Best St. John's Wort Supplements of 2025

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 15, 2025

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St. John's Wort supplements have been used for centuries as a natural remedy for depression, anxiety, and sleep disorders. Extracted from the flowering plant, Hypericum perforatum, these supplements contain a compound called hypericin, which is believed to increase levels of serotonin and other neurotransmitters in the brain. St. John's Wort supplements are available in various forms, including capsules, tablets, and teas. While they are generally considered safe and effective, it is important to consult with a healthcare professional before using them, especially if taking any medications or experiencing severe symptoms.

At a Glance: Our Top Picks

Nature's Bounty St. John's Wort Capsules Cover #TOP 1
Nature's Bounty St. John's Wort Capsules
ftb score rating icon 9.9
Nature's Way St. John's Wort Cover #TOP 2
Nature's Way St. John's Wort
ftb score rating icon 9.8
Clean Nutraceuticals St Johns Wort Rhodiola Rosea Ashwagandha Holy Basil Capsules Cover #TOP 3
Clean Nutraceuticals St Johns Wort Rhodiola Rosea Ashwagandha Holy Basil Capsules
ftb score rating icon 9.6

Top 10 St. John's Wort Supplements

#TOP 1

Nature's Bounty St. John's Wort Capsules

Nature's Bounty St. John's Wort Capsules Cover
Nature's Bounty St. John’s Wort 300mg Capsules, Herbal Health Supplement, Promotes a Positive Mood, 100 Capsules

Looking for a quality St. John’s Wort supplement for mood support? Nature’s Bounty St. John’s Wort offers the mood support you need to feel calm, relaxed and ready to take on life’s challenges. Trusted for centuries as a tonic and popularly used to promote mental well-being, St. John’s Wort at a daily dose of 900 mg per day can help you maintain a positive mood and healthy emotional outlook. Simply take three capsules of Nature’s Bounty St. John’s Wort per day. Capsules may also be opened and prepared as a soothing tea. Each pack contains 100 capsules.

What We Like
Improves mood significantly
Helps with focus and daily tasks
Natural alternative to prescription meds
Easy to swallow capsules
Long-lasting effects over time
What We Don't Like
Possible mild digestive issues
May affect menstrual cycle temporarily
#TOP 2

Nature's Way St. John's Wort

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Nature's Way St. John's Wort Cover
Nature's Way St. John’s Wort Herb, Promotes a Positive Outlook*, 700 mg per 2-Capsule Serving, Non-GMO Project Verified, Vegan, 180 Capsules (Packaging May Vary)

Nature's Way Premium Herbal St. John’s Wort Herb is a supplement designed to help promote a positive outlook and support the body's ability to adapt to everyday stress. It is Non-GMO Project Verified, gluten-free, vegan, and free of salt, yeast-derived ingredients, wheat, soy, corn, dairy, or artificial colors, flavors, or preservatives. Adults take 2 capsules twice daily, and for best results, use for at least 2 months. Customer reviews suggest that it can help with mild to moderate depression, anxiety, and brain fog, although it is not FDA approved and should be discussed with a professional.

What We Like
Improves mood significantly
Quick effects on mood
Natural supplement option
Increases energy levels
Affordable price
What We Don't Like
Possible interaction with medications
Individual results may vary
#TOP 3

Clean Nutraceuticals St Johns Wort Rhodiola Rosea Ashwagandha Holy Basil Capsules

CLN-RHODIOLA-STJHN
Clean Nutraceuticals St Johns Wort Rhodiola Rosea Ashwagandha Holy Basil Capsules Cover
Clean Nutraceuticals St Johns Wort Rhodiola Rosea Holy Basil Ashwagandha - Mood Support for Women and Men with Vitamin C & Black Pepper Extract - 90 Caps

Clean Nutraceuticals Mood Support Capsules is an advanced supplement that combines St. John's Wort, Rhodiola Herb, Ashwagandha, Holy Basil, Vitamin C, and Black Pepper Extract for mood support in women and men. The Positeava All In One Supplement provides 4 full-dose products in one support complex containing a full St Johns Wart, Rhodiola Rosea Supplement, Ashwagandha Pills, and Holy Basil Leaf. This powerful herbal complex supplement can be a convenient alternative to various supplements such as Ashwagandha Gummies, Rhodiola Tincture, St Johns Wort Oil, St Johns Wort Tincture, and Tulsi Capsules. With vetted and trusted ingredients, this all-in-one supplement is proudly made in the USA in a registered and certified facility. Experience the benefits of this mood support supplement that can help you maintain a positive mood, reduce stress, and support overall well-being.

