Best Natural MSM Supplements of 2025

Elisa Drew Avatar
Elisa Drew
Last Updated: Sep 28, 2025

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Natural MSM supplements are gaining popularity among individuals looking for a natural way to support joint health and reduce inflammation. MSM, or methylsulfonylmethane, is a natural sulfur compound found in plants, animals, and humans. MSM supplements are typically derived from plant sources and are believed to have anti-inflammatory properties that can help reduce joint pain and stiffness. They are also often used to support skin, hair, and nail health. Natural MSM supplements are a safe and effective way to support overall health and wellness.

At a Glance: Our Top Picks

NOW MSM 1000mg Joint Health Capsules Cover #TOP 1
NOW MSM 1000mg Joint Health Capsules
ftb score rating icon 9.9
Pure Organic Ingredients MSM Powder - Natural Sulfur Dietary Supplement Cover #TOP 2
Pure Organic Ingredients MSM Powder - Natural Sulfur Dietary Supplement
ftb score rating icon 9.8
Doctor's Best MSM with OptiMSM, Joint Support, 120 Tablets Cover #TOP 3
Doctor's Best MSM with OptiMSM, Joint Support, 120 Tablets
ftb score rating icon 9.6

Top 10 Natural MSM Supplements

NOW MSM 1000mg Joint Health Capsules

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NOW MSM 1000mg Joint Health Capsules Cover
NOW FOODS M.S.M 1000mg Capsules, 240 CT

NOW MSM 1000mg Joint Health Capsules provides joint sulfur for connective tissue and supports healthy cartilage. The MSM helps to create the chemical links needed to form and maintain various types of structural tissues in the human body. It contains sulfur compounds that are found in all body cells and are essential for life. The product is Non-GMO, Dairy Free, Egg Free, Made without Gluten, Corn Free, Soy Free, Kosher, Vegan/Vegetarian. The GMP Quality Assured product is packaged in the USA by a family-owned company since 1968.

What We Like
Effective joint pain relief
Improved skin and hair health
Supports digestive health and detox
Fast-acting, noticeable results
Helps with allergies and inflammation
What We Don't Like
Price increase may feel steep
Possible mild stomach upset initially

Pure Organic Ingredients MSM Powder - Natural Sulfur Dietary Supplement

2 Pound (Pack of 1)
Pure Organic Ingredients MSM Powder - Natural Sulfur Dietary Supplement Cover
Methylsulfonylmethane MSM Powder (2 lbs), Always Pure, Natural Sulfur Dietary Supplement

This Pure Organic Ingredients MSM Powder is a natural sulfur dietary supplement made from a single ingredient without any fillers or additives. MSM is a natural source of bioavailable sulfur which is found naturally in some green vegetables and in the human body. This supplement provides digestive health support and helps maintain connective tissue health as well as respiratory and digestive support. The powder is packaged in Utah, USA, and comes in a 32-ounce bag.

What We Like
High purity and quality
Affordable price
Improves joint and skin health
Easy dissolving in liquids
Comes in eco-friendly packaging
What We Don't Like
Bitter taste
No scoop included

Doctor's Best MSM with OptiMSM, Joint Support, 120 Tablets

DRB-00097
Doctor's Best MSM with OptiMSM, Joint Support, 120 Tablets Cover
Doctors Best MSM, Supports Hair, Skin, Nails, & Joints, Non-GMO, Gluten Free, Vegan 120 Tablets

Doctor's Best MSM with OptiMSM is a non-GMO and gluten-free supplement that contains natural sulfur compound to support the formation of healthy connective tissues, improve joint function, reduce joint pain, and increase range of motion. It also offers support for immune function and provides essential nutrients for healthy skin, hair, and nails. Numerous clinical studies prove the safety and efficacy of OptiMSM.

