Best MSM Supplements of 2025

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Elisa Drew
Last Updated: Jan 15, 2025

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MSM (methylsulfonylmethane) supplements are a popular option for those looking to improve their joint health and reduce inflammation. MSM is a naturally occurring sulfur compound found in plants, animals, and humans. It has been shown to have anti-inflammatory and antioxidant properties, making it a potentially effective treatment for arthritis and other inflammatory conditions. MSM supplements are available in various forms, including capsules, powders, and creams. They are generally safe and well-tolerated, but as with any supplement, it is important to consult with a healthcare provider before use.

At a Glance: Our Top Picks

NOW MSM 1000mg Joint Health Capsules Cover #TOP 1
NOW MSM 1000mg Joint Health Capsules
ftb score rating icon 9.9
Doctor's Best MSM with OptiMSM, Joint Support, 120 Tablets Cover #TOP 2
Doctor's Best MSM with OptiMSM, Joint Support, 120 Tablets
ftb score rating icon 9.8
Horbäach MSM Capsules 1500mg Cover #TOP 3
Horbäach MSM Capsules 1500mg
ftb score rating icon 9.6

Top 10 MSM Supplements

#TOP 1

NOW MSM 1000mg Joint Health Capsules

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NOW MSM 1000mg Joint Health Capsules Cover
NOW MSM 1000 mg,240 Capsules

NOW MSM 1000mg Joint Health Capsules provides joint sulfur for connective tissue and supports healthy cartilage. The MSM helps to create the chemical links needed to form and maintain various types of structural tissues in the human body. It contains sulfur compounds that are found in all body cells and are essential for life. The product is Non-GMO, Dairy Free, Egg Free, Made without Gluten, Corn Free, Soy Free, Kosher, Vegan/Vegetarian. The GMP Quality Assured product is packaged in the USA by a family-owned company since 1968.

What We Like
Effective pain relief
Improves joint flexibility
Supports digestive health
Promotes hair and skin health
Beneficial for pets' allergies
What We Don't Like
Price increase concerns
#TOP 2

Doctor's Best MSM with OptiMSM, Joint Support, 120 Tablets

DRB-00097
Doctor's Best MSM with OptiMSM, Joint Support, 120 Tablets Cover
Doctor's Best MSM with OptiMSM, Non-GMO, Gluten Free, Joint Support, 1500 mg, 120 Tablets (DRB-00097)

Doctor's Best MSM with OptiMSM is a non-GMO and gluten-free supplement that contains natural sulfur compound to support the formation of healthy connective tissues, improve joint function, reduce joint pain, and increase range of motion. It also offers support for immune function and provides essential nutrients for healthy skin, hair, and nails. Numerous clinical studies prove the safety and efficacy of OptiMSM.

What We Like
Improves hair texture
Supports nail growth
May alleviate joint pain
Safe with no side effects
Quality supplement
What We Don't Like
Large pill size
Slow initial results
#TOP 3

Horbäach MSM Capsules 1500mg

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Horbäach MSM Capsules 1500mg Cover
Horbäach MSM Capsules 1500mg | 240 Count | Non-GMO, Gluten Free Supplement | Berkshire Labs

The Horbäach MSM Capsules offer a powerful dose of 1,500 mg of methylsulfonylmethane, a mineral that supports overall health. You can trust that these capsules are crafted with advanced sourcing methods, ensuring both purity and effectiveness in every dose. They are laboratory-tested, giving you confidence in the quality of the ingredients. Additionally, this supplement is free from common allergens and artificial additives, making it a safe choice for many consumers. With Horbäach MSM Capsules, you can conveniently incorporate this beneficial supplement into your daily routine.

What We Like
Effective pain relief
Good product quality
Well received by long-time users
Supports joint health
Great value for price
What We Don't Like
Serving size may be misleading
#TOP 4

Life Extension MSM 1000 mg Capsules

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Life Extension MSM 1000 mg Capsules Cover
Life Extension MSM, 1000 mg, methylsulfonylmethane, Supports Healthy Joints, Helps Relieve Muscle and Joint discomfort, antioxidant Support, Gluten-Free, Non-GMO, 100 Capsules

Life Extension MSM 1000 mg Capsules are designed to alleviate muscle and joint discomfort, promoting joint mobility, and function. It contains 1000mg joint-friendly nutrient that helps inhibit inflammation and protects against oxidative stress. MSM acts as a complement to other popular joint health compounds such as glucosamine and chondroitin. This gluten-free and non-GMO product is sourced using only the finest raw ingredients to ensure purity and potency. A Certificate of Analysis is available for every product, and it is manufactured in the USA.

