Best Alpha Lipoic Acid Supplements of 2026

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 27, 2026

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Alpha Lipoic Acid Supplements are a popular type of dietary supplement that are known for their potential health benefits. These supplements are often taken by individuals looking to support their overall health and well-being, as they are believed to have antioxidant properties that can help protect cells from damage caused by free radicals. In addition, Alpha Lipoic Acid Supplements are also thought to support healthy blood sugar levels and improve nerve function. They are available in various forms, including capsules, tablets, and powders, and can be found at most health food stores and online retailers.

At a Glance: Our Top Picks

Nutricost Alpha Lipoic Acid: 240 Capsules Cover #TOP 1
Nutricost Alpha Lipoic Acid: 240 Capsules
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Nervive Nerve Health Tablets Cover #TOP 2
Nervive Nerve Health Tablets
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Nervive Nerve Relief with Alpha Lipoic Acid and B Vitamins Cover #TOP 3
Nervive Nerve Relief with Alpha Lipoic Acid and B Vitamins
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Top 10 Alpha Lipoic Acid Supplements

#TOP 1

Nutricost Alpha Lipoic Acid: 240 Capsules

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Nutricost Alpha Lipoic Acid: 240 Capsules Cover
Nutricost Alpha Lipoic Acid 600mg Per Serving, 240 Capsules - Gluten Free, Vegetarian Capsules, Soy Free & Non-GMO

Nutricost Alpha Lipoic Acid is a potent supplement that provides 600mg of Alpha Lipoic Acid per serving. It is Non-GMO, Gluten Free, Soy Free, Vegetarian Friendly, and 3rd Party Tested. It is designed to help with inflammation management and is suitable for adults. It comes in a 240 count bottle.

What We Like
Effective nerve pain relief
High potency 600mg dosage
Easy to swallow capsules
Good value bottle size
Trusted, reliable brand
What We Don't Like
Mild stomach sensitivity possible
Limited ingredient transparency
#TOP 2

Nervive Nerve Health Tablets

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Nervive Nerve Health Tablets Cover
Nervive Nerve Health, Alpha Lipoic Acid, Fortify Nerve Health, Healthy Nerve Function, Healthy Blood Circulation, Supplement, Tablet, 30 Tablets

Nervive Nerve Health Tablets are designed to promote healthy nerve function in fingers, hands, toes, and feet. With Alpha Lipoic Acid, Vitamins B12, B6, and B1, these tablets fortify nerve health, enhance nerve communication, and build nerve insulation and myelin sheath. They also nourish and generate energy for your nerves, and promote healthy blood flow. Nervive is the world's #1 selling nerve care company, with over 50 years of expertise in global nerve care.

What We Like
Fast pain relief
Reduces nerve tingling
Effective for neuropathy
Improves sleep quality
Works for post-surgery pain
What We Don't Like
Possible mild sensitivity
Price could be lower
#TOP 3

Nervive Nerve Relief with Alpha Lipoic Acid and B Vitamins

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Nervive Nerve Relief with Alpha Lipoic Acid and B Vitamins Cover
Nervive Nerve Relief, Occasional Nerve Discomfort II, Nerve Relief, Starts Working in 7 Days, Stabbing, Burning, Alpha Lipoic Acid, B Vitamins, Turmeric, Ginger, Supplement, 60 Tablets

Nervive Nerve Relief is a nerve care supplement designed to reduce occasional nerve aches, weakness, and discomfort in your hands or feet. The product contains Alpha Lipoic Acid, which has been shown to reduce nerve discomfort by over 50% after 5 weeks. With daily use, Nervive Nerve Relief starts working in as little as 14 days to support nerve health. Additionally, the supplement is fortified with B complex vitamins, which nourish nerves, enhance neurotransmission, and build nerve insulation.

What We Like
Pain relief and mobility improvement
Reduced neuropathy symptoms
Alternative to prescription medication
Noticeable effect within a week
What We Don't Like
Large pill size
Mild stomach discomfort
#TOP 4

Nervive Nerve Relief: Alpha Lipoic Acid for Nerve Aches & Discomfort

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Nervive Nerve Relief: Alpha Lipoic Acid for Nerve Aches & Discomfort Cover
Nervive Nerve Relief, Occasional Nerve Discomfort II, Nerve Relief, Starts Working in 7 Days, Stabbing, Burning, Alpha Lipoic Acid, B Vitamins, Turmeric, Ginger, Nervive Supplement, 30 Tablets

Nervive Nerve Relief is a natural supplement designed to help reduce nerve aches, weakness, and discomfort in fingers, hands, toes, and feet. It contains Alpha Lipoic Acid, B Vitamins, Turmeric, and Ginger, and is shown to reduce nerve discomfort by over 50% after 5 weeks. Customers report positive results in as little as 14 days, with many noting significant pain relief. However, some customers have reported an unpleasant smell in their urine.

