Best DMAE Supplements of 2026

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Elisa Drew
Last Updated: Jan 9, 2026

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DMAE supplements are a popular nootropic supplement that has been known to improve cognitive function and memory. DMAE, or Dimethylaminoethanol, is a compound that is naturally found in the brain and is believed to help increase the production of acetylcholine, a neurotransmitter that is essential for cognitive function. DMAE supplements are available in capsule or powder form and are often used by students, professionals, and seniors to help improve focus, concentration, and memory retention. It is important to note that while DMAE supplements have been shown to be effective in some studies, more research is needed to fully understand its benefits and potential side effects.

At a Glance: Our Top Picks

Mind and Memory Supplement for Brain Health Cover #TOP 1
Mind and Memory Supplement for Brain Health
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NATURE'S BRANCH 40-in-1 Brain Booster Cover #TOP 2
NATURE'S BRANCH 40-in-1 Brain Booster
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NOW Supplements DMAE 250mg Cover #TOP 3
NOW Supplements DMAE 250mg
ftb score rating icon 9.6

Top 10 DMAE Supplements

#TOP 1

Mind and Memory Supplement for Brain Health

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Mind and Memory Supplement for Brain Health Cover
Nootropic Brain Supplement for Memory and Focus Enhancement - Vitamins for Mental Health & Clarity with VIT A, B6, Riboflavin, Niacin, Thiamin & Folate - Cognitive Complex for Mind Vitality - 60 Ct

Boost your mental performance with this brain health supplement that supports cognitive function, memory, and focus. This herbal formula includes L-glutamine, DMAE, bacopa monnieri, green tea extract, bilberry, and more. The natural brain support and aging minds help make this energy and focus supplement ideal for mental clarity.

What We Like
Improves cognitive function, memory, and focus
All-natural herbal formula
Includes non-GMO ingredients
#TOP 2

NATURE'S BRANCH 40-in-1 Brain Booster

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NATURE'S BRANCH 40-in-1 Brain Booster Cover
40-in-1 Brain Booster Supplement for Focus, Memory, Clarity, Energy | Advanced Vitamins Plus eBook | for Men & Women, Cognitive Function Nootropic Support with DMAE, Mind Health Formula | 60 Capsules

The NATURE'S BRANCH Brain Booster is designed to help you improve focus, memory, and mental clarity with a powerful blend of 40 carefully chosen ingredients. It supports your brain health and boosts concentration, making it easier to stay alert during work, study, or daily tasks. Whether you're juggling a busy schedule or facing mental fatigue, this supplement helps fuel your energy and keeps you sharp throughout the day. The formula includes DMAE and L-Glutamine, which work together to enhance cognitive function without causing jitters. Plus, it comes in easy-to-swallow capsules, making it convenient to include in your daily routine.

What We Like
40-ingredient brain support
Boosts focus and memory
Enhances energy and alertness
Contains DMAE and L-Glutamine
Easy-to-swallow capsules
#TOP 3

NOW Supplements DMAE 250mg

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NOW Supplements DMAE 250mg Cover
NOW Supplements, DMAE (Dimethylaminoethanol) 250 mg, Healthy Brain Function*, 100 Veg Capsules

NOW Supplements DMAE (Dimethylaminoethanol) 250 mg is a dietary supplement that supports healthy brain function*. It contains Amino Acid and is suitable for adults. It is packaged in the USA by a family owned and operated company since 1968 and is GMP Quality Assured. Customers report feeling more alert, sharper, and better able to concentrate after taking this supplement.

What We Like
Supports Neurotransmitter Production*
GMP Quality Assured
Packaged in the USA by a family owned and operated company since 1968
#TOP 4

Source Naturals DMAE, Dimethylaminoethanol Bitartrate - 200 Capsules

Source Naturals DMAE, Dimethylaminoethanol Bitartrate - 200 Capsules Cover
Source Naturals DMAE, Dimethylaminoethanol Bitartrate - Supports Mental Concentration - 200 Capsules

Source Naturals DMAE is a well-made supplement that supports mental concentration. With its ability to easily cross the blood-brain barrier, DMAE plays a crucial role in the formation of acetylcholine, an important neurotransmitter responsible for memory and muscle movement. By taking 1 to 2 capsules daily, you can provide the support that your neurotransmitters need to perform their vital functions in the brain. This supplement is manufactured in the USA and is free from yeast, gluten, corn, sugar, starch, salt, preservatives, artificial color, flavor, or fragrance. Trust Source Naturals, a brand that has been trusted for over 35 years, to help you reach your optimal health potential.

What We Like
Supports mental concentration
Well-made supplement
No artificial additives
#TOP 5

Nature's Nutrition Brain Memory Supplement

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Nature's Nutrition Brain Memory Supplement Cover
Brain Memory Supplement Pills - 3X Strength Nootropics for Concentration, Clarity & Focus Support - Brain Health Cognitive Vitamins with Bacopa, Phosphatidylserine & DMAE, Brain Booster - 60 Capsules

Nature's Nutrition Brain Booster is designed to help you improve your mental clarity, focus, and alertness. This supplement uses powerful nootropics like Bacopa Monnieri, Phosphatidylserine, and DMAE to support your brain’s memory health, helping you stay sharp and attentive throughout the day. It also includes essential vitamins such as B12 and Vitamin C, which contribute to long-term brain health and memory maintenance. Each capsule is carefully tested to ensure high quality, giving you confidence in a reliable brain support supplement that can enhance your cognitive performance and keep your mind clear.

