Best MSM Supplements for Immune Support of 2025

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 3, 2025

* We independently evaluate all recommended products and services. If you click on links we provide, we may receive compensation.

MSM supplements are becoming increasingly popular for their immune-boosting properties. MSM, or methylsulfonylmethane, is a naturally occurring compound found in plants, animals, and humans. It is believed to support the immune system by reducing inflammation, improving circulation, and promoting the production of glutathione, a powerful antioxidant. MSM supplements are available in various forms, including capsules, powders, and creams. They are often used to treat allergies, arthritis, and other inflammatory conditions. While research on the effectiveness of MSM for immune support is still ongoing, many people swear by its benefits and incorporate it into their daily routine.

At a Glance: Our Top Picks

Doctor's Best MSM with OptiMSM, Joint Support, Immune System, Antioxidant and Protein-Building Role Cover #TOP 1
Doctor's Best MSM with OptiMSM, Joint Support, Immune System, Antioxidant and Protein-Building Role
ftb score rating icon 9.9
Pure Encapsulations MSM Capsules Cover #TOP 2
Pure Encapsulations MSM Capsules
ftb score rating icon 9.8
Emerald Labs MSM 1000mg - 200 Vegetable Capsules Cover #TOP 3
Emerald Labs MSM 1000mg - 200 Vegetable Capsules
ftb score rating icon 9.6

Top 10 MSM Supplements for Immune Support

Doctor's Best MSM with OptiMSM, Joint Support, Immune System, Antioxidant and Protein-Building Role

DRB-00317
Doctor's Best MSM with OptiMSM, Joint Support, Immune System, Antioxidant and Protein-Building Role Cover
Doctor's Best MSM with OptiMSM, Joint Support, Immune System, Antioxidant and Protein-Building Role, Non-GMO, Gluten Free, 1000 mg, 360 Capsules

Doctor's Best MSM with OptiMSM is a natural sulfur compound that helps support the formation of healthy connective tissues. It improves joint function, protects cartilage, increases range of motion, and helps reduce joint pain. MSM provides support for immune function, and for the body's antioxidant and overall protective capacities resulting in a stronger immune response. Additionally, it restores collagen production that supports healthy skin and is a building block of keratin, an essential protein for improving skin, hair, and nails.

What We Like
Supports joint health and helps reduce joint pain
Improves immune function and response
Restores collagen and improves skin, hair, and nail health

Pure Encapsulations MSM Capsules

Pure Encapsulations MSM Capsules Cover
Pure Encapsulations MSM Capsules | Sulfur Supplement to Support Joints, Immune System, Connective Tissue, and Respiratory Health* | 250 Capsules

Pure Encapsulations MSM Capsules are a natural sulfur supplement that promotes joint health, immune function, and healthy hair, skin, and nails. The formula contains methylsulfonylmethane to support connective tissue health, immune function, and tissue containing significant amounts of collagen and keratin. The product is made with premium ingredients and is free from wheat, eggs, tree nuts & peanuts, gluten, artificial colors, flavors & sweeteners, coatings and shellacs, GMOs, and unnecessary binders, fillers & preservatives.

What We Like
Promotes joint health and comfort
Supports immune function
Helps maintain healthy hair, skin, and nails
Made with premium ingredients
Free from common allergens and unnecessary additives
#TOP 3

Emerald Labs MSM 1000mg - 200 Vegetable Capsules

ub10104
Emerald Labs MSM 1000mg - 200 Vegetable Capsules Cover
EMERALD LABS MSM 1000mg - Joint, Liver & Immune Support Supplement with Methylsulfonylmethane - Gluten-Free & Additive-Free - 200 Vegetable Capsules (Up to 100-Day Supply)

Emerald Labs MSM 1000mg is a dietary supplement with plant-sourced Methylsulfonylmethane that helps support overall health. Its highly bioavailable sulfur-containing compound maintains collagen and keratin levels, which benefits the joints and skin. The supplement also supports and maintains healthy liver functions and existing levels of the antioxidant glutathione in the body. It is additive-free, ensuring that it is made with care.