What We Like
Improved hair growth and texture
Stronger and faster-growing nails
Supports joint pain relief
Moisturizes and softens skin
No noticeable side effects
What We Don't Like
Large pill size
Possible mild side effects at high doses

Organic Sulfur Crystals, Premium MSM Supplement - 1 LBS Pack

ORGSFR-1pk
1 Pound (Pack of 1)
Organic Sulfur Crystals, Premium MSM Supplement - 1 LBS Pack Cover
Organic Sulfur Crystals - 99% Pure MSM Crystals, Premium MSM Supplement - Excellent Quality and Absorption. 1 LB Pack.

The Organic Sulfur Crystals by HAPPY BODY are a premium quality, additive-free MSM supplement that provides a minimum of 99.9% pure MSM. The product is certified for purity by 3rd-party independent labs, is free from gluten and GMO, and vegan-friendly. Each bag provides 45 - 90 days of supply, and the product is easy to use by taking a 1/4 to 1/2 teaspoon twice daily with water or juice. The product also comes with a 100% satisfaction guarantee.

What We Like
Hair and nail improvement
High purity and quality
Effective absorption
Joint and pain relief
Good packaging and quantity
What We Don't Like
Occasional strong taste
Sometimes leaves gritty residue

Doctor's Best MSM with OptiMSM, Joint Support, Immune System, Antioxidant and Protein-Building Role

DRB-00317
Doctor's Best MSM with OptiMSM, Joint Support, Immune System, Antioxidant and Protein-Building Role Cover
Doctor's BEST MSM, Supports Hair, Skin, Nails, & Joints, Non-GMO, Gluten Free, 3000 mg Per Serving, 360 Capsules

Doctor's Best MSM with OptiMSM is a natural sulfur compound that helps support the formation of healthy connective tissues. It improves joint function, protects cartilage, increases range of motion, and helps reduce joint pain. MSM provides support for immune function, and for the body's antioxidant and overall protective capacities resulting in a stronger immune response. Additionally, it restores collagen production that supports healthy skin and is a building block of keratin, an essential protein for improving skin, hair, and nails.

What We Like
Mood improvement
Better sleep quality
Joint pain relief
Clearer skin (acne control)
Consistent long-term benefits
What We Don't Like
Requires consistent daily use

Solgar Skin, Nails & Hair, Advanced MSM Formula, 120 Tablets

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Solgar Skin, Nails & Hair, Advanced MSM Formula, 120 Tablets Cover
Solgar Skin, Nails & Hair, Advanced MSM Formula, 120 Tablets - Supports Collagen for Hair, Nail and Skin Health - Provides Zinc, Vitamin C & Copper - Non GMO, Vegan, Gluten & Dairy Free - 60 Servings ,Standard Packaging , 120 Count

Solgar Skin, Nails & Hair, Advanced MSM Formula, 120 Tablets is a specialized formula designed to support collagen in the body to help maintain healthy skin, hair and nails. It also delivers additional nutrients like Vitamin C and Copper to support hair, skin and nail health. All tablets are KOF-K Kosher certified, non-GMO and certified gluten free, making it suitable for vegans. The product note states that exposure to heat or sunlight may lead to melting/damage of product.

What We Like
Supports hair growth and reduces shedding
Improves nail strength and skin health
High quality and good value
Gluten-free and dairy-free
Promotes overall vitality and well-being
What We Don't Like
Tablets can be difficult to swallow
Mild stomach discomfort if taken without food
#TOP 7

Best Naturals Pure MSM Powder 1Lb

BD27282
1 Pound (Pack of 1)
Best Naturals Pure MSM Powder 1Lb Cover
Best Naturals 100% Pure MSM Powder, 1Lb

The Best Naturals MSM Powder offers a pure and reliable supplement to support your wellness routine. It comes with third-party lab testing, ensuring you get a high-quality product free from impurities. Each serving provides a precise ½ teaspoon dose, giving you 252 servings per bottle, which makes it easy to manage your intake and last longer. The powder is non-GMO and gluten-free, making it suitable for those with dietary restrictions. Plus, it’s made in the USA in a GMP-compliant, FDA-registered facility, so you can trust its safety and manufacturing standards every time you use it.