What We Like
Fast neuropathy pain relief
Improved sleep quality
Affordable price
Effective for diabetic nerve pain
What We Don't Like
Possible acid reflux irritation
Large pill size
#TOP 5

Life Extension Super R-Lipoic Acid

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Life Extension Super R-Lipoic Acid Cover
Life Extension Super R-Lipoic Acid – Healthy Aging, oxidative Stress Defense – with 240 mg of Active R-Form of R-Lipoic Acid – Gluten-Free – Non-GMO – Vegetarian – 60 Capsules

Life Extension Super R-Lipoic Acid is a powerful antioxidant supplement that helps protect your mitochondria from oxidative stress caused by free radicals. It contains a highly bioavailable form of lipoic acid that is up to 30 times more bioavailable than standard R-lipoic formulas, allowing for rapid uptake from the plasma into the tissues. It is non-GMO, gluten-free, and vegetarian friendly, making it a great choice for those looking to support their liver health and anti-aging efforts.

What We Like
Effective pain relief
Supports cellular and heart health
High bioavailability
Easy to swallow
Improved energy and resilience
What We Don't Like
Occasional damaged capsules
Relatively expensive
#TOP 6

SciatiEase Sciatic Nerve Support Supplement

SciatiEase
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SciatiEase Sciatic Nerve Support Supplement Cover
SciatiEase Sciatic Nerve Health Support Supplement - Nerve Support Formula with AlphaPalm, Pea, Vitamin B Complex, Alpha Lipoic Acid 300mg - 120 Capsules

The SciatiEase Nerve Relief supplement is designed to help ease nerve discomfort and promote nerve health, making it a helpful choice if you’ve been dealing with sciatic pain for a while. It contains a unique blend of 12 ingredients, including 300mg of alpha lipoic acid, which works together to support your nerve function and reduce inflammation. The formula also includes natural herbs like feverfew and passionflower, known for their soothing properties. Plus, it’s made with highly absorbable ingredients, so your body can use them quickly for faster relief and improved mobility. Taking it twice daily with meals can help you feel more comfortable and active.

What We Like
Immediate pain relief
Improved mobility
Alternative to NSAIDs
Positive effects after first dose
Highly recommended by users
What We Don't Like
High price
Occasional stomach upset
#TOP 7

NUTRAHARMONY Alpha Lipoic Acid 600mg

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NUTRAHARMONY Alpha Lipoic Acid 600mg Cover
Alpha Lipoic Acid 600mg - ALA Supplement Antioxidant for Nerve, Energy & Metabolism Support - Extra Strength with Benfotiamine, B1 & B12 - Lab Tested, NON-GMO & Vegan - 120 Capsules, 2 Month Supply

NUTRAHARMONY ALA Supplement offers a powerful 600mg of alpha-lipoic acid to enhance your body's antioxidant defenses and support overall health. This supplement features a unique blend that includes Benfotiamine along with vitamins B1 and B12, which promotes nerve health and boosts energy metabolism. By maintaining thiamine levels, it helps ensure your nerves, muscles, and heart function properly. Additionally, this antioxidant-rich formula aids in enhancing your energy, focus, and mood, providing valuable support for cognitive functions. With its high-quality ingredients, you can trust this product to deliver significant health benefits.

What We Like
Nerve pain relief
Reduces tingling and burning
Improved mobility
Supports blood sugar stability
Easy to swallow
What We Don't Like
Slight odor in bottle
Mild acid reflux in some
#TOP 8

Stabilized R-Alpha Lipoic Acid ((True))

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Stabilized R-Alpha Lipoic Acid ((True)) Cover
IMMUNOVITES Stabilized R-Alpha Lipoic Acid ((True)) 600mg per Serving [[High Potency & up to 40x Increased Absorption]] (Na R-ALA) (Na R-LA) (Na R-Lipoate) (1 Bottle)

Stabilized R-Alpha Lipoic Acid ((True)) is a high potency supplement that provides a powerful antioxidant, R-ALA, which is essential to maintain good health. This supplement is stabilized with sodium, which prevents the R-ALA from becoming unstable and inactive. It has high absorption rates, and it is free from S-ALA, an ineffective and hindering product. Always check the supplement facts box to ensure that the label states "STABILIZED (Na) R-Alpha Lipoic Acid" and does not contain “S”-Alpha Lipoic Acid.

