Best Acetaminophen for Sleep Aid of 2025

Bonnie Salem Avatar
Bonnie Salem
Last Updated: Jan 5, 2025

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Acetaminophen for Sleep Aid is a popular over-the-counter medication that provides relief for those struggling with occasional sleeplessness. This non-habit forming sleep aid contains acetaminophen, a trusted pain reliever, and fever reducer. The carefully formulated blend assists in easing the discomfort that may hinder a good night's sleep. With its proven effectiveness, Acetaminophen for Sleep Aid helps individuals fall asleep faster and wake up feeling refreshed without grogginess. It is important to always follow the recommended dosage and consult a healthcare professional if sleep issues persist.

At a Glance: Our Top Picks

Rite Aid Pain Relief Acetaminophen PM Caplets Cover #TOP 1
Rite Aid Pain Relief Acetaminophen PM Caplets
ftb score rating icon 9.8
Right Remedies Extra Strength PM Pain Relief Cover #TOP 2
Right Remedies Extra Strength PM Pain Relief
ftb score rating icon 9.7
HealthA2Z Extra Strength Pain Relief PM Caplets Cover #TOP 3
HealthA2Z Extra Strength Pain Relief PM Caplets
ftb score rating icon 9.5

Top 10 Acetaminophen for Sleep Aid

Rite Aid Pain Relief Acetaminophen PM Caplets

Rite Aid Pain Relief Acetaminophen PM Caplets Cover
Rite Aid Extra Strength Pain Relief Acetaminophen PM Caplets, 500mg Acetaminophen / 25mg Diphenhydramine - 300 Count - Nighttime Pain Reliever + Sleep Aid

Rite Aid Pain Relief PM is a trusted brand that offers a non-habit forming solution for pain relief and sleep aid. With its extra strength acetaminophen, it effectively reduces pain while the diphenhydramine HCI aids in getting a good night's sleep. Whether you're dealing with headaches, migraines, menstrual pain, or body aches, this aspirin-free medication provides relief. The 500mg of acetaminophen also helps to reduce fevers temporarily. Rite Aid Pain Relief PM is the perfect choice for those who want to wake up feeling refreshed and ready to take on the day.

What We Like
Non-habit forming
Nighttime sleep aid
Pain and fever relief
#TOP 2

Right Remedies Extra Strength PM Pain Relief

Right Remedies Extra Strength PM Pain Relief Cover
Right Remedies Extra Strength Pain Relief PM & Nighttime Sleep Aid Caplets,(300 count), Acetaminophen 500 mg & Diphenhydramine HCl 25 mg, Non-Habit Forming, Compare to Active ingredients of Tylenol PM

Right Remedies PM Pain Relief offers effective support for those struggling with minor aches and pains, thanks to its 500 mg of acetaminophen. This ingredient helps alleviate discomfort from common ailments like headaches and muscle aches. Additionally, it contains 25 mg of diphenhydramine HCl, which not only relieves pain but also aids in falling asleep quickly. The caplets are designed to be easy to swallow, making them convenient for nighttime use. With a formulation that mirrors the active ingredients found in Tylenol PM, you can trust this product for reliable relief.

What We Like
Effective pain relief
Helps with sleep
Easy to swallow
Non-habit forming
#TOP 3

HealthA2Z Extra Strength Pain Relief PM Caplets

FP0772
HealthA2Z Extra Strength Pain Relief PM Caplets Cover
HealthA2Z® Extra Strength Pain Relief PM| Acetaminophen 500mg | Diphenhydramine 25mg | Pain Reliever & Nighttime Sleep Aid | Non-Habit Forming (365 Count (Pack of 1))

HealthA2Z Extra Strength Pain Relief PM Caplets are an effective pain reliever that contains 500mg of Acetaminophen to help relieve muscle, joint, headache, and arthritis pain quickly. It also contains 25mg of Diphenhydramine to help you fall asleep and stay asleep, while also relieving fever and minor aches and pain. This product is gentle, non-habit forming, and free of aspirin. The recommended dosage for adults and children 12 years and over is 2 caplets at bedtime.