What We Like
Large 1-lb package
Pure, no extra ingredients
Pain relief and muscle tension help
Supports hair, eyebrow, eyelash growth
Safe, effective, good price
What We Don't Like
Unpleasant taste if overdosed
Package sometimes half full
#TOP 8

NOW Supplements MSM Powder for Joint Health, 1lb

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1 Pound (Pack of 1)
NOW Supplements MSM Powder for Joint Health, 1lb Cover
NOW Foods Supplements, MSM (Methylsulfonylmethane) Powder, Supports Healthy Cartilage*, Joint Health*, 1-Pound

Support your joint health with NOW Supplements MSM Powder. MSM helps create chemical links needed to form and maintain structural tissues, including cartilage and skin. This product is non-GMO, dairy-free, egg-free, gluten-free, soy-free, kosher, vegan, vegetarian, sugar-free, and nut-free. It is packaged in the USA by a family-owned company and has undergone NPA A-rated GMP certification. Be mindful of exposure to heat or sunlight, which may cause the product to melt or become damaged.

What We Like
Improved nail growth
Reduced joint stiffness
Enhanced skin clarity and glow
Affordable and long-lasting
Supports hair health
What We Don't Like
Bitter taste manageable with water or lemon
Possible mild headaches if dehydrated
#TOP 9

Best Naturals MSM 1000 mg Capsules

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Best Naturals MSM 1000 mg Capsules Cover
Best Naturals MSM 1000 mg 180 Capsules

The Best Naturals MSM Capsules provide 1000 mg of MSM in each capsule, offering a convenient way to support your joint health and overall wellness. These capsules are third-party lab tested, ensuring that you receive a pure and high-quality product. Being non-GMO and gluten-free, they cater to various dietary needs, making them suitable for many users. Additionally, they are manufactured in a GMP-compliant, FDA-registered facility in the USA, giving you peace of mind about their safety and quality.

What We Like
Effective for urinary tract infections
Improves skin elasticity
May help regrow hair
Easy-to-take capsules
Good value for multiple bottles
What We Don't Like
Mixed results for arthritic pain
#TOP 10

BulkSupplements MSM Capsules 3000mg

BulkSupplements MSM Capsules 3000mg Cover
BulkSupplements.com MSM Capsules - Methylsulfonylmethane, MSM 3000mg - Joint Supplements, Gluten Free, 4 Capsules per Serving, 240 Count (Pack of 1)

BulkSupplements MSM Capsules are designed to elevate your active lifestyle. With a generous 3000mg per serving, these capsules help you reach your fitness goals, whether you're an athlete or just someone who enjoys staying active. The capsules are easy to incorporate into any diet, making them suitable for various lifestyles. Each serving consists of four capsules, allowing you to manage your intake conveniently. Plus, you can trust that these supplements meet high-quality standards through third-party testing, ensuring you get consistent and reliable performance with every batch.

What We Like
Effective for muscle and joint relief
Clear labeling of capsule contents
Easy to swallow, no taste
Trusted brand with third-party testing
Can be used for pet pain relief
What We Don't Like
May cause noticeable digestive gas
Buying Guide Image

Frequently Asked Questions (FAQs)

1. What does MSM do to your body?

MSM has anti-inflammatory and antioxidant effects. It is rich in sulphur, which plays a vital role in collagen and glucosamine production, essential for healthy bones and joints. It also aids in the production of immunoglobulins, supporting the immune system.

2. What is the best source of MSM?

Protein-rich foods like eggs, meat, poultry, fish, and legumes are good sources of MSM. Other sources include garlic, onions, Brussels sprouts, asparagus, kale, and wheat germ.

3. What is the purest form of MSM?

The purest form of MSM is called OptiMSM®. It is the only MSM that undergoes multi-stage distillation for purification. OptiMSM® is produced in the United States by Bergstrom Nutrition and is available in powder, tablet, capsule, and gel forms.