What We Like
Helps with joint and muscle pain
Improves mood and strength
Quick delivery
Good alternative to expensive brands
No upset stomach reported
What We Don't Like
Effects may vary over time
Consult doctor if diagnosed as BiPolar
#TOP 5

Doctor's Best MSM with OptiMSM, Joint Support, Immune System, Antioxidant and Protein-Building Role

DRB-00317
Doctor's Best MSM with OptiMSM, Joint Support, Immune System, Antioxidant and Protein-Building Role Cover
Doctor's Best MSM with OptiMSM, Joint Support, Immune System, Antioxidant and Protein-Building Role, Non-GMO, Gluten Free, 1000 mg, 360 Capsules

Doctor's Best MSM with OptiMSM is a natural sulfur compound that helps support the formation of healthy connective tissues. It improves joint function, protects cartilage, increases range of motion, and helps reduce joint pain. MSM provides support for immune function, and for the body's antioxidant and overall protective capacities resulting in a stronger immune response. Additionally, it restores collagen production that supports healthy skin and is a building block of keratin, an essential protein for improving skin, hair, and nails.

What We Like
Improves mood and energy
Supports joint health
Effective for acne control
Good value for quality
Long-term user satisfaction
What We Don't Like
Requires patience for results
May need dosage adjustments
#TOP 6

Pure Encapsulations MSM Capsules

Pure Encapsulations MSM Capsules Cover
Pure Encapsulations MSM Capsules | Sulfur Supplement to Support Joints, Immune System, Connective Tissue, and Respiratory Health* | 250 Capsules

Pure Encapsulations MSM Capsules are a natural sulfur supplement that promotes joint health, immune function, and healthy hair, skin, and nails. The formula contains methylsulfonylmethane to support connective tissue health, immune function, and tissue containing significant amounts of collagen and keratin. The product is made with premium ingredients and is free from wheat, eggs, tree nuts & peanuts, gluten, artificial colors, flavors & sweeteners, coatings and shellacs, GMOs, and unnecessary binders, fillers & preservatives.

What We Like
Improves nail thickness
Boosts skin glow
Relieves joint pain
High purity
Effective for allergies
What We Don't Like
Premium price
Variable results
#TOP 7

Horbaach MSM Supplement - 3000mg/300 Caplets

CL54
Horbaach MSM Supplement - 3000mg/300 Caplets Cover
Horbäach MSM Supplement | 3000mg | 300 Coated Caplets | Methylsulfonylmethane with Calcium | Vegetarian, Non-GMO, Gluten Free

Horbaach MSM Supplement is a vegetarian, non-GMO, gluten-free supplement that contains 3000mg of Methylsulfonylmethane per serving. This supplement is professionally crafted using advanced sourcing to ensure purity and potency. It is naturally free of gluten, wheat, yeast, milk, lactose, soy, artificial color & flavor & non-GMO. Methylsulfonylmethane is a common mineral found in plants, animals, and humans and is known to provide maximum daily support.

What We Like
Significantly reduces cholesterol
Knee pain relief
High dosage of MSM
No unnecessary ingredients
What We Don't Like
Large caplets difficult to swallow
Initial gagging experience
#TOP 8

Amazing Formulas MSM Supplement

Amazing Formulas MSM Supplement Cover
Amazing Formulas MSM (Methylsulfonylmethane) Supplement | 2000 Mg per Serving | 120 Capsules | Non-GMO | Gluten-Free | Made in USA

Get the Amazing Formulas MSM 2000mg supplement and experience the benefits of this powerful formula. With 60 servings per bottle and 2 capsules per serving, you'll enjoy a convenient and long-lasting supply. This non-GMO and gluten-free supplement is third-party tested for quality, ensuring you're getting the best. Manufactured in accordance with GMP standards, you can trust the purity and potency of this product. Made in the USA, this supplement is a reliable choice for those seeking the benefits of MSM. Support your overall well-being and enjoy the convenience of the Amazing Formulas MSM 2000mg supplement.

What We Like
Promotes healing
Fast-growing nails and hair
Easy to swallow tablets
Joint relief
Positive recommendations from friends
What We Don't Like
Causes vivid dreams
#TOP 9

Doctor's Best MSM Powder with OptiMSM

DRB-00076
Doctor's Best MSM Powder with OptiMSM Cover
Doctor's Best MSM Powder with OptiMSM, Non-GMO, Vegan, Gluten Free, Soy Free, 250g

Doctor's Best MSM Powder with OptiMSM is a natural sulfur compound that helps support the formation of healthy connective tissues. It also helps support overall joint mobility, reduces joint pain, and increases range of motion. MSM provides support for immune function, and for the body's antioxidant and overall protective capacities resulting in a stronger immune response. It also restores collagen production that supports healthy skin and is a building block of keratin, an essential protein for improving skin, hair and nails. With numerous clinical studies, MSM can help support healthy skin, joint mobility, cartilage, and the antioxidant response.