What We Like
Supports memory and focus
Contains powerful nootropics
Includes essential brain vitamins
Third-party quality tested
#TOP 6

Natures Craft Mind and Memory Matrix

Natures Craft Mind and Memory Matrix Cover
Advanced Brain Supplement for Memory and Focus - Nootropics Brain Support Supplement with Memory and Focus Vitamins for Adults of All Ages - for Brain Fog Clarity Energy and Recall

Natures Craft Brain Booster is designed to support your brain health in multiple ways. It combines key vitamins that help improve memory and focus, making it easier for you to stay sharp throughout the day. This supplement works as a nootropic, helping unlock your brain's full potential by providing essential nutrients that boost cognitive function. With ingredients like DMAE, Huperzine A, and Bacopa, it supports better memory and mental clarity, helping you feel more alert and energized. Made in American GMP-certified labs and tested by third parties, you can trust the quality and effectiveness of this brain support supplement.

What We Like
Multi-purpose brain support
Memory and focus enhancement
Nootropic cognitive boost
High-quality GMP manufacturing
#TOP 7

Natures Craft Memory Supplement

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Natures Craft Memory Supplement Cover
Nootropic Memory Supplement for Brain Support - Memory Pills for Brain Boost and Natural Energy Booster - Vitamin B 12 Bacopa Monnieri Rhodiola Rosea DMAE Ginkgo Biloba Phosphatidylserine Supplement

Natures Craft Memory Pills is a brain health supplement that can help you improve focus, energy, memory, and clarity. With powerful ingredients like Ginkgo Biloba, Rhodiola Rosea Extract, Bacopa Monnieri, and Vitamin B12, these brain memory supplements can help you maintain a sharp mind and say goodbye to brain fog. The vitamin B12 energy boost can provide natural energy to support mental clarity, while the brain clarity and focus supplement contains the best vitamins for memory and brain focus. These natural nootropics pills for energy can be a popular brain focus aid to maintain a sharp mind that other focus pills just can't match.

What We Like
Boosts focus
Improves memory
Natural energy booster
Contains powerful ingredients
#TOP 8

TWINLEAF Dopamine Brain Support Supplement

TwinLeaf Dopamine Booster
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TWINLEAF Dopamine Brain Support Supplement Cover
TWINLEAF Dopamine Brain Support Supplement, 1000 mg Blend - Made in USA - with DMAE, Vitamin B12 and L-Tyrosine - Enhance Mental Well-Being - 60 Capsules

The TWINLEAF Brain Support supplement is designed to help both men and women maintain healthy brain function by using natural ingredients like L-Tyrosine and Mucuna Pruriens. These ingredients support the production of important brain chemicals, which can improve your overall mental well-being. The formula also includes vitamin B12, ginkgo biloba, Panax ginseng, and phosphatidylserine, which are known to boost focus, memory, and mental clarity. Developed by American healthcare experts, this supplement is made with high-quality ingredients and strict safety controls to ensure you get a reliable and effective product.

What We Like
Supports brain health
Enhances mental well-being
Improves focus and memory
High-quality American-made formula
#TOP 9

Life Extension DMAE Bitartrate - Brain Health, Focus and Memory Supplement

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Life Extension DMAE Bitartrate - Brain Health, Focus and Memory Supplement Cover
Life Extension DMAE Bitartrate, Supports neurotransmitter Production, 6-Month Supply, Gluten-Free, Non-GMO, Vegetarian, 200 Capsules

Life Extension DMAE Bitartrate is a brain health supplement designed to support essential neurotransmitter choline production. It contains 150 mg of DMAE to help protect cell membranes and support free radical scavenging activity. This product is certified non-GMO and gluten-free, and is suitable for vegetarians. Customers report improved memory recall, increased clarity of mind, and better concentration with no side effects.

What We Like
Supports essential neurotransmitter choline production
Protects cell membranes
Certified non-GMO and gluten-free
Suitable for vegetarians
Customers report improved memory recall, clarity of mind, and better concentration
#TOP 10

Source Naturals DMAE, Dimethylaminoethanol Bitartrate - 100 Tablets

Source Naturals DMAE, Dimethylaminoethanol Bitartrate - 100 Tablets Cover
Source Naturals DMAE, Dimethylaminoethanol Bitartrate - Supports Mental Concentration - 100 Tablets

Source Naturals DMAE is a well-made supplement that supports mental concentration. It contains DMAE, which easily crosses the blood-brain barrier to form acetylcholine, a neurotransmitter vital for memory and muscle movement. By supporting neurotransmitters, Source Naturals DMAE helps improve mental focus and concentration. With a suggested use of 1 tablet 1 to 2 times daily, it's easy to incorporate into your daily routine. Plus, it's free from yeast, gluten, corn, sugar, starch, salt, preservatives, and artificial color, flavor or fragrance. With over 35 years of trust, Source Naturals is dedicated to supporting each individual's potential for optimal health. Manufactured in the USA, you can trust the quality of Source Naturals DMAE.