What We Like
Contains proven pain reliever Acetaminophen.
Includes non-habit forming sleep aid Diphenhydramine.
Free of aspirin.
#TOP 4

ValuMeds PM Pain Reliever and Nighttime Sleep Aid

ValuMeds PM Pain Reliever and Nighttime Sleep Aid Cover
ValuMeds PM Pain Reliever and Nighttime Sleep Aid (375 Count) Acetaminophen 500mg | Fast-Acting Relief for Headaches, Migraines, Minor Aches | Non-Habit Forming Compare to Tylenol PM

ValuMeds PM Relief is a pain reliever and nighttime sleep aid that comes in easy-to-swallow pills. It contains 500mg of Acetaminophen, which helps relieve muscle, joint, headache, and arthritis pain rapidly. Additionally, each serving has 25mg of Diphenhydramine HCl, which helps you relax and unwind for a deep, restful sleep. ValuMeds PM Relief also has extra-strength support, containing maximum strength ingredients for faster and extended results. The pills are a smooth oval shape, making them pain-free to consume before bed. Lastly, this sleep-aid is non-habit forming, so it is safe for regular use and is gentle on the stomach.

What We Like
Rapid pain relief
Deep, restful sleep
Extra-strength support
#TOP 5

Tylenol PM Extra Strength Pain Reliever & Sleep Aid Caplets

JJ-2404
100ct
Tylenol PM Extra Strength Pain Reliever & Sleep Aid Caplets Cover
Tylenol PM Extra Strength Nighttime Pain Reliever & Sleep Aid Caplets, 500 mg Acetaminophen & 25 mg Diphenhydramine HCl, Relief for Nighttime Aches & Pains, Non-Habit Forming, 100 ct

Tylenol PM Extra Strength Caplets Nighttime Pain Reliever & Non-Habit Forming Sleep Aid contains 25 mg diphenhydramine HCl and 500 mg acetaminophen per caplet. It effectively relieves nighttime pain and helps you fall asleep fast. This non-habit forming nighttime sleep aid and pain relief medicine is suitable for adults and children who are 12 years of age and older. Tylenol PM is the #1 doctor-recommended brand for pain relief and fever reduction, ensuring a better night's sleep for a better day ahead.

What We Like
Non-habit forming when used as directed
Effectively relieves nighttime pain and helps you fall asleep fast
Can be used by adults and children who are 12 years of age and older
#TOP 6

Tylenol PM Extra Strength Caplets

Tylenol PM Extra Strength Caplets Cover
Tylenol PM Extra Strength Nighttime Pain Reliever & Sleep Aid Caplets, 500 mg Acetaminophen & 25 mg Diphenhydramine HCl, Relief for Nighttime Aches & Pains, Non-Habit Forming, 50 ct

Tylenol PM Extra Strength Caplets is a nighttime pain reliever and sleep aid that provides minor pain relief and helps you fall asleep fast. With 25 mg of diphenhydramine HCl and 500 mg of acetaminophen per caplet, it effectively relieves nighttime pain and helps you get the sleep you need. This non-habit forming sleep aid is recommended by doctors and is suitable for adults and children aged 12 and older. With Tylenol PM Extra Strength Caplets, you can fall asleep quickly, stay asleep, and wake up refreshed, so you can be the best version of yourself every day.

What We Like
Fast pain relief
Non-habit forming
Recommended by doctors
#TOP 7

Rite Aid Extra Strength PM Pain Relief Gelcaps

556-31-UPCR
Rite Aid Extra Strength PM Pain Relief Gelcaps Cover
Rite Aid Extra Strength PM Pain Relief Gelcaps, 500 mg Acetaminophen / 25 mg Diphenhydramine - 80 Count | Nighttime PM Pain Reliever + Sleep Aid | Arthritis Pain Relief | Menstrual Pain Relief

Rite Aid Extra Strength PM Pain Relief Gelcaps is a non-habit forming, aspirin-free pain reliever with a nighttime sleep aid. Each gelcap contains acetaminophen extra strength 500mg and diphenhydramine HCI 25mg, offering relief from headaches, migraines, menstrual pain, muscular or body aches, and arthritis and/or joint pain. It is a trusted brand since 1962 and is formulated for those with aspirin allergies or sensitivities.

What We Like
Non-habit forming
A nighttime sleep aid
Aspirin-free
Offers relief from various types of pain
Trusted brand since 1962
#TOP 8

Quality Choice Acetaminophen Pain Reliever and Sleep Aid

635515995970
Quality Choice Acetaminophen Pain Reliever and Sleep Aid Cover
Quality Choice Extra Strength Pain Relief PM, Pain Reliever and Nighttime Sleep Aid, Acetaminophen 500 mg & Diphenhydramine HCI 25 mg (Sleep Aid), 50 Count Package of Caplets

Quality Choice Acetaminophen is an extra-strength pain reliever that also doubles as a nighttime sleep aid. It comes in a bottle of 50 caplets, providing you with a long-lasting supply.