What We Like
Supports hair growth
Improves nail strength
Reduces joint pain
Enhances skin appearance
Increases energy levels
What We Don't Like
May cause hair growth elsewhere
Possible mild headaches
#TOP 10

Organic Sulfur Crystals, Premium MSM Supplement - 1 LBS Pack

ORGSFR-1pk
1 Pound (Pack of 1)
Organic Sulfur Crystals, Premium MSM Supplement - 1 LBS Pack Cover
Organic Sulfur Crystals - 99% Pure MSM Crystals, Premium MSM Supplement - Excellent Quality and Absorption. 1 LB Pack.

The Organic Sulfur Crystals by HAPPY BODY are a premium quality, additive-free MSM supplement that provides a minimum of 99.9% pure MSM. The product is certified for purity by 3rd-party independent labs, is free from gluten and GMO, and vegan-friendly. Each bag provides 45 - 90 days of supply, and the product is easy to use by taking a 1/4 to 1/2 teaspoon twice daily with water or juice. The product also comes with a 100% satisfaction guarantee.

What We Like
High quality and purity
Effective absorption
Improves hair and nail health
Good value for money
Supports joint health
What We Don't Like
Strong taste
Occasional dissolvability issues
Buying Guide Image

What to Look for in MSM Supplements

Introduction

When it comes to choosing a dietary supplement, there are many factors to consider. This is especially true for supplements containing methylsulfonylmethane (MSM), which is a naturally occurring compound found in some plants and animals. In this article, we will explore some of the key considerations for choosing an MSM supplement, including the potential health benefits, potential side effects, and how to evaluate the quality and purity of different products.

The potential health benefits of MSM supplements

One of the most common reasons people take MSM supplements is for their potential health benefits. Some people believe that MSM can help with a wide range of health conditions, including joint pain, inflammation, allergies, and even cancer. However, it's important to note that most of these potential benefits are based on anecdotal evidence and have not been extensively studied in scientific research.

That being said, there is some evidence to suggest that MSM supplements may be beneficial for certain conditions. For example, a study published in the Journal of Alternative and Complementary Medicine found that MSM supplements were effective at reducing pain and improving joint function in people with osteoarthritis. Additionally, a study published in the Journal of the International Society of Sports Nutrition found that MSM supplements were effective at reducing muscle damage and speeding up recovery time in athletes.

Potential side effects of MSM supplements

While MSM supplements are generally considered safe, there are some potential side effects to be aware of. The most common side effects of MSM supplements include nausea, diarrhea, and bloating. In some cases, MSM supplements can also cause allergic reactions, such as hives, rash, or difficulty breathing.

It's important to note that the potential side effects of MSM supplements may vary depending on the dose and the individual. Some people may be more sensitive to MSM than others, and it's always a good idea to talk to a healthcare provider before starting a new supplement regimen.

Evaluating the quality and purity of MSM supplements

When choosing an MSM supplement, it's important to evaluate the quality and purity of the product. This is because dietary supplements are not regulated by the FDA, which means that the quality and purity of different products can vary greatly.

One of the best ways to evaluate the quality and purity of an MSM supplement is to look for a product that has been certified by a third-party organization, such as the USP (United States Pharmacopeia) or NSF International. These organizations conduct independent testing to ensure that the product meets certain quality standards. Additionally, you can also look for products that have been certified as "GMP" (good manufacturing practice) compliant, which means that the product was manufactured according to certain quality standards.

Conclusion

In conclusion, choosing an MSM supplement can be a challenging task. However, by considering the potential health benefits, potential side effects, and the quality and purity of the product, you can make an informed decision that is right for you. Always remember to talk to a healthcare provider before starting any new supplement regimen, and to follow the dosage instructions on the product label.

Frequently Asked Questions (FAQs)

1. What is the MSM supplement good for?

MSM supplements provide a source of natural sulfur and may be beneficial for various conditions, such as joint pain, skin inflammation, arthritis, muscle recovery after exercise, and allergy relief. However, it's important to note that MSM supplements typically contain a synthetic form of MSM.

2. What are the potential side effects of MSM?

Some people may experience side effects such as nausea, diarrhea, bloating, and stomach discomfort when taking MSM supplements. When applied topically, MSM is generally safe when used with other ingredients for a limited period of time.

