joint pain, and occasional sleeplessness related to minor aches and pains.

What We Like
Provides relief for various types of pain
300 count bottle lasts for up to 6 hours
Advil PM Caplets provide restful sleep and relief for headaches, arthritis pain, joint pain, and occasional sleeplessness
#TOP 3

Advil PM Pain Reliever & Sleep Aid

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Advil PM Pain Reliever & Sleep Aid Cover
Advil PM Pain Reliever and Nighttime Sleep Aid, Ibuprofen for Pain Relief and Diphenhydramine Citrate for a Sleep Aid - 120 Coated Caplets and Pain Reliever and Fever Reducer, 10 Count Tablets

Advil PM Sleep Aid combines pain relief and sleep support in one easy-to-use product. It contains ibuprofen, which helps alleviate various types of pain, including headaches, backaches, and menstrual discomfort. Additionally, the diphenhydramine citrate in the formula aids in falling asleep, making it ideal for those who struggle with occasional sleeplessness due to minor aches. With a convenient dosage of just two caplets at bedtime, this product is perfect for adults and children aged 12 and older. Plus, it’s a great option for those sensitive to melatonin, providing a safe way to help you rest without sleep hormones.

What We Like
Effective pain relief
Helps with sleep
Convenient dosage
No melatonin
#TOP 4

Advil PM Liqui-Gels Pain Reliever and Nighttime Sleep Aid

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Advil PM Liqui-Gels Pain Reliever and Nighttime Sleep Aid Cover
Advil PM Liqui-Gels Pain Reliever and Nighttime Sleep Aid, Pain Medicine with Ibuprofen for Pain Relief and Diphenhydramine HCL for a Sleep Aid - 40 Liquid Filled Capsules - Back to College

Advil PM Liqui-Gels is a pain reliever and nighttime sleep aid with Ibuprofen and Diphenhydramine HCL. This medicine helps relieve occasional sleeplessness related to minor aches and pains, headache, minor arthritis pain, and back pain. The liquid-filled capsules rush relief right where it hurts and help you fall asleep and stay asleep. The new packaging will feature 20% less plastic to keep nearly 500,000 pounds of plastic out of landfills.

What We Like
Effective pain relief and sleep aid
Fast-acting liquid relief
Relieves headache, minor arthritis pain, and back pain
New packaging with 20% less plastic
#TOP 5

Advil PM Pain Reliever and Nighttime Sleep Aid, Pain Medicine - 50x2 Coated Caplets

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Advil PM Pain Reliever and Nighttime Sleep Aid, Pain Medicine - 50x2 Coated Caplets Cover
Advil PM Pain Reliever and Nighttime Sleep Aid, Pain Medicine with Ibuprofen for Pain Relief and Diphenhydramine Citrate for a Sleep Aid - 50x2 Coated Caplets

Advil PM Pain Reliever and Nighttime Sleep Aid is a pain medicine with ibuprofen for pain relief and diphenhydramine citrate for a sleep aid. It comes in 50 packets of 2 coated caplets, which can help you relieve occasional sleeplessness related to minor aches and pains. The ibuprofen PM sleep aid and nighttime pain reliever is also portable, making it perfect for use at home or away. The new packaging will feature 20% less plastic, which helps keep nearly 500,000 pounds of plastic out of landfills by 2022.

What We Like
Relieves occasional sleeplessness related to minor aches and pains
Helps you fall asleep and stay asleep
Portable for use at home or away
New packaging features 20% less plastic
#TOP 6

A+Health Ibuprofen PM Softgels, 120 Count

IBUPM120
Blue
A+Health Ibuprofen PM Softgels, 120 Count Cover
A+Health Ibuprofen PM Softgels, Pain Reliever/Nighttime Sleep Aid (NSAID), Made in USA, 120 Count

A+Health Ibuprofen PM Softgels are a pain reliever and nighttime sleep aid that are made in the USA. The softgels contain active ingredients including Ibuprofen and Diphenhydramine, which can temporarily reduce fever and relieve minor aches and pains. The medication is designed to help those who have difficulty swallowing pills, and can provide relief from occasional sleeplessness when associated with minor aches and pains. The product comes with 120 softgels.

What We Like
Provides temporary relief from common pain and sleeplessness
Softgels are easier to swallow than traditional pills
Contains active ingredients Ibuprofen and Diphenhydramine
#TOP 7

Advil PM Pain Reliever and Nighttime Sleep Aid - 120 Caplets

305730164436
Other
120 Coated Caplets
Advil PM Pain Reliever and Nighttime Sleep Aid - 120 Caplets Cover
Advil PM Pain Reliever/Nighttime Sleep Aid Coated Caplet, 200mg Ibuprofen, 38mg Diphenhydramine, Other, 120 Count

Advil PM Pain Reliever and Nighttime Sleep Aid is a medication that offers relief from occasional sleeplessness, minor aches, and pains. It is a nighttime sleep aid and pain medication that helps you fall asleep and stay asleep. The medication is portable, so you can take it with you wherever you go. The new packaging features 20 percent less plastic, which helps keep nearly 500,000 pounds of plastic out of landfills by 2022.