What We Like
Extra-strength pain relief
Doubles as a nighttime sleep aid
Comes in a bottle of 50 caplets
#TOP 9

NUVICARE Extra Strength Pain Relief PM

NUVICARE
Blue
NUVICARE Extra Strength Pain Relief PM Cover
NUVICARE Extra Strength Pain Relief PM - Acetaminophen 500mg & Diphenhydramine 25mg - Compare to Tylenol PM Extra Strength Sleep Aid - Adult PM Pain Reliever for Nighttime Aches & Pains (100 Tablets)

NUVICARE Pain Relief PM offers effective nighttime relief from pain and discomfort. Each tablet contains 500mg of acetaminophen, which helps alleviate headaches, muscle aches, and arthritis pain that disrupt your sleep. Additionally, it includes 25mg of diphenhydramine, a compound that promotes relaxation and aids in restful sleep. This combination targets nighttime aches, ensuring you can manage pain and fever symptoms while enjoying a more peaceful night. With Nuvicare, you can wake up feeling refreshed and ready for the day ahead.

What We Like
Extra strength pain relief
Promotes restful sleep
Combines pain relief and relaxation
Quality manufacturing standards
#TOP 10

ZzzQuil Nighttime Pain Relief Sleep Aid Liquid

ZzzQuil Nighttime Pain Relief Sleep Aid Liquid Cover
ZzzQuil Vicks Night Pain Liquid, Nighttime Sleep-Aid Pain Reliever, Midnight Berry Flavored, 2x12 FL OZ

ZzzQuil Nighttime Pain Relief Sleep Aid Liquid is a non-habit forming sleep aid that provides pain relief and helps you fall asleep fast. Its max strength relief formula allows you to wake up refreshed. The product contains Diphenhydramine HCI to help you sleep and Acetaminophen for pain relief. From the trusted Sleep Experts at Vicks, America's #1 Sleep Brand.*

What We Like
Non-habit forming ingredients
Fall asleep in as little as 20 minutes
Max strength relief for sleep and pain
Buying Guide Image

Frequently Asked Questions (FAQs)

1. Is acetaminophen a sleep aid?

Acetaminophen helps to reduce fever and/or mild to moderate pain (such as headache, backache, aches/pains due to muscle strain, cold, or flu). The antihistamine in this product may cause drowsiness, so it can also be used as a nighttime sleep aid.

2. How much acetaminophen should I take to sleep?

Typical dosing for Tylenol PM (acetaminophen / diphenhydramine) Adults and children aged 12 years and over: The typical dose is 1,000 mg/50 mg (acetaminophen/diphenhydramine) by mouth at bedtime. Don't take more than this amount in 24 hours.

3. Which is better for sleep ibuprofen or acetaminophen?

People use Advil PM as a nighttime sleep aid and pain reliever, while Tylenol PM can reduce pain and fever at night. Both medications are for nighttime use to help aid sleep.

Editor's Notes

During our acetaminophen for sleep aid research, we found 24 acetaminophen for sleep aid products and shortlisted 10 quality products. We collected and analyzed 195,200 customer reviews through our big data system to write the acetaminophen for sleep aid list. We found that most customers choose acetaminophen for sleep aid with an average price of $13.60.

The acetaminophen for sleep aid are available for purchase. We have researched hundreds of brands and picked the top brands of acetaminophen for sleep aid, including Rite Aid, RIGHT REMEDIES, HealthA2Z, ValuMeds, Tylenol. The seller of top 1 product has received honest feedback from 6,296 consumers with an average rating of 4.9.

Written by
Bonnie Salem Avatar

Bonnie Salem is a stay-at-home mother with two-year-old twins and has spent almost half of her life surrounded by baby products. As a mother and a professional copywriter, she has an insightful and unique eye for researching products suitable for infants. Bonnie Salem is an expert in health and nutrition who lives with her family in New Jersey. She has over 15 years of working experience in an institute of medicine after graduating from the University of Toronto. She is highly interested in personal health and wellness.