What We Like
All-natural ingredients
Improved mood and focus
Increased energy levels
Convenient combination of supplements
Good sleep quality
What We Don't Like
Large capsule size
Potential thyroid impact

Horbäach St John's Wort 300mg

CL3698
Horbäach St John's Wort 300mg Cover
Horbäach St John's Wort Capsules 300mg | 120 Count | Non-GMO, Gluten Free | Herbal Extract

Horbäach St John's Wort offers a powerful 300 mg of this traditional herbal extract in easy-to-take capsules. This advanced formula is designed for quick release, making it convenient for you to incorporate into your daily routine. With a focus on purity and potency, this product ensures that you receive a high-quality supplement. Additionally, it is formulated without gluten, wheat, yeast, milk, and artificial additives, providing peace of mind for those with dietary restrictions. You can trust that you are choosing a product that is laboratory tested and backed by a commitment to superior quality.

What We Like
Effective for mood swings
Helps reduce anxiety
Easy-to-read information
Good alternative to prescriptions
Reputable brand
What We Don't Like
Preference for other brands
#TOP 5

Toniiq St. John's Wort Capsules

Toniiq St. John's Wort Capsules Cover
1,000mg Ultra High Strength St. John's Wort Capsules (Non-GMO) - 7X Concentrated Extract - 0.3% Hypericin - Highly Purified and Bioavailable - 120 Capsules

Toniiq St. John's Wort Capsules contain 1,000mg of the highest quality St. John's wort powder in each serving, ethically sourced, grown and cultivated using an extraction process to ensure a 7:1 extract ratio. Each serving provides one of the highest concentrations of hypericin on the market, making this one of the most potent St. John's Wort supplements available. Produced in a GMP-certified and NSF-approved state-of-the-art manufacturing facility in the USA, each batch is tested for quality and purity both during and after manufacturing.

What We Like
Effective for mental health
High potency and quality
Improves mood and clarity
Good sleep quality
Rigorous quality standards
What We Don't Like
Possible hair loss reported
Brain fog in some users
#TOP 6

NOW Supplements St. John's Wort

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NOW Supplements St. John's Wort Cover
NOW Foods Supplements, St. John's Wort (Hypericum perforatum) 300 mg, Standardized Extract, 250 Veg Capsules

NOW Supplements St. John's Wort (Hypericum perforatum) is a standardized extract of 300 mg in vegan capsules. It has a long history of traditional use by herbalists dating back more than 2000 years. It is Non-GMO Project Verified, Kosher, Soy Free, Vegan/Vegetarian, Nut Free, Made without Gluten, Dairy Free, and Egg Free. Customers have reported it to be helpful with mood and depression, mental clarity, and hormone balance. It is recommended to take 1 capsule 3 times daily, preferably with food.

What We Like
Increased motivation and energy
Improved mood and mental clarity
Effective for depression symptoms
Affordable larger bottle option
Natural alternative to medications
What We Don't Like
Possible nerve sensitivity issues
Strong herbal odor

Zazzee Extra Strength St. John’s Wort 20:1 Extract

Zazzee Extra Strength St. John’s Wort 20:1 Extract Cover
Zazzee Extra Strength St. John’s Wort 20:1 Extract, 8000 mg Strength, 0.3% Hypericin, 150 Vegan Capsules, 5 Month Supply, Concentrated, Standardized 20X Extract, 100% Vegetarian, Non-GMO, All-Natural

Zazzee St. John’s Wort Extract offers exceptional value with 8000 mg strength per capsule and 150 capsules per bottle, providing a 5-month supply. The potent 20:1 extract with 0.3% Hypericin makes it one of the strongest dosages available. Hypericin, the beneficial compound, is standardized to a minimum of 0.3%, ensuring potent results. The product is natural, vegan, and non-GMO, free from harmful additives. Manufactured in the USA under stringent quality control, ensuring the best value for your health.

