Best St. John's Wort Supplements of 2026

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 23, 2026

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St. John's Wort supplements have been used for centuries as a natural remedy for depression, anxiety, and sleep disorders. Extracted from the flowering plant, Hypericum perforatum, these supplements contain a compound called hypericin, which is believed to increase levels of serotonin and other neurotransmitters in the brain. St. John's Wort supplements are available in various forms, including capsules, tablets, and teas. While they are generally considered safe and effective, it is important to consult with a healthcare professional before using them, especially if taking any medications or experiencing severe symptoms.

At a Glance: Our Top Picks

Micro Ingredients Saffron+ Advanced 10-in-1 Supplement Cover #TOP 1
Micro Ingredients Saffron+ Advanced 10-in-1 Supplement
ftb score rating icon 9.9
Nature's Way St. John's Wort Cover #TOP 2
Nature's Way St. John's Wort
ftb score rating icon 9.8
Futurebiotics Chill Pill + Ashwagandha, Rhodiola, St. John’s Wort, & L-Theanine 2000 MG per Serving - Non-GMO, 120 Vegetarian Tablets Cover #TOP 3
Futurebiotics Chill Pill + Ashwagandha, Rhodiola, St. John’s Wort, & L-Theanine 2000 MG per Serving - Non-GMO, 120 Vegetarian Tablets
ftb score rating icon 9.6

Top 10 St. John's Wort Supplements

#TOP 1

Micro Ingredients Saffron+ Advanced 10-in-1 Supplement

BA-MI-SAF060
Micro Ingredients Saffron+ Advanced 10-in-1 Supplement Cover
Saffron+ Advanced Supplements, 60 Veggie Capsules | 10-in-1 with Saffron Extract, High Absorption Fat-Soluble Vitamin C, Magnesium, Turmeric & KSM-66 Ashwagandha | Filler Free

The Micro Ingredients Saffron+ Complex is a carefully crafted supplement that combines 10 powerful ingredients in one bottle. It features freshly harvested saffron extract, known for its unique benefits and rich heritage, to support your daily wellness. You get a month's supply with 60 veggie capsules, making it easy to maintain your routine. This formula also includes fat-soluble vitamin C, magnesium glycinate, and a blend of calming and adaptogenic herbs like St. John's Wort and KSM-66 ashwagandha. Together, these ingredients work to promote balance, mental clarity, and overall well-being in your everyday life.

What We Like
Mood enhancement
Increased energy and motivation
Mental clarity
No noticeable taste or odor
Natural stress support
What We Don't Like
Mild digestive discomfort
Rare overheating sensation
#TOP 2

Nature's Way St. John's Wort

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Nature's Way St. John's Wort Cover
Nature's Way St. John's Wort Herb, Promotes a Positive Outlook*, 700 mg per 2-Capsule Serving, Non-GMO Project Verified, Vegan, 180 Capsules (Packaging May Vary)

Nature's Way Premium Herbal St. John’s Wort Herb is a supplement designed to help promote a positive outlook and support the body's ability to adapt to everyday stress. It is Non-GMO Project Verified, gluten-free, vegan, and free of salt, yeast-derived ingredients, wheat, soy, corn, dairy, or artificial colors, flavors, or preservatives. Adults take 2 capsules twice daily, and for best results, use for at least 2 months. Customer reviews suggest that it can help with mild to moderate depression, anxiety, and brain fog, although it is not FDA approved and should be discussed with a professional.

What We Like
Depression and mood support
Helps with anxiety and stress
Positive effect on energy
Affordable and cost-effective
Easy to take daily
What We Don't Like
May not address root causes
Possible medication interactions

Futurebiotics Chill Pill + Ashwagandha, Rhodiola, St. John’s Wort, & L-Theanine 2000 MG per Serving - Non-GMO, 120 Vegetarian Tablets

FB180-120
Futurebiotics Chill Pill + Ashwagandha, Rhodiola, St. John’s Wort, & L-Theanine 2000 MG per Serving - Non-GMO, 120 Vegetarian Tablets Cover
Futurebiotics Chill Pill + Ashwagandha, Rhodiola, St. John’s Wort, & L-Theanine - Non-GMO, 120 Vegetarian Tablets

Futurebiotics Chill Pill offers an advanced calming formula with Ashwagandha, Rhodiola Rosea, St. John's Wort, and L-Theanine for superior support. It is carefully manufactured in a cGMP Registered Facility in New York, ensuring purity and quality. The product is Vegan/Vegetarian friendly and free of GMOs, Gluten & Soy. Futurebiotics Chill Pill sources high-quality ingredients from around the world to provide you with the best. Experience premium ingredients working synergistically to help you relax and unwind.