What We Like
Offers relief from occasional sleeplessness, minor aches, and pains
Helps you fall asleep and stay asleep
Portable, making it easy to take with you
Uses 20% less plastic in its new packaging, helping to reduce plastic waste
#TOP 8

Advil PM Pain Reliever/Nighttime Sleep Aid Caplets

305730164207
Advil PM Pain Reliever/Nighttime Sleep Aid Caplets Cover
Advil PM (20 Count) Pain Reliever/Nighttime Sleep Aid Coated Caplet, 200mg Ibuprofen, 38mg Diphenhydramine

Advil PM is a dual-layer coated caplet that helps relieve occasional sleeplessness and minor aches and pains, allowing you to fall asleep faster and stay asleep longer. Its bi-layer patented formula combines Ibuprofen, the world's No.1 OTC pain reliever, with Diphenhydramine, the No.1 soothing sleep aid, providing safe and effective pain relief for over 30 years. The product is safe, gentle, and non-habit forming, with two active ingredients that have a long history of safe and effective treatment when used as directed.

What We Like
Helps you fall asleep faster and stay asleep longer
Dual-layer patented formula for effective pain relief
Safe, gentle, and non-habit forming
#TOP 9

Advil PM Pain Reliever and Nighttime Sleep Aid

305730164306
Advil PM Pain Reliever and Nighttime Sleep Aid Cover
Advil PM Pain Reliever and Nighttime Sleep Aid, Pain Medicine with Ibuprofen for Pain Relief and Diphenhydramine Citrate for a Sleep Aid - 40 Coated Caplets

Advil PM Sleep Aid is a pain reliever and nighttime sleep aid that helps you fall asleep and stay asleep. It contains Ibuprofen for pain relief and Diphenhydramine Citrate for a sleep aid. This medication is ideal for those who have trouble sleeping due to minor aches and pains. The portable caplets make it easy to take with you wherever you go, ensuring a restful night's sleep. Additionally, the new packaging will feature 20 percent less plastic by 2022, keeping nearly 500,000 pounds of plastic out of landfills. Advil PM Sleep Aid is suitable for adults and children 12 years and older.

What We Like
Pain relief
Sleep aid
Portable
Eases minor aches and pains
New eco-friendly packaging
#TOP 10

Motrin PM Caplets 200mg

JJ-1752
Multicolor
Motrin PM Caplets 200mg Cover
Motrin PM Caplets, 200 mg Ibuprofen & 38 mg Sleep Aid, Nighttime Relief for Minor Pains, 20 ct

Motrin PM Caplets are designed to provide effective relief from minor aches and pains while promoting a restful night’s sleep. Each caplet contains 200 mg of ibuprofen paired with a gentle sleep aid, helping you tackle discomfort from headaches, backaches, arthritis, and menstrual cramps. This product is especially beneficial when occasional sleeplessness accompanies these pains, allowing you to fall asleep faster and stay asleep longer. Safe for individuals aged 12 and older, Motrin PM Caplets ensure that you wake up refreshed and ready to face the day ahead.

What We Like
Effective pain relief
Promotes restful sleep
Safe for ages 12
Convenient nighttime use
Buying Guide Image

Frequently Asked Questions (FAQs)

1. Can you take diphenhydramine with ibuprofen?

Diphenhydramine and ibuprofen combination is used to relieve trouble sleeping caused by minor aches and pains. It also helps you fall asleep and stay asleep. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is used in this combination to relieve inflammation, swelling, and pain.

2. Does ibuprofen contain diphenhydramine?

Ibuprofen/diphenhydramine is a combination of two medications, ibuprofen (non-steroidal anti-inflammatory drug (NSAID)) and diphenhydramine (antihistamine). It's available over the counter (OTC) and is used to treat difficulty sleeping from minor aches and pains.

Editor's Notes

During our diphenhydramine ibuprofen research, we found 24 diphenhydramine ibuprofen products and shortlisted 10 quality products. We collected and analyzed 119,420 customer reviews through our big data system to write the diphenhydramine ibuprofen list. We found that most customers choose diphenhydramine ibuprofen with an average price of $17.30.

The diphenhydramine ibuprofen are available for purchase. We have researched hundreds of brands and picked the top brands of diphenhydramine ibuprofen, including Advil, A+Health, TENA. The seller of top 1 product has received honest feedback from 385 consumers with an average rating of 4.7.

Written by
Bonnie Salem Avatar

Bonnie Salem is a stay-at-home mother with two-year-old twins and has spent almost half of her life surrounded by baby products. As a mother and a professional copywriter, she has an insightful and unique eye for researching products suitable for infants. Bonnie Salem is an expert in health and nutrition who lives with her family in New Jersey. She has over 15 years of working experience in an institute of medicine after graduating from the University of Toronto. She is highly interested in personal health and wellness.