What We Like
Effective for sleep improvement
All-natural herbal remedy
Long-lasting supply per bottle
Easy to swallow capsules
Good value for the price
What We Don't Like
Delayed mood improvement noted

Nutricost St. John’s Wort Capsules (500mg) - Vegetarian and Non-GMO

NTC211101
Nutricost St. John’s Wort Capsules (500mg) - Vegetarian and Non-GMO Cover
Nutricost St John’s Wort Capsules (500mg) 120 Capsules - Vegetarian, Gluten Free and Non-GMO

Nutricost St. John’s Wort Capsules features 120 vegetarian capsules with 500mg of St. John's Wort per capsule. The product is non-GMO, gluten-free, soy-free, and vegetarian-friendly. Its only active ingredient is St. John's Wort, and it is made in a GMP compliant, FDA registered facility, which is third-party tested.

What We Like
Vegetarian-friendly
Non-GMO and gluten-free
Only active ingredient is St. John's Wort
#TOP 9

Eagle Shine Vitamins St. John's Wort Extract

Eagle Shine Vitamins St. John's Wort Extract Cover
DEAL SUPPLEMENT St. John's Wort Extract 1000mg - 240* Capsules, Retains 3000mcg Active Hypericins | Premium North American Source

Eagle Shine Vitamins St. John's Wort Extract offers naturally grown and harvested premium St John's Wort from North America. It provides a potent extract that comes from pure flower heads and provides a minimum standardized 0.3% active hypericin level per serving. Take it in the morning or right before bed to enjoy lasting mental calmness and relaxation. The important active ingredients work to promote mind and body clarity in any situation. Only 2 capsules per serving that will provide an extra strength 1,000mg dose and retains 3,000mcg of active hypericins. Enjoy 240 total capsules which equals up to a 120-day supply. It can be taken daily to recharge your mind and body outlook with natural herbal benefits. Made without gluten, dairy, eggs, peanuts, soy, wheat, yeast, and tree nuts.

What We Like
Effective mood support
Easy to swallow capsules
Long-term user satisfaction
Helps with anxiety relief
Convenient dosage options
What We Don't Like
Variable effectiveness across batches
Quality concerns for some users
#TOP 10

Healths Harmony St. John's Wort

1H-JVTK-OQKE
Healths Harmony St. John's Wort Cover
St. John's Wort - 120 Capsules (Non-GMO) Effective St Johns Wort Capsules - Powerful 900mcg Hypericin - Standardized Extract & Whole Herb Supplement - No Oil, Pills, Tea, Tincture - 500mg Per Capsule

Healths Harmony St. John's Wort is a natural mood helper that provides 900mcg of Hypericin in every serving. It comes in 120 capsules per bottle, with each capsule containing 500mg of St. John's Wort extract. It is manufactured in a GMP-certified facility in the USA using globally sourced ingredients. Customers have reported feeling a sense of calm and reduced anxiety after taking this product, and it has helped some quit nicotine with fewer side effects than other medications.

What We Like
Improves mood stability
Reduces anxiety symptoms
Fast-acting results
Supports lifestyle changes
Good quality product
What We Don't Like
Not effective for everyone
Requires consistent usage
Buying Guide Image

Find Your Fit: How to Buy the Right St. John's Wort Supplements

Introduction to St. John's Wort Supplements

St. John's Wort is a plant that has been used for centuries as a natural remedy for a variety of conditions, including anxiety and depression. In recent years, St. John's Wort has gained popularity as a dietary supplement for its potential mood-boosting effects. However, not all St. John's Wort supplements are created equal, so it's important to choose the right one for you.

Understand the Different Forms of St. John's Wort Supplements

St. John's Wort supplements come in a few different forms, including capsules, tablets, and tinctures. Capsules and tablets are the most common form of St. John's Wort supplements, and they typically contain a standardized extract of the plant. Tinctures, on the other hand, are liquid extracts of the plant that are taken by mouth.

Consider the Dosage and Potency of the Supplement

When choosing a St. John's Wort supplement, it's important to consider the dosage and potency. Most St. John's Wort supplements recommend a daily dosage of 300mg, but some may contain more or less. It's also important to look for a supplement that contains a standardized extract of the plant, as this ensures a consistent level of active ingredients in each dose.

