Best Acetaminophen for Sleep Aid of 2026

Tylenol PM Extra Strength Caplets Nighttime Pain Reliever & Non-Habit Forming Sleep Aid contains 25 mg diphenhydramine HCl and 500 mg acetaminophen per caplet. It effectively relieves nighttime pain and helps you fall asleep fast. This non-habit forming nighttime sleep aid and pain relief medicine is suitable for adults and children who are 12 years of age and older. Tylenol PM is the #1 doctor-recommended brand for pain relief and fever reduction, ensuring a better night's sleep for a better day ahead.

Amazon Basic Care Acetaminophen PM is a pain reliever and nighttime sleep aid that contains 500 mg of acetaminophen and 25 mg of diphenhydramine HCl in each caplet. It helps relieve minor aches and pains and promotes restful sleep for adults and children 12 years and over. The extra-strength formula is non-habit forming and contains no aspirin or gluten.

Excedrin PM Sleep Aid with Headache Relief Caplets provide temporary relief of pain associated with headaches and muscle aches accompanied by sleeplessness. This caffeine-free diphenhydramine, aspirin, and acetaminophen caplet is perfect for nighttime headache sufferers. Its triple action formula combines two effective pain relievers with a nighttime sleep-aid, helping you get to sleep faster. The pain reliever is available in convenient caplet form, ensuring effective headache and muscle pain relief whenever you need it.

Right Remedies PM Pain Relief offers effective support for those struggling with minor aches and pains, thanks to its 500 mg of acetaminophen. This ingredient helps alleviate discomfort from common ailments like headaches and muscle aches. Additionally, it contains 25 mg of diphenhydramine HCl, which not only relieves pain but also aids in falling asleep quickly. The caplets are designed to be easy to swallow, making them convenient for nighttime use. With a formulation that mirrors the active ingredients found in Tylenol PM, you can trust this product for reliable relief.

Goody's PM Nighttime Powder is a dual action powder formula that provides fast relief for occasional headaches and minor aches and pains with accompanying sleeplessness. With its convenient on-the-go stick packs, Goody's PM Powder is easier to open and faster to take. Each stick powder contains 500 mg of Acetaminophen and 38 mg of Diphenhydramine Citrate, providing effective pain relief for adults and children 12 years and older. This FSA- and HSA-eligible product is perfect for those looking for a convenient solution to alleviate pain and sleeplessness.

HealthA2Z Extra Strength Pain Relief PM Caplets are an effective pain reliever that contains 500mg of Acetaminophen to help relieve muscle, joint, headache, and arthritis pain quickly. It also contains 25mg of Diphenhydramine to help you fall asleep and stay asleep, while also relieving fever and minor aches and pain. This product is gentle, non-habit forming, and free of aspirin. The recommended dosage for adults and children 12 years and over is 2 caplets at bedtime.

Timely PM is a reliable and affordable pain reliever and nighttime sleep-aid offered by TIME-CAP LABS, INC. With its maximum strength formulation of acetaminophen 500mg and Diphenhydramine HCl 25mg, it provides fast and reliable relief from headaches and other minor aches and pains, allowing you to rest better at night. This non-habit forming pain relief is safe for regular use, giving you the confidence to take a dose without worrying about dependence. Timely PM offers National Brand Equivalency, ensuring the same efficacy as national brands at a lower cost. With 400 caplets per bottle, it is a must-have in every medicine cabinet for adults and children 12 years and over, providing long-term relief for the whole family.

GenCare Extra Strength Acetaminophen PM 500mg is a bulk value bottle that contains 375 tablets, formulated to provide total pain relief for headaches, migraines, sore muscles, inflammation, menstrual cramps and common cold and flu symptoms. Its nighttime formula contains 25 mg of Diphenhydramine to help with sleep, non-habit forming, and helpful for people suffering from insomnia. The combination of 500 mg Acetaminophen and 25 mg of Diphenhydramine gives fast-acting relief for aches and pain, and reduces allergy symptoms and common cold symptoms. It also comes with a 100% satisfaction guarantee.