What We Like
Supports overall health
Maintains collagen and keratin levels for healthy skin, joints, and hair
Supports and maintains healthy liver functions
Helps support existing levels of the antioxidant glutathione in the body
Additive-free

Pure Encapsulations MSM Powder

MSMP
8 Ounce (Pack of 1)
Pure Encapsulations MSM Powder Cover
Pure Encapsulations MSM Powder | Hypoallergenic Supplement Supports Joint, Immune, and Respiratory Health | 8 Ounces

Pure Encapsulations MSM Powder is a hypoallergenic supplement designed to provide support for joint, immune and respiratory health. It contains MSM, which is a naturally-derived sulfur formula that helps support joint functionality, immune and respiratory health, as well as hair, skin, and nails. It is made with premium ingredients sourced from trusted suppliers, and is free from common allergens, artificial additives, and unnecessary fillers.

What We Like
Supports joint functionality and comfort
Potentially supports immune and respiratory health
Supports tissue containing significant amounts of collagen and keratin, including hair, skin, and nails
#TOP 5

Ultra Botanicals Emerald Labs MSM Supplement

Ultra Botanicals
ub10105
Ultra Botanicals Emerald Labs MSM Supplement Cover
Emerald Labs MSM 1000mg - Gluten-Free MSM Supplement to Help Maintain Joint & Immune Health - Also Supports Healthy Hair & Skin - 100 Vegetable Capsules

Ultra Botanicals Emerald Labs MSM Supplement is a highly bioavailable sulfur-containing compound that can support overall health. It may support the levels of glutathione in the body, maintain collagen and keratin levels for healthy skin, joints, and hair, and help support and maintain healthy liver functions. Additionally, the product is made with care and free of additives.

What We Like
May support the levels of glutathione in the body
Maintains collagen and keratin levels for healthy skin, joints, and hair
Helps support and maintain healthy liver functions
Highly bioavailable sulfur-containing compound
Made with care and free of additives

Doctor's Best MSM with OptiMSM, Joint Support, 120 Tablets

DRB-00097
Doctor's Best MSM with OptiMSM, Joint Support, 120 Tablets Cover
Doctor's Best MSM with OptiMSM, Non-GMO, Gluten Free, Joint Support, 1500 mg, 120 Tablets (DRB-00097)

Doctor's Best MSM with OptiMSM is a non-GMO and gluten-free supplement that contains natural sulfur compound to support the formation of healthy connective tissues, improve joint function, reduce joint pain, and increase range of motion. It also offers support for immune function and provides essential nutrients for healthy skin, hair, and nails. Numerous clinical studies prove the safety and efficacy of OptiMSM.

What We Like
Contains natural sulfur to improve joint function and reduce joint pain
Provides essential nutrients for healthy skin, hair, and nails
Backed by numerous clinical studies for safety and efficacy
#TOP 7

Doctor's Best MSM with OptiMSM

DRB-00331
Doctor's Best MSM with OptiMSM Cover
Doctor's Best MSM with OptiMSM, Joint Support, Immune System, Antioxidant and Protein-Building Role, Non-GMO, Gluten Free, 1000 mg, 180 Veggie Caps

Doctor's Best MSM with OptiMSM is a natural sulfur compound that helps support the formation of healthy connective tissues. MSM is a key structural nutrient in healthy joints that improves joint function, protects cartilage, reduces joint pain and increases range of motion. It provides support for immune function, and for the body's antioxidant and overall protective capacities resulting in a stronger immune response. MSM provides sulfur and is often called “nature's beauty mineral”. It restores collagen production that supports healthy skin and is a building block of keratin, an essential protein for improving skin, hair and nails.

What We Like
Joint support
Immune system
Antioxidant
Protein-building
Non-GMO, Gluten Free
#TOP 8

KALA HEALTH MSMPure MSM Capsules

0805000
KALA HEALTH MSMPure MSM Capsules Cover
KALA HEALTH MSMPure MSM Vegetarian Capsules – 1,000 mg Organic Sulfur per Capsule for Joint Flexibility, Skin Appearance, Hair & Nail Support – 500 Count, USA Made MSM

KALA HEALTH MSM Capsules provide numerous benefits for your joints, skin, and overall health. With each capsule containing 1,000 mg of organic sulfur, these supplements help maintain joint flexibility and promote collagen production, making movement easier and more comfortable for you. They also enhance your skin's texture and elasticity, helping you achieve a more youthful appearance. Additionally, these capsules support your active lifestyle by aiding in recovery after exercise and reducing oxidative stress. They even contribute to your immune health, helping your body defend against various challenges.