What We Like
Noticeable mood improvement
Effective stress relief
Affordable price
Easy to swallow tablets
Supports better sleep
What We Don't Like
Mild morning grogginess
Anxiety rebound after stopping
#TOP 4

Nature's Bounty St. John's Wort Capsules

Nature's Bounty St. John's Wort Capsules Cover
Nature's Bounty St. John’s Wort 300mg Capsules, Herbal Health Supplement, Promotes a Positive Mood, 100 Capsules

Looking for a quality St. John’s Wort supplement for mood support? Nature’s Bounty St. John’s Wort offers the mood support you need to feel calm, relaxed and ready to take on life’s challenges. Trusted for centuries as a tonic and popularly used to promote mental well-being, St. John’s Wort at a daily dose of 900 mg per day can help you maintain a positive mood and healthy emotional outlook. Simply take three capsules of Nature’s Bounty St. John’s Wort per day. Capsules may also be opened and prepared as a soothing tea. Each pack contains 100 capsules.

What We Like
No major side effects
Mood stabilization
Natural herbal remedy
Improved stress management
Affordable pricing
What We Don't Like
Possible placebo effect
Results may vary
#TOP 5

Joy-Filled Mood Support Supplement

Joy-Filled Mood Support Supplement Cover
Joy-Filled Mood Support Supplement - 7 Herb Complex w/St. Johns Wort | Stress Relief – Helps Calm The Mind & Body | 100% Plant-Based Happy Pills, Ashwagandha, Rhodiola Rosea | Adaptogens, 60 Ct

The Joy-Filled Mood Support Supplement is a 100% plant-based supplement designed to calm the mind and body, relieve stress, and boost mood. Formulated with 7 natural herbs such as Ginkgo Biloba, Rhodiola Rosea, and St. John's Wort, it helps you find inner joy and promotes an overall calming effect. It is vegan, non-GMO, and made with natural ingredients. It also comes with a 60-day return policy for customer satisfaction.

What We Like
Contains 7 natural herbs to promote relaxation and reduce stress
Vegan, non-GMO, and made with natural ingredients
Comes with a 60-day return policy for customer satisfaction
#TOP 6

Clean Nutraceuticals Mellomood Saffron Mood Support

Clean Nutraceuticals Mellomood Saffron Mood Support Cover
Clean Nutraceuticals Saffron Supplements Extract 100mg + Ashwagandha L-Theanine 200mg - Mood Support Ginkgo Biloba, St. John's Wort, Rhodiola Rosea & 5-HTP Capsules Pills Men Women

The Clean Nutraceuticals Mellomood Saffron is designed to help you feel more positive, clear-headed, and calm by combining saffron with adaptogenic herbs and amino acids for better absorption. It includes mood-boosting ingredients like St. John's Wort and 5-HTP to lift your spirits and increase energy. If you’re dealing with stress or burnout from work, this supplement offers natural support with Ashwagandha, Rhodiola, Ginkgo Biloba, and L-Theanine to help your body manage stress effectively. Plus, it promotes relaxation and healthy sleep habits, helping you recover both mentally and physically after a hectic day.

What We Like
Improved mood stability
Reduced anxiety symptoms
Enhanced focus and calmness
Natural alternative to medication
Easy to swallow pills
What We Don't Like
Potential medication interactions
Possible heart racing for some

Nutricost St. John’s Wort Capsules (500mg) - Vegetarian and Non-GMO

NTC211101
Nutricost St. John’s Wort Capsules (500mg) - Vegetarian and Non-GMO Cover
Nutricost St John’s Wort Capsules (500mg) 120 Capsules - Vegetarian, Gluten Free and Non-GMO

Nutricost St. John’s Wort Capsules features 120 vegetarian capsules with 500mg of St. John's Wort per capsule. The product is non-GMO, gluten-free, soy-free, and vegetarian-friendly. Its only active ingredient is St. John's Wort, and it is made in a GMP compliant, FDA registered facility, which is third-party tested.