4. Who should not use MSM?

There is insufficient information to determine if MSM is safe for use during pregnancy or breastfeeding. It is recommended to avoid using MSM in such cases.

5. Why not to take MSM?

Most studies have shown minimal side effects when taking MSM orally, but some people may experience mild gastrointestinal discomfort or diarrhea. It is recommended to avoid MSM if pregnant or breastfeeding to err on the side of caution.

6. What are the bad side effects of MSM?

In some cases, MSM may cause nausea, diarrhea, bloating, and stomach discomfort. When used topically, MSM is generally safe when combined with other ingredients for up to 20 days.

7. What to avoid when taking MSM?

When taking MSM, it is advised to avoid medications that treat or prevent blood clots, NSAIDs for pain and inflammation, and other herbal supplements.

8. What are the symptoms of MSM deficiency?

MSM deficiency can lead to various issues, including lost flexibility, scar tissue, wrinkles, varicose veins, hardened arteries, damaged lung tissues, dry and cracked skin, digestive disorders, joint problems, and increased susceptibility to food allergies.

Editor's Notes

During our natural msm supplement research, we found 24 natural msm supplement products and shortlisted 10 quality products. We collected and analyzed 134,923 customer reviews through our big data system to write the natural msm supplements list. We found that most customers choose natural msm supplements with an average price of $19.08.

The natural msm supplements are available for purchase. We have researched hundreds of brands and picked the top brands of natural msm supplements, including NOW Foods, PURE ORIGINAL INGREDIENTS, Doctor's Best, HAPPY BODY, Solgar. The seller of top 1 product has received honest feedback from 384 consumers with an average rating of 4.7.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.

Natural MSM Supplements Comparison Table

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Brand NOW Foods PURE ORIGINAL INGREDIENTS Doctor's Best HAPPY BODY Doctor's Best Solgar Best Naturals NOW Foods Best Naturals BulkSupplements
Flavor Unflavored Bitter Unflavored Can be Bitter, Add Juice Unflavored Unflavored Unflavored Unflavored Unflavoured Unflavored
Unit Count 240 Count 32.0 Ounce 120 Count 16 Ounce 360 Count 120 Count 16.0 Ounce 16.0 Ounce 180 Count 240 Count
Item Form Capsule Powder Tablet Granule 0Tablets Tablet Powder Powder Capsule Capsule
Item Weight 0.8 Pounds 0.89 Kilograms 0.24 Kilograms 1 Pounds 16 ounces 0.63 Pounds 1.05 Pounds 1.15 Pounds 0.02 Pounds -
Primary Supplement Type multivitamin - mineral - mineral Copper, Zinc MSM multivitamin MSM extract MSM
Item dimensions L x W x H 3.15 x 3.15 x 6.25 inches - 2.63 x 2.63 x 5.06 inches 6.5 x 1 x 9.5 inches 3.25 x 3.25 x 6.75 inches 2.57 x 2.57 x 4.67 inches - 4.25 x 4.25 x 7 inches 2.3 x 2.3 x 2.3 inches 3 x 3 x 5 inches
Product Benefits Bone & Joint Support Digestive Health Support Bone & Joint Support - Bone & Joint Support Stress Relief - Bone & Joint Support Bone & Joint Support Bone & Joint Support
Diet Type Halal, Kosher, Vegan Vegan Vegan - Gluten Free Gluten Free - Halal, Kosher, Vegan, Vegetarian - Gluten Free
Age Range (Description) - Adult - Adult - - Adult Adult Adult Adult
Package Information - Bag - Bag - - Bottle - Bottle Bottle
FTB Score
ftb score rating icon 9.9
ftb score rating icon 9.8
ftb score rating icon 9.6
ftb score rating icon 9.4
ftb score rating icon 9.2
ftb score rating icon 9.0
ftb score rating icon 9.0
ftb score rating icon 9.0
ftb score rating icon 8.9
ftb score rating icon 8.9
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