Best Aspirin Acetaminophen of 2025

Bonnie Salem Avatar
Bonnie Salem
Last Updated: Jan 5, 2025

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Aspirin and acetaminophen are two common over-the-counter pain relievers that are widely used to manage mild to moderate pain. Aspirin, also known as acetylsalicylic acid, works by blocking the production of prostaglandins, which are chemicals that cause inflammation and pain in the body. Acetaminophen, on the other hand, works by inhibiting the production of certain enzymes that cause pain and fever. Both aspirin and acetaminophen are effective in relieving pain, but they have different mechanisms of action and may be more suitable for different types of pain. It is important to read the label and follow the recommended dosage instructions when using these medications.

At a Glance: Our Top Picks

Timely Extra Strength Headache Relief - Acetaminophen, Aspirin, Caffeine Cover #TOP 1
Timely Extra Strength Headache Relief - Acetaminophen, Aspirin, Caffeine
ftb score rating icon 9.9
Timely Extra Strength Headache Relief Cover #TOP 2
Timely Extra Strength Headache Relief
ftb score rating icon 9.8
GenCare Extra Strength Headache Relief Acetaminophen (300 Caplets) Cover #TOP 3
GenCare Extra Strength Headache Relief Acetaminophen (300 Caplets)
ftb score rating icon 9.6

Top 10 Aspirin Acetaminophen

Timely Extra Strength Headache Relief - Acetaminophen, Aspirin, Caffeine

TIME-CAP LABS, INC.
TS0417-B700ML-M1690
Timely Extra Strength Headache Relief - Acetaminophen, Aspirin, Caffeine Cover
Timely Extra Strength Headache Relief - Acetaminophen with Aspirin & Caffeine (200 Caplets) - Headache, Migraine & Back and Body Pain & Muscle Aches - Compares to Excedrin Extra Strength - Made In USA

Timely Headache Relief combines Acetaminophen, Aspirin, and Caffeine for effective management of headaches and migraines. This unique trio works together to tackle various pain aspects, providing you with a powerful solution. You will appreciate the fast-acting relief that allows you to return to your daily activities without delay. Moreover, the inclusion of caffeine enhances the effectiveness of the pain relief, making it a useful option for those who need quick help. With 200 caplets in each bottle, it’s perfect for both home use and travel, ensuring you’re always prepared for discomfort.

What We Like
Fast-acting relief
Triple-action formula
Convenient for travel
Effective for various pains

Timely Extra Strength Headache Relief

TIME-CAP LABS, INC.
Timely Extra Strength Headache Relief Cover
Timely Extra Strength Headache Relief - Acetaminophen with Aspirin & Caffeine (300 Caplets) - Headache, Migraine & Back and Body Pain & Muscle Aches - Compares to Excedrin Extra Strength - Made In USA

Timely Headache Relief combines Acetaminophen, Aspirin, and Caffeine for powerful headache management. This triple-action formula works together to target various aspects of your discomfort, providing you with effective relief. The inclusion of caffeine enhances its effectiveness, making it comparable to prescription options. Plus, you'll appreciate the quick action of Timely Headache Relief, allowing you to return to your daily activities without delay. With 300 caplets per bottle, it's a perfect staple for your medicine cabinet and convenient for travel, ensuring you have relief at your fingertips whenever you need it.

What We Like
Triple-action formula
Fast-acting relief
Convenient for travel
Effective for various pains

GenCare Extra Strength Headache Relief Acetaminophen (300 Caplets)

GenCare
EB-009
GenCare Extra Strength Headache Relief Acetaminophen (300 Caplets) Cover
GenCare - Headache Relief Acetaminophen with Aspirin (NSAID) & Caffeine (300 Caplets) Value Pack | Head Pain, Muscle Aches, Back Pain & Body | Generic Excedrin Extra Strength

GenCare Extra Strength Headache Relief Acetaminophen is a family-size pain relief bottle with 300 caplets for headaches, migraines, muscle aches, toothaches, menstrual cramps, arthritis, joint pain, and more. Each caplet contains 250mg of Acetaminophen, 250mg of Aspirin (NSAID), and 65mg of Caffeine that act fast to energize and restore mental focus. Adults and children over 12 can take 2 caplets every 6 hours not to exceed 8 caplets in 24 hours. GenCare offers a 100% satisfaction guarantee.