What We Like
Vegetarian-friendly
Non-GMO and gluten-free
Only active ingredient is St. John's Wort
#TOP 8

Clean Nutraceuticals St Johns Wort Rhodiola Rosea Ashwagandha Holy Basil Capsules

CLN-RHODIOLA-STJHN
Clean Nutraceuticals St Johns Wort Rhodiola Rosea Ashwagandha Holy Basil Capsules Cover
Clean Nutraceuticals St Johns Wort Rhodiola Rosea Holy Basil Ashwagandha - Mood Support for Women and Men with Vitamin C & Black Pepper Extract - 90 Caps

Clean Nutraceuticals Mood Support Capsules is an advanced supplement that combines St. John's Wort, Rhodiola Herb, Ashwagandha, Holy Basil, Vitamin C, and Black Pepper Extract for mood support in women and men. The Positeava All In One Supplement provides 4 full-dose products in one support complex containing a full St Johns Wart, Rhodiola Rosea Supplement, Ashwagandha Pills, and Holy Basil Leaf. This powerful herbal complex supplement can be a convenient alternative to various supplements such as Ashwagandha Gummies, Rhodiola Tincture, St Johns Wort Oil, St Johns Wort Tincture, and Tulsi Capsules. With vetted and trusted ingredients, this all-in-one supplement is proudly made in the USA in a registered and certified facility. Experience the benefits of this mood support supplement that can help you maintain a positive mood, reduce stress, and support overall well-being.

What We Like
Improved focus and energy
Effective mood regulation
No noticeable side effects
Natural, clean ingredients
Easy to take by mouth
What We Don't Like
Large capsule size
Possible headaches and insomnia

Zazzee Extra Strength St. John’s Wort 20:1 Extract

StJohnsWort150
Zazzee Extra Strength St. John’s Wort 20:1 Extract Cover
Zazzee Extra Strength St. John’s Wort 20:1 Extract, 8000 mg Strength, 0.3% Hypericin, 150 Vegan Capsules, 5 Month Supply, Concentrated, Standardized 20X Extract, 100% Vegetarian, Non-GMO, All-Natural

Zazzee St. John’s Wort Extract offers exceptional value with 8000 mg strength per capsule and 150 capsules per bottle, providing a 5-month supply. The potent 20:1 extract with 0.3% Hypericin makes it one of the strongest dosages available. Hypericin, the beneficial compound, is standardized to a minimum of 0.3%, ensuring potent results. The product is natural, vegan, and non-GMO, free from harmful additives. Manufactured in the USA under stringent quality control, ensuring the best value for your health.

What We Like
Stress and anxiety relief
Improved mood
Better sleep quality
Natural herbal remedy
Long-lasting supply
What We Don't Like
Delayed mood improvement noted
#TOP 10

Toniiq St. John's Wort Capsules

Toniiq St. John's Wort Capsules Cover
Toniiq 1,000mg Ultra High Strength St. John's Wort Capsules (Non-GMO) - 7X Concentrated Extract - 0.3% Hypericin - Highly Purified and Bioavailable - 120 Capsules

Toniiq St. John's Wort Capsules contain 1,000mg of the highest quality St. John's wort powder in each serving, ethically sourced, grown and cultivated using an extraction process to ensure a 7:1 extract ratio. Each serving provides one of the highest concentrations of hypericin on the market, making this one of the most potent St. John's Wort supplements available. Produced in a GMP-certified and NSF-approved state-of-the-art manufacturing facility in the USA, each batch is tested for quality and purity both during and after manufacturing.

What We Like
High potency extract
Noticeable mood improvement
Stringent quality standards
Enhanced mental clarity
Supports restful sleep
What We Don't Like
Some brands work better for others
Buying Guide Image

Find Your Fit: How to Buy the Right St. John's Wort Supplements

Introduction to St. John's Wort Supplements

St. John's Wort is a plant that has been used for centuries as a natural remedy for a variety of conditions, including anxiety and depression. In recent years, St. John's Wort has gained popularity as a dietary supplement for its potential mood-boosting effects. However, not all St. John's Wort supplements are created equal, so it's important to choose the right one for you.

Understand the Different Forms of St. John's Wort Supplements

St. John's Wort supplements come in a few different forms, including capsules, tablets, and tinctures. Capsules and tablets are the most common form of St. John's Wort supplements, and they typically contain a standardized extract of the plant. Tinctures, on the other hand, are liquid extracts of the plant that are taken by mouth.