3. When should I take MSM supplements?

It is recommended to start with 1/4 teaspoon of MSM twice per day, dissolved in a glass of water on an empty stomach. After 2-3 days, you can gradually increase the dosage. It's important to take MSM twice daily and avoid taking it too late in the day or in the evening.

4. Can I take MSM and magnesium together?

Yes, taking MSM and magnesium together can be a beneficial combination. MSM can help relieve inflammation while magnesium works as a muscle relaxant, making them work well together.

5. What happens when you start taking MSM?

Studies have shown that MSM has anti-inflammatory and antioxidant effects. It contains sulfur, which plays a crucial role in the production of collagen, glucosamine, and immunoglobulins, important for healthy bones, joints, and the immune system.

6. Is it safe to take MSM everyday?

Studies have shown minimal side effects when taking MSM orally in a dosage of 3 grams daily for six months. However, some individuals may experience mild gastrointestinal side effects. It's important to consult with a healthcare professional, especially if pregnant or breastfeeding.

7. What should you avoid when taking MSM?

When taking MSM, it is advisable to avoid medications that treat or prevent blood clots, NSAIDs for pain and inflammation, and other herbal supplements. It's important to consult with a healthcare professional to ensure there are no potential interactions.

8. Is MSM hard on the liver?

Research suggests that MSM may actually improve liver function and suppress hepatic tumorigenesis through activating apoptosis.

9. Who should not take MSM?

There is limited information on the safety of using MSM during pregnancy or while breastfeeding. It is recommended to avoid using MSM in these situations to err on the side of caution.

Editor's Notes

During our msm supplement research, we found 24 msm supplement products and shortlisted 10 quality products. We collected and analyzed 165,676 customer reviews through our big data system to write the msm supplements list. We found that most customers choose msm supplements with an average price of $19.76.

The msm supplements are available for purchase. We have researched hundreds of brands and picked the top brands of msm supplements, including NOW Foods, Doctor's BEST, Life Extension, Pure Encapsulations, Amazing Nutrition. The seller of top 1 product has received honest feedback from 385 consumers with an average rating of 4.7.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.

MSM Supplements Comparison Table

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#TOP10
Brand NOW Foods Doctor's BEST Horbäach Life Extension Doctor's BEST Pure Encapsulations Horbäach Amazing Nutrition Doctor's Best HAPPY BODY
Unit Count 240 Count 120 Count - 100 Count 360 Count 250.00 Count 300.00 Count 120.0 Count 8.8 Ounce 16 Ounce
Item Form Capsule Tablet - Capsule 0Tablets Capsule Caplet Capsule Powder Granule
Item Weight 0.8 Pounds 0.24 Kilograms - 0.15 Kilograms 16 ounces 0.01 Ounces 24.51 Ounces 4.8 ounces 0.25 Kilograms 1 Pounds
Flavor Unflavored Unflavored - Unflavored Unflavored Flavor Free - Unflavored Unflavored Can be Bitter, Add Juice
Item dimensions L x W x H 3.15 x 3.15 x 6.25 inches 2.63 x 2.63 x 5.06 inches - 2.51 x 2.51 x 4.48 inches 3.25 x 3.25 x 6.75 inches 4.3 x 3.7 x 3.7 inches 3.5 x 3.5 x 6.5 inches - 3.19 x 3.19 x 4.5 inches 6.5 x 1 x 9.5 inches
Product Benefits Bone & Joint Support Bone & Joint Support - Preserves joint mobility & function, Helps relieve muscle & joint discomfort after exercise, Helps inhibit oxidative stress Bone & Joint Support Hypoallergenic - Dietary Supplement Hair, Skin, Nail & Joint Support -
Primary Supplement Type multivitamin mineral - Methylsulfonylmethane mineral - - Methylsulfonylmethane mineral -
Special Ingredients Methylsulfonylmethane Methylsulfonylmethane - Methylsulfonylmethane Collagen, Methylsulfonylmethane - - Methylsulfonylmethane Methylsulfonylmethane -
Diet Type Halal, Kosher, Vegan Vegan - Gluten Free Gluten Free - - Gluten Free Gluten Free, Vegan -
FTB Score
ftb score rating icon 9.9
ftb score rating icon 9.8
ftb score rating icon 9.6
ftb score rating icon 9.4
ftb score rating icon 9.2
ftb score rating icon 9.1
ftb score rating icon 8.9
ftb score rating icon 8.9
ftb score rating icon 8.8
ftb score rating icon 8.7
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