Look for Quality and Purity

When it comes to dietary supplements, quality and purity are crucial. It's important to choose a St. John's Wort supplement that is made by a reputable manufacturer and has been tested for purity and potency. Look for supplements that have been certified by organizations such as the U.S. Pharmacopeia (USP), the National Sanitation Foundation (NSF), or ConsumerLab.com.

Consult with a Healthcare Professional

Before starting any new supplement, it's always a good idea to consult with a healthcare professional. This is especially important if you are taking any medications, as St. John's Wort can interact with certain drugs. Your healthcare provider can help you choose the right St. John's Wort supplement for you and provide guidance on the appropriate dosage.

Conclusion

In conclusion, choosing the right St. John's Wort supplement can be a daunting task. By understanding the different forms of the supplement, considering the dosage and potency, looking for quality and purity, and consulting with a healthcare professional, you can make an informed decision and find a supplement that is right for you.

Frequently Asked Questions (FAQs)

1. What is St John's wort supplement good for?

St. John's wort supplements are commonly used for various conditions, including depression, menopausal symptoms, ADHD, somatic symptom disorder, and obsessive-compulsive disorder. It may also have topical applications when applied to the skin.

2. Is it safe to take St John's wort everyday?

St. John's wort is generally considered safe when taken orally in doses up to 900 mg daily for up to 12 weeks. However, it can cause side effects such as diarrhea, dizziness, trouble sleeping, restlessness, and skin tingling.

3. Does St John's Wort cure anxiety?

While St. John's wort is known to help with mild-to-moderate depression symptoms, its effectiveness in treating anxiety has not been conclusively proven by researchers.

4. Who shouldn't take St John's wort?

St. John's wort may interact with medications used to treat depression or other mood disorders, such as tricyclic antidepressants, SSRIs, and MAOIs. It is important to consult with a healthcare professional before taking St. John's wort if you are on any of these medications.

5. What should you avoid when taking St John's wort?

When taking St. John's wort, it is important to avoid certain medications that may interact with it, including HIV/AIDS antiretroviral medications, immunosuppressants, anticoagulants, heart medications, anticonvulsants, SSRIs, triptans, and contraceptive drugs. Consult with a healthcare professional for specific guidance.

6. Is St John's Wort safer than SSRI?

Studies suggest that St. John's wort extract is equally effective as SSRIs in managing depression but may have superior safety. However, it is important to consult with a healthcare professional to determine the most appropriate treatment option for your specific condition.

7. Does St John's Wort calm you down?

Research indicates that St. John's wort works similarly to standard antidepressant medications by increasing the activity of brain chemicals like serotonin and noradrenaline, which play a role in regulating mood. However, its specific calming effects may vary from person to person.

Editor's Notes

During our st. john's wort supplement research, we found 24 st. john's wort supplement products and shortlisted 10 quality products. We collected and analyzed 104,542 customer reviews through our big data system to write the st. john's wort supplements list. We found that most customers choose st. john's wort supplements with an average price of $19.73.

The st. john's wort supplements are available for purchase. We have researched hundreds of brands and picked the top brands of st. john's wort supplements, including Nature's Bounty, Nature's Way, Clean Nutraceuticals, Toniiq, NOW Foods. The seller of top 1 product has received honest feedback from 385 consumers with an average rating of 4.7.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.

St. John's Wort Supplements Comparison Table

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Brand Nature's Bounty Nature's Way Clean Nutraceuticals Horbäach Toniiq NOW Foods Zazzee Nutricost DEAL SUPPLEMENT Healths Harmony
Item Form Capsules Capsule Capsule - Capsule Capsule Capsule capsules Capsule Capsule
Item Package Quantity 1 1 1 - 120 1 1 1 1 1
Package Information Bottle Bottle Bottle - Bottle Bottle Bottle Bottle Bottle Bottle
FTB Score
ftb score rating icon 9.9
ftb score rating icon 9.8
ftb score rating icon 9.6
ftb score rating icon 9.5
ftb score rating icon 9.5
ftb score rating icon 9.5
ftb score rating icon 9.5
ftb score rating icon 9.5
ftb score rating icon 9.5
ftb score rating icon 9.5
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