Consider the Dosage and Potency of the Supplement

When choosing a St. John's Wort supplement, it's important to consider the dosage and potency. Most St. John's Wort supplements recommend a daily dosage of 300mg, but some may contain more or less. It's also important to look for a supplement that contains a standardized extract of the plant, as this ensures a consistent level of active ingredients in each dose.

Look for Quality and Purity

When it comes to dietary supplements, quality and purity are crucial. It's important to choose a St. John's Wort supplement that is made by a reputable manufacturer and has been tested for purity and potency. Look for supplements that have been certified by organizations such as the U.S. Pharmacopeia (USP), the National Sanitation Foundation (NSF), or ConsumerLab.com.

Consult with a Healthcare Professional

Before starting any new supplement, it's always a good idea to consult with a healthcare professional. This is especially important if you are taking any medications, as St. John's Wort can interact with certain drugs. Your healthcare provider can help you choose the right St. John's Wort supplement for you and provide guidance on the appropriate dosage.

Conclusion

In conclusion, choosing the right St. John's Wort supplement can be a daunting task. By understanding the different forms of the supplement, considering the dosage and potency, looking for quality and purity, and consulting with a healthcare professional, you can make an informed decision and find a supplement that is right for you.

Frequently Asked Questions (FAQs)

1. What is St John's wort supplement good for?

St. John's wort supplements are commonly used for various conditions, including depression, menopausal symptoms, ADHD, somatic symptom disorder, and obsessive-compulsive disorder. It may also have topical applications when applied to the skin.

2. Is it safe to take St John's wort everyday?

St. John's wort is generally considered safe when taken orally in doses up to 900 mg daily for up to 12 weeks. However, it can cause side effects such as diarrhea, dizziness, trouble sleeping, restlessness, and skin tingling.

3. Does St John's Wort cure anxiety?

While St. John's wort is known to help with mild-to-moderate depression symptoms, its effectiveness in treating anxiety has not been conclusively proven by researchers.

4. Who shouldn't take St John's wort?

St. John's wort may interact with medications used to treat depression or other mood disorders, such as tricyclic antidepressants, SSRIs, and MAOIs. It is important to consult with a healthcare professional before taking St. John's wort if you are on any of these medications.

5. What should you avoid when taking St John's wort?

When taking St. John's wort, it is important to avoid certain medications that may interact with it, including HIV/AIDS antiretroviral medications, immunosuppressants, anticoagulants, heart medications, anticonvulsants, SSRIs, triptans, and contraceptive drugs. Consult with a healthcare professional for specific guidance.

6. Is St John's Wort safer than SSRI?

Studies suggest that St. John's wort extract is equally effective as SSRIs in managing depression but may have superior safety. However, it is important to consult with a healthcare professional to determine the most appropriate treatment option for your specific condition.

7. Does St John's Wort calm you down?

Research indicates that St. John's wort works similarly to standard antidepressant medications by increasing the activity of brain chemicals like serotonin and noradrenaline, which play a role in regulating mood. However, its specific calming effects may vary from person to person.

Editor's Notes

During our st. john's wort supplement research, we found 24 st. john's wort supplement products and shortlisted 10 quality products. We collected and analyzed 152,344 customer reviews through our big data system to write the st. john's wort supplements list. We found that most customers choose st. john's wort supplements with an average price of $16.08.

The st. john's wort supplements are available for purchase. We have researched hundreds of brands and picked the top brands of st. john's wort supplements, including Micro Ingredients, Nature's Way, Futurebiotics, Nature's Bounty, Happy Healthy Hippie. The seller of top 1 product has received honest feedback from 29,138 consumers with an average rating of 4.9.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.

St. John's Wort Supplements Comparison Table

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Brand Micro Ingredients Nature's Way Futurebiotics Nature's Bounty Happy Healthy Hippie Clean Nutraceuticals Nutricost Clean Nutraceuticals Zazzee Toniiq
Item Form Capsule Capsule Tablet Capsules Capsule Capsule capsules Capsule Capsule Capsule
Item Package Quantity 1 1 1 1 1 1 1 1 1 120
Package Information Bottle Bottle Bottle Bottle Bottle Bottle Bottle Bottle Bottle Bottle
FTB Score
ftb score rating icon 9.9
ftb score rating icon 9.8
ftb score rating icon 9.6
ftb score rating icon 9.5
ftb score rating icon 9.5
ftb score rating icon 9.4
ftb score rating icon 9.2
ftb score rating icon 9.0
ftb score rating icon 8.9
ftb score rating icon 8.7
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