What We Like
High absorption and bioavailability
Noticeable neuropathy relief
Reduces inflammation and joint pain
Improved mental clarity
Third-party purity tested
What We Don't Like
Mild heartburn or nausea
Minor billing issue
#TOP 9

NOW Supplements Alpha Lipoic Acid

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NOW Foods Supplements, Alpha Lipoic Acid 600 mg with Grape Seed Extract & Bioperine®, Extra Strength, 120 Veg Capsules

NOW Supplements Alpha Lipoic Acid 600 mg with Grape Seed Extract & Bioperine® is a vegan-based, extra strength supplement that helps support heart health and metabolism management. It is certified Kosher, Dairy Free, Egg Free, Gluten Free, Nut Free, and Soy Free, and is packaged in the USA by a family owned and operated company since 1968. Customers have reported positive results with nerve pain, diabetes, and lower back nerve damage.

What We Like
Neuropathy pain relief
Increased energy levels
Supports metabolism
Easy to swallow capsules
Affordable price
What We Don't Like
Strong urine odor
Timing dosage may be tricky
#TOP 10

Thorne Alpha-Lipoic Acid - 300 mg - 60 Capsules

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Thorne Alpha-Lipoic Acid - 300 mg - 60 Capsules Cover
THORNE - Alpha-Lipoic Acid - 300 mg - Supplement for Liver Detox, Antioxidant Support, Nerve Health & Mental Sharpness* - 60 Servings

Thorne Alpha-Lipoic Acid is a dietary supplement that supports nerve health, helps maintain mental sharpness, and promotes liver health. It also has important nerve protective effects. This supplement is made from the purest sources worldwide and does not contain gluten, GMOs, artificial preservatives, or sweeteners. Thorne is a trusted brand by health professionals and U.S. Olympic teams. Thorne Alpha-Lipoic Acid can benefit you by protecting your nerves, improving mental clarity, supporting liver function, and promoting overall health.

What We Like
Reliable supplement brand
Easy-to-swallow capsules
Improved daily energy
Reduces neuropathy symptoms
Helps prevent dehydration
What We Don't Like
Results may vary individually
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The Right Alpha Lipoic Acid Supplements for You

Introduction to Alpha Lipoic Acid

Alpha lipoic acid (ALA) is a naturally occurring compound that is produced by the human body. It is an antioxidant that helps to protect cells from damage and is involved in energy production. ALA is found in small amounts in a variety of foods, including red meat, broccoli, and spinach. In supplement form, ALA is often used to treat a variety of health conditions, including diabetes and liver disease.

Choosing the Right ALA Supplement

When choosing an ALA supplement, it's important to consider a few key factors. Here are some things to consider:

  1. Quality: As with any dietary supplement, it's important to choose a high-quality product. Look for supplements that are made by reputable manufacturers and are certified by independent organizations such as the US Pharmacopeia or ConsumerLab.

  2. Dosage: ALA supplements come in a variety of dosages, from as little as 50mg to as much as 600mg. The appropriate dosage for you will depend on your health condition and your doctor's recommendations. It's important to follow the dosage instructions on the label carefully and not exceed the recommended dose.

  3. Form: ALA supplements are available in a variety of forms, including capsules, tablets, and powders. The form you choose will depend on your personal preferences and your doctor's recommendations. Capsules and tablets are easy to swallow and may be the best choice for people who have difficulty swallowing pills. Powders are a good option for people who prefer to mix their supplements with water or juice.

  4. Timing: ALA supplements should be taken at a specific time of day to maximize their effectiveness. Some studies have suggested that taking ALA with meals may improve its absorption, while others have found that taking it on an empty stomach may be more effective. It's important to talk to your doctor about the best time to take your ALA supplement.

Potential Side Effects

ALA supplements are generally safe and well-tolerated. However, like any dietary supplement, they can cause side effects in some people. The most common side effects of ALA supplements include nausea, stomach upset, and skin rash. Less commonly, ALA supplements can cause allergic reactions, including hives and difficulty breathing. If you experience any side effects after taking an ALA supplement, stop taking the supplement and talk to your doctor.

Conclusion

ALA supplements can be a useful addition to your health regimen, but it's important to choose the right product and follow the dosage instructions carefully. Talk to your doctor before taking an ALA supplement, and be sure to report any side effects that you experience. By taking the time to carefully select an ALA supplement and use it as directed, you can help to ensure that you get the maximum benefit from this powerful antioxidant.

Frequently Asked Questions (FAQs)

1. What is alpha-lipoic acid supplement good for?

Alpha-lipoic acid supplements are used to manage and treat chronic diseases associated with oxidative stress, such as diabetic neuropathy. They can also help slow down the onset of metabolic syndrome by acting as an antioxidant.

2. What should you not take alpha-lipoic acid with?

It is important to avoid using alpha-lipoic acid supplements together with other herbal or health supplements that can lower blood sugar. Some examples of these supplements include devil's claw, fenugreek, garlic, guar gum, horse chestnut, Panax ginseng, psyllium, and Siberian ginseng.