What We Like
Joint flexibility support
Improves skin and hair appearance
Enhances recovery after exercise
Boosts immune health
#TOP 9

KALA HEALTH MSMPure Fruit Punch MSM Powder

300012
Fruit Punch
1 Pound (Pack of 1)
KALA HEALTH MSMPure Fruit Punch MSM Powder Cover
KALA HEALTH MSMPure Fruit Punch Flavored Coarse MSM Powder Flakes – Organic Sulfur for Joint Flexibility, Skin Appearance, and Hair & Nail Support – 1 lb, USA Made, Distilled Crystals

KALA HEALTH MSM Powder offers a delicious fruit punch flavor that masks the natural bitterness of MSM, making it easy to incorporate into your daily routine. This supplement supports joint flexibility, helping you maintain comfort and mobility as you go about your day. It also contributes to the health and appearance of your skin, enhancing its texture and elasticity while aiding in hydration. Additionally, it promotes recovery after physical activity, ensuring that you feel your best and can continue enjoying your active lifestyle.

What We Like
Great fruit punch flavor
Supports joint flexibility
Enhances skin texture
Aids recovery after exercise

Kala Health MSMPure Tablets

2501200
Kala Health MSMPure Tablets Cover
KALA HEALTH MSMPure MSM Tablets– 1,000 mg Organic Sulfur per Tablet for Joint Flexibility, Skin Appearance, Hair & Nail Support – 120 Count, USA Made MSM

MSMPure Tablets by Kala Health is a pure MSM organic sulfur supplement made in the USA. It uses Optimsm, which is the purest MSM on the planet, to ensure 99.9% purity. This non-GMO, gluten-free, allergen-free, and vegan MSM is Kosher and Halal certified. MSMPure Tablets offer many benefits to joints such as improving joint function and mobility, reducing joint pain and stiffness, increasing range of motion, protecting cartilage, and decreasing swelling and inflammation. It is also commonly used for inflammation in various parts of the body. In addition, it is known as "Nature's Beauty Mineral" for promoting faster hair and nail growth, improving skin texture, reducing fine lines and wrinkles, restoring collagen production, and improving acne. Sulfur, an active component of MSMPure, supports restorative balance for the immune system. Kala Health offers a no-risk 100% satisfaction guarantee to its customers.

What We Like
Pure MSM organic sulfur supplement
Joint pain and inflammation relief
Improves hair, skin, and nails
Buying Guide Image

Frequently Asked Questions (FAQs)

1. Does MSM help your immune system?

MSM also supports the immune system and the body's ability to repair connective tissue. Methylsulfonylmethane contains sulfur, which is the third most abundant element in the body. Your nails, skin, and hair all contain sulfur, and your body uses it throughout to produce protein and collagen.

2. What is MSM supplement good for?

People take MSM by mouth or apply it to the skin, mostly using it to lessen inflammation. They take MSM to try to relieve pain or swelling from: Osteoarthritis or rheumatoid arthritis. Bursitis, tendinitis, or tenosynovitis.

3. What are the dangers of MSM?

Stomach upset, diarrhea and headache have been reported in human trials of MSM lasting up to 12 weeks. However, people taking a placebo also reported similar symptoms. Since little is known about the long-term safety of MSM , it's no surprise that the efficacy also is unclear.

4. Is MSM good to take everyday?

Evidence suggests that MSM is well tolerated as a short-term treatment, even with high doses. A daily dose of 1,500 mg per day for up to three months was used in one RCT in participants with osteoarthritis, but doses up to 2,600 mg per day have been used in non-RCT studies.

Editor's Notes

During our msm supplement for immune support research, we found 24 msm supplement for immune support products and shortlisted 10 quality products. We collected and analyzed 75,510 customer reviews through our big data system to write the msm supplements for immune support list. We found that most customers choose msm supplements for immune support with an average price of $19.09.

The msm supplements for immune support are available for purchase. We have researched hundreds of brands and picked the top brands of msm supplements for immune support, including Doctor's BEST, Pure Encapsulations, EMERALD LABS, Ultra Botanicals, KALA HEALTH. The seller of top 1 product has received honest feedback from 385 consumers with an average rating of 4.7.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.