What We Like
Acts fast with 65mg of caffeine to energize and restore mental focus
Bulk savings bottle with 300 caplets for family use
Helps with a variety of aches and pains
#TOP 4

Amazon Basic Care Migraine Relief Caplets

Amazon Basic Care
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Amazon Basic Care Migraine Relief Caplets Cover
Amazon Basic Care Migraine Relief Acetaminophen, Aspirin (NSAID) and Caffeine Tablets, Pain Reliever/Pain Reliever Aid, 250mg, 200 Count (Packaging may vary)

Amazon Basic Care Migraine Relief Caplets contain acetaminophen, aspirin (NSAID), and caffeine to relieve migraine pain. These coated caplets are gluten-free and suitable for adults. They are designed to treat migraine headaches so you can get back to your normal activities. Each 2-caplet dose offers effective pain relief.

What We Like
Contains active ingredients found in Excedrin Migraine
Coated caplets are easy to swallow
Effective in treating migraine pain in adults
Gluten-free
#TOP 5

Rite Aid Extra Strength Pain Reliever - 100 Tablets

011822317283
Rite Aid Extra Strength Pain Reliever - 100 Tablets Cover
Rite Aid Extra Strength Pain Reliever, Acetaminophen 250mg, Aspirin 250mg, Caffeine 65mg – 100 Tablets | Pain Reliever/Fever Reducer | NSAID Anti-Inflammatory | Migraine Relief Products

Rite Aid Extra Strength Pain Reliever is a migraine relief medication that contains 250mg of acetaminophen, 250mg of aspirin, and 65mg of caffeine. This easy-to-swallow coated tablet is perfect for those with sensitivities or allergies to ibuprofen. Its caffeine content has been proven to help with migraines and tension headaches by opening the constricted blood vessels in your brain. The product is formulated to relieve pain, migraines, and tension headaches, making it a great alternative to the leading national brand. Since 1962, Rite Aid has been a trusted brand in providing customers with the best products, services, and advice for their everyday health and wellness needs.

What We Like
Extra strength formula for effective pain relief
Contains caffeine, which has been proven to help with migraines and tension headaches
Ibuprofen-free, making it a great alternative for those with sensitivities or allergies to ibuprofen
Easy-to-swallow coated tablet design
Trusted brand since 1962
#TOP 6

HealthA2Z Pain Relief Caplets

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HealthA2Z Pain Relief Caplets Cover
HealthA2Z® Pain Relief Extended Release | Acetaminophen 650mg | 250 Caplets | 8 Hours | Arthiritis Pain | Pain Reliever - Fever Reducer | Contains no Aspirin

HealthA2Z Pain Relief offers effective relief for those suffering from arthritis pain and other discomforts. With its extended-release formula, you can enjoy up to eight hours of pain relief, allowing you to go about your day without constant interruptions. This product not only alleviates pain but also helps reduce fever, making it a versatile option for various ailments. Whether you're managing chronic pain or just need temporary relief, these caplets are designed for your convenience, helping you feel better and get back to what you love.

What We Like
Long-lasting pain relief
Effective fever reducer
Convenient extended-release formula
No aspirin included
#TOP 7

NUVICARE Acetaminophen & Aspirin Pain Relief

NUVICARE
NUVICARE Acetaminophen & Aspirin Pain Relief Cover
NUVICARE Headache Relief with Acetaminophen 250 mg, Aspirin (NSAID) 250 mg, Caffeine 65 mg - Temporary Relief of Minor Aches & Pains - Compare to Excedrin Extra Strength Pain Reliever (100 Caplets)

NUVICARE Headache Relief offers a powerful combination of acetaminophen, aspirin, and caffeine to help you tackle headaches and minor pains effectively. With its fast-acting formula, you can expect relief shortly after taking the caplet, allowing you to resume your daily activities without discomfort. This triple-action formula is specifically designed to alleviate various types of pain, including migraines, muscle aches, and menstrual cramps. For those 12 years and older, simply take two caplets every six hours for the relief you need when it matters most.

What We Like
Fast-acting relief
Triple-action formula
Effective for multiple pain types
Quality you can trust
#TOP 8

Amazon Basic Care Migraine Relief Geltabs

Amazon Basic Care
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Amazon Basic Care Migraine Relief Geltabs Cover
Amazon Basic Care Migraine Relief Geltabs, Acetaminophen, Aspirin (NSAID) and Caffeine, 80 Count

Amazon Basic Care Migraine Relief Geltabs contain acetaminophen, aspirin, and caffeine to treat migraine pain. With just one dose, you can temporarily reduce headache pain caused by migraines and get back to enjoying life's special moments. These headache pain relief pills are also gluten-free and compare to the active ingredients of Excedrin Migraine Geltabs.