3. Is it safe to take alpha-lipoic acid supplements?

In general, alpha-lipoic acid supplements are safe to take. However, it is important to note that there may be exceptions. For example, high doses of beta carotene have been linked to a higher risk of lung cancer in smokers, and extra calcium and vitamin D may increase the risk of kidney stones. It is always recommended to consult with a healthcare professional before starting any new supplement.

4. What happens when you take alpha-lipoic acid?

Studies have suggested that alpha-lipoic acid supplements may enhance the body's ability to use its own insulin to lower blood sugar in people with type 2 diabetes. It may also help reduce the symptoms of peripheral neuropathy, which is nerve damage that can be caused by diabetes.

5. When should I take alpha-lipoic acid morning or night?

The best time to take alpha-lipoic acid supplements is typically in the morning, at least 30 minutes before eating or drinking anything.

6. Is alpha-lipoic acid hard on kidneys?

Alpha-lipoic acid given as a dietary supplement has actually been shown to have a protective and preventative effect on kidney aging. It has been found to reverse age-related decline in kidney function and serum total proteins. However, it is important to consult with a healthcare professional before starting any new supplement, especially if you have existing kidney issues.

7. Is alpha-lipoic acid hard on the liver?

Alpha-lipoic acid, whether consumed in foods or taken as a supplement, seems to work like an antioxidant. It may provide protection to the brain and be helpful in certain liver diseases. However, as with any supplement, it is important to consult with a healthcare professional before starting alpha-lipoic acid supplements, especially if you have liver conditions.

Editor's Notes

During our alpha lipoic acid supplement research, we found 24 alpha lipoic acid supplement products and shortlisted 10 quality products. We collected and analyzed 359,061 customer reviews through our big data system to write the alpha lipoic acid supplements list. We found that most customers choose alpha lipoic acid supplements with an average price of $27.19.

The alpha lipoic acid supplements are available for purchase. We have researched hundreds of brands and picked the top brands of alpha lipoic acid supplements, including Nutricost, Nervive, Life Extension, SciatiEase, NUTRAHARMONY. The seller of top 1 product has received honest feedback from 33,455 consumers with an average rating of 4.9.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.

Alpha Lipoic Acid Supplements Comparison Table

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Brand Nutricost Nervive Nervive Nervive Life Extension SciatiEase NUTRAHARMONY IMMUNOVITES NOW Foods THORNE
Product Benefits Inflammation Management Inflammation Management Anti-Aging Anti-Aging 240 mg of R lipoic acid in each vegetarian capsule, Helps protect against oxidative stress, Provides the active form of alpha lipoic acid Rejuvenating,Soothing Antioxidant, Nerve Support Antioxidant Heart Health Support, Metabolism Management Cognition & Focus
Flavor Unflavored Unflavored - Ginger Unflavored Unflavored Unflavored Unflavored Unflavored Unflavored
Primary Supplement Type Lipoic Acid B-Complex - B-Complex Sodium, Stabilized Na-RALA sodium R-lipoate (providing 240 mg of R-Lipoic acid) Alpha Lipoic Acid Alpha Lipoic Acid sodium lipoic acid Non-specific
Unit Count 240 Count 30 Count - 30 Count 60.0 Count 120 Count 120.0 Count 60 Count 120 Count 60 Count
Item Form Capsule Tablet - Tablet Capsule Capsule Capsule Capsule Capsule Capsule
Item Weight 6 Ounces - 0.29 Pounds 0.11 Pounds 0.12 Pounds 0.22 Pounds - 0.05 Kilograms 0.12 Kilograms 1.4 Ounces
Item dimensions L x W x H 2.5 x 2.5 x 5 inches 2.13 x 2.88 x 5.4 inches - 2.13 x 2.88 x 5.4 inches 1.96 x 1.96 x 3.8 inches - - 2 x 2 x 3.75 inches 2.5 x 2.5 x 4.44 inches 2.09 x 2.09 x 3.72 inches
Diet Type Vegan - - Vegetarian Vegetarian - Vegan Vegan Vegan Gluten Free
Special Ingredients Lipoic Acid - - - Sodium, Stabilized Na-RALA sodium R-lipoate - Alpha Lipoic Acid Na R-Alpha Lipoic Acid Lipoic Acid Amino Acid
FTB Score
ftb score rating icon 9.8
ftb score rating icon 9.7
ftb score rating icon 9.5
ftb score rating icon 9.4
ftb score rating icon 9.3
ftb score rating icon 9.3
ftb score rating icon 9.3
ftb score rating icon 9.2
ftb score rating icon 9.2
ftb score rating icon 9.2
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