What We Like
Supports mental concentration
Well-made supplement
Free from harmful additives
Buying Guide Image

Everything You Need to Know About DMAE Supplements

What is DMAE?

DMAE is an abbreviation for dimethylaminoethanol, which is a compound found naturally in the human brain. It is a precursor to the neurotransmitter acetylcholine, which is important for memory and learning. DMAE has been studied for its potential to improve mental focus, and is thought to help reduce inflammation, support immune system health, and possibly even improve skin tone.

Benefits of DMAE Supplements

The potential benefits of taking DMAE supplements include improved mental focus, concentration, and memory; increased energy levels; improved immune system health; and reduced inflammation. Additionally, some studies suggest that DMAE may improve skin tone, although further research is needed to confirm this.

What to Look for in DMAE Supplements

When selecting a DMAE supplement, it is important to look for one that is of high quality and contains the right ingredients. Quality DMAE supplements should be made from natural sources, such as sardines, anchovies, and other cold-water fish, as these are the best sources of DMAE. The supplement should also be free of any artificial ingredients, fillers, preservatives, or additives. Additionally, it is important to make sure the supplement is third-party tested for purity and potency.

Dosage and Side Effects

The recommended dosage of DMAE supplements varies depending on the individual’s age and health status. It is important to speak to a healthcare professional before starting any supplement regimen. Common side effects of DMAE supplements include headache, upset stomach, and insomnia. If any of these side effects occur, it is important to stop taking the supplement and consult a healthcare professional.

Conclusion

DMAE supplements may offer potential benefits such as improved mental focus, increased energy levels, and improved immune system health. When selecting a DMAE supplement, it is important to look for one that is of high quality and contains the right ingredients. Additionally, it is important to speak to a healthcare professional before starting any supplement regimen and to be aware of potential side effects. With the right supplement and dosage, DMAE may offer a range of potential health benefits.

Frequently Asked Questions (FAQs)

1. What is DMAE supplement used for?

DMAE supplements are used for various cognitive and disruptive disorders, including ADHD and memory lapses. It is also used in skincare products to address sagging skin and age spots.

2. Are DMAE supplements safe?

The safety of DMAE supplements is not well-established. Some studies have reported side effects like stomach upset and drowsiness in a percentage of patients taking DMAE for tardive dyskinesia. It is recommended to exercise caution when using DMAE supplements.

3. Does DMAE have side effects?

Clinical studies have used up to 1,600 mg of DMAE per day with no reported side effects. However, higher intakes for Alzheimer's disease patients have shown symptoms of drowsiness and confusion. Overall, DMAE is considered relatively nontoxic, but individual responses may vary.

4. Is DMAE a stimulant?

DMAE is classified as a mild central nervous system stimulant. It can improve moods and reduce sluggishness. This stimulant effect is attributed to DMAE's ability to stabilize cell membranes, benefiting both the skin and brain functions.

5. Is DMAE anti-inflammatory?

In vitro studies suggest that DMAE has moderate anti-inflammatory properties. While its mechanisms of action in the skin are not fully understood, evidence indicates that the skin is actively involved in acetylcholine synthesis, storage, secretion, metabolism, and receptivity.

6. Can you take DMAE daily?

Clinical studies have used doses of up to 1,600 mg of DMAE per day without reporting side effects or known drug interactions. Regular supplementation with DMAE is generally well-tolerated, but it is advisable to be aware of potential side effects and consider individual circumstances.

7. How long does it take for DMAE to start working?

It typically takes about three weeks of continuous DMAE intake before initial results become noticeable. For optimal results, it is recommended to take DMAE daily for three months.

8. When is the best time to take DMAE?

DMAE is best taken in the morning, preferably with breakfast. It is advised to dose DMAE a few times a week rather than daily. If using DMAE, consider stacking it with a good source of choline, as DMAE can inhibit choline metabolism.

9. What foods are high in dimethylaminoethanol?

Fish and seafood, such as salmon, oysters, rainbow trout, mackerel, tuna, halibut, sardines, and anchovies, contain high amounts of dimethylaminoethanol (DMAE). These foods are natural sources of DMAE.

10. Does DMAE cause cell death?

In vitro studies have shown that DMAE can cause damage to cells and lead to vacuolization. This vacuolization can inhibit cell division and secretion, potentially resulting in cell death after a certain period of time.

Editor's Notes

During our dmae supplement research, we found 24 dmae supplement products and shortlisted 10 quality products. We collected and analyzed 65,104 customer reviews through our big data system to write the dmae supplements list. We found that most customers choose dmae supplements with an average price of $15.73.

The dmae supplements are available for purchase. We have researched hundreds of brands and picked the top brands of dmae supplements, including Natures Craft, NATURE'S BRANCH, NOW Foods, Source Naturals, Nature's Nutrition. The seller of top 1 product has received honest feedback from 2,744 consumers with an average rating of 4.9.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.