What We Like
Offers headache pain relief
Temporarily reduces headache pain caused by migraines with just one dose
Combines acetaminophen, aspirin, and caffeine to treat migraine pain
Gluten-free

Amazon Basic Care Pain Relief Tablets, 100 Count

Amazon Basic Care
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Amazon Basic Care Pain Relief Tablets, 100 Count Cover
Amazon Basic Care Pain Relief, Acetaminophen Tablets 325 mg, Regular Strength, Pain Reliever and Fever Reducer, 100 Count (Packaging may vary)

Amazon Basic Care Pain Relief Tablets are an effective remedy to temporarily relieve minor aches and pains due to headache, arthritis, and menstrual cramps. It also reduces fever. The active ingredient is acetaminophen 325 mg, a potent pain reliever and fever reducer. It is suitable for both adults and children over six years old. Additionally, it is gluten-free and contains no aspirin.

What We Like
Contains acetaminophen 325mg, a strong pain reliever and fever reducer
Temporarily relieves minor aches and pains, including headache, arthritis, and menstrual cramps
Suitable for adults and children over six years old
Gluten-free and contains no aspirin
#TOP 10

RIGHT REMEDIES Headache Relief Value Pack

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RIGHT REMEDIES Headache Relief Value Pack Cover
RIGHT REMEDIES Extra Strength Headache Relief Geltabs with Acetaminophen, Aspirin (NSAID) & Caffeine, Value Pack (200 Geltabs), Muscle Aches, Back & Body Pain Relief, Generic Excedrin Extra Strength

RIGHT REMEDIES Extra Strength Headache Relief is an over-the-counter medication that provides safe and effective pain relief for headache, cold, arthritis, muscle aches, toothache, menstrual and premenstrual cramps. Its fast-acting formula with two pain fighters and caffeine helps energize and restore mental focus, providing headache relief in as little as 15 minutes. This value pack contains 200 geltabs and is a cost-effective solution packaged and quality-assured in the USA.

What We Like
Fast-acting formula for headache relief in as little as 15 minutes
Contains two pain fighters and caffeine to energize and restore mental focus
Value pack with 200 geltabs that saves you money
Buying Guide Image

Frequently Asked Questions (FAQs)

1. Is aspirin an ibuprofen or acetaminophen?

There are basically two types of OTC pain relievers. Some contain acetaminophen, which is processed in the liver. Others contain non-steroidal anti-inflammatory drugs (NSAIDs), which are processed elsewhere. Examples of OTC NSAIDs are aspirin, ibuprofen (Advil) and naproxen sodium (Aleve).

2. Can I take aspirin with acetaminophen?

If you need additional pain relief, you can combine aspirin, naproxen, or ibuprofen with acetaminophen. However, do not take aspirin, naproxen, or ibuprofen within 8-12 hours of each other. Also, watch out for pain medications that might be included in combination products such as those used for cough and cold.

3. Is acetaminophen better than aspirin?

Aspirin is safer than acetaminophen, he said, though to be used as a pain reliever it requires much higher doses — which can have side effects like stomach upset. Aspirin also interferes with blood coagulation for days after taking it.

4. How much aspirin and acetaminophen can I take together?

Adults and teenagers—The usual dose is 2 tablets (250 mg acetaminophen, and 250 mg of aspirin, and 65 mg of caffeine in combination) every six hours as necessary for relief from migraine headaches. Do not take for relief of migraine headache for more than two days, unless otherwise directed by your doctor.

Editor's Notes

During our aspirin acetaminophen research, we found 24 aspirin acetaminophen products and shortlisted 10 quality products. We collected and analyzed 68,051 customer reviews through our big data system to write the aspirin acetaminophen list. We found that most customers choose aspirin acetaminophen with an average price of $10.66.

The aspirin acetaminophen are available for purchase. We have researched hundreds of brands and picked the top brands of aspirin acetaminophen, including TIME-CAP LABS, INC., GenCare, Rite Aid, HealthA2Z, NUVICARE. The seller of top 1 product has received honest feedback from 4,707 consumers with an average rating of 4.9.

Written by
Bonnie Salem Avatar

Bonnie Salem is a stay-at-home mother with two-year-old twins and has spent almost half of her life surrounded by baby products. As a mother and a professional copywriter, she has an insightful and unique eye for researching products suitable for infants. Bonnie Salem is an expert in health and nutrition who lives with her family in New Jersey. She has over 15 years of working experience in an institute of medicine after graduating from the University of Toronto. She is highly interested in personal health and wellness.